Deletion of the laminin α4 chain leads to impaired microvessel maturation

Molecular and Cellular Biology

Volumn 22, Issue 4, 2002, Pages 1194-1202

  Thyboll, Jill ^a   Kortesmaa, Jarkko ^a   Cao, Renhai ^a   Soininen, Raija ^a   Wang, Ling ^a   Iivanainen, Antti ^a   Sorokin, Lydia ^a   Risling, Mårten ^a   Cao, Yihai ^a   Tryggvason, Karl ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 LAMININ; LAMININ; UNCLASSIFIED DRUG; COLLAGEN; ENTACTIN; FIBROBLAST GROWTH FACTOR 2; ISOPROTEIN; LAMA4 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANEMIA; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CAPILLARY BASEMENT MEMBRANE; ELECTRON MICROSCOPY; GENE DELETION; GENOTYPE; HISTOPATHOLOGY; LOCOMOTION; MICROVASCULATURE; MOUSE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; ANIMAL; BASEMENT MEMBRANE; CAPILLARY; CHEMISTRY; CORNEA; CORNEA NEOVASCULARIZATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; PHYSIOLOGY; PRENATAL DEVELOPMENT; SKELETAL MUSCLE; TRANSGENIC MOUSE; ULTRASTRUCTURE; VASCULARIZATION;

ANEMIA; ANIMALS; ANIMALS, NEWBORN; BASEMENT MEMBRANE; CAPILLARIES; COLLAGEN; CORNEA; CORNEAL NEOVASCULARIZATION; FIBROBLAST GROWTH FACTOR 2; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; LAMININ; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PROTEIN ISOFORMS;

EID: 0036007196     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.4.1194-1202.2002     Document Type: Article

References (49)

1. Vascular development: Cellular and molecular regulation
2. Angiogenesis inhibited by drinking tea
3. Vascular endothelial growth factor C induces angiogenesis in vivo
4. Form and function: The laminin family of heterotrimers
5. Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation
6. Cloning of the mouse laminin alpha 4 cDNA. Expression in a subset of endothelium
7. Blood platelets contain and secrete laminin-8 (alpha4beta1gamma1) and adhere to laminin-8 via alpha6beta1 integrin
8. Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains
9. Localization of a major nidogen-binding site to domain III of laminin B2 chain
10. Junctional epidermolysis bullosis: Defects in expression of epiligrin/nicein/kalinin and integrin beta 4 that inhibit hemidesmosome formation
11. Signaling vascular morphogenesis and maintenance
12. Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosindeficient congenital muscular dystrophy
13. Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain
14. Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain
15. Primary structure and expression of a novel human laminin alpha 4 chain
16. Laminin alpha 2 is a component of brain capillary basement membrane: Reduced expression in dystrophic dy mice
17. A model of angiogenesis in the mouse cornea
18. A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethal (Herlitz) junctional epidermolysis bullosa
19. Characterization and expression of the laminin gamma3 chain: A novel, non-basement membrane-associated, laminin chain
20. Recombinant laminin-8 (alpha4:beta1:gamma1). Production, purification, and interactions with integrins
21. Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice
22. IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa
23. Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine
24. Appearance and distribution of collagens and laminin in the early mouse embryo
25. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
26. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
27. The complete cDNA coding sequence and tissue-specific expression of the mouse laminin alpha 4 chain
28. Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain
29. The laminin alpha chains: Expression, developmental transitions, and chromosomal locations of alpha1-a5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
30. Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4
31. Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
32. New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo
33. Two noncontiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin gamma 1 chain
34. Neuronal laminins and their cellular receptors
35. Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa
36. A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa
37. Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice
38. Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells
39. Expression of laminin isoforms in mouse myogenic cells in vitro and in vivo
40. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
41. Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation
42. Monoclonal antibodies against laminin A chain fragment E3 and their effects on binding to cells and proteoglycan and on kidney development
43. Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation
44. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues
45. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells
46. Supramolecular assembly of basement membranes
47. Congenital muscular dystrophy with merosin deficiency
48. Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene
49. The alpha chain of laminin-1 is independently secreted and drives secretion of its beta- and gamma-chain partners