Anorexia during acute and chronic disease

Nutrition

Volumn 12, Issue 2, 1996, Pages 69-78

  Plata Salaman, C R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANOREXIA; CACHEXIA; CHRONIC DISEASE; CLINICAL FEATURE; HUMAN; IMMUNOPATHOGENESIS; IMMUNOTHERAPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TASTE AVERSION;

EID: 0030013783     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(96)90702-9     Document Type: Article

References (147)

1. B.L. Hart Behavioral adaptations to pathogens and parasites: Five strategies Neurosci Biobehav Rev 14 1990 273
2. M.J. Murray A.B. Murray Anorexia of infection as a mechanism of host defense Am J Clin Nutr 32 1979 593
3. G.J. Kontoghiorghes E.D. Weinberg Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches Blood Rev 9 1995 33
4. A Aubert G Goodall R Dantzer Compared effects of cold ambient temperature and cytokines on macronutrient intake in rats Physiol Behav 5 1995 869
5. H MacDonald S Stamford H.D. McCarthy Acute effect of peripheral interleukin-1β administration on macronutrient selection in the rat 6th ed. Proc Nutr Soc 52 1993 358A
6. M.J. Tisdale Cancer cachexia Anti-Cancer Drugs 4 1993 115
7. G.O. Coodley M.O. Loveless T.M. Merrill The HIV wasting syndrome: A review J Acquired Immune Defic Syndr 7 1994 681
8. D.S. Levine Immune modulating therapies for idiopathic inflammatory bowel diseases Adv Pharmacol 25 1994 171
9. H Tilg The role of cytokines in the pathophysiology of chronic liver diseases Int J Clin Lab Res 23 1993 179
10. M Difrancia D Barbier J.L. Mege Tumor necrosis factor-α levels and weight loss in chronic obstructive pulmonary disease Am J Respir Crit Care Med 150 1994 1453
11. L.M. Freeman R Roubenoff The nutrition implications of cardiac cachexia Nutr Rev 52 1994 340
12. R Roubenoff L.C. Rall Humoral mediation of changing body composition during aging and chronic inflammation Nutr Rev 51 1993 1
13. E.H. Kaplan S.T. Rosen D.B. Norris Phase II study of recombinant human interferon gamma for treatment of cutaneous T-cell lymphoma J Natl Cancer Inst 82 1990 208
14. C.A. Meyers R.R. Scheibel A.D. Forman Persistent neurotoxicity of systemically administered interferon-alpha Neurology 41 1991 672
15. 2-microglobulin, a marker of immune activation Am J Physiol 268 1995 R1513
16. C.R. Plata-Salamán Meal patterns in response to the intracerebroventricular administration of interleukin-1β in rats Physiol Behav 55 1994 727
17. C.R. Plata-Salamán J.M.H. ffrench-Mullen Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1β Physiol Behav 51 1992 1277
18. C.R. Plata-Salamán J.P. Borkoski Interleukin-8 modulates feeding by direct action in the central nervous system Am J Physiol 265 1993 R877
19. C.R. Plata-Salamán Dexamethasone inhibits food intake suppression induced by low doses of interleukin-1β administered intracerebroventricularly Brain Res Bull 27 1991 737
20. Z.J. Yang M Koseki M.M. Meguid Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats Am J Physiol 267 1994 R1056
21. J.M. Lipton A Catania Pyrogenic and inflammatory actions of cytokines and their modulation by neuropeptides: Techniques and interpretations Methods Neurosci 17 1993 61
22. J.M. Krueger L Kapás M Kimura M.R. Opp Somnogenic cytokines: Methods and overview Methods Neurosci 17 1993 111
23. S Rivest C Rivier The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions Endocr Rev 16 1995 177
24. A.S.J.P.A.M van Miert F Kaya C.T.M. van Duin Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1β, IL-2) and IFN-γ Physiol Behav 52 1992 859
