메뉴 건너뛰기




Volumn 26, Issue 6, 2012, Pages 867-879

Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signaling

Author keywords

Anorexia; Arcuate nucleus; Electrophysiology; Ghrelin; Hypothalamus; Inflammation; Lipopolysaccharide; Nitric oxide

Indexed keywords

CYCLIC GMP; GHRELIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NITRIC OXIDE; STAT1 PROTEIN;

EID: 84863860028     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.03.005     Document Type: Article
Times cited : (19)

References (63)
  • 1
    • 0034534383 scopus 로고    scopus 로고
    • Plasma cytokine response in mice with bacterial infection
    • Abram M., Vu kovic D., Wraber B., Doric M. Plasma cytokine response in mice with bacterial infection. Mediators Inflamm. 2000, 9:229-234.
    • (2000) Mediators Inflamm. , vol.9 , pp. 229-234
    • Abram, M.1    Vu kovic, D.2    Wraber, B.3    Doric, M.4
  • 3
    • 77955474312 scopus 로고    scopus 로고
    • Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice
    • Becskei C., Lutz T.A., Riediger T. Reduced fasting-induced activation of hypothalamic arcuate neurons is associated with hyperleptinemia and increased leptin sensitivity in obese mice. Am. J. Physiol. 2010, 299:R632-641.
    • (2010) Am. J. Physiol. , vol.299
    • Becskei, C.1    Lutz, T.A.2    Riediger, T.3
  • 4
    • 0033615543 scopus 로고    scopus 로고
    • Role of the cyclic AMP-protein kinase a pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2
    • Chen C.C., Chiu K.T., Sun Y.T., Chen W.C. Role of the cyclic AMP-protein kinase a pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. J. Biol. Chem. 1999, 274:31559-31564.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31559-31564
    • Chen, C.C.1    Chiu, K.T.2    Sun, Y.T.3    Chen, W.C.4
  • 6
    • 0028890949 scopus 로고
    • Changes in eating behavior and thermogenic activity following inhibition of nitric oxide formation
    • De Luca B., Monda M., Sullo A. Changes in eating behavior and thermogenic activity following inhibition of nitric oxide formation. Am. J. Physiol. 1995, 268:R1533-1538.
    • (1995) Am. J. Physiol. , vol.268
    • De Luca, B.1    Monda, M.2    Sullo, A.3
  • 10
    • 0031057817 scopus 로고    scopus 로고
    • Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6
    • Dickson S.L., Luckman S.M. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 1997, 138:771-777.
    • (1997) Endocrinology , vol.138 , pp. 771-777
    • Dickson, S.L.1    Luckman, S.M.2
  • 11
    • 0032940785 scopus 로고    scopus 로고
    • The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin
    • Edwards C.M., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 1999, 160:R7-12.
    • (1999) J. Endocrinol. , vol.160
    • Edwards, C.M.1    Abusnana, S.2    Sunter, D.3    Murphy, K.G.4    Ghatei, M.A.5    Bloom, S.R.6
  • 12
    • 16244394062 scopus 로고    scopus 로고
    • Orexin-a-induced feeding is dependent on nitric oxide
    • Farr S.A., Banks W.A., Kumar V.B., Morley J.E. Orexin-a-induced feeding is dependent on nitric oxide. Peptides 2005, 26:759-765.
    • (2005) Peptides , vol.26 , pp. 759-765
    • Farr, S.A.1    Banks, W.A.2    Kumar, V.B.3    Morley, J.E.4
  • 13
    • 39349090970 scopus 로고    scopus 로고
    • NO/cGMP-dependent modulation of synaptic transmission
    • Feil R., Kleppisch T. NO/cGMP-dependent modulation of synaptic transmission. Handb. Exp. Pharmacol. 2008, 529-560.
    • (2008) Handb. Exp. Pharmacol. , pp. 529-560
    • Feil, R.1    Kleppisch, T.2
  • 14
    • 35549012275 scopus 로고    scopus 로고
    • Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers
    • Garcia J.M., Polvino W.J. Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteers. Oncologist 2007, 12:594-600.
    • (2007) Oncologist , vol.12 , pp. 594-600
    • Garcia, J.M.1    Polvino, W.J.2
  • 16
    • 37649021033 scopus 로고    scopus 로고
    • A phase II randomized, placebo-controlled, double-blind study of the efficacy abd safety of RC-1291 (RC) for the treatment of cancer cachexia
