-
1
-
-
0037507286
-
Rapid induction of cell death by selenium compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
-
Anestal K., and Arnér E.S.J. Rapid induction of cell death by selenium compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. J. Biol. Chem. 278 (2003) 15966-15972
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15966-15972
-
-
Anestal, K.1
Arnér, E.S.J.2
-
2
-
-
36249026968
-
Selenium compromised thioredoxin reductase-derived apoptotic proteins (SecTRAPs): potent killers of cancer cells
-
Meeting Abstract
-
Arnér E.S.J. Selenium compromised thioredoxin reductase-derived apoptotic proteins (SecTRAPs): potent killers of cancer cells. Free Radic. Res. 40 Suppl. 1 (2006) S51-S51 Meeting Abstract
-
(2006)
Free Radic. Res.
, vol.40
, Issue.SUPPL. 1
-
-
Arnér, E.S.J.1
-
3
-
-
24644441050
-
The thioredoxin reductase/thioredoxin system - novel redox targets for cancer therapy
-
Biaglow J.E., and Miller R.A. The thioredoxin reductase/thioredoxin system - novel redox targets for cancer therapy. Cancer Biol. Ther. 4 (2005) 6-13
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 6-13
-
-
Biaglow, J.E.1
Miller, R.A.2
-
4
-
-
33644848640
-
Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite
-
Bruggemann S.K., Radike K., Braasch K., Hinrichs J., Kisro J., Hagenah W., Peters S.O., and Wagner T. Chloroacetaldehyde: mode of antitumor action of the ifosfamide metabolite. Cancer Chemother. Pharmacol. 57 (2006) 349-356
-
(2006)
Cancer Chemother. Pharmacol.
, vol.57
, pp. 349-356
-
-
Bruggemann, S.K.1
Radike, K.2
Braasch, K.3
Hinrichs, J.4
Kisro, J.5
Hagenah, W.6
Peters, S.O.7
Wagner, T.8
-
5
-
-
33646806762
-
Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells
-
Cenas N., Prast S., Nivinskas H., Sarlauskas J., and Arnér E.S.J. Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells. J. Biol. Chem. 281 (2006) 5593-5603
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5593-5603
-
-
Cenas, N.1
Prast, S.2
Nivinskas, H.3
Sarlauskas, J.4
Arnér, E.S.J.5
-
7
-
-
0026014796
-
Ifosfamide/MESNA. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer
-
Dechant K.L., Brogden R.N., Pilkington T., and Faulds D. Ifosfamide/MESNA. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs 42 (1991) 428-467
-
(1991)
Drugs
, vol.42
, pp. 428-467
-
-
Dechant, K.L.1
Brogden, R.N.2
Pilkington, T.3
Faulds, D.4
-
9
-
-
21644477778
-
Thioredoxin reductase is irreversibly modified by curcumin - a novel molecular mechanism for its anticancer activity
-
Fang J.G., Lu J., and Holmgren A. Thioredoxin reductase is irreversibly modified by curcumin - a novel molecular mechanism for its anticancer activity. J. Biol. Chem. 280 (2005) 25284-25290
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25284-25290
-
-
Fang, J.G.1
Lu, J.2
Holmgren, A.3
-
10
-
-
0242288548
-
Pharmacology of ifosfamide
-
Furlanut M., and Franceschi L. Pharmacology of ifosfamide. Oncology 65 Suppl 2 (2003) 2-6
-
(2003)
Oncology
, vol.65
, Issue.SUPPL. 2
, pp. 2-6
-
-
Furlanut, M.1
Franceschi, L.2
-
11
-
-
0035155873
-
Thioredoxin reductase activity in rat liver is not affected by supranutritional levels of monomethylated selenium in vivo and is inhibited only by high levels of selenium in vitro
-
Ganther H., and Ip C. Thioredoxin reductase activity in rat liver is not affected by supranutritional levels of monomethylated selenium in vivo and is inhibited only by high levels of selenium in vitro. J. Nutr. 131 (2001) 301-304
-
(2001)
J. Nutr.
, vol.131
, pp. 301-304
-
-
Ganther, H.1
Ip, C.2
-
12
-
-
0016275313
-
Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation
-
Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 7130-7139
-
-
Habig, W.H.1
Pabst, M.J.2
Jakoby, W.B.3
-
13
-
-
0029187491
-
Thioredoxin and thioredoxin reductase
-
Holmgren A., and Bjǒrnstedt M. Thioredoxin and thioredoxin reductase. Methods Enzymol. 252 (1995) 199-208
-
(1995)
Methods Enzymol.
, vol.252
, pp. 199-208
-
-
Holmgren, A.1
Bjǒrnstedt, M.2
-
14
-
-
33748683582
-
Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation
-
Korkmaz A., Yaren H., Topal T., and Oter S. Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Arch. Toxicol. 80 (2006) 662-670
-
(2006)
Arch. Toxicol.
