Angiogenesis

Cold Spring Harbor Perspectives in Biology

Volumn 3, Issue 8, 2011, Pages 1-19

  Senger, Donald R ^a   Davis, George E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN;

ANGIOGENESIS; ANIMAL; BLOOD VESSEL; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; GROWTH, DEVELOPMENT AND AGING; HUMAN; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW;

ANIMALS; BLOOD VESSELS; EMBRYONIC DEVELOPMENT; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 84863876464     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a005090     Document Type: Article

References (142)

1. Akiyama SK, Yamada SS, Chen WT, Yamada KM. 1989. Analysis of fibronectin receptor function with monoclonal antibodies: Roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J Cell Biol 109: 863-875.
2. Aloisi M, Schiaffino S. 1971. Growth of elementary blood vessels in diffusion chambers: Electron microscopy of capillary morphogenesis. Virchows Arch Abt B Zellpath 8: 328-341.
3. Aoudjit F, Vuori K. 2001. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis. J Cell Biol 152: 633-643.
4. Aplin AE, Short SM, Juliano RL. 1999. Anchoragedependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin α chains. J Biol Chem 274: 31223-31228.
5. Aplin AC, Fogel E, Zorzi P, Nicosia RF. 2008. The aortic ring model of angiogenesis. Meth Enzymol 443: 119-136.
6. Armstrong LC, Bornstein P. 2003. Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol 22: 63-71.
7. Assoian RK. 1997. Anchorage-dependent cell cycle progression. J Cell Biol 136: 1-4.
8. Assoian RK, Schwartz MA. 2001. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr Opin Genet Dev 11: 48-53.
9. Astrof S, Hynes RO. 2009. Fibronectins in vascular morphogenesis. Angiogenesis 12: 165-175.
10. Astrof S, Crowley D, Hynes RO. 2007. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol 311: 11-24.
11. Ausprunk DH, Folkman J. 1977. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 14: 53-65.
12. Avraamides CJ, Garmy-Susini B, Varner JA. 2008. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 8: 604-617.
13. Bayless KJ, Davis GE. 2002. The Cdc42 and Rac1 GTPases are required for capillary lumen formation in threedimensional extracellular matrices. J Cell Sci 115: 1123-1136.
14. Bayless KJ, Salazar R, Davis GE. 2000. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the α(v)β(3) and α(5)β(1) integrins. Am J Pathol 156: 1673-1683.
15. Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. 1999. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-165.
16. Bix G, Iozzo RV. 2005. Matrix revolutions: "Tails" of basement-membrane components with angiostatic functions. Trends Cell Biol 15: 52-60.
17. Bix G, Iozzo RV. 2008. Novel interactions of perlecan: Unraveling perlecan's role in angiogenesis. Microsc Res Tech 71: 339-348.
18. Bonanno E, Iurlaro M, Madri JA, Nicosia RF. 2000. Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model. In Vitro Cell Dev Biol Anim 36: 336-340.
19. Carlson TR, Feng Y, Maisonpierre PC, Mrksich M, Morla AO. 2001. Direct cell adhesion to the angiopoietins mediated by integrins. J Biol Chem 276: 26516-26525.
20. Cascone I, Napione L, Maniero F, Serini G, Bussolino F. 2005. Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J Cell Biol 170: 993-1004.
21. Chang SH, Kanasaki K, GochevaV, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, et al. 2009. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res 69: 4537-4544.
22. Chen TT, Luque A, Lee S, Anderson SM, Segura T, Iruela-Arispe ML. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188: 595-609.
23. Chun TH, Sabeh F, Ota I, Murphy H, McDonagh KT, Holmbeck K, Birkedal-Hansen H, Allen ED, Weiss SJ. 2004. MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol 167: 757-767.
24. Costell M, Gustafsson E, Aszodi A, Morgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fassler R. 1999. Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol 147: 1109-1122.
