Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes

Osteoarthritis and Cartilage

Volumn 19, Issue 1, 2011, Pages 118-125

  Cheng, A W M ^a   Stabler, T V ^a   Bolognesi, M ^a   Kraus, V B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chondrocyte; Inflammation; INOS, COX2; NO; PEG2; Selenomethionine

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; RNA; SELENOMETHIONINE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOASSAY; INFLAMMATION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGED; BLOTTING, WESTERN; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; DINOPROSTONE; HUMANS; INTERLEUKIN-1BETA; MIDDLE AGED; NITRIC OXIDE SYNTHASE; RNA, MESSENGER; SELENOMETHIONINE;

EID: 78650304654     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.10.019     Document Type: Article

References (51)

1. Rayman M.P. The importance of selenium to human health. Lancet 2000, 356(9225):233-241.
2. Ryan-Harshman M., Aldoori W. The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Can J Diet Pract Res 2005, 66(2):98-102.
3. Allander E. Kashin-Beck disease. An analysis of research and public health activities based on a bibliography 1849-1992. Scand J Rheumatol Suppl 1994, 99:1-36.
4. Jordan J., Fang F., Arab L., Morris J., Renner J., Ngwenyama R., et al. Low selenium levels are associated with increased odds of radiographic knee and multijoint OA. Osteoarthritis Cartilage 2005, 13(Suppl 1). S35.
5. Jordan J., Fang F., Schwartz T., Morris J., Renner J., Chen J., et al. Low selenium levels are associated with increased odds of radiographic hip osteoarthritis in African American and White women. Osteoarthritis Cartilage 2007, 15(Suppl 3). C33.
6. Meulenbelt I., Min J.L., Bos S., Riyazi N., Houwing-Duistermaat J.J., van der Wijk H.J., et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008, 17(12):1867-1875.
7. Downey C.M., Horton C.R., Carlson B.A., Parsons T.E., Hatfield D.L., Hallgrimsson B., et al. Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. PLoS Genet 2009, 5(8). e1000616.
8. Vunta H., Belda B.J., Arner R.J., Channa Reddy C., Vanden Heuvel J.P., Sandeep Prabhu K. Selenium attenuates pro-inflammatory gene expression in macrophages. Mol Nutr Food Res 2008, 52(11):1316-1323.
9. Prabhu K.S., Zamamiri-Davis F., Stewart J.B., Thompson J.T., Sordillo L.M., Reddy C.C. Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation. Biochem J 2002, 366(Pt 1):203-209.
10. Cao Y.Z., Reddy C.C., Sordillo L.M. Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. Free Radic Biol Med 2000, 28(3):381-389.
11. Zamamiri-Davis F., Lu Y., Thompson J.T., Prabhu K.S., Reddy P.V., Sordillo L.M., et al. Nuclear factor-kappaB mediates over-expression of cyclooxygenase-2 during activation of RAW 264.7 macrophages in selenium deficiency. Free Radic Biol Med 2002, 32(9):890-897.
12. Andriamanalijaona R., Kypriotou M., Bauge C., Renard E., Legendre F., Raoudi M., et al. Comparative effects of 2 antioxidants, selenomethionine and epigallocatechin-gallate, on catabolic and anabolic gene expression of articular chondrocytes. J Rheumatol 2005, 32(10):1958-1967.
13. Lazzerini P.E., Capecchi P.L., Nerucci F., Fioravanti A., Chellini F., Piccini M., et al. Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. Ann Rheum Dis 2004, 63(7):867-869.
14. Zhou P.H., Liu S.Q., Peng H. The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. J Orthop Res 2008, 26(12):1643-1648.
15. Panico A.M., Cardile V., Garufi F., Puglia C., Bonina F., Ronsisvalle G. Protective effect of Capparis spinosa on chondrocytes. Life Sci 2005, 77(20):2479-2488.
16. Thomas B., Thirion S., Humbert L., Tan L., Goldring M.B., Bereziat G., et al. Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. Biochem J 2002, 362(Pt 2):367-373.
17. Kuettner K.E., Pauli B.U., Gall G., Memoli V.A., Schenk R.K. Synthesis of cartilage matrix by mammalian chondrocytes in vitro. I. Isolation, culture characteristics, and morphology. J Cell Biol 1982, 93(3):743-750.
18. Westacott C.I., Whicher J.T., Barnes I.C., Thompson D., Swan A.J., Dieppe P.A. Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 1990, 49(9):676-681.
19. Kahle P., Saal J.G., Schaudt K., Zacher J., Fritz P., Pawelec G. Determination of cytokines in synovial fluids: correlation with diagnosis and histomorphological characteristics of synovial tissue. Ann Rheum Dis 1992, 51(6):731-734.
20. Schrauzer G.N. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr 2000, 130(7):1653-1656.
21. Yazar M., Sarban S., Kocyigit A., Isikan U.E. Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis. Biol Trace Elem Res 2005, 106(2):123-132.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4):402-408.
