-
1
-
-
84889379110
-
Antitumour Antibiotics
-
(Missailidis, S. Ed.), John Wiley and Sons, Chichester, United Kingdom
-
Paz, M. M. (2008) Antitumour Antibiotics. In Anticancer Therapeutics (Missailidis, S., Ed.), pp 112-115, John Wiley and Sons, Chichester, United Kingdom.
-
(2008)
Anticancer Therapeutics
, pp. 112-115
-
-
Paz, M.M.1
-
2
-
-
77954034365
-
Use of mitomycin-C for phototherapeutic keratectomy and photorefractive keratectomy surgery
-
Shah, R. and Wilson, S. (2010) Use of mitomycin-C for phototherapeutic keratectomy and photorefractive keratectomy surgery Curr. Opin. Ophthalmol. 21, 269-273
-
(2010)
Curr. Opin. Ophthalmol.
, vol.21
, pp. 269-273
-
-
Shah, R.1
Wilson, S.2
-
3
-
-
33846114279
-
Mitomycin C and endoscopic sinus surgery: Where are we?
-
Tabaee, A., Brown, S. M., and Anand, V. K. (2007) Mitomycin C and endoscopic sinus surgery: Where are we? Curr. Opin. Otolaryngol. Head Neck Surg. 15, 40-43
-
(2007)
Curr. Opin. Otolaryngol. Head Neck Surg.
, vol.15
, pp. 40-43
-
-
Tabaee, A.1
Brown, S.M.2
Anand, V.K.3
-
4
-
-
80052144651
-
Evidence-based applications of mitomycin C in the nose
-
Karkos, P. D., Leong, S. C., Sastry, A., Assimakopoulos, A. D., and Swift, A. C. (2011) Evidence-based applications of mitomycin C in the nose Am. J. Otolaryngol. 32, 422-425
-
(2011)
Am. J. Otolaryngol.
, vol.32
, pp. 422-425
-
-
Karkos, P.D.1
Leong, S.C.2
Sastry, A.3
Assimakopoulos, A.D.4
Swift, A.C.5
-
5
-
-
0029360580
-
Mitomycin C: Small, fast and deadly (but very selective)
-
Tomasz, M. (1995) Mitomycin C: Small, fast and deadly (but very selective) Chem. Biol. 2, 575-579
-
(1995)
Chem. Biol.
, vol.2
, pp. 575-579
-
-
Tomasz, M.1
-
6
-
-
77953397142
-
Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity
-
Wang, Y., Gray, J. P., Mishin, V., Heck, D. E., Laskin, D. L., and Laskin, J. D. (2010) Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity Mol. Cancer Ther. 9, 1852-1863
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 1852-1863
-
-
Wang, Y.1
Gray, J.P.2
Mishin, V.3
Heck, D.E.4
Laskin, D.L.5
Laskin, J.D.6
-
7
-
-
0024278435
-
Reductive activation of mitomycin C
-
Hoey, B. M., Butler, J., and Swallow, A. J. (1988) Reductive activation of mitomycin C Biochemistry 27, 2608-2614
-
(1988)
Biochemistry
, vol.27
, pp. 2608-2614
-
-
Hoey, B.M.1
Butler, J.2
Swallow, A.J.3
-
8
-
-
0031278015
-
The mitomycin bioreductive antitumor agents: Cross-linking and alkylation of DNA as the molecular basis of their activity
-
Tomasz, M. and Palom, Y. (1997) The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity Pharmacol. Ther. 76, 73-87
-
(1997)
Pharmacol. Ther.
, vol.76
, pp. 73-87
-
-
Tomasz, M.1
Palom, Y.2
-
9
-
-
0036852787
-
Relative toxicities of DNA cross-links and monoadducts: New insights from studies of decarbamoyl mitomycin C and mitomycin C
-
Palom, Y., Suresh Kumar, G., Tang, L.-Q., Paz, M. M., Musser, S. M., Rockwell, S., and Tomasz, M. (2002) Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C Chem. Res. Toxicol. 15, 1398-1406
-
(2002)
Chem. Res. Toxicol.
