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Volumn 157, Issue 11, 1996, Pages 5002-5008

Humoral Immunity and Regulation of Intrapulmonary Growth of Legionella pneumophila in the Immunocompetent Host

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; COMPLEMENT; OPSONIN;

EID: 0030471144     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (49)
  • 1
    • 0018885613 scopus 로고
    • Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes
    • Horwitz, M. A., and S. C. Silverstein. 1980. Legionnaires' disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes. J. Clin. Invest. 66:441.
    • (1980) J. Clin. Invest. , vol.66 , pp. 441
    • Horwitz, M.A.1    Silverstein, S.C.2
  • 2
    • 0002834378 scopus 로고
    • Modes of transmission epidemic and nonepidemic Legionella infection: Directions for further study
    • J. M. Barbaree, R. F. Breiman, and A. P. Duflour, eds. American Society for Microbiology, Washington, DC
    • Breiman, R. F. 1993. Modes of transmission epidemic and nonepidemic Legionella infection: directions for further study. In Legionella; Current Status and Emerging Perspectives. J. M. Barbaree, R. F. Breiman, and A. P. Duflour, eds. American Society for Microbiology, Washington, DC, p. 30.
    • (1993) Legionella; Current Status and Emerging Perspectives , pp. 30
    • Breiman, R.F.1
  • 3
    • 0021346850 scopus 로고
    • Phagocytosis of Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: Engulfment within a pseudopod coil
    • Horwitz, M. A. 1984. Phagocytosis of Legionnaires' disease bacterium (Legionella pneumophila) occurs by a novel mechanism: engulfment within a pseudopod coil. Cell 36:27.
    • (1984) Cell , vol.36 , pp. 27
    • Horwitz, M.A.1
  • 4
    • 0020591330 scopus 로고
    • Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes
    • Horwitz, M. A. 1983. Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes. J. Exp. Med. 158:1319.
    • (1983) J. Exp. Med. , vol.158 , pp. 1319
    • Horwitz, M.A.1
  • 5
    • 0021014278 scopus 로고
    • The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes
    • Horwitz, M. A. 1983. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J. Exp. Med. 158:2108.
    • (1983) J. Exp. Med. , vol.158 , pp. 2108
    • Horwitz, M.A.1
  • 6
    • 0021718023 scopus 로고
    • Legionella pneumophila inhibits acidification of its phagosome in human monocytes
    • Horwitz, M. A., and F. R. Maxfield. 1984. Legionella pneumophila inhibits acidification of its phagosome in human monocytes. J. Cell. Biol. 99:1936.
    • (1984) J. Cell. Biol. , vol.99 , pp. 1936
    • Horwitz, M.A.1    Maxfield, F.R.2
  • 8
    • 0022507071 scopus 로고
    • Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung
    • Conlan, J. W., A. Baskerville, and L. A. Ashworth. 1986. Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung. J. Gen. Microbiol. 132:1565.
    • (1986) J. Gen. Microbiol. , vol.132 , pp. 1565
    • Conlan, J.W.1    Baskerville, A.2    Ashworth, L.A.3
  • 9
    • 0023905942 scopus 로고
    • In vivo production of a tissue-destructive protease by Legionella pneumophila in the lungs of experimentally infected guinea pigs
    • Conlan, J. W., A. Williams, and L. A Ashworth. 1988. In vivo production of a tissue-destructive protease by Legionella pneumophila in the lungs of experimentally infected guinea pigs. J. Gen. Microbiol. 134:143.
    • (1988) J. Gen. Microbiol. , vol.134 , pp. 143
    • Conlan, J.W.1    Williams, A.2    Ashworth, L.A.3
  • 10
    • 0342268426 scopus 로고
    • Immunity to Legionella
    • S. M. Katz, ed. CRC Press, Boca Raton, FL
    • Eisenstein, T. K., and H. Friedman. 1985. Immunity to Legionella. In Legionellosis, Vol. 2. S. M. Katz, ed. CRC Press, Boca Raton, FL, p. 159.
    • (1985) Legionellosis , vol.2 , pp. 159
    • Eisenstein, T.K.1    Friedman, H.2
  • 11
    • 0020516350 scopus 로고
    • Cellular immunity to Legionella pneumophila in guinea pigs assessed by direct and indirect migration inhibition reactions in vitro
    • Friedman, H. P., R. Widen, I. Lee, and T. Klein. 1983. Cellular immunity to Legionella pneumophila in guinea pigs assessed by direct and indirect migration inhibition reactions in vitro. Infect. Immun. 41:1132.
