Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32313-32323

  Alvira, Daniel ^a   Naughton, Ruth ^a   Bhatt, Lavinia ^a   Tedesco, Sara ^a   Landry, William D ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINES; CELL VIABILITY; CHIMERIC PROTEINS; CHRONIC MYELOGENOUS LEUKEMIA; IMATINIB; IMATINIB MESYLATE; KINASE ACTIVITY; MOLECULAR LEVELS; MYELOPROLIFERATIVE DISORDERS; PHOSPHATASE ACTIVITY; PROTEIN STABILITY; PROTEIN-TYROSINE PHOSPHATASE 1B; REACTIVE OXYGEN SPECIES; THERAPEUTIC AGENTS; TYROSINE KINASE; TYROSINE PHOSPHORYLATION; UBIQUITINATION;

AMINO ACIDS; CELL CULTURE; DEGRADATION; PHOSPHATASES; PHOSPHORYLATION;

PROTEINS;

BCR ABL PROTEIN; IMATINIB; PROTEIN TYROSINE PHOSPHATASE 1B;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; UBIQUITINATION;

FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LYSOSOMES; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN STABILITY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PYRIMIDINES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; UBIQUITINATION;

EID: 80052727153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.249060     Document Type: Article

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