    • Garcia J.M., Boccia R.V., Graham C., Kumor K., Polvino W.J. A phase II randomized, placebo-controlled, double-blind study of the efficacy abd safety of RC-1291 (RC) for the treatment of cancer cachexia. J. Clin. Oncol. 2007, 25:9133.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 9133
    • Garcia, J.M.1    Boccia, R.V.2    Graham, C.3    Kumor, K.4    Polvino, W.J.5
  • 17
    • 0031040613 scopus 로고    scopus 로고
    • 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey E.P., Oplinger J.A., Furfine E.S., Kiff R.J., Laszlo F., Whittle B.J., Knowles R.G. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 1997, 272:4959-4963.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4959-4963
    • Garvey, E.P.1    Oplinger, J.A.2    Furfine, E.S.3    Kiff, R.J.4    Laszlo, F.5    Whittle, B.J.6    Knowles, R.G.7
  • 19
    • 0037025051 scopus 로고    scopus 로고
    • Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge
    • Gautron L., Lafon P., Chaigniau M., Tramu G., Laye S. Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge. Neuroscience 2002, 112:717-729.
    • (2002) Neuroscience , vol.112 , pp. 717-729
    • Gautron, L.1    Lafon, P.2    Chaigniau, M.3    Tramu, G.4    Laye, S.5
  • 20
    • 33846849033 scopus 로고    scopus 로고
    • Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter
    • Guo Z., Shao L., Du Q., Park K.S., Geller D.A. Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter. Faseb J. 2007, 21:535-542.
    • (2007) Faseb J. , vol.21 , pp. 535-542
    • Guo, Z.1    Shao, L.2    Du, Q.3    Park, K.S.4    Geller, D.A.5
  • 22
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12:123-137.
    • (1988) Neurosci. Biobehav. Rev. , vol.12 , pp. 123-137
    • Hart, B.L.1
  • 23
    • 0344394263 scopus 로고    scopus 로고
    • Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome
    • Hataya Y., Akamizu T., Hosoda H., Kanamoto N., Moriyama K., Kangawa K., Takaya K., Nakao K. Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome. Endocrinology 2003, 144:5365-5371.
    • (2003) Endocrinology , vol.144 , pp. 5365-5371
    • Hataya, Y.1    Akamizu, T.2    Hosoda, H.3    Kanamoto, N.4    Moriyama, K.5    Kangawa, K.6    Takaya, K.7    Nakao, K.8
  • 24
    • 77649339778 scopus 로고    scopus 로고
    • Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression
    • Hollis J.H., Lemus M., Evetts M.J., Oldfield B.J. Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression. Neuropharmacology 2010, 58:730-738.
    • (2010) Neuropharmacology , vol.58 , pp. 730-738
    • Hollis, J.H.1    Lemus, M.2    Evetts, M.J.3    Oldfield, B.J.4
  • 25
    • 79953325301 scopus 로고    scopus 로고
    • The endocannabinoid arachidonylethanolamide attenuates aspects of lipopolysaccharide-induced changes in energy intake, energy expenditure and hypothalamic Fos expression
    • Hollis J.H., Jonaidi H., Lemus M., Oldfield B.J. The endocannabinoid arachidonylethanolamide attenuates aspects of lipopolysaccharide-induced changes in energy intake, energy expenditure and hypothalamic Fos expression. J. Neuroimmunol. 2011, 233:127-134.
    • (2011) J. Neuroimmunol. , vol.233 , pp. 127-134
    • Hollis, J.H.1    Jonaidi, H.2    Lemus, M.3    Oldfield, B.J.4
  • 27
    • 0037174916 scopus 로고    scopus 로고
    • JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells
    • Kim O.S., Park E.J., Joe E.H., Jou I. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J. Biol. Chem. 2002, 277:40594-40601.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40594-40601
    • Kim, O.S.1    Park, E.J.2    Joe, E.H.3    Jou, I.4
  • 29
    • 78649736380 scopus 로고    scopus 로고
    • The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation
    • Kobayashi Y. The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J. Leukocyte Biol. 2010, 88:1157-1162.
    • (2010) J. Leukocyte Biol. , vol.88 , pp. 1157-1162
    • Kobayashi, Y.1
  • 30
    • 0037382853 scopus 로고    scopus 로고
