Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells

Chemico-Biological Interactions

Volumn 182, Issue 2-3, 2009, Pages 191-198

  Al Anati, Lauy ^a   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

HepG2; Mdm2; NDL PCBs; p53

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; ETOPOSIDE; LEPTOMYCIN B; MITOGEN ACTIVATED PROTEIN KINASE; POLYCHLORINATED BIPHENYL; PROTEIN MDM2; PROTEIN P53; SERINE; TYROSINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

MUS; RATTUS;

EID: 70350125897     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.09.004     Document Type: Article

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