    • (1983) Infect. Immun. , vol.41 , pp. 1132
    • Friedman, H.P.1    Widen, R.2    Lee, I.3    Klein, T.4
  • 12
    • 0021334868 scopus 로고
    • Legionella pneumophila induced blastogenesis of murine lymphoid cells in vitro
    • Friedman, H., R. Widen, T. Klein, L. Searls, and K. Cabrian. 1984. Legionella pneumophila induced blastogenesis of murine lymphoid cells in vitro. Infect. Immun. 43:314.
    • (1984) Infect. Immun. , vol.43 , pp. 314
    • Friedman, H.1    Widen, R.2    Klein, T.3    Searls, L.4    Cabrian, K.5
  • 14
    • 0342703612 scopus 로고
    • Cellular and humoral immunity to Legionella pneumophila
    • C. Krasermann, ed. deGruytes Press, Amsterdam, The Netherlands
    • Freidman, H., T. Klein, R. Widen. 1983. Cellular and humoral immunity to Legionella pneumophila. In Infect. Colloquium. C. Krasermann, ed. deGruytes Press, Amsterdam, The Netherlands, p. 99.
    • (1983) Infect. Colloquium , pp. 99
    • Freidman, H.1    Klein, T.2    Widen, R.3
  • 15
    • 2342603159 scopus 로고
    • Immunodiagnostic assays for legionellosis
    • Friedman, H., R. Widen, and T. Klein. 1983. Immunodiagnostic assays for legionellosis. Lab. Manage. 21:19.
    • (1983) Lab. Manage. , vol.21 , pp. 19
    • Friedman, H.1    Widen, R.2    Klein, T.3
  • 16
    • 0021334868 scopus 로고
    • Legionella pneumophila induced blastogenesis of murine lymphoid cells in vitro
    • Friedman, H., R. Widen, T. Klein, L. Searls, and K. Cabrian. 1984. Legionella pneumophila induced blastogenesis of murine lymphoid cells in vitro. Infect. Immun. 43:314.
    • (1984) Infect. Immun. , vol.43 , pp. 314
    • Friedman, H.1    Widen, R.2    Klein, T.3    Searls, L.4    Cabrian, K.5
  • 17
    • 0018957418 scopus 로고
    • Background prevalence of microagglutination antibodies to Legionella pneumophila serogroups 1, 2, 3 and 4
    • Helms, C. M., W. Johnson, E. D. Renner, W. J. Heirholzer, L. A. Wintermeyer, and J. P. Viner. 1980. Background prevalence of microagglutination antibodies to Legionella pneumophila serogroups 1, 2, 3 and 4. Infect. Immun. 30:612.
    • (1980) Infect. Immun. , vol.30 , pp. 612
    • Helms, C.M.1    Johnson, W.2    Renner, E.D.3    Heirholzer, W.J.4    Wintermeyer, L.A.5    Viner, J.P.6
  • 18
    • 0009516460 scopus 로고
    • Prevalence of antibodies against Legionella species in healthy patient populations
    • J. M. Barbaree, R. F. Breiman, and A. P. Duflour, eds. American Society for Microbiology, Washington, DC
    • Paszko-Kolva, C., M. Shahamat, J. Keiser, and R. R. Colwell. 1993. Prevalence of antibodies against Legionella species in healthy patient populations. In Legionella: Current Status and Emerging Perspectives. J. M. Barbaree, R. F. Breiman, and A. P. Duflour, eds. American Society for Microbiology, Washington, DC, p. 24.
    • (1993) Legionella: Current Status and Emerging Perspectives , pp. 24
    • Paszko-Kolva, C.1    Shahamat, M.2    Keiser, J.3    Colwell, R.R.4
  • 19
    • 0019509569 scopus 로고
    • Detection of antibodies to Legionella pneumophila in immune guinea pig serum by solid phase immunofluorescence
    • Vogel, F. R., T. W. Klein, S. C. Spector, M. Hitchings, and H. Friedman. 1981. Detection of antibodies to Legionella pneumophila in immune guinea pig serum by solid phase immunofluorescence. J Clin. Microbiol. 13:726.
