The antigen dose determines T helper subset development by regulation of CD40 ligand

European Journal of Immunology

Volumn 30, Issue 7, 2000, Pages 2056-2064

  Ruedl, Christiane ^a   Bachmann, Martin F ^a   Kopf, Manfred ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

CD40 CD40 ligand; Dendritic cell; LFA 1 ICAM; Th1 vs. th2 development

Indexed keywords

ANTIGEN; CD4 ANTIGEN; GLYCOPROTEIN GP 39; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 4; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; OVALBUMIN;

ANIMAL CELL; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD40; CD40 LIGAND; CELL ADHESION MOLECULES; CELLS, CULTURED; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; LEUKOPOIESIS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 0033949795     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200007)30:7<2056::AID-IMMU2056>3.0.CO;2-S     Document Type: Article

References (49)

1. Abbas, A, K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
2. O'Garra, A., Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998. 8: 275-283.
3. Aloisi, F., Ria, F., Penna, G. and Adorini, L., Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J. Immunol. 1998. 160: 4671-4780.
4. Guler, M. L., Gorham, J. D., Hsieh, C. S., Mackey, A. J., Steen, R. G., Dietrich, W. F. and Murphy, K. M., Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development [see comments]. Science 1996. 271: 984-987.
5. Bix, M., Wang, Z. E., Thiel, B., Schork, N. J. and Locksley, R. M., Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J. Exp. Med. 1998. 188: 2289-2299.
6. Agarwal, S. and Rao, A., Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 1998. 9: 765-775.
7. Bird, J. J., Brown, D. R., Mullen, A. C., Moskowitz, N. H., Mahowald, M. A., Sider, J. R., Gajewski, T. F., Wang, C. R. and Reiner, S. L., Helper T cell differentiation is controlled by the cell cycles. Immunity 1998. 9: 229-237.
8. + T cell responses: the alternative approaches. Annu. Rev. Immunol. 1997. 15: 297-322.
9. Bluestone, J. A., New perspectives of CD28-B7-mediated T cell costimulation. Immunity 1995. 2: 555-559.
10. Murray, J. S., How the MHC selects Th1/Th2 immunity. Immunol. Today 1998. 19: 157-163.
11. Parish, C. R. and Liew, F. Y., Immune response to chemically modified flagellin. 3. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 1972. 135: 298-311.
12. Bretscher, P. A, Wei, G., Menon, J. N. and Bielefeld-Ohmann, H., Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 1992. 257: 539-542.
13. + T cells. J. Exp. Med. 1995. 182: 1591-1596.
14. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J. Exp. Med. 1995. 182: 1579-1584.
15. Evavold, B. D. and Allen, P. M., Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991. 252: 1308-1310.
16. Windhagen, A., Scholz, C., Hollsberg, P., Fukaura, H., Sette, A. and Hafler, D. A., Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995. 2: 373-380.
17. Pfeiffer, C., Stein, J., Southwood, S., Ketelaar, H., Sette, A. and Bottomly, K., Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 1995. 181: 1569-1574.
18. Schountz, T., Kasselman, J. P., Martinson, F. A., Brown, L. and Murray, J. S., MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo. J. Immunol 1996. 157: 3893-3901.
19. Pearson, C. I., van Ewijk, W. and McDevitt, H. O., Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 1997: 185: 583-599.
20. Fowell, D. J., Magram, J., Turck, C. W., Killeen, N. and Locksley, R. M., Impaired Th2 subset development in the absence of CD4. Immunity 1997. 6: 559-569.
21. Brown, D. R., Moskowitz, N. H., Killeen, N. and Reiner, S. L., A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 1997. 186: 101-107.
22. Leitenberg, D., Boutin, Y., Constant, S. and Bottomly, K., CD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR. J. Immunol 1998. 161: 1194-1203.
23. Rulifson, I. C., Sperling, A. I., Fields, P. E., Fitch, F. W. and Bluestone, J. A., CD28 costimulation promotes the production of Th2 cytokines. J. Immunol. 1997. 158: 658-665.