, vol.15
, pp. 1398-1406
-
-
Palom, Y.1
Suresh Kumar, G.2
Tang, L.-Q.3
Paz, M.M.4
Musser, S.M.5
Rockwell, S.6
Tomasz, M.7
-
10
-
-
0028300426
-
Conjugation of glutathione and other thiols with bioreductively activated mitomycin C. Effect of thiols on the reductive activation rate
-
Sharma, M. and Tomasz, M. (1994) Conjugation of glutathione and other thiols with bioreductively activated mitomycin C. Effect of thiols on the reductive activation rate Chem. Res. Toxicol. 7, 390-400
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 390-400
-
-
Sharma, M.1
Tomasz, M.2
-
11
-
-
0028230878
-
Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct
-
Sharma, M., He, Q. Y., and Tomasz, M. (1994) Effects of glutathione on alkylation and cross-linking of DNA by mitomycin C. Isolation of a ternary glutathione-mitomycin-DNA adduct Chem. Res. Toxicol. 7, 401-407
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 401-407
-
-
Sharma, M.1
He, Q.Y.2
Tomasz, M.3
-
12
-
-
77953486102
-
Mitomycin C inhibits ribosomal RNA: A novel cytotoxic mechanism for bioreductive drugs
-
Snodgrass, R. G., Collier, A. C., Coon, A. E., and Pritsos, C. A. (2010) Mitomycin C inhibits ribosomal RNA: A novel cytotoxic mechanism for bioreductive drugs J. Biol. Chem. 285, 19068-19075
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19068-19075
-
-
Snodgrass, R.G.1
Collier, A.C.2
Coon, A.E.3
Pritsos, C.A.4
-
13
-
-
35848968258
-
Thioredoxin-like domains required for glucose regulatory protein 58 mediated reductive activation of mitomycin C leading to DNA cross-linking
-
Adikesavan, A. K. and Jaiswal, A. K. (2007) Thioredoxin-like domains required for glucose regulatory protein 58 mediated reductive activation of mitomycin C leading to DNA cross-linking Mol. Cancer Ther. 6, 2719-2727
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2719-2727
-
-
Adikesavan, A.K.1
Jaiswal, A.K.2
-
14
-
-
0141619285
-
Role of GRP58 in mitomycin C-induced DNA cross-linking
-
Celli, C. M. and Jaiswal, A. K. (2003) Role of GRP58 in mitomycin C-induced DNA cross-linking Cancer Res. 63, 6016-6025
-
(2003)
Cancer Res.
, vol.63
, pp. 6016-6025
-
-
Celli, C.M.1
Jaiswal, A.K.2
-
15
-
-
33746035307
-
Si RNA inhibition of GRP58 associated with decrease in mitomycin C-induced DNA cross-linking and cytotoxicity
-
Su, S., Adikesavan, A. K., and Jaiswal, A. K. (2006) Si RNA inhibition of GRP58 associated with decrease in mitomycin C-induced DNA cross-linking and cytotoxicity Chem.-Biol. Interact. 162, 81-87
-
(2006)
Chem.-Biol. Interact.
, vol.162
, pp. 81-87
-
-
Su, S.1
Adikesavan, A.K.2
Jaiswal, A.K.3
-
16
-
-
70350239993
-
Reductive activation of mitomycin C by thiols: Kinetics, mechanism, and biological implications
-
Paz, M. M. (2009) Reductive activation of mitomycin C by thiols: Kinetics, mechanism, and biological implications Chem. Res. Toxicol. 22, 1663-1668
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 1663-1668
-
-
Paz, M.M.1
-
17
-
-
77955686271
-
Cross-linking of dithiols by mitomycin C
-
Paz, M. M. (2010) Cross-linking of dithiols by mitomycin C Chem. Res. Toxicol. 23, 1384-1392
-
(2010)
Chem. Res. Toxicol.
