Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4610-4626

  Xu, Ze Qi ^a   Pupek, Krzysztof ^b   Suling, William J ^c   Enache, Livia ^b   Flavin, Michael T ^a  

^a Advanced Life Sciences Inc   (United States)

^b DeCODE Chemistry & Biostructures   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Mycobacterium tuberculosis; Pharmacophore; Pyranocoumarin

Indexed keywords

2 (2,2 DIMETHYL 8 OXO 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H,8H PYRANO[2,3 F]CHROMEN 6 CARBOXYLIC ACID ETHYL ESTER; 2,2 DIMETHYL 5 (2 HYDROXYETHOXY) 6 (1 HYDROXYPROPYL) 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 (2 HYDROXYETHOXY) 6 PROPIONYL 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 (2 HYDROXYETHOXY) 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 (2 HYDROXYETHOXY) 6 PROPIONYL 10 PROPYL 3,4,9,10 TETRAHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 (2 HYDROXYETHOXY) 8 OXO 10 PROPYL 3,4 DIHYDRO 2H,8H PYRANO[2,3 F]CHROMEN 6 CARBOXYLIC ACID METHYL ESTER; 2,2 DIMETHYL 5 (2 MORPHOLIN 4 YLETHOXY) 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 ETHOXY 6 PROPIONYL 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 ETHOXY 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 HYDROXY 6 (1 HYDROXYPROPYL) 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 HYDROXY 6 (1 HYDROXYPROPYL) 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 HYDROXY 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 ISOPROPOXY 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 METHOXY 6 PROPIONYL 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 METHOXY 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 5 METHOXYMETHOXY 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 6 (1 HYDROXYPROPYL) 10 PROPYL 5 (PROP 2 YNYLOXY) 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 6 (1 HYDROXYPROPYL) 5 ETHOXY 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 6 (1 HYDROXYPROPYL) 5 METHOXY 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 5 (PROP 2 YNYLOXY) 2H PYRANO[2,3 F]CHROMEN 8 ONE; 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 5 (PROP 2 YNYLOXY) 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5 (2 ACETOXYETHOXY) 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5 ACETOXY 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5 ACETOXY 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5 OXY 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5 OXY 2,2 DIMETHYL 6 PROPIONYL 10 PROPYL 3,4 DIHYDRO 2H PYRANO[2,3 F]CHROMEN 8 ONE; 5,10 DIHYDROXY 8,9 DIMETHYL 4 PROPYL 9,10 DIHYDRO 8H PYRANO[2,3 F]CHROMEN 8 ONE; 8,8 DIMETHYL 5 HYDROXY 10 PROPIONYL 4 PROPYL 7,9A DIHYDRO 8H PYRANO[3,2 G]CHROMEN 8 ONE; PYRANOCOUMARIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACOPHORE; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANTIBIOTICS, ANTITUBERCULAR; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PYRANOCOUMARINS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 33646589655     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.017     Document Type: Article

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