Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats

Reproductive Toxicology

Volumn 27, Issue 1, 2009, Pages 41-45

  Elumalai, Perumal ^a   Krishnamoorthy, Gunasekaran ^a   Selvakumar, Kandaswamy ^a   Arunkumar, Ramachandran ^a   Venkataraman, Prabhu ^a   Arunakaran, Jagadeesan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cytochrome P450 scc enzyme; Leydig cells; Lycopene; PCB; StAR protein; Testosterone

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AROCLOR 1254; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORN OIL; LYCOPENE; POLYCHLORINATED BIPHENYL; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CELL ISOLATION; CONTROLLED STUDY; DECAPITATION; ENZYME ACTIVITY; LEYDIG CELL; NONHUMAN; PROTECTION; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SPECTROPHOTOMETRY; TESTIS; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ANTIOXIDANTS; CAROTENOIDS; CHEMOPREVENTION; CHLORODIPHENYL (54% CHLORINE); CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; ENVIRONMENTAL POLLUTANTS; LEYDIG CELLS; MALE; ORGAN SIZE; PHOSPHOPROTEINS; RATS; RATS, WISTAR; TESTIS; TESTOSTERONE;

ANIMALIA; MAMMALIA; RATTUS; VIRIDIPLANTAE; ZEA MAYS;

EID: 58749086004     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2008.11.053     Document Type: Article

References (52)

