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Volumn 47, Issue 2, 2012, Pages 234-242

Curcumin has neuroprotection effect on homocysteine rat model of Parkinson

Author keywords

Curcumin; Homocysteine; Intracerebroventricular; Locomotor activity; Rat; Stress oxidative

Indexed keywords

CURCUMIN; HOMOCYSTEINE;

EID: 84863862289     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9727-3     Document Type: Article
Times cited : (52)

References (60)
  • 1
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal BB, Sung B (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 30(2):85-94
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.2 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 2
    • 29144506083 scopus 로고    scopus 로고
    • Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity
    • DOI 10.1016/j.expneurol.2005.07.003, PII S001448860500230X
    • Algaidi SA, Christie LA, Jenkinson AM, Whalley L, Riedel G, Platt B (2006) Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity. Exp Neurol 197(1):8-21 (Pubitemid 41817217)
    • (2006) Experimental Neurology , vol.197 , Issue.1 , pp. 8-21
    • Algaidi, S.A.1    Christie, L.A.2    Jenkinson, A.McE.3    Whalley, L.4    Riedel, G.5    Platt, B.6
  • 3
    • 77956061835 scopus 로고    scopus 로고
    • Neuroprotective effects of the polyphenolic antioxidant agent, curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat
    • Ataie A, Sabetkasaei M, Haghparast A, Moghaddam AH, Kazeminejad B (2010) Neuroprotective effects of the polyphenolic antioxidant agent, curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 96(4):378-385
    • (2010) Pharmacol Biochem Behav , vol.96 , Issue.4 , pp. 378-385
    • Ataie, A.1    Sabetkasaei, M.2    Haghparast, A.3    Moghaddam, A.H.4    Kazeminejad, B.5
  • 4
    • 26044482418 scopus 로고    scopus 로고
    • Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels
    • DOI 10.1016/j.neuroscience.2005.05.048, PII S0306452205006159
    • Baydas G, Reiter RJ, Akbulut M, Tuzcu M, Tamer S (2005) Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience 135(3):879-886 (Pubitemid 41407750)
    • (2005) Neuroscience , vol.135 , Issue.3 , pp. 879-886
    • Baydas, G.1    Reiter, R.J.2    Akbulut, M.3    Tuzcu, M.4    Tamer, S.5
  • 5
    • 0035026438 scopus 로고    scopus 로고
    • Antiapoptotic proteins: The Bcl-2 and inhibitor of apoptosis protein families
    • Deveraux QL, Schendel SL, Reed JC (2001) Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families. Cardiol Clin 19(1):57-74 (Pubitemid 32433916)
    • (2001) Cardiology Clinics , vol.19 , Issue.1 , pp. 57-74
    • Deveraux, Q.L.1    Schendel, S.L.2    Reed, J.C.3
  • 8
    • 0036421484 scopus 로고    scopus 로고
    • Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain
    • DOI 10.1016/S1043-6618(02)00123-8
    • Ghoneim AI, Abdel-Naim AB, Khalifa AE, El-Denshary ES (2002) Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 46(3):273-279 (Pubitemid 35300767)
    • (2002) Pharmacological Research , vol.46 , Issue.3 , pp. 273-279
    • Ghoneim, A.I.1    Abdel-Naim, A.B.2    Khalifa, A.E.3    El-Denshary, E.S.4
  • 9
    • 0344898557 scopus 로고    scopus 로고
    • Clinical and quantitative pathologic correlates of dementia with Lewy bodies
    • Gomez-Tortosa E, Newell K, Irizarry MC, Albert M, Growdon JH, Hyman BT (1999) Clinical and quantitative pathologic correlates of dementia with Lewy bodies. Neurology 53(6):1284-1291 (Pubitemid 29480089)
    • (1999) Neurology , vol.53 , Issue.6 , pp. 1284-1291
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Albert, M.4    Growdon, J.H.5    Hyman, B.T.6
  • 10
    • 0031768722 scopus 로고    scopus 로고
    • Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease
    • DOI 10.1007/s007020050094
    • Gottfries CG, Lehmann W, Regland B (1998) Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease. J Neural Transm 105(8-9):773-786 (Pubitemid 28539829)
