2,7-Diaminomitosene, a monofunctional mitomycin C derivative, alkylates DNA in the major groove. Structure and base-sequence specificity of the DNA adduct and mechanism of the alkylation

Journal of the American Chemical Society

Volumn 118, Issue 39, 1996, Pages 9209-9217

  Kumar, Gopinatha Suresh ^a,d   Musser, Steven M ^b   Cummings, Jeffrey ^c   Tomasz, Maria ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2,7 DIAMINOMITOSENE; MITOMYCIN C DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DNA ALKYLATION; DNA BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; REACTION ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0001229584     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9607401     Document Type: Article

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