25. C.R. Plata-Salamán Interferons and central regulation of feeding Am J Physiol 263 1992 R1222
26. L.L. Moldawer C Andersson J Gelin Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines Am J Physiol 254 1988 G450
27. N.J. Roberts Jr. Impact of temperature elevation on immunologic defenses Rev Infect Dis 13 1991 462
28. L.A. Toth E.A. Tolley J.M. Krueger Sleep as a prognostic indicator during infectious disease in rabbits 6th ed. Proc Soc Exp Biol Med 203 1993 179
29. D.T. Boumpas F Paliogianni E.D. Anastassiou Glucocorticosteroid action on the immune system: molecular and cellular aspects Clin Exp Rheumatol 9 1991 413
30. C.R. Plata-Salamán Regulation of hunger and satiety in man Dig Dis 9 1991 253
31. W.T. Chance J.E. Fischer Aphagic and adipsic effects of interleukin-1 Brain Res 568 1991 261
32. C.R. Plata-Salamán Y Oomura Y Kai Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system Brain Res 448 1988 106
33. M.K. Hellerstein S.N. Meydani M Meydani Interleukin-1-induced anorexia in the rat Influence of prostaglandins J Clin Invest 84 1989 228
34. Y Shimomura T Inukai S Kuwabara Both cyclooxygenase and lipoxygenase inhibitor partially restore the anorexia by interleukin-1β Life Sci 51 1992 1419
35. A Uehara Y Ishikawa T Okumura Indomethacin blocks the anorexic action of interleukin-1 Eur J Pharmacol 170 1989 257
36. C.R. Plata-Salamán Strategies for potential manipulation of anorexia during acute and chronic disease Nutrition 11 1995 702
37. A.C.E Linthorst C Flachskamm P Muller-Preuss Effect of bacterial endotoxin and interleukin-1β on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study J Neurosci 15 1995 2920
38. F Shintani S Kanba T Nakaki Interleukin-1β augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus J Neurosci 13 1993 3574
39. P Montuschi G Tringali D Currò Evidence that interleukin-1β and tumor necrosis factor inhibit gastric fundus motility via the 5-lipoxygenase pathway Eur J Pharmacol 252 1994 253
40. G Sütó Á Király Y Taché Interleukin-1β inhibits gastric emptying in rats: Mediation through prostaglandin and corticotropin-releasing factor Gastroenterology 106 1994 1568
41. E Saperas H Yang Y Taché Interleukin-1β acts at hypothalamic sites to inhibit gastric acid secretion in rats Am J Physiol 263 1992 G414
42. M.J. Fargeas J Fioramonti L Bueno Central action of interleukin-1β on intestinal motility in rats: Mediation by two mechanisms Gastroenterology 104 1993 377
43. A Uehara C Sekiya Y Takasugi Anorexia induced by interleukin 1: involvement of corticotropin-releasing factor Am J Physiol 257 1989 R613
44. J.M. Daun D.O. McCarthy The role cholecystokinin in interleukin-1-induced anorexia Physiol Behav 54 1993 237
45. C.R. Plata-Salamán Immunoregulators in the nervous system Neurosci Biobehav Rev 15 1991 185
46. W.T. Chance A Balasubramaniam R Dayal Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats Life Sci. 54 1994 1869
47. W.T. Chance A Balasubramaniam J.E Fischer Neuropeptide Y and the development of cancer anorexia Ann Surg 221 1995 579
48. E.I. Opara A Laviano M.M. Meguid Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats NeuroReport 6 1995 750
49. C.A. Dinarello The interleukin-1 family: 10 years of discovery FASEB J 8 1994 1314
50. C.R. Plata-Salamán Immunomodulators and feeding regulation: A humoral link between the immune and nervous systems Brain Behav Immun 3 1989 193
51. C.R. Plata-Salamán J.P. Borkoski Chemokines/intercrines and central regulation of feeding Am J Physiol 266 1994 R1711