25. Davis GE, Bayless KJ. 2003. An integrin and Rho GTPasedependent pinocytic vacuole mechanism controls capillary lumen formation in collagen and fibrin matrices. Microcirculation 10: 27-44.
26. Davis GE, Camarillo CW. 1995. Regulation of endothelial cell morphogenesis by integrins, mechanical forces, and matrix guidance pathways. Exp Cell Res 216: 113-123.
27. Davis GE, Camarillo CW. 1996. An α2β1 integrindependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix. Exp Cell Res 224: 39-51.
28. Davis GE, Senger DR. 2005. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res 97: 1093-1107.
29. Davis GE, Senger DR. 2008. Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. Curr Opin Hematol 15: 197-203.
30. Davis GE, Bayless KJ, Davis MJ, Meininger GA. 2000. Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules. Am J Pathol 156: 1489-1498.
31. Davis GE, Koh W, Stratman AN. 2007. Mechanisms controlling human endothelial lumen formation and tube assembly in three-dimensional extracellular matrices. Birth Defects Res C Embryo Today 81: 270-285.
32. Dejana E, Languino LR, Polentarutti N, Balconi G, Ryckewaert JJ, Larrieu MJ, Donati MB, Mantovani A, Marguerie G. 1985. Interaction between fibrinogen and cultured endothelial cells. Induction of migration and specific binding. J Clin Invest 75: 11-18.
33. Delvos U, Gajdusek C, Sage H, Harker LA, Schwartz SM. 1982. Interactions of vascular wall cells with collagen gels. Lab Invest 46: 61-72.
34. Dong L, Chen Y, Lewis M, Hsieh JC, Reing J, Chaillet JR, Howell CY, Melhem M, Inoue S, Kuszak JR, et al. 2002. Neurologic defects and selective disruption of basement membranes in mice lacking entactin-1/nidogen-1. Lab Invest 82: 1617-1630.
35. Drake CJ, Little CD. 1999. VEGF and vascular fusion: Implications for normal and pathological vessels. J Histochem Cytochem 47: 1351-1355.
36. Drake CJ, Brandt SJ, Trusk TC, Little CD. 1997. TAL1SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis. Dev Biol 192: 17-30.
37. Eble JA, Niland S. 2009. The extracellular matrix of blood vessels. Curr Pharm Des 15: 1385-1400.
38. Egginton S, Gerritsen M. 2003. Lumen formation: In vivo versus in vitro observations. Microcirculation 10: 45-61.
39. Fang F, Orend G, Watanabe N, Hunter T, Ruoslahti E. 1996. Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271: 499-502.
40. Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV. 2008. The angiogenic response is dictated by β3 integrin on bone marrow-derived cells. J Cell Biol 183: 1145-1157.
41. Folkman J, Haudenschild C. 1980. Angiogenesis in vitro. Nature 288: 551-556.
42. Fouser L, Iruela-Arispe L, Bornstein P, Sage EH. 1991. Transcriptional activity of the α1(I)-collagen promoter is correlated with the formation of capillary-like structures by endothelial cells in vitro. J Biol Chem 266: 18345-18351.
43. Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D, Hynes RO. 2002. Central roles of α5β1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol 22: 927-933.
44. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, ChereshDA. 1995. Definition of two angiogenic pathways by distinct α v integrins. Science 270: 1500-1502.
45. Fukai N, Eklund L, Marneros AG, Oh SP, Keene DR, Tamarkin L, Niemela M, Ilves M, Li E, Pihlajaniemi T, et al. 2002. Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J 21: 1535-1544.
46. Gao M, Craig D, Lequin O, Campbell ID, Vogel V, Schulten K. 2003. Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Proc Natl Acad Sci 100: 14784-14789.
47. Garcia JG, Liu F, Verin AD, Birukova A, Dechert MA, Gerthoffer WT, Bamberg JR, English D. 2001. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest 108: 689-701.