, vol.23
, pp. 1384-1392
-
-
Paz, M.M.1
-
18
-
-
0034705133
-
Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
-
Zhong, L., Arnér, E. S. J., and Holmgren, A. (2000) Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence Proc. Natl. Acad. Sci. U.S.A. 97, 5854-5859
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 5854-5859
-
-
Zhong, L.1
Arnér, E.S.J.2
Holmgren, A.3
-
19
-
-
10744226522
-
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity
-
Davioud-Charvet, E., McLeish, M. J., Veine, D. M., Giegel, D., Arscott, L. D., Andricopulo, A. D., Becker, K., Müller, S., Schirmer, R. H., Williams, C. H., and Kenyon, G. L. (2003) Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity Biochemistry 42, 13319-13330
-
(2003)
Biochemistry
, vol.42
, pp. 13319-13330
-
-
Davioud-Charvet, E.1
McLeish, M.J.2
Veine, D.M.3
Giegel, D.4
Arscott, L.D.5
Andricopulo, A.D.6
Becker, K.7
Müller, S.8
Schirmer, R.H.9
Williams, C.H.10
Kenyon, G.L.11
-
20
-
-
77952311188
-
Thioredoxin and thioredoxin reductase: Current research with special reference to human disease
-
Holmgren, A. and Lu, J. (2010) Thioredoxin and thioredoxin reductase: Current research with special reference to human disease Biochem. Biophys. Res. Commun. 396, 120-124
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.396
, pp. 120-124
-
-
Holmgren, A.1
Lu, J.2
-
22
-
-
33744958179
-
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells
-
Yoo, M.-H., Xu, X.-M., Carlson, B. a, Gladyshev, V. N., and Hatfield, D. L. (2006) Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells J. Biol. Chem. 281, 13005-13008
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13005-13008
-
-
Yoo, M.-H.1
Xu, X.-M.2
Carlson, B.A.3
Gladyshev, V.N.4
Hatfield, D.L.5
-
23
-
-
68349128500
-
Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift
-
Rigobello, M. P., Gandin, V., Folda, A., Rundlöf, A.-K., Fernandes, A. P., Bindoli, A., Marzano, C., and Björnstedt, M. (2009) Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift Free Radical Biol. Med. 47, 710-721
-
(2009)
Free Radical Biol. Med.
, vol.47
, pp. 710-721
-
-
Rigobello, M.P.1
Gandin, V.2
Folda, A.3
Rundlöf, A.-K.4
Fernandes, A.P.5
Bindoli, A.6
Marzano, C.7
Björnstedt, M.8
-
24
-
-
0033536575
-
High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes
-
Arnér, E. S. J., Sarioglu, H., Lottspeich, F., Holmgren, A., and Böck, A. (1999) High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes J. Mol. Biol. 292, 1003-1016
-
(1999)
J. Mol. Biol.
, vol.292
, pp. 1003-1016
-
-
Arnér, E.S.J.1
Sarioglu, H.2
Lottspeich, F.3
Holmgren, A.4
Böck, A.5
-
25
-
-
0029187491
-
Thioredoxin and thioredoxin reductase
-
Holmgren, A. and Björnstedt, M. (1995) Thioredoxin and thioredoxin reductase Methods Enzymol. 252, 199-208
-
(1995)
Methods Enzymol.
, vol.252
, pp. 199-208
-
-
Holmgren, A.1
Björnstedt, M.2
-
26
-
-
73649151319
-
Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase
-
Kitz, R. and Wilson, I. B. (1962) Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase J. Biol. Chem. 237, 3245-3249
-
(1962)
J. Biol. Chem.
, vol.237
, pp. 3245-3249
-
-
Kitz, R.1
Wilson, I.B.2
-
27
-
-
0016612022
-
Structure and stereochemistry of some 1,2-disubstituted mitosenes from solvolysis of mitomycin C and Mitomycin A
-
Taylor, W. G. and Remers, W. A. (1975) Structure and stereochemistry of some 1,2-disubstituted mitosenes from solvolysis of mitomycin C and Mitomycin A J. Med. Chem. 18, 307-311
-
(1975)
J. Med. Chem.
, vol.18
, pp. 307-311
-
-
Taylor, W.G.1
Remers, W.A.2
-
28
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays J. Immunol. Methods 65, 55-63
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
29
-
-
0028930481
-
Mechanism-based enzyme inactivators
-
Silverman, R. B. (1995) Mechanism-based enzyme inactivators Methods Enzymol. 249, 240-283
-
(1995)
Methods Enzymol.
, vol.249
, pp. 240-283
-
-
Silverman, R.B.1
-
31
-
-
0035818011
-
Reductive activation of mitomycin A by thiols
-
Paz, M. M. and Tomasz, M. (2001) Reductive activation of mitomycin A by thiols Org. Lett. 3, 2789-2792
-
(2001)
Org. Lett.