52. W Langhans G Balkowski D Savoldelli Differential feeding responses to bacterial lipopolysaccharide and muramyl dipeptide Am J Physiol 261 1991 R659
53. C.R. Plata-Salamán J.P. Borkoski Centrally administered bacterial lipopolysaccharide depresses feeding in rats Pharmacol Biochem Behav 46 1993 787
54. M.J.M Van der Meer C.G.J.F. Sweep G.J. Pesman Synergism between IL-1β and TNF-α on the activity of the pituitary-adrenal axis and on food intake of rats Am J Physiol 268 1995 E551
55. W Langhans D Savoldelli S Weingarten Comparison of the feeding response to bacterial lipopolysaccharide and interleukin-1β Physiol Behav 53 1993 643
56. W.A. Banks L Ortiz S.R. Plotkin Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism J Pharmacol Exp Ther 259 1991 988
57. W.F. Hickey B.L. Hsu H Kimura T-lymphocyte entry into the central nervous system J. Neurosci. Res. 28 1991 254
58. L.E. Goehler C.R. Busch N Tartaglia Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: Further evidence for vagal mediation of immune-brain communication Neurosci Lett 185 1995 163
59. W.E. Thomas Brain macrophages: Evaluation of microglia and their functions Brain Res Rev 17 1992 61
60. D Giulian M Corpuz Microglial secretion products and their impact on the nervous system Series: Adv Neurol 59 1993 315
61. F Aloisi A Care G Borsellino Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1β and tumor necrosis factor-α J Immunol 149 1992 2358
62. C.D. Breder C.A. Dinarello C.B. Saper Interleukin-1 immunoreactive innervation of the human hypothalamus Science 240 1988 321
63. M Freidin M.V.L. Bennett J.A. Kessler Cultured sympathetic neurons synthesize and release the cytokine interleukin 1β 6th ed. Proc Natl Acad Sci USA 89 1992 10440
64. G.J. Molenaar F Berkenbosch A.M. van Dam Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus Brain Res 608 1993 169
65. K Kuriyama T Hori T Mori Actions of interferon-α and interleukin-1β on the glucose-responsive neurons in the ventromedial hypothalamus Brain Res Bull 24 1990 803
66. C.R. Plata-Salamán J.M.H. ffrench-Mullen Interleukin-1β inhibits calcium channel currents in isolated hippocampal CA1 neurons through protein kinase C Eur J Pharmacol 266 1994 1
67. S Weingarten M Senn W Langhans Does a learned taste aversion contribute to the anorectic effect of bacterial lipopolysaccharide? Physiol Behav 54 1993 961
68. L.J. Janz R Brown L Zuo Conditioned taste aversion but not adrenal activity develops to ICV administration of interleukin-1 in rats Physiol Behav 49 1991 691
69. A Tazi F Crestani R Dantzer Aversive effects of centrally injected interleukin-1 Neurosci Res Commun 7 1990 159
70. C Bauer S Weingarten M Senn Limited importance of a learned aversion in the hypophagic effect of interleukin-1β Physiol Behav 57 1995 1145
71. Y Fong L.L. Moldawer M Marano Cachectin/TNF or IL-1α induces cachexia with redistribution of body proteins Am J Physiol 256 1989 R659
72. J Gelin C Andersson K Lundholm Effects of indomethacin, cytokines, and cyclosporin-A on tumor growth and the subsequent development of cancer cachexia Cancer Res 51 1991 880
73. H Iseki N Kajimura C Ohue Cytokine production in five tumor cell lines with activity to induce cancer cachexia syndrome in nude mice Jpn J Cancer Res 86 1995 562
74. G Strassmann C.O. Jacob R Evans Mechanisms of experimental cancer cachexia Interaction between mononuclear phagocytes and colon-26 carcinoma and its relevance to IL-6-mediated cancer cachexia J Immunol 148 1992 3674