48. George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO. 1993. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119: 1079-1091.
49. George EL, Baldwin HS, Hynes RO. 1997. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood 90: 3073-3081.
50. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, et al. 2003. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161: 1163-1177.
51. Giancotti FG, Ruoslahti E. 1999. Integrin signaling. Science 285: 1028-1032.
52. Grant DS, Kleinman HK. 1997. Regulation of capillary formation by laminin and other components of the extracellular matrix. EXS 79: 317-333.
53. Haas TL, Davis SJ, Madri JA. 1998. Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinasesMT1-MMPandMMP-2 in microvascular endothelial cells. J Biol Chem 273: 3604-3610.
54. Hallmann R, Horn N, Selg M, Wendler O, Pausch F, Sorokin LM. 2005. Expression and function of laminins in the embryonic and mature vasculature. Physiol Rev 85: 979-1000.
55. Hayashi K, Madri JA, Yurchenco PD. 1992. Endothelial cells interact with the core protein of basement membrane perlecan through β1 and β3 integrins: An adhesion modulated by glycosaminoglycan. J Cell Biol 119: 945-959.
56. HoangMV, Whelan MC, Senger DR. 2004. Rho activity critically and selectively regulates endothelial cell organization during angiogenesis. Proc Natl Acad Sci 101: 1874-1879.
57. Huang G, Zhang Y, Kim B, Ge G, Annis DS, Mosher DF, Greenspan DS. 2009. Fibronectin binds and enhances the activity of bone morphogenetic protein 1. J Biol Chem 284: 25879-25888.
58. Hynes RO. 2007. Cell-matrix adhesion in vascular development. J Thromb Haemost 5: 32-40.
59. Hynes RO. 2009. The extracellular matrix: Not just pretty fibrils. Science 326: 1216-1219.
60. Ilan N, Mahooti S, Madri JA. 1998. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. J Cell Sci 111: 3621-3631.
61. Ingber D, Folkman J. 1988. Inhibition of angiogenesis through modulation of collagen metabolism. Lab Invest 59: 44-51.
62. Iruela-Arispe ML, Davis GE. 2009. Cellular and molecular mechanisms of vascular lumen formation. Dev Cell 16: 222-231.
63. Iruela-Arispe ML, Diglio CA, Sage EH. 1991. Modulation of extracellular matrix proteins by endothelial cells undergoing angiogenesis in vitro. Arterioscler Thromb 11: 805-815.
64. Jackson CJ, Knop A, Giles I, Jenkins K, Schrieber L. 1994. VLA-2 mediates the interaction of collagen with endothelium during in vitro vascular tube formation. Cell Biol Int 18: 859-867.
65. Kamei M, SaundersWB, Bayless KJ, Dye L, Davis GE, Weinstein BM. 2006. Endothelial tubes assemble from intracellular vacuoles in vivo. Nature 442: 453-456.
66. Kanematsu A, Yamamoto S, Ozeki M, Noguchi T, Kanatani I, Ogawa O, Tabata Y. 2004. Collagenous matrices as release carriers of exogenous growth factors. Biomaterials 25: 4513-4520.
67. Koh W, Stratman AN, Sacharidou A, Davis GE. 2008. In vitro three dimensional collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis. Meth Enzymol 443: 83-101.
68. Koh W, Sachidanandam K, Stratman AN, Sacharidou A, Mayo AM, Murphy EA, Cheresh DA, Davis GE. 2009. Formation of endothelial lumens requires a coordinated PKCfepsilong-, Src-, Pak-and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. J Cell Sci 122: 1812-1822.
69. Liu Y, Senger DR. 2004. Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells. FASEB J 18: 457-468.
70. Lu P, Takai K, Weaver V, Werb Z. 2011. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a005058.
71. Lubarsky B, KrasnowMA. 2003. Tube morphogenesis: Making and shaping biological tubes. Cell 112: 19-28.
72. Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, et al. 2006. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 116: 2610-2621.