1. Kimbrough R.D. Polychlorinated biphenyls (PCBs) and human health: an update. Crit Rev Toxicol 25 (1995) 133-163
2. Nessel C.S., and Gallo M.A. Dioxins and related compounds. In: Lippmann M. (Ed). Environmental toxicants: human exposure and their health effects (1994), Van Nostrand Reinhold, New York 163-182
3. Ahmad S.U., Tariq S., Jalali S., and Ahmad M.M. Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male rhesus monkeys (Macaca mulatta). Environ Res 93 (2003) 272-278
4. Safe S.H. Modulation of gene expression and endocrine response pathways by 2,3,7,8- tetrachlorodibenzo-p-dioxin and relatedcompounds. Pharmacol Ther 67 (1995) 247-281
5. Massaad C., Entezami F., Massade L., Benahined M., Olivenner F., Barouki R., and Hamamah S. How can chemical compounds alter human fertility?. Eur J Obst Gynecol Reprod Biol 100 (2002) 127
6. Gray E.L., Ostly J., Marshall R., and Andrews J. Reproductive and thyroid effects of low-level polychlorinated biphenyl (Aroclor 1254) exposure. Fundam Appl Toxicol 20 (1993) 288-294
7. Murgesan P., Senthil kumar J., Balasubramanian K., Aruldhas M.M., and Arunakaran J. Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats. Hum Exp Toxicol 24 (2005) 61-66
8. Rozati R., Reddy P.P., Reddanna P., and Mujtaba R. Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril 78 (2002) 1187-1194
9. Cooke P.S., Zhao Y.D., and Hansen L.G. Neonatal polychlorinated biphenyl treatment increase adult testis size and sperm production in the rat. Toxicol Appl Pharmacol 136 (1996) 112-117
10. Kim I.S., and Ariyaratne H.B. Chamindrani Mendis-Handagama SM. Effects of continuous and intermittent exposure of lactating mothers to Aroclor 1242 on testicular steroidogenic function in the adult male offspring. Tissue Cell 33 (2001) 169-177
11. Murugesan P., Muthusamy T., Balasubramanian K., and Arunakaran J. Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254) induced oxidative damage in Leydig cells. Free Radic Res 39 (2005) 1259-1272
12. Muthuvel R., Venkataraman P., Krishnamoorthy G., Gunadharini D.N., Kanagaraj P., Jone Stanley A., Arunakaran J., et al. Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rats. Clin Chim Acta 365 (2006) 297-303
13. Senthilkumar J., Banudevi S., Sharmila M., Murugesan P., Srinivasan N., Arunakaran J., et al. Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reprod Toxicol 19 (2004) 201-208
14. Krishnamoorthy G., Murugesan P., Muthuvel R., Gunadharini D.N., Vijayababu M.R., Arunkumar A., Venkataraman P., Aruldhas M.M., and Arunakaran J. Effect of Aroclor 1254 on Sertoli cellular antioxidant system,androgen binding protein and lactate in adult rat in vitro. Toxicology 212 (2005) 195-205
15. Murgesan P., Kanagaraj P., Balasubramanian K., Aruldhas M.M., and Arunakaran J. The inhibitory effects of polychlorinated biphenyl (Aroclor 1254) on Leydig cell LH receptors, steroidogenic enzymes, and antioxidant enzymes in adult rats. Reprod Toxicol 20 (2005) 117-126
16. Murugesan P., Muthusamy T., Balasubramanian K., and Arunakaran J. Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reprod Toxicol 4 (2008) 447-454
17. Payne A.H., and Hales D.B. Overviewof steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25 (2004) 947-970
18. Clark B.J., Wells J., King S.R., and Stocco D.M. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269 (1994) 28314-28322
19. Velmurugan B., Santhiya S.T., and Nagini S. Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N-nitro-N-nitrosoguanidine-induced genotoxicity. Pol J Pharmacol 56 (2004) 241-245
20. Tapiero H., Townsend D.M., and Tew K.D. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother 58 (2004) 100-110
21. Cohen L.A. A review of animal model studies of tomato carotenoids, lycopene and cancer chemoprevention. Exp Biol Med 227 (2002) 864-868
22. Jonker D., Kuper C.F., Frail N., Estrella A., Rodrigues, and Otero C. Ninety-day oral toxicity study of lycopene from Blakesleatrispora in rats. Regul Toxicol Phamacol 37 (2003) 396-406
23. Michael McClain R., and Bausch I. Summary of safety studies conducted with synthetic lycopene. Regul Toxicol Pharmacol 37 (2003) 274-285
24. Turk G., Atessahin A., Sonmez M., Yuce A., and Ceribas A.O. Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology 67 (2007) 778-785
25. Atessahin A., Karahan I., Turk G., Gur S., Yi{dotless}lmaz S., and Ceribas A.O. Protective role of lycopene on cisplatin induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol 21 (2006) 42-47
26. Atessahin A., Turk G., and Karahan I. Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil Steril 85 (2005) 1216-1222
27. Karahan I., Ates A., Yilmaz S., Ceribas A.O., and Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 215 (2005) 198-204
28. Yilmaz S., Atessahin A., Sahna E., Karahan I., and Ozer S. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 218 (2006) 164-171
29. Kaya H., Hany J., Fastabend A., Roth-Harev A., Winneke G., and Lilinthal H. Effects of maternal exposure to a reconstituted mixture of polychlorinated biphenyls on sex-dependent behaviors and steroid hormone concentration in rats: dose-response relationship. Toxicol Appl Pharmacol 78 (2002) 71-81
30. Rigaudiere N., Loubassou S., Grizard G., and Boucher D. Characterization of insulin binding and comperative action of insulin and insulin-like growth factor I on purified Leydig cells, from the adult rat. J Androl 11 (1988) 165-178
31. Sharpe R.M., and Cooper I. Stimulatory effect of LHRH and its agonists on Leydig cell steroidogenesis in vitro. Mol Cell Endocrinol 26 (1982) 141-150
32. Bergmeyer M.U. Steroid dehydrogenases. In: Bergmeyer M.U. (Ed). Methods of enzymatic analysis (1974), Academic Press, New York 447-476
33. Anbalagan J., Kanagaraj P., Srinivasan N., Aruldhas M.M., and Arunakaran J. Effect of polychlorinated biphenyl Aroclor 1254 on rat epididymis. Indian J Med Res 118 (2003) 236-242
34. Venkataraman P., Sridhar M., Dhanammal S., Vijayababu M.R., Arunkumar A., Srinivasan N., and Arunakaran J. Effects of vitamins supplementation on PCB (Aroclor 1254) induced changes in ventral prostatic androgen and estrogen receptors. Endocr Res 30 (2004) 469-480
35. Murgesan P., Muthusamy T., Balasubramanian K., and Arunakaran J. Effects of vitamin C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology 232 (2007) 170-182
36. Collins A.R., Olmedilla B., Southon S., Granado F., and Duthie S.J. Serum carotenoids and oxidative DNA damage in human lymphocytes. Carcinogenesis 19 (1998) 2159-2162
37. Scolastici C., Alves de Lima R.O., Barbisan L.F., Ferreira A.L., Ribeiro D.A., and Salvadori D.M. Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells. Toxicol In Vitro 5 (2007) 840-845
38. Bohm F., Tinkler J.H., and Truscott T.G. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nature Med 1 (1995) 98-99
39. Lowe G.M., Booth L.A., Young A.J., and Bilton R.F. Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 30 (1999) 141-151
40. Akingbemi B.T., Ge R., Klinefelter G.R., Zirkin B.R., and Hardy M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc Natl Acad Sci USA 101 (2004) 775-780
41. Desaulniers D., Leingartner K., Wade M., Fintelman E., Yagminas A., and Foster W.A. Effect of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats. Toxicol Sci 47 (1999) 158-169
42. Sridhar M., Venkataraman P., Dhanammal S., Arunkumar A., Aruldhas M.M., Srinivasan N., and Arunakaran J. Impact of polychlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate. Asian J Androl 6 (2004) 19-22
43. Miller W.L. Molecular biology of steroid hormone synthesis. Endocr Rev 9 (1988) 295-318
44. Hanukoglu I., Suh B.S., Himmelhoch S., and Amsterdam A. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. J Cell Biol 111 (1990) 1373-1382
45. Stocco D.M., and Clark B.J. Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17 (1996) 221-244
46. Stocco D.M. StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol 63 (2001) 193-213
47. Walsh L.P., and Stocco D.M. The role of the steroidogenic acute regulatory (StAR) protein in environment endocrine disruptor inhibited steroidogenesis. Proc. 52nd Universal Acadamy press Inc, Tayoko, Japan. Yamada conference Mol Steroidogenesis (2000) 253-266
48. Walsh L.P., McCormick C., and Stocco D.M. Roundup inhibits steroidogenesis by distrupting StAR expression. Environ Health Persp 108 (2000) 769-776
49. Clark B.J., and Cochrum R.K. The steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction. Drug Metab Rev 39 2-3 (2007) 353-370
50. Chen H., Cangello D., Benson S., Folmer J., Zhu H., Trush M.A., et al. Age-related increase in mitochondrial superoxide generation in the testosterone producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?. Exp Gerontol 36 (2001) 1361-1373
51. Cao L., Leers-Sucheta S., and Azhar S. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J Steroid Biochem Mol Biol 88 (2004) 61-67
52. Chen H., Liu J., Luo L., Baig M.U., Kim J.M., Zirkin B.R., and Vitamin E. aging and Leydig cell steroidogenesis. Exp Gerontol 40 (2005) 728-736