, vol.80
, pp. 662-670
-
-
Korkmaz, A.1
Yaren, H.2
Topal, T.3
Oter, S.4
-
15
-
-
0026611465
-
Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation
-
Lee S.M., Crowther D., Scarffe J.H., Dougal M., Elder R.H., Rafferty J.A., and Margison G.P. Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation. Br. J. Cancer 66 (1992) 331-336
-
(1992)
Br. J. Cancer
, vol.66
, pp. 331-336
-
-
Lee, S.M.1
Crowther, D.2
Scarffe, J.H.3
Dougal, M.4
Elder, R.H.5
Rafferty, J.A.6
Margison, G.P.7
-
16
-
-
31344450220
-
Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy
-
Lerch S., Kupfer A., Idle J.R., and Lauterburg B.H. Cerebral formation in situ of S-carboxymethylcysteine after ifosfamide administration to mice: a further clue to the mechanism of ifosfamide encephalopathy. Toxicol. Lett. 161 (2006) 188-194
-
(2006)
Toxicol. Lett.
, vol.161
, pp. 188-194
-
-
Lerch, S.1
Kupfer, A.2
Idle, J.R.3
Lauterburg, B.H.4
-
17
-
-
0024334410
-
The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo
-
Lind M.J., McGown A.T., Hadfield J.A., Thatcher N., Crowther D., and Fox B.W. The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo. Biochem. Pharmacol. 36 (1989) 1835-1840
-
(1989)
Biochem. Pharmacol.
, vol.36
, pp. 1835-1840
-
-
Lind, M.J.1
McGown, A.T.2
Hadfield, J.A.3
Thatcher, N.4
Crowther, D.5
Fox, B.W.6
-
18
-
-
34547644483
-
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
-
Lu J., Chew E.H., and Holmgren A. Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 12288-12293
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 12288-12293
-
-
Lu, J.1
Chew, E.H.2
Holmgren, A.3
-
19
-
-
0028094936
-
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by MESNA
-
Meier T., Allenbacher A., Mueller E., Multhoff G., Botzler C., Wiesnet M., and Issels R. Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by MESNA. Anticancer Drugs 5 (1994) 405-409
-
(1994)
Anticancer Drugs
, vol.5
, pp. 405-409
-
-
Meier, T.1
Allenbacher, A.2
Mueller, E.3
Multhoff, G.4
Botzler, C.5
Wiesnet, M.6
Issels, R.7
-
20
-
-
0026100542
-
Clinical pharmacokinetics of cyclophosphamide
-
Moore M.J. Clinical pharmacokinetics of cyclophosphamide. Clin. Pharmacokinet. 20 (1991) 194-208
-
(1991)
Clin. Pharmacokinet.
, vol.20
, pp. 194-208
-
-
Moore, M.J.1
-
22
-
-
33746430147
-
Thioredoxin reductase as a novel molecular target for cancer therapy
-
Nguyena P., Awwada R.T., Smarta D.D.K., Spitzb D.R., and Giusa D. Thioredoxin reductase as a novel molecular target for cancer therapy. Cancer Lett. 236 (2006) 164-174
-
(2006)
Cancer Lett.
, vol.236
, pp. 164-174
-
-
Nguyena, P.1
Awwada, R.T.2
Smarta, D.D.K.3
Spitzb, D.R.4
Giusa, D.5
-
23
-
-
0035584857
-
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
-
Nordberg J., and Arnér E.S.J. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 31 (2001) 1287-1312
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 1287-1312
-
-
Nordberg, J.1
Arnér, E.S.J.2
-
24
-
-
0036249958
-
Induction of thioredoxin reductase gene expression by peroxynitrite in human umbilical vein endothelial cells
-
Park Y.S., Fujiwara N., Koh Y.H., Miyamoto Y., Suzuki K., Honke K., and Taniguchi N. Induction of thioredoxin reductase gene expression by peroxynitrite in human umbilical vein endothelial cells. Biol. Chem. 383 (2002) 683-691
-
(2002)
Biol. Chem.
, vol.383
, pp. 683-691
-
-
Park, Y.S.1
Fujiwara, N.2
Koh, Y.H.3
Miyamoto, Y.4
Suzuki, K.5
Honke, K.6
Taniguchi, N.7
-
25
-
-
12344329415
-
Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells
-
Park Y.S., Misonou Y., Fujiwar N., Takahashi M., Miyamoto Y., Koh Y.M., Suzuki K., and Taniguch N. Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 327 (2005) 1058-1065
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.327
, pp. 1058-1065
-
-
Park, Y.S.1
Misonou, Y.2
Fujiwar, N.3
Takahashi, M.4
Miyamoto, Y.5
Koh, Y.M.6
Suzuki, K.7
Taniguch, N.8
-
26
-
-
0015918166
-
Selenium: biochemical role as a component of glutathione peroxidase
-
Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., and Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 179 (1973) 588-590
-
(1973)
Science
, vol.179
, pp. 588-590
-
-
Rotruck, J.T.1
Pope, A.L.2
Ganther, H.E.3
Swanson, A.B.4
Hafeman, D.G.5
Hoekstra, W.G.6
-
27
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
Saitoh M., Nishitoh H., Fujii M., Takeda K., Tobiume K., Sawada Y., Kawabata M., Miyazono K., and Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17 (1998) 2596-2606
-
(1998)
EMBO J.
