Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach

Toxicology and Applied Pharmacology

Volumn 236, Issue 3, 2009, Pages 282-292

  Eveillard, Alexandre ^a   Lasserre, Frédéric ^a   de Tayrac, Marie ^b   Polizzi, Arnaud ^a   Claus, Sandrine ^c   Canlet, Cécile ^d   Mselli Lakhal, Laïla ^a   Gotardi, Gaëlle ^d   Paris, Alain ^d   Guillou, Hervé ^a   Martin, Pascal G P ^a   Pineau, Thierry ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d CEMAGREF   (France)

Author keywords

CAR; DEHP; Endocrine disruptor; Rev erb ; Systems biology; Testis

Indexed keywords

3 HYDROXYBUTYRIC ACID; BILE ACID; CITRIC ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; ENZYME; GENE PRODUCT; GLUTAMINE; GLUTATHIONE; GLYCEROL; GLYCEROL DERIVATIVE; GLYCEROPHOSPHORYLCHOLINE; GLYCOPROTEIN; HEME; ISOLEUCINE; LEUCINE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENYLALANINE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PROTEIN ALAS1; PROTEIN BMAL1; PROTEIN PCK1; PROTEIN REV ERBALPHA; PROTEIN REV ERBBETA; TRIACYLGLYCEROL; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMICS; CONTROLLED STUDY; ENERGY METABOLISM; EXPOSURE; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE TARGETING; HEME SYNTHESIS; IN VIVO STUDY; LIVER TOXICITY; MALE; METABOLIC REGULATION; METABOLITE; METABONOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; TESTIS; TRANSCRIPTOMICS; UNINDEXED SEQUENCE;

ANIMALS; DIETHYLHEXYL PHTHALATE; GENE EXPRESSION PROFILING; HEME; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MICE; SYSTEMS BIOLOGY; TRANSCRIPTION, GENETIC;

MUS;

EID: 63949086443     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.008     Document Type: Article

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