    • 2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • 2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 2003, 52:948-956.
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 31
    • 1642319121 scopus 로고    scopus 로고
    • Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli
    • Konsman J.P., Vigues S., Mackerlova L., Bristow A., Blomqvist A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J. Comp. Neurol. 2004, 472:113-129.
    • (2004) J. Comp. Neurol. , vol.472 , pp. 113-129
    • Konsman, J.P.1    Vigues, S.2    Mackerlova, L.3    Bristow, A.4    Blomqvist, A.5
  • 32
    • 0033781059 scopus 로고    scopus 로고
    • Anorexia of infection: current prospects
    • Langhans W. Anorexia of infection: current prospects. Nutrition 2000, 16:996-1005.
    • (2000) Nutrition , vol.16 , pp. 996-1005
    • Langhans, W.1
  • 33
    • 34447512947 scopus 로고    scopus 로고
    • Signals generating anorexia during acute illness
    • Langhans W. Signals generating anorexia during acute illness. Proc. Nutr. Soc. 2007, 66:321-330.
    • (2007) Proc. Nutr. Soc. , vol.66 , pp. 321-330
    • Langhans, W.1
  • 34
    • 0024424126 scopus 로고
    • Verapamil and indomethacin attenuate endotoxin-induced anorexia
    • Langhans W., Harlacher R., Scharrer E. Verapamil and indomethacin attenuate endotoxin-induced anorexia. Physiol. Behav. 1989, 46:535-539.
    • (1989) Physiol. Behav. , vol.46 , pp. 535-539
    • Langhans, W.1    Harlacher, R.2    Scharrer, E.3
  • 35
    • 0027254078 scopus 로고
    • Comparison of the feeding responses to bacterial lipopolysaccharide and interleukin-1 beta
    • Langhans W., Savoldelli D., Weingarten S. Comparison of the feeding responses to bacterial lipopolysaccharide and interleukin-1 beta. Physiol. Behav. 1993, 53:643-649.
    • (1993) Physiol. Behav. , vol.53 , pp. 643-649
    • Langhans, W.1    Savoldelli, D.2    Weingarten, S.3
  • 36
    • 33750040230 scopus 로고    scopus 로고
    • Structure, function, and regulation of STAT proteins
    • Lim C.P., Cao X. Structure, function, and regulation of STAT proteins. Mol. Biosyst. 2006, 2:536-550.
    • (2006) Mol. Biosyst. , vol.2 , pp. 536-550
    • Lim, C.P.1    Cao, X.2
  • 38
    • 0032852850 scopus 로고    scopus 로고
    • Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding
    • Morley J.E., Alshaher M.M., Farr S.A., Flood J.F., Kumar V.B. Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 1999, 20:595-600.
    • (1999) Peptides , vol.20 , pp. 595-600
    • Morley, J.E.1    Alshaher, M.M.2    Farr, S.A.3    Flood, J.F.4    Kumar, V.B.5
  • 39
    • 79952816658 scopus 로고    scopus 로고
    • Nitric oxide is a central component in neuropeptide regulation of appetite
    • Morley J.E., Farr S.A., Sell R.L., Hileman S.M., Banks W.A. Nitric oxide is a central component in neuropeptide regulation of appetite. Peptides 2011, 32:776-780.
    • (2011) Peptides , vol.32 , pp. 776-780
    • Morley, J.E.1    Farr, S.A.2    Sell, R.L.3    Hileman, S.M.4    Banks, W.A.5
  • 44
    • 0030013783 scopus 로고    scopus 로고
    • Anorexia during acute and chronic disease
    • Plata-Salaman C.R. Anorexia during acute and chronic disease. Nutrition 1996, 12:69-78.
    • (1996) Nutrition , vol.12 , pp. 69-78
    • Plata-Salaman, C.R.1
  • 45
    • 0344407033 scopus 로고    scopus 로고
    • Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus
    • Riediger T., Traebert M., Schmid H.A., Scheel C., Lutz T.A., Scharrer E. Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus. Neurosci. Lett. 2003, 341:151-155.
    • (2003) Neurosci. Lett. , vol.341 , pp. 151-155
    • Riediger, T.1    Traebert, M.2    Schmid, H.A.3    Scheel, C.4    Lutz, T.A.5    Scharrer, E.6
  • 46
    • 4444266408 scopus 로고    scopus 로고
    • Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression
    • Riediger T., Bothe C., Becskei C., Lutz T.A. Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression. Neuroendocrinology 2004, 79:317-326.
    • (2004) Neuroendocrinology , vol.79 , pp. 317-326