, vol.3
, pp. 2789-2792
-
-
Paz, M.M.1
Tomasz, M.2
-
32
-
-
0021721159
-
Circular dichroism spectroscopy as a probe for the stereochemistry of aziridine cleavage reactions of mitomycin C. Application to adducts of mitomycin with DNA constituents
-
Tomasz, M., Jung, M., Verdine, G., and Nakanishi, K. (1984) Circular dichroism spectroscopy as a probe for the stereochemistry of aziridine cleavage reactions of mitomycin C. Application to adducts of mitomycin with DNA constituents J. Am. Chem. Soc. 106, 7367-7370
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 7367-7370
-
-
Tomasz, M.1
Jung, M.2
Verdine, G.3
Nakanishi, K.4
-
33
-
-
0026571917
-
Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds
-
Mau, B. L. and Powis, G. (1992) Mechanism-based inhibition of thioredoxin reductase by antitumor quinoid compounds Biochem. Pharmacol. 43, 1613-1620
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 1613-1620
-
-
Mau, B.L.1
Powis, G.2
-
35
-
-
0018567024
-
Formation of 1-ethylxanthyl-2,7-diaminomitosene and 1,10-diethylxanthyl- 2,7-diaminodecarbamoylmitosene in aqueous solution upon reduction-reoxidation of mitomycin C in the presence of potassium ethylxanthate
-
Hornemann, U., Keller, P. J., and Kozlowski, J. F. (1979) Formation of 1-ethylxanthyl-2,7-diaminomitosene and 1,10-diethylxanthyl-2,7- diaminodecarbamoylmitosene in aqueous solution upon reduction-reoxidation of mitomycin C in the presence of potassium ethylxanthate J. Am. Chem. Soc. 101, 7121-7124
-
(1979)
J. Am. Chem. Soc.
, vol.101
, pp. 7121-7124
-
-
Hornemann, U.1
Keller, P.J.2
Kozlowski, J.F.3
-
36
-
-
0021078732
-
Reactions of mitomycin C with potassium ethyl xanthate in neutral aqueous solution
-
Hornemann, U., Iguchi, K., Keller, P. J., Vu, H. M., Kozlowski, J. F., and Kohn, H. (1983) Reactions of mitomycin C with potassium ethyl xanthate in neutral aqueous solution J. Org. Chem. 48, 5026-5033
-
(1983)
J. Org. Chem.
, vol.48
, pp. 5026-5033
-
-
Hornemann, U.1
Iguchi, K.2
Keller, P.J.3
Vu, H.M.4
Kozlowski, J.F.5
Kohn, H.6
-
37
-
-
0035859927
-
Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme
-
Sandalova, T., Zhong, L., Lindqvist, Y., Holmgren, A., and Schneider, G. (2001) Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme Proc. Natl. Acad. Sci. U.S.A. 98, 9533-9538
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9533-9538
-
-
Sandalova, T.1
Zhong, L.2
Lindqvist, Y.3
Holmgren, A.4
Schneider, G.5
-
38
-
-
0027717389
-
PH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin
-
Siegel, D., Beall, H., Kasai, M., Arai, H., Gibson, N. W., and Ross, D. (1993) pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin Mol. Pharmacol. 44, 1128-1134
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 1128-1134
-
-
Siegel, D.1
Beall, H.2
Kasai, M.3
Arai, H.4
Gibson, N.W.5
Ross, D.6
-
39
-
-
27144469008
-
Selenocysteine in proteins-properties and biotechnological use
-
Johansson, L., Gafvelin, G., and Arnér, E. S. J. (2005) Selenocysteine in proteins-properties and biotechnological use Biochim. Biophys. Acta 1726, 1-13
-
(2005)
Biochim. Biophys. Acta
, vol.1726
, pp. 1-13
-
-
Johansson, L.1
Gafvelin, G.2
Arnér, E.S.J.3
-
40
-
-
0343131152
-
Use of differential second-derivative UV and FTIR spectroscopy in structural studies of multichromophoric compounds
-
Verdine, G. L. and Nakanishi, K. (1985) Use of differential second-derivative UV and FTIR spectroscopy in structural studies of multichromophoric compounds J. Am. Chem. Soc. 107, 6118-6120
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 6118-6120
-
-
Verdine, G.L.1
Nakanishi, K.2
-
41
-
-
0001229584
-
2,7-Diaminomitosene, a Monofunctional Mitomycin C Derivative, Alkylates DNA in the Major Groove. Structure and Base-Sequence Specificity of the DNA Adduct and Mechanism of the Alkylation
-
Suresh Kumar, G., Musser, S. M., Cummings, J., Tomasz, M., and Kumar, G. S. (1996) 2,7-Diaminomitosene, a Monofunctional Mitomycin C Derivative, Alkylates DNA in the Major Groove. Structure and Base-Sequence Specificity of the DNA Adduct and Mechanism of the Alkylation J. Am. Chem. Soc. 118, 9209-9217
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 9209-9217
-
-
Suresh Kumar, G.1
Musser, S.M.2
Cummings, J.3
Tomasz, M.4
Kumar, G.S.5
-
42
-
-
0000797824
-
Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells
-
Palom, Y., Belcourt, M. F., Musser, S. M., Sartorelli, A. C., Rockwell, S., and Tomasz, M. (2000) Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells Chem. Res. Toxicol. 13, 479-488
-
(2000)
Chem. Res. Toxicol.