    • (1998) Journal of Neural Transmission , vol.105 , Issue.8-9 , pp. 773-786
    • Gottfries, C.G.1    Lehmann, W.2    Regland, B.3
  • 11
    • 0036892748 scopus 로고    scopus 로고
    • Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage
    • DOI 10.1002/jnr.10416
    • Ho PI, Ortiz D, Rogers E, Shea TB (2002) Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 70(5):694-702 (Pubitemid 35397143)
    • (2002) Journal of Neuroscience Research , vol.70 , Issue.5 , pp. 694-702
    • Ho, P.I.1    Ortiz, D.2    Rogers, E.3    Shea, T.B.4
  • 12
    • 0023173619 scopus 로고
    • Parkinson's disease: Progression and mortality
    • Hoehn MM (1987) Parkinson's disease: progression and mortality. Adv Neurol 45:457-461
    • (1987) Adv Neurol , vol.45 , pp. 457-461
    • Hoehn, M.M.1
  • 13
    • 39149124146 scopus 로고    scopus 로고
    • Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: Therapeutic implications for Parkinson's disease explained via in silico studies
    • Jagatha B, Mythri RB, Vali S, Bharath MM (2008) Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic Biol Med 44(5):907-917
    • (2008) Free Radic Biol Med , vol.44 , Issue.5 , pp. 907-917
    • Jagatha, B.1    Mythri, R.B.2    Vali, S.3    Bharath, M.M.4
  • 14
    • 23844461866 scopus 로고    scopus 로고
    • Dieldrin-induced neurotoxicity: Relevance to Parkinson's disease pathogenesis
    • DOI 10.1016/j.neuro.2004.07.010, PII S0161813X04001135
    • Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V (2005) Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology 26(4):701-719 (Pubitemid 41175903)
    • (2005) NeuroToxicology , vol.26 , Issue.4 SPEC. ISS. , pp. 701-719
    • Kanthasamy, A.G.1    Kitazawa, M.2    Kanthasamy, A.3    Anantharam, V.4
  • 15
    • 0030604041 scopus 로고    scopus 로고
    • Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture
    • Kim WK, Pae YS (1996) Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci Lett 216(2):117-120
    • (1996) Neurosci Lett , vol.216 , Issue.2 , pp. 117-120
    • Kim, W.K.1    Pae, Y.S.2
  • 18
    • 0034666267 scopus 로고    scopus 로고
    • Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    • Kruman C II, Culmsee SL, Chan Y, Kruman Z, Guo LP, Mattson MP (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20(18):6920-6926
    • (2000) J Neurosci , vol.20 , Issue.18 , pp. 6920-6926
    • Kruman II, C.1    Culmsee, S.L.2    Chan, Y.3    Kruman, Z.4    Guo, L.P.5    Mattson, M.P.6
  • 20
    • 20344396838 scopus 로고    scopus 로고
    • Effects of homocysteine on the dopaminergic system and behavior in rodents
    • DOI 10.1016/j.neuro.2005.01.008, PII S0161813X05000203
    • Lee ES, Chen H, Soliman KF, Charlton CG (2005) Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology 26(3):361-371 (Pubitemid 40780013)
    • (2005) NeuroToxicology , vol.26 , Issue.3 , pp. 361-371
    • Lee, E.-S.Y.1    Chen, H.2    Soliman, K.F.A.3    Charlton, C.G.4
  • 22
    • 78951493875 scopus 로고    scopus 로고
    • Curcumin attenuates peroxynitrite-induced neurotoxicity in spiral ganglion neurons
    • Liu W, Fan Z, Han Y, Lu S, Zhang D, Bai X, Xu W, Li J, Wang H (2011) Curcumin attenuates peroxynitrite-induced neurotoxicity in spiral ganglion neurons. Neurotoxicology 32(1):150-157
    • (2011) Neurotoxicology , vol.32 , Issue.1 , pp. 150-157
    • Liu, W.1    Fan, Z.2    Han, Y.3    Lu, S.4    Zhang, D.5    Bai, X.6    Xu, W.7    Li, J.8    Wang, H.9
  • 23
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
    • Lotharius J, Brundin P (2002) Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 3(12):932-942
    • (2002) Nat Rev Neurosci , vol.3 , Issue.12 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 24
    • 67650729973 scopus 로고    scopus 로고
    • Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun Nterminal kinase signaling: Suppression by omega-3 fatty acids and curcumin
    • Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM (2009) Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun Nterminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci 29(28):9078-9089
    • (2009) J Neurosci , vol.29 , Issue.28 , pp. 9078-9089
    • Ma, Q.L.1    Yang, F.2    Rosario, E.R.3    Ubeda, O.J.4    Beech, W.5    Gant, D.J.6    Chen, P.P.7    Hudspeth, B.8    Chen, C.9    Zhao, Y.10    Vinters, H.V.11    Frautschy, S.A.12    Cole, G.M.13
  • 26
    • 0033215252 scopus 로고    scopus 로고
    • 'Apoptotic' biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders
    • DOI 10.1002/(SICI)1097-4547(19991001)58:1<152::AID-JNR15>3.0.CO;2-V
    • Mattson MP, Duan W (1999) "Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neuro-degenerative disorders. J Neurosci Res 58(1):152-166 (Pubitemid 29463701)
    • (1999) Journal of Neuroscience Research , vol.58 , Issue.1 , pp. 152-166
    • Mattson, M.P.1    Duan, W.2
  • 27
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(03)00032-8
    • Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26(3):137-146 (Pubitemid 36183675)
    • (2003) Trends in Neurosciences , vol.26 , Issue.3 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 28
    • 0033396991 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
    • Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann N Y Acad Sci 893:154-175 (Pubitemid 30038074)
    • (1999) Annals of the New York Academy of Sciences , vol.893 , pp. 154-175
    • Mattson, M.P.1    Pedersen, W.A.2    Duan, W.3    Culmsee, C.4    Camandola, S.5
  • 29
    • 0034727493 scopus 로고    scopus 로고
    • Expression of bcl-2, bax, and caspase-3 in the brain of the developing rat
    • Mooney SM, Miller MW (2000) Expression of bcl-2, bax, and caspase-3 in the brain of the developing rat. Brain Res Dev Brain Res 123(2):103-117
    • (2000) Brain Res Dev Brain Res , vol.123 , Issue.2 , pp. 103-117
    • Mooney, S.M.1    Miller, M.W.2
  • 30
    • 17144464115 scopus 로고    scopus 로고
    • Nigral endothelial dysfunction, homocysteine, and Parkinson's disease
    • DOI 10.1016/S0140-6736(99)01660-8
    • Muller T, Werne B, Fowler B, Kuhn W (1999) Nigral endothelial dysfunction, homocysteine, and Parkinson's disease. Lancet 354(9173):126-127 (Pubitemid 29313150)
    • (1999) Lancet , vol.354 , Issue.9173 , pp. 126-127
    • Muller, T.1    Werne, B.2    Fowler, B.3    Kuhn, W.4
  • 31
    • 0035958821 scopus 로고    scopus 로고
    • Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease
    • DOI 10.1016/S0304-3940(01)01972-3, PII S0304394001019723
    • Muller T, Woitalla D, Hauptmann B, Fowler B, Kuhn W (2001) Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease. Neurosci Lett 308(1):54-56 (Pubitemid 32607679)
    • (2001) Neuroscience Letters , vol.308 , Issue.1 , pp. 54-56
    • Muller, T.1    Woitalla, D.2    Hauptmann, B.3    Fowler, B.4    Kuhn, W.5
  • 32
    • 0036186658 scopus 로고    scopus 로고
    • 3-OMD and homocysteine plasma levels in parkinsonian patients
    • DOI 10.1007/s007020200013
    • Muller T, Woitalla D, Fowler B, Kuhn W (2002) 3-OMD and homocysteine plasma levels in parkinsonian patients. J Neural Transm 109(2):175-179 (Pubitemid 34185663)
    • (2002) Journal of Neural Transmission , vol.109 , Issue.2 , pp. 175-179
    • Muller, T..1    Woitalla, D.2    Fowler, B.3    Kuhn, W.4
  • 34
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • DOI 10.1016/0092-8674(93)90509-O
    • Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74(4):609-619 (Pubitemid 23259742)
    • (1993) Cell , vol.74 , Issue.4 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 35
    • 0026058318 scopus 로고
    • Cell death during development of the nervous system
    • Oppenheim RW (1991) Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501
    • (1991) Annu Rev Neurosci , vol.14 , pp. 453-501
    • Oppenheim, R.W.1
  • 37
    • 47349123450 scopus 로고    scopus 로고
    • Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation
    • Park SY, Kim HS, Cho EK, Kwon BY, Phark S, Hwang KW, Sul D (2008) Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol 46(8):2881-2887
    • (2008) Food Chem Toxicol , vol.46 , Issue.8 , pp. 2881-2887
    • Park, S.Y.1    Kim, H.S.2    Cho, E.K.3    Kwon, B.Y.4    Phark, S.5    Hwang, K.W.6    Sul, D.7
  • 39
    • 0034679899 scopus 로고    scopus 로고
    • Decreased apoptosis in proliferative and postmitotic regions of the caspase 3-deficient embryonic central nervous system
    • DOI 10.1002/1096-9861(20000717)423:1<1::AID-CNE1>3.0.CO;2-S
    • Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J (2000) Decreased apoptosis in proliferative and postmitotic regions of the caspase 3-deficient embryonic central nervous system. J Comp Neurol 423(1):1-12 (Pubitemid 30407785)
    • (2000) Journal of Comparative Neurology , vol.423 , Issue.1 , pp. 1-12
    • Pompeiano, M.1    Blaschke, A.J.2    Flavell, R.A.3    Srinivasan, A.4    Chun, J.5
  • 40
    • 2942616544 scopus 로고    scopus 로고
    • Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid
    • Quinn CT, Griener JC, Bottiglieri T, Arning E, Winick NJ (2004) Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. J Pediatr Hematol Oncol 26(6):386-388
    • (2004) J Pediatr Hematol Oncol , vol.26 , Issue.6 , pp. 386-388
    • Quinn, C.T.1    Griener, J.C.2    Bottiglieri, T.3    Arning, E.4    Winick, N.J.5
  • 41
    • 42049109707 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice
    • Rajeswari A, Sabesan M (2008) Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology 16(2):96-99
    • (2008) Inflammopharmacology , vol.16 , Issue.2 , pp. 96-99
    • Rajeswari, A.1    Sabesan, M.2
  • 42
    • 33747286388 scopus 로고    scopus 로고
    • Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets
    • Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545(1):51-64
    • (2006) Eur J Pharmacol , vol.545 , Issue.1 , pp. 51-64
    • Ramassamy, C.1
  • 44
    • 0036741957 scopus 로고    scopus 로고
    • Homocysteine in neuropsychiatric disorders of the elderly
    • Reutens S, Sachdev P (2002) Homocysteine in neuropsychiatric disorders of the elderly. Int J Geriatr Psychiatry 17(9):859-864
    • (2002) Int J Geriatr Psychiatry , vol.17 , Issue.9 , pp. 859-864
    • Reutens, S.1    Sachdev, P.2
  • 45
    • 0035895844 scopus 로고    scopus 로고
    • Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: Behavioral and histochemical evidence
    • DOI 10.1016/S0006-8993(00)03296-0, PII S0006899300032960
    • Roghani M, Behzadi G (2001) Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence. Brain Res 892(1):211-217 (Pubitemid 32126584)
    • (2001) Brain Research , vol.892 , Issue.1 , pp. 211-217
    • Roghani, M.1    Behzadi, G.2
  • 46
    • 34248595238 scopus 로고    scopus 로고
    • Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes
    • Shen SQ, Zhang Y, Xiang JJ, Xiong CL (2007) Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol 13(13):1953-1961 (Pubitemid 46758857)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.13 , pp. 1953-1961
    • Shen, S.-Q.1    Zhang, Y.2    Xiang, J.-J.3    Xiong, C.-L.4
  • 47
    • 3242676904 scopus 로고    scopus 로고
    • Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task
    • DOI 10.1016/j.bbr.2003.12.013, PII S0166432803004820
    • Streck EL, Bavaresco CS, Netto CA, Wyse AT (2004) Chronic hyper-homocysteinemia provokes a memory deficit in rats in the Morris water maze task. Behav Brain Res 153(2):377-381 (Pubitemid 38953111)
    • (2004) Behavioural Brain Research , vol.153 , Issue.2 , pp. 377-381
    • Streck, E.L.1    Bavaresco, C.S.2    Netto, C.A.3    Wyse, A.T.D.S.4
  • 48
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su JH, Anderson AJ, Cummings BJ, Cotman CW (1994) Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuro-report 5(18):2529-2533
