The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a down syndrome mouse model

PLoS Genetics

Volumn 8, Issue 5, 2012, Pages

  Raveau, Matthieu ^a   Lignon, Jacques M ^b   Nalesso, Valérie ^a   Duchon, Arnaud ^a   Groner, Yoram ^c   Sharp, Andrew J ^d   Dembele, Doulaye ^a   Brault, Véronique ^a   Hérault, Yann ^a,e,f  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITÉ D'ORLÉANS   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e CNRS   (France)

^f INSTITUT CLINIQUE DE LA SOURIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 40; CONNEXIN 43; HIGH MOBILITY GROUP B1 PROTEIN; TRANSCRIPTION FACTOR RUNX1; VON WILLEBRAND FACTOR;

ADAM19 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APP GENE; ARTICLE; BIRTH DEFECT; CONGENITAL HEART MALFORMATION; CONNEXIN 40 GENE; CONNEXIN 43 GENE; CONTROLLED STUDY; COQ7 GENE; DEVELOPMENTAL GENE; DOWN SYNDROME; DYRK1A GENE; ECG ABNORMALITY; FEMALE; GABPA GENE; GENE; GENE DOSAGE; GENE EXPRESSION; GENOTYPE PHENOTYPE CORRELATION; HEART MUSCLE CONDUCTION DISTURBANCE; HISTOPATHOLOGY; HMG1 GENE; MALE; MOLECULAR PATHOLOGY; MORC3 GENE; MOUSE; NONHUMAN; PDE10A GENE; RCAN1 GENE; RUNX1 GENE; SLC5A3 GENE; SLC8A1 GENE; TFB1M GENE; VWF GENE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CONGENITAL ABNORMALITIES; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DISEASE MODELS, ANIMAL; DOWN SYNDROME; ELECTROCARDIOGRAPHY; GENE DOSAGE; GENE EXPRESSION REGULATION; HEART BLOCK; HEART DEFECTS, CONGENITAL; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE;

MUS;

EID: 84863661494     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002724     Document Type: Article

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