Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus

Journal of Neuroendocrinology

Volumn 14, Issue 7, 2002, Pages 580-586

  Traebert, M ^a   Riediger, T ^b   Whitebread, S ^a   Scharrer, E ^b   Schmid, H A ^a,c  

^a Novartis Pharma AG   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Electrophysiology; Fos; GHS R; Immunohistochemistry; OB R

Indexed keywords

ANOREXIGENIC AGENT; APPETITE STIMULANT; DEXTRO LYSINE; GHRELIN; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; LEPTIN; LEPTIN RECEPTOR; LIGAND; PROTEIN FOS;

ANIMAL CELL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BINDING AFFINITY; BRAIN NERVE CELL; BRAIN SLICE; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; ENERGY EXPENDITURE; FOOD INTAKE; HORMONE RESPONSE; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IC 50; IN VITRO STUDY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RODENT; STAINING;

ANIMALS; ARCUATE NUCLEUS; BINDING, COMPETITIVE; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; LEPTIN; NEURONS; OLIGOPEPTIDES; PEPTIDE HORMONES; PEPTIDES; PROTO-ONCOGENE PROTEINS C-FOS; RADIOLIGAND ASSAY; RATS;

EID: 0036080459     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2002.00810.x     Document Type: Article

References (42)

1. A receptor in pituitary and hypothalamus that functions in growth hormone release
2. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors
3. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
4. A role for ghrelin in the central regulation of feeding
5. Ghrelin induces adiposity in rodents
6. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
7. Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurones in the mediobasal hypothalamus
8. Co-localisation of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
9. Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats
10. Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurones
11. Central actions of peptide and non-peptide growth hormone secretagogues in the rat
12. GHRP-6-induced changes in electrical activity of single cells in the arcuate, ventromedial and periventricular nucleus neurones [correction of nuclei] of a hypothalamic slice preparation in vitro
13. Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro
14. Positional cloning of the mouse obese gene and its human homologue
15. Unraveling the central nervous system pathways underlying responses to leptin
16. Leptin receptor immunoreactivity in chemically defined target neurones of the hypothalamus
17. Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats
18. Acetylation alters the feeding response to MSH and beta-endorphin
19. Distributions of leptin receptor mRNA isoforms in the rat brain
20. Polonsky. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
21. Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats
22. Orexin A activates leptin-responsive neurones in the arcuate nucleus
23. Effects of the obese gene product on body weight regulation in ob/ob mice
24. Regulation of in vivo growth hormone secretion by leptin
25. A nonpeptidyl growth hormone secretagogue
26. 2 on growth hormone (GH) releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture
27. Circumventricular organ capillaries
28. Leptin enters the brain by a saturable system independent of insulin
29. c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems
30. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurones in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6
31. Central nervous system control of food intake
32. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones
33. Localization of leptin receptor mRNA expression in mouse brain
34. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
35. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
36. Circulating ghrelin levels are decreased in human obesity
37. The anatomy of neuropeptide-Y-containing neurones in rat brain
38. Identification of targets of leptin action in rat hypothalamus
39. Identification and expression cloning of a leptin receptor, OB-R
40. The leptin receptor
41. Leptin inhibits hypothalamic neurones by activation of ATP-sensitive potassium channels