    • (1994) Neuro-report , vol.5 , Issue.18 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 49
    • 34548653551 scopus 로고    scopus 로고
    • Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus
    • DOI 10.1248/bpb.30.1732
    • Sumanont Y, Murakami Y, Tohda M, Vajragupta O, Watanabe H, Matsumoto K (2007) Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biol Pharm Bull 30(9):1732-1739 (Pubitemid 47403254)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.9 , pp. 1732-1739
    • Sumanont, Y.1    Murakami, Y.2    Tohda, M.3    Vajragupta, O.4    Watanabe, H.5    Matsumoto, K.6
  • 51
    • 0346850976 scopus 로고    scopus 로고
    • Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    • DOI 10.1016/j.lfs.2003.06.042
    • Thiyagarajan M, Sharma SS (2004) Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci 74(8):969-985 (Pubitemid 37522132)
    • (2004) Life Sciences , vol.74 , Issue.8 , pp. 969-985
    • Thiyagarajan, M.1    Sharma, S.S.2
  • 52
    • 58849109761 scopus 로고    scopus 로고
    • Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease
    • Thomas P, Wang YJ, Zhong JH, Kosaraju S, O'Callaghan NJ, Zhou XF, Fenech M (2009) Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease. Mutat Res 661(1-2):25-34
    • (2009) Mutat Res , vol.661 , Issue.1-2 , pp. 25-34
    • Thomas, P.1    Wang, Y.J.2    Zhong, J.H.3    Kosaraju, S.4    O'Callaghan, N.J.5    Zhou, X.F.6    Fenech, M.7
  • 53
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267(5203):1456-1462
    • (1995) Science , vol.267 , Issue.5203 , pp. 1456-1462
    • Thompson, C.B.1
  • 55
    • 0344438108 scopus 로고    scopus 로고
    • The hematoxylin and eosin
    • Bancroft JD, Gamble (eds) 5th edn. Churchill Livingstone, London
    • Wilson I, Gamble M (2002) The hematoxylin and eosin. In: Bancroft JD, Gamble (eds) Theory and practice of histological techniques, 5th edn. Churchill Livingstone, London, pp 125-138
    • (2002) Theory and Practice of Histological Techniques , pp. 125-138
    • Wilson, I.1    Gamble, M.2
  • 57
    • 0021019874 scopus 로고
    • Concentrations of sulfur-containing free aminoacids in lumbar cerebrospinal fluid from patients with consciousness disturbances
    • Yanai Y, Shibasaki T, Kohno N, Mitsui T, Nakajima H (1983) Concentrations of sulfur-containing free amino acids in lumbar cerebrospinal fluid from patients with consciousness disturbances. Acta Neurol Scand 68(6):386-393 (Pubitemid 14214459)
    • (1983) Acta Neurologica Scandinavica , vol.68 , Issue.6 , pp. 386-393
    • Yanai, Y.1    Shibasaki, T.2    Kohno, N.3
  • 58
    • 51749116969 scopus 로고    scopus 로고
    • Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    • Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS (2008) Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res 33(10):2044-2053
    • (2008) Neurochem Res , vol.33 , Issue.10 , pp. 2044-2053
    • Yang, S.1    Zhang, D.2    Yang, Z.3    Hu, X.4    Qian, S.5    Liu, J.6    Wilson, B.7    Block, M.8    Hong, J.S.9
  • 59
    • 25444508963 scopus 로고    scopus 로고
    • Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
    • DOI 10.1080/10715760500233113
    • Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT (2005) Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res 39(10):1119-1125 (Pubitemid 41358566)
    • (2005) Free Radical Research , vol.39 , Issue.10 , pp. 1119-1125
    • Zbarsky, V.1    Datla, K.P.2    Parkar, S.3    Rai, D.K.4    Aruoma, O.I.5    Dexter, D.T.6
  • 60
    • 0035929641 scopus 로고    scopus 로고
    • Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
    • Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276(38):35867-35874
    • (2001) J Biol Chem , vol.276 , Issue.38 , pp. 35867-35874
    • Zhang, C.1    Cai, Y.2    Adachi, M.T.3    Oshiro, S.4    Aso, T.5    Kaufman, R.J.6    Kitajima, S.7


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