73. Margosio B, Marchetti D, Vergani V, Giavazzi R, Rusnati M, Presta M, Taraboletti G. 2003. Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2. Blood 102: 4399-4406.
74. Meredith JE, Schwartz MA. 1997. Integrins, adhesion and apoptosis. Trends Cell Biol 7: 146-150.
75. Meyer GT, Matthias LJ, Noack L, Vadas MA, Gamble JR. 1997. Lumen formation during angiogenesis in vitro involves phagocytic activity, formation and secretion of vacuoles, cell death, and capillary tube remodelling by different populations of endothelial cells. Anat Rec 249: 327-340.
76. Miner JH, Yurchenco PD. 2004. Laminin functions in tissue morphogenesis. Annu Rev Cell Dev Biol 20: 255-284.
77. Miner JH, Cunningham J, Sanes JR. 1998. Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin α5 chain. J Cell Biol 143: 1713-1723.
78. Miosge N, Sasaki T, Timpl R. 2002. Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice. Matrix Biol 21: 611-621.
79. Mitsi M, Forsten-Williams K, Gopalakrishnan M, Nugent MA. 2008. A catalytic role of heparin within the extracellular matrix. J Biol Chem 283: 34796-34807.
80. Montesano R, Orci L, Vassalli P. 1983. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J Cell Biol 97: 1648-1652.
81. Morla A, Ruoslaht E. 1992. A fibronectin self-assembly site involved in fibronectin matrix assembly: Reconstruction in a synthetic peptide. J Cell Biol 118: 421-429.
82. Murshed M, Smyth N, Miosge N, Karolat J, Krieg T, Paulsson M, Nischt R. 2000. The absence of nidogen 1 does not affect murine basement membrane formation. Mol Cell Biol 20: 7007-7012.
83. Nakatsu MN, Hughes CC. 2008. An optimized threedimensional in vitro model for the analysis of angiogenesis. Methods Enzymol 443: 65-82.
84. Nicosia RF, Madri JA. 1987. The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model. Am J Pathol 128: 78-90.
85. Paku S, Paweletz N. 1991. First steps of tumor-related angiogenesis. Lab Invest 65: 334-346.
86. Perruzzi CA, de Fougerolles AR, Koteliansky VE, Whelan MC, Westlin WF, Senger DR. 2003. Functional overlap and cooperativity among αv and β1 integrin subfamilies during skin angiogenesis. J Invest Dermatol 120: 1100-1109.
87. Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U. 2004. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 131: 1619-1628.
88. Rahman S, Patel Y, Murray J, Patel KV, Sumathipala R, Sobel M, Wijelath ES. 2005. Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplifiedMet-integrin induced signalling pathway in endothelial cells. BMCCell Biol 6: 8.
89. Ramirez F, Dietz HC. 2007. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events. J Cell Physiol 213: 326-330.
90. Ramirez F, Dietz HC. 2009. Extracellular microfibrils in vertebrate development and disease processes. J Biol Chem 284: 14677-14681.
91. Rhodes JM, Simons M. 2007. The extracellular matrix and blood vessel formation: Not just a scaffold. J Cell Mol Med 11: 176-205.
92. Richard L, Velasco P, Detmar M. 1998. A simple immunomagnetic protocol for the selective isolation and longterm culture of human dermal microvascular endothelial cells. Exp Cell Res 240: 1-6.
93. Risau W, Lemmon V. 1988. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev Biol 125: 441-450.
94. Roovers K, Assoian RK. 2000. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22: 818-826.
95. Rowe RG, Weiss SJ. 2008. Breaching the basement membrane: Who, when and how? Trends Cell Biol 18: 560-574.
96. Ruehl M, Somasundaram R, Schoenfelder I, Farndale RW, Knight CG, Schmid M, Ackermann R, Riecken EO, Zeitz M, Schuppan D. 2002. The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. J Biol Chem 277: 26872-26878.