23. Motulsky H: GraphPad Instat Version 3.0 The Instat guide to choosing and interpreting statistical tests; 1990.
24. Goldring S.R., Goldring M.B. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 2004, 427(Suppl):S27-S36.
25. Jacques C., Gosset M., Berenbaum F., Gabay C. The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation. Vitam Horm 2006, 74:371-403.
26. Abramson S.B. Osteoarthritis and nitric oxide. Osteoarthritis Cartilage 2008, 16(Suppl 2):S15-S20.
27. Vuolteenaho K., Moilanen T., Al-Saffar N., Knowles R.G., Moilanen E. Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage. Osteoarthritis Cartilage 2001, 9(7):597-605.
28. Geng Y., Blanco F.J., Cornelisson M., Lotz M. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes. J Immunol 1995, 155(2):796-801.
29. Charles I.G., Palmer R.M., Hickery M.S., Bayliss M.T., Chubb A.P., Hall V.S., et al. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci U S A 1993, 90(23):11419-11423.
30. Attur M., Al-Mussawir H.E., Patel J., Kitay A., Dave M., Palmer G., et al. Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. J Immunol 2008, 181(7):5082-5088.
31. Li X., Ellman M., Muddasani P., Wang J.H., Cs-Szabo G., van Wijnen A.J., et al. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum 2009, 60(2):513-523.
32. Tung J.T., Arnold C.E., Alexander L.H., Yuzbasiyan-Gurkan V., Venta P.J., Richardson D.W., et al. Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures. Am J Vet Res 2002, 63(7):987-993.
33. Goldring M.B., Suen L.F., Yamin R., Lai W.F. Regulation of collagen gene expression by prostaglandins and interleukin-1beta in cultured chondrocytes and fibroblasts. Am J Ther 1996, 3(1):9-16.
34. Schwartz Z., Gilley R.M., Sylvia V.L., Dean D.D., Boyan B.D. The effect of prostaglandin E2 on costochondral chondrocyte differentiation is mediated by cyclic adenosine 3′,5′-monophosphate and protein kinase C. Endocrinology 1998, 139(4):1825-1834.
35. Brochhausen C., Neuland P., Kirkpatrick C.J., Nusing R.M., Klaus G. Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ-prostaglandin E2 dependent proliferation of growth plate chondrocytes. Arthritis Res Ther 2006, 8(3):R78.
36. Dray A., Read S.J. Arthritis and pain. Future targets to control osteoarthritis pain. Arthritis Res Ther 2007, 9(3):212.
37. Taskiran D., Stefanovic-Racic M., Georgescu H., Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 1994, 200(1):142-148.
38. Sasaki K., Hattori T., Fujisawa T., Takahashi K., Inoue H., Takigawa M. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem 1998, 123(3):431-439.
39. Pelletier J.P., Mineau F., Ranger P., Tardif G., Martel-Pelletier J. The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. Osteoarthritis Cartilage 1996, 4(1):77-84.
40. Maneiro E., Lopez-Armada M.J., de Andres M.C., Carames B., Martin M.A., Bonilla A., et al. Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. Ann Rheum Dis 2005, 64(3):388-395.
41. Wu G.J., Chen T.G., Chang H.C., Chiu W.T., Chang C.C., Chen R.M. Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes. J Cell Biochem 2007, 101(6):1520-1531.
42. Loeser R.F., Carlson C.S., Del Carlo M., Cole A. Detection of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. Arthritis Rheum 2002, 46(9):2349-2357.
43. Kim S.H., Johnson V.J., Shin T.Y., Sharma R.P. Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways. Exp Biol Med (Maywood) 2004, 229(2):203-213.
44. Yun C.H., Yang J.S., Kang S.S., Yang Y., Cho J.H., Son C.G., et al. NF-kappaB signaling pathway, not IFN-beta/STAT1, is responsible for the selenium suppression of LPS-induced nitric oxide production. Int Immunopharmacol 2007, 7(9):1192-1198.
45. Fermor B., Weinberg J.B., Pisetsky D.S., Guilak F. The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage 2005, 13(10):935-941.
46. Shakibaei M., John T., Schulze-Tanzil G., Lehmann I., Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem Pharmacol 2007, 73(9):1434-1445.
47. Masuko-Hongo K., Berenbaum F., Humbert L., Salvat C., Goldring M.B., Thirion S. Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum 2004, 50(9):2829-2838.
48. Lianxu C., Hongti J., Changlong Y. NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. Osteoarthritis Cartilage 2006, 14(4):367-376.
49. Heart E., Sung C.K. Insulin-like and non-insulin-like selenium actions in 3T3-L1 adipocytes. J Cell Biochem 2003, 88(4):719-731.
50. Monick M.M., Robeff P.K., Butler N.S., Flaherty D.M., Carter A.B., Peterson M.W., et al. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem 2002, 277(36):32992-33000.
51. Monteiro H.P., Ivaschenko Y., Fischer R., Stern A. Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts. FEBS Lett 1991, 295(1-3):146-148.