, vol.13
, pp. 479-488
-
-
Palom, Y.1
Belcourt, M.F.2
Musser, S.M.3
Sartorelli, A.C.4
Rockwell, S.5
Tomasz, M.6
-
43
-
-
0031594193
-
A mitomycin-N6-deoxyadenosine adduct isolated from DNA
-
Palom, Y., Lipman, R., Musser, S. M., and Tomasz, M. (1998) A mitomycin-N6-deoxyadenosine adduct isolated from DNA Chem. Res. Toxicol. 11, 203-210
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 203-210
-
-
Palom, Y.1
Lipman, R.2
Musser, S.M.3
Tomasz, M.4
-
44
-
-
0023123806
-
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
-
Tomasz, M., Lipman, R., Chowdary, D., Pawlak, J., Verdine, G. L., and Nakanishi, K. (1987) Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA Science 235, 1204-1208
-
(1987)
Science
, vol.235
, pp. 1204-1208
-
-
Tomasz, M.1
Lipman, R.2
Chowdary, D.3
Pawlak, J.4
Verdine, G.L.5
Nakanishi, K.6
-
45
-
-
0030726348
-
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C
-
Suresh Kumar, G., Lipman, R., Cummings, J., and Tomasz, M. (1997) Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C Biochemistry 36, 14128-14136
-
(1997)
Biochemistry
, vol.36
, pp. 14128-14136
-
-
Suresh Kumar, G.1
Lipman, R.2
Cummings, J.3
Tomasz, M.4
-
46
-
-
67649847825
-
Potent activity of indolequinones against human pancreatic cancer: Identification of thioredoxin reductase as a potential target
-
Yan, C., Shieh, B., Reigan, P., Zhang, Z., Colucci, M. A., Chilloux, A., Newsome, J. J., Siegel, D., Chan, D., Moody, C. J., and Ross, D. (2009) Potent activity of indolequinones against human pancreatic cancer: Identification of thioredoxin reductase as a potential target Mol. Pharmacol. 76, 163-172
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 163-172
-
-
Yan, C.1
Shieh, B.2
Reigan, P.3
Zhang, Z.4
Colucci, M.A.5
Chilloux, A.6
Newsome, J.J.7
Siegel, D.8
Chan, D.9
Moody, C.J.10
Ross, D.11
-
47
-
-
78651117965
-
A molecular mechanism of mitomycin action: Linking of complementary DNA strands
-
Iyer, V. N. and Szybalski, W. (1963) A molecular mechanism of mitomycin action: linking of complementary DNA strands Proc. Natl. Acad. Sci. U.S.A. 50, 355-362
-
(1963)
Proc. Natl. Acad. Sci. U.S.A.