75. K Fujimoto-Ouchi S Tamura K Mori Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma Int J Cancer 61 1995 522
76. J.T. Henderson N.A. Seniuk P.M. Richardson Systemic administration of ciliary neurotrophic factor induces cachexia in rodents J Clin Invest 93 1994 2632
77. G Fantuzzi F Benigni M Sironi Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice Cytokine 7 1995 150
78. H.J.L.M. Ulenkate E.C.A. Kaal F.G.I. Jennekens Ciliary neurotrophic factor induces hypophagia, hypodipsia, and diminished weight gain in young adult rats Neurosci Res Commun 16 1995 67
79. H.N. Langstein G.M. Doherty D.L. Fraker The roles of γ-interferon and TNF α in an experimental rat model of cancer cachexia Cancer Res 51 1991 2302
80. P Matthys R Dijkmans P Proost Severe cachexia in mice inoculated with interferon-γ-producing tumor cells Int J Cancer 49 1991 77
81. K.J. Tracey A Cerami Tumor necrosis factor in the malnutrition (cachexia) of infection and cancer Am J Trop Med Hyg 47 1992 2 (Suppl.)
82. M.A. Pelleymounter M.J. Cullen C.L. Wellman Characteristics of BDNF-induced weight loss Exp Neurol 131 1995 229
83. J Cheng K Turksen Q.C. Yu Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNFα transgenic mice Genes Dev 6 1992 1444
84. U Keller Pathophysiology of cancer cachexia Support Care Cancer 1 1993 290
85. A Oliff D Defeo-Jones M Boyer Tumours secreting human TNF/cachectin induce cachexia in mice Cell 50 1987 555
86. B.K. Smith C.A. Conn M.J. Kluger Experimental cachexia: effects of MCA sarcoma in the Fischer rat Am J Physiol 265 1994 R376
87. N Mrosovsky L.A. Molony C.A. Conn Anorexic effects of interleukin-1 in the rat Am J Physiol 257 1989 R1315
88. I.G. Otterness P.A. Seymour H.W. Golden The effects of continuous administration of murine interleukin-1α in the rat Physiol Behav 43 1988 797
89. S Weingarten D Savoldelli W Langhans Enhancement or loss of the hypophagic effect of interleukin-1 upon chronic administration Physiol Behav 52 1992 831
90. H.D. Mulligan S.M. Mahony J.A. Ross Weight loss in a murine cachexia model is not associated with the cytokines tumour necrosis factor-α or interleukin-6 Cancer Lett 65 1992 239
91. S.M. Mahony S.A. Beck M.J. Tisdale Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour Br J Cancer 57 1988 385
92. G Shenouda M Labateya L Souhami Elevated serum cytokines in patients with malignancy and weight loss Int J Oncol 2 1993 115
93. G.V. Scagliotti E Gatti G Ferrari TNF-α determination in serum and pleural effusion in patients with lung cancer Int J Oncol 6 1995 147
94. P Aukrust N.B. Liabakk F Muller Serum levels of TNF-α and soluble TNF receptors in human immunodeficiency virus type 1 infection—Correlations to clinical, immunological, and virologic parameters J Infect Dis 169 1994 420
95. M Ciardi M.K. Sharief E.J. Thompson High cerebrospinal fluid and serum levels of TNF-α in asymptomatic HIV-1 seropositive individuals Correlation with interleukin-2 and soluble IL-2 receptor J Neurol Sci 125 1994 175
96. S.E. Weinroth D.M. Parenti G.L. Simon Wasting syndrome in AIDS: Pathophysiologic mechanisms and therapeutic approaches Infect Agents Dis 4 1995 76
97. K.L. Madson T.L. Moore J.M. Lawrence Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis J Rheumatol 21 1994 2359
98. A Green S.B. Dobias D.J.A. Walters Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone sensitive lipase Endocrinology 134 1994 2581
99. K Nonogaki G.M. Fuller N.L. Fuentes Interleukin-6 stimulates hepatic triglyceride secretion in rats Endocrinology 136 1995 2143