24. Flynn, S., Toellner, K. M., Raykundalia, C., Goodall, M. and Lane, P., CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 1998. 188: 297-304.
25. Salomon, B. and Bluestone, J. A., LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J. Immunol. 1998. 161: 5138-5142.
26. Grewal, I. S. and Flavell, R. A., The role of CD40 ligand in costimulation and T-cell activation. Immunol. Rev. 1996. 153: 85-106.
27. Vogel, L. A. and Noelle, R. J., CD40 and its crucial role as a member of the TNFR family. Semin. Immunol. 1998. 10: 435-442.
28. van Essen, D., Kikutani, H. and Gray, D., CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature 1995. 378: 620-623.
29. Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimito, T. and Kikutani, H., Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996. 4: 275-281.
30. Soong, L., Xu, J. C., Grewal, I. S., Kima, P., Sun, J., Longley, B. J., Jr., Ruddle, N. H., McMahon-Pratt, D. and Flavell, R. A., Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 1996. 4: 263-273.
31. Campbell, K. A., Ovendale, P. J., Kennedy, M. K., Fanslow, W. C., Reed, S. G. and Maliszewski, C. R., CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 1996. 4: 283-289.
32. + T cells. J. Immunol. 1995. 154: 5071-5079.
33. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N. and Schuler, G., High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 [published erratum appears in J. Exp. Med. 1996. 184: following 1590]. J. Exp. Med. 1996. 184: 741-766.
34. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
35. Barner, M., Mohrs, M., Brombacher, F. and Kopf, M., Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr. Biol. 1998. 8: 669-672.
36. Rogers, P. R., Huston, G. and Swain, S. L., High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines. J. Immunol. 1998. 161: 3844-3852.
37. Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Malefyt, R. and Liu. Y. J., Reciprocal control of T helper cell and dendritic cell differentiation [see comments]. Science 1999. 283: 1183-1186.
38. Poudrier, J., van Essen, D., Morales-Alcelay, S., Leanderson, T., Bergthorsdottir, S. and Gray, D., CD40 ligand signals optimize T helper cell cytokine production: role in Th2 development and induction of germinal centers. Eur. J. Immunol. 1998. 28: 3371-3383.
39. Szabo, S. J., Dighe, A. S., Gubler, U. and Murphy, K. M., Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997. 185: 817-824.
40. Denfeld, R. W., Hollenbaugh, D., Fehrenbach, A., Weiss, J. M., von Leoprechting, A., Mai, B., Voith, U., Schopf, E., Aruffo, A. and Simon, J. C., CD40 is functionally expressed on human keratinocytes. Eur. J. Immunol. 1996. 26: 2329-2334.
41. Kopf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B. and Bachmann, M. F., OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity 1999. 11: 699-708.
42. Luksch, C. R., Winqvist, O., Ozaki, M. E., Karlsson, L., Jackson, M. R., Peterson, P. A. and Webb, S. R., Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc. Natl. Acad. Sci. USA 1999. 96: 3023-3028.
43. Bachmann, M. F., McKall-Faienza, K., Schmits, R., Bouchard, D., Beach, J., Speiser, D. E., Mak, T. W. and Ohashi, P. S., Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 1997. 7: 549-557.
44. Thompson, C. B., Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 1995. 81: 979-982.
45. +TCRIo thymocytes in vivo. Science 1990. 250: 1720-1723.
46. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C. Y., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D. A. and Gately, M. K., IL-12-defieicnt mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996. 4: 471-481.
47. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M. C, Bluethmann, H. and Köhler, G., Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993. 362: 245-248.
48. + dendritic cell population in mouse Peyer's patches. Eur. J. Immunol. 1996. 26: 1801-1806.
49. Kopf, M., Coyle, A. J., Schmitz, N., Barner, M., Oxenius, A., Gallimore, A., Gutierrez-Ramos, J. C., and Bachmann, M. F., ICOS mediates both CD28-dependent and CD28-independent Th subset polarization after virus and parasite infection, J. Exp. Med. 2000, in press.