, vol.50
, pp. 355-362
-
-
Iyer, V.N.1
Szybalski, W.2
-
48
-
-
0002548343
-
Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA
-
Iyer, V. N. and Szybalski, W. (1964) Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA Science 145, 55-58
-
(1964)
Science
, vol.145
, pp. 55-58
-
-
Iyer, V.N.1
Szybalski, W.2
-
49
-
-
39749177838
-
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
-
Yoo, M.-H., Xu, X.-M., Carlson, B. A., Patterson, A. D., Gladyshev, V. N., and Hatfield, D. L. (2007) Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication PloS One 2, e1112
-
(2007)
PloS One
, vol.2
, pp. 1112
-
-
Yoo, M.-H.1
Xu, X.-M.2
Carlson, B.A.3
Patterson, A.D.4
Gladyshev, V.N.5
Hatfield, D.L.6
-
50
-
-
36749022747
-
Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy
-
Pennington, J. D., Jacobs, K. M., Sun, L., Bar-Sela, G., Mishra, M., and Gius, D. (2007) Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy Curr. Pharm. Des. 13, 3368-3377
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 3368-3377
-
-
Pennington, J.D.1
Jacobs, K.M.2
Sun, L.3
Bar-Sela, G.4
Mishra, M.5
Gius, D.6
-
51
-
-
24644441050
-
The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy
-
Biaglow, J. E. and Miller, R. A. (2005) The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy Cancer Biol. Ther. 4, 6-13
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 6-13
-
-
Biaglow, J.E.1
Miller, R.A.2
-
52
-
-
84856837495
-
HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia
-
Naranjo-Suarez, S., Carlson, B. A., Tsuji, P. A., Yoo, M.-H., Gladyshev, V. N., and Hatfield, D. L. (2012) HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia PLoS One 7, e30470
-
(2012)
PLoS One
, vol.7
, pp. 30470
-
-
Naranjo-Suarez, S.1
Carlson, B.A.2
Tsuji, P.A.3
Yoo, M.-H.4
Gladyshev, V.N.5
Hatfield, D.L.6
-
53
-
-
0023233931
-
Generation of photoemissive species by mitomycin C redox cycling in rat liver microsomes
-
Napetschnig, S. and Sies, H. (1987) Generation of photoemissive species by mitomycin C redox cycling in rat liver microsomes Biochem. Pharmacol. 36, 1617-21
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 1617-1621
-
-
Napetschnig, S.1
Sies, H.2
-
54
-
-
0020385188
-
Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase
-
Komiyama, T., Kikuchi, T., and Sugiura, Y. (1982) Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase Biochem. Pharmacol. 31, 3651-3656
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 3651-3656
-
-
Komiyama, T.1
Kikuchi, T.2
Sugiura, Y.3
-
55
-
-
0029051872
-
Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide
-
Yokomizo, A., Ono, M., Nanri, H., Makino, Y., Ohga, T., Wada, M., Okamoto, T., Yodoi, J., Kuwano, M., and Kohno, K. (1995) Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide Cancer Res. 55, 4293-4296
-
(1995)
Cancer Res.
, vol.55
, pp. 4293-4296
-
-
Yokomizo, A.1
Ono, M.2
Nanri, H.3
Makino, Y.4
Ohga, T.5
Wada, M.6
Okamoto, T.7
Yodoi, J.8
Kuwano, M.9
Kohno, K.10
-
56
-
-
67349120863
-
Focus on mammalian thioredoxin reductases-Important selenoproteins with versatile functions
-
Arnér, E. S. J. (2009) Focus on mammalian thioredoxin reductases-Important selenoproteins with versatile functions Biochim. Biophys. Acta 1790, 495-526
-
(2009)
Biochim. Biophys. Acta
, vol.1790
, pp. 495-526
-
-
Arnér, E.S.J.1
-
57
-
-
0035890009
-
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
-
Arnér, E. S. J., Nakamura, H., Sasada, T., Yodoi, J., Holmgren, A., and Spyrou, G. (2001) Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex Free Radical Biol. Med. 31, 1170-1178
-
(2001)
Free Radical Biol. Med.
, vol.31
, pp. 1170-1178
-
-
Arnér, E.S.J.1
Nakamura, H.2
Sasada, T.3
Yodoi, J.4
Holmgren, A.5
Spyrou, G.6
-
58
-
-
23444435104
-
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
-
Witte, A.-B., Anestål, K., Jerremalm, E., Ehrsson, H., and Arnér, E. S. J. (2005) Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds Free Radical Biol. Med. 39, 696-703
-
(2005)
Free Radical Biol. Med.
, vol.39
, pp. 696-703
-
-
Witte, A.-B.1
Anestål, K.2
Jerremalm, E.3
Ehrsson, H.4
Arnér, E.S.J.5
-
59
-
-
37549006456
-
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy
-
Wang, X., Zhang, J., and Xu, T. (2008) Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy Eur. J. Pharmacol. 579, 66-73
-
(2008)
Eur. J. Pharmacol.