97. Sacharidou A, Koh W, Stratman AN, Mayo AM, Fisher KE, Davis GE. 2010. Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42-and MT1-MMP-mediated events. Blood 115: 5259-5269.
98. Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, et al. 2008. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 10: 527-537.
99. Sainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, Hughes CC. 2005. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J 19: 1027-1029.
100. Sakai T, Larsen M, Yamada KM. 2003. Fibronectin requirement in branching morphogenesis. Nature 423: 876-881.
101. San Antonio JD, Zoeller JJ, Habursky K, Turner K, Pimtong W, Burrows M, Choi S, Basra S, Bennett JS, DeGrado WF, et al. 2009. A key role for the integrin α2β1 in experimental and developmental angiogenesis. Am J Pathol 175: 1338-1347.
102. SaundersWB, Bohnsack BL, Faske JB, Anthis NJ, Bayless KJ, Hirschi KK, Davis GE. 2006. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol 175: 179-191.
103. Schwarzbauer JE, DeSimone DW. 2011. Fibronectins, their fibrillogenesis, and in vivo functions. Cold Spring Harb Perspect Biol 3: a005041.
104. Seger R, Krebs EG. 1995. The MAPK signaling cascade. FASEB J 9: 726-735.
105. Senger DR. 1996. Molecular framework for angiogenesis: A complexweb of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines. Am J Pathol 149: 1-7.
106. Senger DR, PerruzziCA. 1996. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim Biophys Acta 1314: 13-24.
107. Senger DR, Claffey KP, Benes JE, Perruzzi CA, Sergiou AP, Detmar M. 1997. Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β1 and α2β1 integrins. Proc Natl Acad Sci 94: 13612-13617.
108. Senger DR, Perruzzi CA, Streit M, Koteliansky VE, de Fougerolles AR, Detmar M. 2002. The α1β1 and α2β1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol 160: 195-204.
109. Short SM, Talbott GA, Juliano RL. 1998. Integrin-mediated signaling events in human endothelial cells. Mol Biol Cell 9: 1969-1980.
110. Smith ML, Gourdon D, Little WC, Kubow KE, Eguiluz RA, Luna-Morris S, Vogel V. 2007. Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol 5: e268.
111. Somanath PR, Ciocea A, Byzova TV. 2009. Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys 53: 53-64.
112. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, et al. 2000. Genes expressed in human tumor endothelium. Science 289: 1197-1202.
113. Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE. 2009a. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood 114: 5091-5101.
114. Stratman AN, Saunders WB, Sacharidou A, Koh W, Fisher KE, Zawieja DC, Davis MJ, Davis GE. 2009b. Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Blood 114: 237-247.
115. Stratman AN, Schwindt AE, Malotte KM, Davis GE. 2010. Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization. Blood 116: 4720-4730.
116. Streit M, Riccardi L, Velasco P, Brown LF, Hawighorst T, Bornstein P, Detmar M. 1999. Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci 96: 14888-14893.
117. Stupack DG, Cheresh DA. 2004. Integrins and angiogenesis. Curr Top Dev Biol 64: 207-238.
118. Sund M, Xie L, Kalluri R. 2004. The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. Apmis 112: 450-462.
119. Sundberg C, Nagy JA, Brown LF, Feng D, Eckelhoefer IA, Manseau EJ, Dvorak AM, Dvorak HF. 2001. Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery. Am J Pathol 158: 1145-1160.
120. Sweeney SM, Guy CA, Fields GB, San Antonio JD. 1998. Defining the domains of type I collagen involved in heparin-binding and endothelial tube formation. Proc Natl Acad Sci 95: 7275-7280.