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
Kawabata, M.7
Miyazono, K.8
Ichijo, H.9
-
28
-
-
18244386712
-
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2
-
Sakurai A., Nishimoto M., Himeno S., Imura N., Tsujimoto M., Kunimoto M., and Hara S. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J. Cell. Physiol. 203 (2005) 529-537
-
(2005)
J. Cell. Physiol.
, vol.203
, pp. 529-537
-
-
Sakurai, A.1
Nishimoto, M.2
Himeno, S.3
Imura, N.4
Tsujimoto, M.5
Kunimoto, M.6
Hara, S.7
-
29
-
-
0032840612
-
Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II)
-
Sasada T., Nakamura H., Ueda S., Sato N., Kitaoka Y., Gon Y., Takabayashi A., Spyrou G., Holmgren A., and Yodoi J. Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II). Free Radic. Biol. Med. 27 (1999) 504-514
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 504-514
-
-
Sasada, T.1
Nakamura, H.2
Ueda, S.3
Sato, N.4
Kitaoka, Y.5
Gon, Y.6
Takabayashi, A.7
Spyrou, G.8
Holmgren, A.9
Yodoi, J.10
-
30
-
-
0033058729
-
Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells
-
Springate J., Chan K., Lu H., Davies S., and Taub M. Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells. In Vitro Cell. Dev. Biol., Anim. 35 (1999) 314-317
-
(1999)
In Vitro Cell. Dev. Biol., Anim.
, vol.35
, pp. 314-317
-
-
Springate, J.1
Chan, K.2
Lu, H.3
Davies, S.4
Taub, M.5
-
31
-
-
0023952554
-
A simple method for clinical assay of superoxide dismutase
-
Sun Y., Larry W., Oberley W., and Ying L. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34 (1988) 497-500
-
(1988)
Clin. Chem.
, vol.34
, pp. 497-500
-
-
Sun, Y.1
Larry, W.2
Oberley, W.3
Ying, L.4
-
32
-
-
0028183382
-
Ifosfamide clinical pharmacokinetics
-
Wagner T. Ifosfamide clinical pharmacokinetics. Clin. Pharmacokinet. 26 (1994) 439-456
-
(1994)
Clin. Pharmacokinet.
, vol.26
, pp. 439-456
-
-
Wagner, T.1
-
33
-
-
33845914554
-
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo
-
Wang X., Zhang J., and Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol. Appl. Pharmacol. 218 (2007) 88-95
-
(2007)
Toxicol. Appl. Pharmacol.
, vol.218
, pp. 88-95
-
-
Wang, X.1
Zhang, J.2
Xu, T.3
-
34
-
-
23444435104
-
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
-
Witte A.B., Anestal K., Jerremalm E., Ehrsson H., and Arnér E.S.J. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free Radic. Biol. Med. 39 (2005) 696-703
-
(2005)
Free Radic. Biol. Med.
, vol.39
, pp. 696-703
-
-
Witte, A.B.1
Anestal, K.2
Jerremalm, E.3
Ehrsson, H.4
Arnér, E.S.J.5
-
35
-
-
4544233514
-
Effect of acrolein and glutathione depleting agents on thioredoxin
-
Yang X.M., Wu X.L., Choi Y.E., Kern J.C., and Kehrer J.P. Effect of acrolein and glutathione depleting agents on thioredoxin. Toxicology 204 (2004) 209-218
-
(2004)
Toxicology
, vol.204
, pp. 209-218
-
-
Yang, X.M.1
Wu, X.L.2
Choi, Y.E.3
Kern, J.C.4
Kehrer, J.P.5
-
36
-
-
33744958179
-
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells
-
Yoo M.H., Xu X.M., Carlson B.A., Gladyshev V.N., and Hatfield D.L. Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J. Biol. Chem. 281 (2006) 13005-13008
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13005-13008
-
-
Yoo, M.H.1
Xu, X.M.2
Carlson, B.A.3
Gladyshev, V.N.4
Hatfield, D.L.5
-
37
-
-
0038771122
-
Comparative toxicity of ifosfamide metabolites and protective effect of MESNA and amifostine in cultured renal tubule cells
-
Zaki E., Springate J., and Taub M. Comparative toxicity of ifosfamide metabolites and protective effect of MESNA and amifostine in cultured renal tubule cells. Toxicol. In Vitro 17 (2003) 397-402
-
(2003)
Toxicol. In Vitro
, vol.17
, pp. 397-402
-
-
Zaki, E.1
Springate, J.2
Taub, M.3
-
38
-
-
30444441659
-
Metabolism and transport of oxazaphosphorines and the clinical implications
-
Zhang J., Tian Q., Chan Y.S., Li S.C., Zhou S., Duan W., and Zhu Y.Z. Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metab. Rev. 37 (2005) 611-703
-
(2005)
Drug Metab. Rev.
, vol.37
, pp. 611-703
-
-
Zhang, J.1
Tian, Q.2
Chan, Y.S.3
Li, S.C.4
Zhou, S.5
Duan, W.6
Zhu, Y.Z.7
|