Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: A possible mechanism for a protective effect against subchondral bone remodelling

Arthritis Research and Therapy

Volumn 10, Issue 3, 2008, Pages

  Boileau, Christelle ^a   Tat, Steeve Kwan ^a   Pelletier, Jean Pierre ^a   Cheng, Saranette ^a   Martel Pelletier, Johanne ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; COLLAGENASE 3; DIACETYLRHEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; RHEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; ANTHRAQUINONE DERIVATIVE; ENZYME INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

AGED; ANIMAL CELL; ARTICLE; BONE; BONE METABOLISM; BONE REMODELING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOARTHRITIS; OSTEOCLAST; OSTEOLYSIS; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ARTICULAR CARTILAGE; CELL CULTURE; CELL LINE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; PATHOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BONE REMODELING; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; MICE; OSTEOARTHRITIS; OSTEOCLASTS;

EID: 47149091513     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2444     Document Type: Article

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