121. GER sequence and possibly p38 MAPK activation and focal adhesion disassembly. J Biol Chem 278: 30516-30524.
122. Thyboll J, Kortesmaa J, Cao R, Soininen R, Wang L, Iivanainen A, Sorokin L, Risling M, Cao Y, Tryggvason K. 2002. Deletion of the laminin α4 chain leads to impaired microvessel maturation. Mol Cell Biol 22: 1194-1202.
123. Vakonakis I, Staunton D, Rooney LM, Campbell ID. 2007. Interdomain association in fibronectin: Insight into cryptic sites and fibrillogenesis. EMBO J 26: 2575-2583.
124. van Hinsbergh VW, Collen A, Koolwijk P. 2001. Role of fibrin matrix in angiogenesis. Ann NY Acad Sci 936: 426-437.
125. Vernon RB, Sage EH. 1995. Between molecules and morphology: Extracellular matrix and creation of vascular form. Am J Pathol 147: 873-883.
126. Vinals F, Pouyssegur J. 1999. Confluence of vascular endothelial cells induces cell cycle exit by inhibiting p42/p44 mitogen-activated protein kinase activity. Mol Cell Biol 19: 2763-2772.
127. Vogel V. 2006. Mechanotransduction involving multimodular proteins: Converting force into biochemical signals. Annu Rev Biophys Biomol Struct 35: 459-488.
128. Wagenseil JE, Mecham RP. 2009. Vascular extracellular matrix and arterial mechanics. Physiol Rev 89: 957-989.
129. Wang X, Harris RE, Bayston LJ, Ashe HL. 2008. Type IV collagens regulate BMP signalling in Drosophila. Nature 455: 72-77.
130. Wary KK, Mainiero F, Isakoff SJ, Marcantonio EE, Giancotti FG. 1996. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87: 733-743.
131. Waschke J, Baumgartner W, Adamson RH, Zeng M, Aktories K, Barth H, Wilde C, Curry FE, Drenckhahn D. 2004. Requirement of Rac activity for maintenance of capillary endothelial barrier properties. Am J Physiol Heart Circ Physiol 286: H394-H401.
132. Whelan MC, Senger DR. 2003. Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMPand protein kinase A. J Biol Chem 278: 327-334.
133. Wijelath ES, Murray J, Rahman S, Patel Y, Ishida A, Strand K, Aziz S, Cardona C, Hammond WP, Savidge GF, et al. 2002. Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity. Circ Res 91: 25-31.
134. Wiradjaja F, DiTommaso T, Smyth I. 2010. Basement membranes in development and disease. Birth Defects Res C Embryo Today 90: 8-31.
135. Wojciak-Stothard B, Ridley AJ. 2002. Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol 39: 187-199.
136. Yang S, Graham J, Kahn JW, Schwartz EA, Gerritsen ME. 1999. Functional roles for PECAM-1 (CD31) and VEcadherin (CD144) in tube assembly and lumen formation in three-dimensional collagen gels. Am J Pathol 155: 887-895.
137. Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM. 2008. α2β1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood 111: 1980-1988.
138. Zhong C, Chrzanowska-Wodnicka M, Brown J, Shaub A, Belkin AM, Burridge K. 1998. Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J Cell Biol 141: 539-551.
139. Zhou Z, Apte SS, Soininen R, Cao R, Baaklini GY, Rauser RW, Wang J, Cao Y, Tryggvason K. 2000. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci 97: 4052-4057.
140. Zhou X, Rowe RG, Hiraoka N, George JP, Wirtz D, Mosher DF, Virtanen I, Chernousov MA, Weiss SJ. 2008. Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev 22: 1231-1243.
141. Zhu X, Ohtsubo M, Bohmer RM, Roberts JM, Assoian RK. 1996. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol 133: 391-403.
142. Zweers MC, Davidson JM, Pozzi A, Hallinger R, Janz K, Quondamatteo F, Leutgeb B, Krieg T, Eckes B. 2007. Integrin α2β1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization. J Invest Dermatol 127: 467-478.