100. K.R. Feingold M Marshall R Gulli Effect of endotoxin and cytokines on lipoprotein lipase activity in mice Arterioscler Thromb 14 1994 1866
101. C Grunfeld K.R. Feingold Tumor necrosis factor, interleukin, and interferon induced changes in lipid metabolism as part of host defense 6th ed. Proc Soc Exp Biol Med 200 1992 224
102. A Hyltander U Körner K.G. Lundholm Evaluation of mechanisms behind elevated energy expenditure in cancer patients with solid tumours Eur J Clin Invest 23 1993 46
103. H.R. Alexander J.A. Norton Pathophysiology of cancer cachexia D Doyle G Hanks N MacDonald Oxford textbook of palliative medicine 1993 Oxford University Press Oxford 316
104. C Cangiano U Testa M Muscaritoli Cytokines, tryptophan and anorexia in cancer patients before and after surgical tumor ablation Anticancer Res 14 1994 1451
105. T.M. McDevitt P.T. Todorov S.A. Beck Purification and characterization of a lipid-mobilizing factor associated with cachexia-inducing tumors in mice and humans Cancer Res 55 1995 1458
106. C.R. Plata-Salamán Tumor necrosis factor (TNF) production in response to lipids: Immunomodulatory activity with clinical applicability? Nutrition 10 1994 179
107. A.L. Cooper L Gibbons M.A. Horan Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers Clin Nutr 12 1993 321
108. S Endres R Ghorbani VE Kelley The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells N Engl J Med 320 1989 265
109. SN Meydani S Endres MM Woods Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women J Nutr 121 1991 547
110. JM Kremer DR Robinson Studies of dietary supplementation with n-3 fatty acids in patients with rheumatoid arthritis World Rev Nutr Diet 66 1991 367
111. RB Zurier Fatty acids, inflammation and immune responses Prostaglandins Leukotrienes Essent Fatty Acids 48 1993 57
112. C Denzlinger T Kless S Sagebiel-Kohler Modulation of the endogenous leukotriene production by fish oil and vitamin E J Lipid Mediators Cell Signalling 11 1995 119
113. GS Kumar UN Das Effect of prostaglandins and their precursors on the proliferation of human lymphocytes and their secretion of tumor necrosis factor and various interleukins Prostaglandins Leukotrienes Essent Fatty Acids 50 1994 331
114. SN Meydani Modulation of cytokine production by dietary polyunsaturated fatty acids 6th ed. Proc Soc Exp Biol Med 200 1992 189
115. HM Mulrooney RF Grimble Influence of butter and of corn, coconut and fish oils on the effects of recombinant human tumour necrosis factor-α in rats Clin Sci 84 1993 105
116. AL Cooper NJ Rothwell Inhibition of the thermogenic and pyrogenic responses to interleukin-1β in the rat by dietary n-3 fatty acid supplementation Prostaglandins Leukotrienes Essent Fatty Acids 49 1993 615
117. PC Dagnelie JD Bell SCR Williams Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors Lipids 29 1994 195
118. M Tisdale SA Beck Inhibition of tumor-induced lypolysis in vitro and cachexia and tumor growth in vivo by eicosapentaenoic acid Biochem Pharmacol 41 1991 103
119. A Ayala IH Chaudry Dietary n-3 polyunsaturated fatty acid modulation of immune cell function before and after trauma Nutrition 11 1995 1
120. J Molvig F Pociot H Worsaae Dietary supplementation with ω-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1β content but not monokine secretion in healthy and insulin-dependent diabetic individuals Scand J Immunol 34 1991 399
121. MH Oster SR Enders SJ Samuels Megestrol acetate in patients with AIDS and cachexia Ann Intern Med 121 1994 400