    • (1981) J Clin. Microbiol. , vol.13 , pp. 726
    • Vogel, F.R.1    Klein, T.W.2    Spector, S.C.3    Hitchings, M.4    Friedman, H.5
  • 20
    • 0025910840 scopus 로고
    • Vaccination with Legionella pneumophila membranes induces cell mediated and protective immunity in a guinea pig model of Legionnaires' disease: Protective immunity independent of the major secretory protein of Legionella pneumophila
    • Blander, S. J., and M. A. Horwitz. 1991. Vaccination with Legionella pneumophila membranes induces cell mediated and protective immunity in a guinea pig model of Legionnaires' disease: protective immunity independent of the major secretory protein of Legionella pneumophila. J. Clin Invest. 87:1054.
    • (1991) J. Clin Invest. , vol.87 , pp. 1054
    • Blander, S.J.1    Horwitz, M.A.2
  • 21
    • 0020521839 scopus 로고
    • Cell mediated immunity in Legionnaires' disease
    • Horwitz, M. A. 1983. Cell mediated immunity in Legionnaires' disease. J. Clin. Invest. 71:1686.
    • (1983) J. Clin. Invest. , vol.71 , pp. 1686
    • Horwitz, M.A.1
  • 22
    • 0026575341 scopus 로고
    • Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection
    • Yamamoto, Y., T. W. Klein, C. Newton, and H. Friedman. 1992. Differing macrophage and lymphocyte roles in resistance to Legionella pneumophila infection. J. Immunol. 148:584.
    • (1992) J. Immunol. , vol.148 , pp. 584
    • Yamamoto, Y.1    Klein, T.W.2    Newton, C.3    Friedman, H.4
  • 23
    • 0019491603 scopus 로고
    • Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes and does not inhibit intracellular multiplication
    • Horwitz, M. A., and S. C. Silverstein. 1981. Interaction of the Legionnaires' disease bacterium (Legionella pneumophila) with human phagocytes. II. Antibody promotes binding of L. pneumophila to monocytes and does not inhibit intracellular multiplication. J. Exp. Med. 153:398.
    • (1981) J. Exp. Med. , vol.153 , pp. 398
    • Horwitz, M.A.1    Silverstein, S.C.2
  • 24
    • 0019412365 scopus 로고
    • Interaction of the Legionnaire's disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody and complement
    • Horwitz, M. A., and S. C. Silverstein. 1981. Interaction of the Legionnaire's disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody and complement. J. Exp. Med. 153:386.
    • (1981) J. Exp. Med. , vol.153 , pp. 386
    • Horwitz, M.A.1    Silverstein, S.C.2
  • 25
    • 0026487020 scopus 로고
    • Adherence of Legionella pneumophila to guinea pig peritoneal macrophages. J774 mouse macrophages and undifferentiated U937 human monocytes: Role of Fc and complement receptors
    • Husmann, L. K., and W. Johnson. 1992. Adherence of Legionella pneumophila to guinea pig peritoneal macrophages. J774 mouse macrophages and undifferentiated U937 human monocytes: role of Fc and complement receptors. Infect. Immun. 60:5212.
    • (1992) Infect. Immun. , vol.60 , pp. 5212
    • Husmann, L.K.1    Johnson, W.2
  • 26
    • 0018540527 scopus 로고
    • Serospecificity and opsonic activity of antisera to Legionella pneumophila
    • Johnson, W., E. Pesanti, and J. Elliot. 1979. Serospecificity and opsonic activity of antisera to Legionella pneumophila. Infect. Immun. 26:698.
    • (1979) Infect. Immun. , vol.26 , pp. 698
    • Johnson, W.1    Pesanti, E.2    Elliot, J.3
  • 28
    • 0021795284 scopus 로고
    • Opsonization of Legionella pneumophila in human serum: Key roles for specific antibodies and the classical complement pathway
    • Verbrugh, H. A., D. A. Lee, G. R. Elliott, W. F. Keane, J. R. Hoidal, and P. K. Peterson. 1985. Opsonization of Legionella pneumophila in human serum: key roles for specific antibodies and the classical complement pathway. Immunology 54:643.
    • (1985) Immunology , vol.54 , pp. 643
    • Verbrugh, H.A.1    Lee, D.A.2    Elliott, G.R.3    Keane, W.F.4    Hoidal, J.R.5    Peterson, P.K.6
  • 29
    • 0023220888 scopus 로고
    • Differential growth of Legionella pneumophila in guinea pig versus mouse macrophage cultures
    • Yamamato, