Mitomycin C inhibits ribosomal RNA: A novel cytotoxic mechanism for bioreductive drugs

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19068-19075

  Snodgrass, Ryan G ^a   Collier, Abby C ^a   Coon, Amy E ^a   Pritsos, Chris A ^a  

^a UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

18S RRNA; BASE LINE; BINDING ASSAYS; BIOLOGICAL REDUCTIONS; BIOREDUCTIVE DRUGS; CELL-FREE SYSTEM; CHEMOTHERAPEUTIC AGENTS; CONCENTRATION-DEPENDENT; CYTOTOXIC MECHANISMS; DE NOVO SYNTHESIS; DNA ADDUCTS; FUNCTIONAL ASSAYS; HYPOXIC CONDITION; IN-VITRO; IN-VIVO; MITOCHONDRIAL GENES; MITOMYCIN C; MRNA EXPRESSION; NATURAL COMPOUNDS; NUCLEAR DNA; PRIMARY MECHANISM; PROTEIN PRODUCTION; PROTEIN TRANSLATION; REVERSE TRANSCRIPTION; RIBOSOMAL RNA; SHIFT-AND; TRANSCRIPT LEVEL; UNTREATED CONTROL;

CELL DEATH; DNA; GELS; GENES; NUCLEIC ACIDS; PLANTS (BOTANY); PROTEINS; RNA; SYNTHESIS (CHEMICAL); TOXICITY;

TRANSCRIPTION;

CELL NUCLEUS DNA; LUCIFERASE; MITOCHONDRIAL PROTEIN; MITOMYCIN C; NUCLEIC ACID; RIBOSOME RNA; RNA 18S;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL FREE SYSTEM; CELL NUCLEUS; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; RNA TRANSLATION;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL LINE, TUMOR; CELL-FREE SYSTEM; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOMYCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, RIBOSOMAL; RNA, RIBOSOMAL, 18S; TIME FACTORS;

EID: 77953486102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.040477     Document Type: Article

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