Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21

Physiological Genomics

Volumn 33, Issue 2, 2008, Pages 230-239

  Lignon, Jacques M ^a   Bichler, Zoë ^b,c   Hivert, Bruno ^a   Gannier, François E ^a   Cosnay, Pierre ^a   Del Rio, José A ^b   Migliore Samour, Danièle ^a   Malécot, Claire O ^a  

^a CNRS   (France)

^b UNIVERSITY OF BARCELONA   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Autonomic nervous system; Cardiac; Down syndrome; Electrocardiogram; GIRK2

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; CARBACHOL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL 2; MESSENGER RNA; METHOXAMINE; URETHAN;

ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME 21; CHRONOTROPISM; CONTROLLED STUDY; ELECTROCARDIOGRAM; FEMALE; GENE; GENE AMPLIFICATION; GENE OVEREXPRESSION; HEART ATRIUM; HEART RATE; HEART RHYTHM; HEART VENTRICLE; HOMOZYGOTE; KCNJ6 GENE; MOUSE; NONHUMAN; P WAVE; PHENOTYPE; PR INTERVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA TRANSLATION; SINUS NODE; STIMULATION; TRANSGENIC MOUSE; WILD TYPE;

ADENOSINE; ANIMALS; CARBACHOL; CHROMOSOMES, HUMAN, PAIR 21; ELECTROCARDIOGRAPHY; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HEART RATE; HUMANS; METHOXAMINE; MICE; MICE, TRANSGENIC; MYOCARDIUM; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MUS; MUS MUSCULUS;

EID: 43049127196     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00143.2007     Document Type: Article

References (44)