    • Riediger, T.1    Bothe, C.2    Becskei, C.3    Lutz, T.A.4
  • 47
    • 33751547882 scopus 로고    scopus 로고
    • Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus
    • Riediger T., Giannini P., Erguven E., Lutz T. Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus. Brain. Res. 2006, 1125:37-45.
    • (2006) Brain. Res. , vol.1125 , pp. 37-45
    • Riediger, T.1    Giannini, P.2    Erguven, E.3    Lutz, T.4
  • 49
    • 24344501250 scopus 로고    scopus 로고
    • Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6
    • Rummel C., Voss T., Matsumura K., Korte S., Gerstberger R., Roth J., Hubschle T. Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6. J. Comp. Neurol. 2005, 491:1-14.
    • (2005) J. Comp. Neurol. , vol.491 , pp. 1-14
    • Rummel, C.1    Voss, T.2    Matsumura, K.3    Korte, S.4    Gerstberger, R.5    Roth, J.6    Hubschle, T.7
  • 50
    • 33751192075 scopus 로고    scopus 로고
    • Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain
    • Rummel C., Sachot C., Poole S., Luheshi G.N. Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain. Am. J. Physiol. 2006, 291:R1316-1326.
    • (2006) Am. J. Physiol. , vol.291
    • Rummel, C.1    Sachot, C.2    Poole, S.3    Luheshi, G.N.4
  • 51
    • 0027284439 scopus 로고
    • The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
    • Schmidt H.H., Lohmann S.M., Walter U. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim. Biophys. Acta 1993, 1178:153-175.
    • (1993) Biochim. Biophys. Acta , vol.1178 , pp. 153-175
    • Schmidt, H.H.1    Lohmann, S.M.2    Walter, U.3
  • 52
    • 0035919144 scopus 로고    scopus 로고
    • Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus
    • Sergeyev V., Broberger C., Hokfelt T. Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus. Brain Res. Mol. Brain Res. 2001, 90:93-100.
    • (2001) Brain Res. Mol. Brain Res. , vol.90 , pp. 93-100
    • Sergeyev, V.1    Broberger, C.2    Hokfelt, T.3
  • 54
    • 34248137994 scopus 로고    scopus 로고
    • Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate
    • Stempelj M., Kedinger M., Augenlicht L., Klampfer L. Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. J. Biol. Chem. 2007, 282:9797-9804.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9797-9804
    • Stempelj, M.1    Kedinger, M.2    Augenlicht, L.3    Klampfer, L.4
  • 57
    • 0034046605 scopus 로고    scopus 로고
    • STAT family of transcription factors in cytokine-mediated biological responses
    • Takeda K., Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 2000, 11:199-207.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 199-207
    • Takeda, K.1    Akira, S.2
  • 58
    • 0141742433 scopus 로고    scopus 로고
    • Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation
    • Tedeschi E., Menegazzi M., Margotto D., Suzuki H., Forstermann U., Kleinert H. Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation. J. Pharmacol. Exp. Ther. 2003, 307:254-261.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 254-261
    • Tedeschi, E.1    Menegazzi, M.2    Margotto, D.3    Suzuki, H.4    Forstermann, U.5    Kleinert, H.6
  • 60
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • Willesen M.G., Kristensen P., Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999, 70:306-316.
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Romer, J.3
  • 61
    • 0034919731 scopus 로고    scopus 로고
    • Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    • Wisse B.E., Frayo R.S., Schwartz M.W., Cummings D.E. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 2001, 142:3292-3301.
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 63
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods S.C., Seeley R.J., Porte D., Schwartz M.W. Signals that regulate food intake and energy homeostasis. Science 1998, 280:1378-1383.
    • (1998) Science , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte, D.3    Schwartz, M.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.