, vol.579
, pp. 66-73
-
-
Wang, X.1
Zhang, J.2
Xu, T.3
-
60
-
-
1642535437
-
Interactions of quinones with thioredoxin reductase: A challenge to the antioxidant role of the mammalian selenoprotein
-
Cenas, N., Nivinskas, H., Anusevicius, Z., Sarlauskas, J., Lederer, F., and Arnér, E. S. J. (2004) Interactions of quinones with thioredoxin reductase: a challenge to the antioxidant role of the mammalian selenoprotein J. Biol. Chem. 279, 2583-2592
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2583-2592
-
-
Cenas, N.1
Nivinskas, H.2
Anusevicius, Z.3
Sarlauskas, J.4
Lederer, F.5
Arnér, E.S.J.6
-
61
-
-
33751181030
-
On the potential of thioredoxin reductase inhibitors for cancer therapy
-
Urig, S. and Becker, K. (2006) On the potential of thioredoxin reductase inhibitors for cancer therapy Sem. Cancer Biol. 16, 452-465
-
(2006)
Sem. Cancer Biol.
, vol.16
, pp. 452-465
-
-
Urig, S.1
Becker, K.2
-
62
-
-
33746430147
-
Thioredoxin reductase as a novel molecular target for cancer therapy
-
Nguyen, P., Awwad, R. T., Smart, D. D. K., Spitz, D. R., and Gius, D. (2006) Thioredoxin reductase as a novel molecular target for cancer therapy Cancer Lett. 236, 164-174
-
(2006)
Cancer Lett.
, vol.236
, pp. 164-174
-
-
Nguyen, P.1
Awwad, R.T.2
Smart, D.D.K.3
Spitz, D.R.4
Gius, D.5
-
63
-
-
70350140433
-
Synthesis of the First Selenium-Containing Acyclic Nucleosides and Anomeric Spironucleosides from Carbohydrate Precursors
-
Maza, S., López, Ó., Martos, S., Maya, I., and Fernández-Bolaños, J. G. (2009) Synthesis of the First Selenium-Containing Acyclic Nucleosides and Anomeric Spironucleosides from Carbohydrate Precursors Eur. J. Org. Chem. 2009, 5239-5246
-
(2009)
Eur. J. Org. Chem.
, vol.2009
, pp. 5239-5246
-
-
Maza, S.1
López, Ó.2
Martos, S.3
Maya, I.4
Fernández- Bolaños, J.G.5
-
64
-
-
77649261685
-
Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer
-
Selenius, M., Rundlöf, A.-K., Olm, E., Fernandes, A. P., and Björnstedt, M. (2010) Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer Antioxid. Redox Signaling 12, 867-880
-
(2010)
Antioxid. Redox Signaling
, vol.12
, pp. 867-880
-
-
Selenius, M.1
Rundlöf, A.-K.2
Olm, E.3
Fernandes, A.P.4
Björnstedt, M.5
-
65
-
-
41549108420
-
From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage
-
Petrelli, A. and Giordano, S. (2008) From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage Curr. Med. Chem. 15, 422-432
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 422-432
-
-
Petrelli, A.1
Giordano, S.2
-
66
-
-
27144443099
-
Drug discovery: Playing dirty
-
Frantz, S. (2005) Drug discovery: Playing dirty Nature 437, 942-943
-
(2005)
Nature
, vol.437
, pp. 942-943
-
-
Frantz, S.1
-
67
-
-
27544446579
-
Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
-
Mencher, S. K. and Wang, L. G. (2005) Promiscuous drugs compared to selective drugs (promiscuity can be a virtue) BMC Clin. Pharmacol. 5, 3
-
(2005)
BMC Clin. Pharmacol.
, vol.5
, pp. 3
-
-
Mencher, S.K.1
Wang, L.G.2
-
68
-
-
26844501695
-
Anticancer therapeutics: "addictive" targets, multi-targeted drugs, new drug combinations
-
Broxterman, H. J. and Georgopapadakou, N. H. (2005) Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations Drug Resist. Updates 8, 183-197
-
(2005)
Drug Resist. Updates
, vol.8
, pp. 183-197
-
-
Broxterman, H.J.1
Georgopapadakou, N.H.2
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