1. Antonarakis S, Lyle R, Dermitzakis E, Reymond A, Deutsch S. Chromosome 21 and Down syndrome: from genomics to pathophysiology. Nat Rev Genet 5: 725-738, 2004.
2. Arron J, Winslow M, Polleri A, Chang CP, Wu H, Gao X, Neilson J, Chen L, Heit J, Kim S, Yamasaki N, Miyakawa T, Francke U, Graef I, Crabtree G. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441: 595-600, 2006.
3. Belardinelli L, Shryock J, Song Y, Wang D, Srinivas M. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J 9: 359-365, 1995.
4. Blom N, Ottenkamp J, Deruiter M, Wenink M, Gittenberger-De Groot A. Development of the cardiac conduction system in atrioventricular septal defect in human trisomy 21. Pediatr Res 58: 516-520, 2005.
5. Borland L, Colligan J, Brandom B. Frequency of anesthesia-related complications in children with Down syndrome under general anesthesia for noncardiac procedures. Pediatr Anesthesia 14: 733-738, 2004.
6. Boyett M, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res 47: 658-687, 2000.
7. Branchi I, Bichler Z, Minghetti L, Delabar JM, Malchiodi-Albedi F, Gonzalez MC, Chettoud Z, Nicolini A, Chabert C, Smith D, Rubin E, Migliore-Samour D, Alleva E. Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol 63: 429-440, 2004.
8. Dahmane N, Ghezala G, Gosset P, Chamoun Z, Dufresne-Zacharia MC, Lopes C, Rabatel N, Gassanova-Maugenre S, Chettouh Z, Abramowski V, Fayet E, Yaspo ML, Korn B, Blouin JL, Lehrach H, Poutska A, Antonarakis SE, Sinet PM, Créau N, Delabar JM. Transcriptional Map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. Genomics 48: 12-23, 1998.
9. + channel. Cell Signal 9: 551-573, 1997.
10. Delabar JM, Aflalo-Rattenbach R, Créau N. Developmental defects in trisomy 21 and mouse models. Sci World J 1: 1945-1964, 2006.
11. Dhein S, Van Koppen C, Brodde OE. Muscarinic receptors in the mammalian heart. Pharmacol Res 44: 161-182, 2001.
12. DiFrancesco D. Funny channels in the control of cardiac rhythm and mode of action of selective blockers. Pharmacol Res 53: 399-406, 2006.
13. Fernhall B, Otterstetter M. Attenuated responses to sympathoexcitation in individuals with Down syndrome. J Appl Physiol 94: 2158-2165, 2003.
14. Ferrer J, Nichols C, Makhina E, Salkoff L, Bernstein J, Gerhardi D, Wasson J, Ramanadham S, Permutt A. Pancreatic islet cells express a family of inwardly rectifying K1 channel subunits which interact to form G protein-activated channels. J Biol Chem 270: 26086-26091, 1995.
15. Figueroa A, Collier S, Baynard T, Giannopoulou I, Goulopoulou S, Fernhall B. Impaired vagal modulation of heart rate in individuals with Down syndrome. Clin Auton Res 15: 45-50, 2005.
16. Fu Y, Huang X, Zhong H, Mortensen R, D'Alecy L, Neubig R. Endogenous RGS proteins and Gα subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circ Res 98: 659-666, 2006.
17. Gehrmann J, Meister M, Maguire C, Martins D, Hammer P, Neer E, Berul CI, Mende U. Impaired parasympathetic heart rate control in mice with a reduction of functional G protein βγ-subunits. Am J Physiol Heart Circ Physiol 282: H445-H456, 2002.
18. Hara K, Harris R. The anesthetic mechanism of urethane: the effects on neurotransmitter-gated ion channels. Anesth Analg 94: 313-318, 2002.
19. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi D, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar JM, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Shibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brandt P, Scharfe M, Schön O, Desario A, Reichelt J, Kauer G, Blöcker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML. The DNA sequence of human chromosome 21. Nature 405: 311-319, 2000.
20. Iellamo F, Galante A, Legramante J, Lippi M, Condoluci C, Albertini G, Volterrani M. Altered autonomic cardiac regulation in individuals with Down syndrome. Am J Physiol Heart Circ Physiol 289: H2387-H2391, 2005.
21. + current in Xenopus oocytes. Biochem Biophys Res Commun 218: 286-291, 1996.
22. Kass DA, Hare J, Georgakopoulos D. Murine cardiac function: a cautionary tail. Circ Res 82: 519-522, 1998.
23. 1 adenosine receptor. Am J Physiol Heart Circ Physiol 285: H145-H153, 2003.
24. + channels in mammalian ventricular myocytes. Am J Physiol Heart Circ Physiol 266: H1812-H1821, 1994.
25. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T.4. Nature 227: 680-685, 1970.
26. Liu G, Iden J, Kovithavongs K, Gulamhusein R, Duff H, Kavanagh K. In vivo temporal and spatial distribution of depolarisation and repolarisation and the illusive murine T Wave. J Physiol 555: 267-279, 2004.
27. + current in adult mouse atria. Br J Pharmacol 140: 576-584, 2003.
28. f) in isolated mouse sino-atrial cells. Cardiovasc Res 52: 51-64, 2001.
29. Martynyuk A, Zima A, Seubert C, Morey T, Belardinelli L, Dennis D. Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism. Basic Res Cardiol 97: 295-304, 2002.
30. Mitchell G, Jeron A, Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol Heart Circ Physiol 274: H747-H751, 1998.
31. Orozco-Buenrostro C, Godinez-Rodriguez C, Winking H, Arguello LC, Torres CM. Altered action potential of myocardial cells from mouse fetuses with trisomy 16: a model of Down syndrome. Arch Med Res 32: 410-418, 2001.
32. Reeves R, Baxter L, Richtsmeier J. Too much of a good thing: mechanisms of gene action in Down syndrome. Trends Genet 17: 83-88, 2001.
33. Roubertoux P, Bichler Z, Pinoteau W, Jamon M, Seregaza Z, Smith D, Rubin E, Migliore-Samour D, Carlier M. Pre-weaning sensorial and motor development in mice transpolygenic for the critical region of trisomy 21. Behav Genet 36: 377-386, 2006.
34. Schindler C, Karcz-Kubicha M, Thorndike E, Müller C, Tella S, Ferre S, Goldberg S. Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists. Br J Pharmacol 144: 642-650, 2005.
35. Shinohara T, Tomizuka K, Miyabara S, Takehara S, Kazuki Y, Inoue J, Katoh M, Nakane H, Iino A, Ohguma A, Ikegami S, Inokuchi K, Ishida I, Reeves RH, Oshimura M. Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome. Hum Mol Genet 10: 1163-1175, 2001.
36. Smith D, Zhu Y, Zhang J, Cheng JF, Rubin E. Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics 27: 425-434, 1995.
37. Smith D, Rubin E. Functional screening and complex traits: human 21q22.2 sequences affecting learning in mice. Hum Mol Genet 6: 1729-1733, 1997.
38. Swynghedauw B, Jasson S, Chevalier B, Clairambault J, Hardouin S, Heymes C, Mangin L, Mansier P, Médigue C, Moalic JM, Thibault N, Carré F. Heart rate and heart rate variability: a pharmacological target. Cardiovasc Drugs Therap 10: 677-685, 1996.
39. Verheijcka E, van Kempenb M, Veereschilda M, Lurvinka J, Jongsma H, Bouman L. Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc Res 52: 40-50, 2001.
40. Webb S, Anderson RH, Lamers W, Brown N. Mechanisms of deficient cardiac septation in the mouse with trisomy 16. Circ Res 84: 897-905, 1999.
41. + current by native muscarinic M2 receptors in rat atrial myocytes. Circ Res 86: 643-648, 2000.
42. Wickman K, Nemec J, Gendler S, Clapham D. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 20:103-114, 1998.
43. Yamada M, Inanobe A, Kurachi Y. G protein regulation of potassium ion channels. Pharmacol Rev 50: 723-757, 1998.
44. Yang Q, Rasmussen S, Friedman JM. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359: 1019-25, 2002.