Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 1, 2012, Pages 20-27

  Flynn, Charles ^a   Zheng, Siyuan ^a   Yan, Ling ^a   Hedges, Lora ^a   Womack, Bethany ^a   Fessel, Josh ^a   Cogan, Joy ^a   Austin, Eric ^a   Loyd, James ^a   West, James ^a   Zhao, Zhongming ^a   Hamid, Rizwan ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMPR2; Connectivity map; Expression signature; Hereditary pulmonary arterial hypertention; ROS

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 2; REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; BMPR2 GENE; CELL GROWTH; CELL METABOLISM; CLINICAL ARTICLE; CONNECTIVITY MAP ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE MUTATION; HEREDITARY PULMONARY ARTERIAL HYPERTENSION; HETEROZYGOTE; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; MALE; NONSENSE MEDIATED MRNA DECAY; PATHOGENESIS; PENETRANCE; PULMONARY HYPERTENSION; RISK ASSESSMENT; UPREGULATION;

AGED; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELL CYCLE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION, PULMONARY; LUNG; LYMPHOCYTES; MALE; MUTATION; PENETRANCE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84863796651     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0251OC     Document Type: Article

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