122. JH VonRoenn Randomized trials of megestrol acetate for AIDS-associated anorexia and cachexia Oncology 51 Suppl. 1 1994 19
123. CL Loprinzi JC Michalak DJ Schaid Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia J Clin Oncol 11 1993 762
124. KK Graham DJ Mikolich AE Fisher Pharmacologic evaluation of megestrol acetate oral suspension in cachectic AIDS patients J Acquired Immune Defic Syndr 7 1994 580
125. B Neri MT Gemelli P Tarantini The role of megestrol acetate in neoplastic anorexia and cachexia Curr Ther Res 56 1995 183
126. AB Kornblith DR Hollis E Zuckerman Effect of megestrol acetate on quality of life in a dose-response trial in women with advanced breast cancer J Clin Oncol 11 1993 2081
127. MC Leinung R Liporace CH Miller Induction of adrenal suppression by megestrol acetate in patients with AIDS Ann Intern Med 122 1995 843
128. KA Steer AB Kurtz JW Honour Megestrol-induced Cushing's syndrome Clin Endocrinol 42 1995 91
129. HD McCarthy RE Crowder S Dryden Megestrol acetate stimulates food and water intake in the rat: effects on regional hypothalamic neuropeptide Y concentrations Eur J Pharmacol 265 1994 99
130. s -subunit in acutely isolated rat ventromedial hypothalamic neurones J Physiol Lond 487 1995 291
131. T Popiela R Lucchi F Giongo Methylprednisolone as palliative therapy for female terminal cancer patients Eur J Cancer Clin Oncol 25 1989 1823
132. Robustelli Della Cuna G A Pellegrini M Piazzi Effect of methylprednisolone sodium succinate on quality of life in pre-terminal cancer patients: a placebo controlled, multi-center study Eur J Cancer Clin Oncol 25 1989 1817
133. KA Nelson D Walsh FA Sheehan The cancer anorexia-cachexia syndrome J Clin Oncol 12 1994 213
134. DL Bartlett S Charland MH Torosian Growth hormone, insulin, and somatostatin therapy of cancer cachexia Cancer 73 1994 1499
135. JE Beal R Olson L Laubenstein Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS J Pain Symptom Manag 10 1995 89
136. CP Samlaska EA Winfield Pentoxifylline J Am Acad Dermatol 30 1994 603
137. P Lissoni A Ardizzoia MS Perego Inhibition of tumor necrosis factor-alpha secretion by pentoxifylline in advanced cancer patients with abnormally high blood levels of tumor necrosis factor-alpha J Biol Regul Homeostatic Agents 7 1993 73
138. BJ Dezube MM Lederman JG Spritzler High-dose pentoxifylline in patients with AIDS: Inhibition of tumor necrosis factor production J Infect Dis 171 1995 1628
139. D Breuillé MC Farge F Rosé Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis Am J Physiol 265 1993 E660
140. D Landman A Sarai S Sathe Use of pentoxifylline therapy for patients with AIDS-related wasting: Pilot study Clin Infect Dis 18 1994 97
141. S Makonkawkeyonn RNR Limson-Pobre AL Moreira Thalidomide inhibits the replication of human immunodeficiency virus type 1 6th ed. Proc Natl Acad Sci USA 90 1993 5974
142. MA Pelleymounter MJ Cullen MB Baker Effects of the obese gene product on body weigh regulation in ob ob mice Science 269 1995 540
143. LA Campfield FJ Smith Y Guisez Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546
144. LA Tartaglia M Dembski X Weng Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263
145. CR Plata-Salamán Anorexia induced by activators of the signal transducer gp 130 NeuroReport 7 1996 in press
146. G Sonti SE Ilyin CR Plata-Salamán Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats Peptides 17 1996 in press
147. G Sonti SE Ilyin CR Plata-Salamán Anorexia induced by cytokine interactions at pathophysiological concentrations Am J Physiol 1996 in press