Relative toxicities of DNA cross-links and monoadducts: New insights from studies of decarbamoyl mitomycin C and mitomycin C

Chemical Research in Toxicology

Volumn 15, Issue 11, 2002, Pages 1398-1406

  Palom, Yolanda ^a,b   Suresh Kumar, Gopinatha ^a,c   Tang, Li Qian ^d,e   Paz, Manuel M ^a,f   Musser, Steven M ^g   Rockwell, Sara ^d   Tomasz, Maria ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b Indian Institute of Chemical Biology ^*  (United States)

^c INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^g CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; DECARBAMOYLMITOMYCIN C; DNA; MITOMYCIN C; MITOMYCIN C DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG; 10-DECARBAMOYLMITOMYCIN C; 2,7 DIAMINOMITOSENE; 2,7-DIAMINOMITOSENE; ANTINEOPLASTIC ANTIBIOTIC; CROSS LINKING REAGENT; MITOMYCIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CHO CELL; CYTOTOXICITY; DNA ADDUCT; DNA ALKYLATION; DNA CROSS LINKING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; NONHUMAN; REDUCTION; STEREOISOMERISM; ULTRAVIOLET RADIATION; ALKYLATION; ANIMAL; ANOXIA; BREAST TUMOR; CATTLE; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; THYMUS; ULTRASTRUCTURE;

ANIMALIA;

ALKYLATION; ANIMALS; ANOXIA; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; BREAST NEOPLASMS; CATTLE; CELL SURVIVAL; CROSS-LINKING REAGENTS; DNA ADDUCTS; DNA DAMAGE; MICE; MITOMYCIN; MITOMYCINS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND; TUMOR CELLS, CULTURED;

EID: 0036852787     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020044g     Document Type: Article

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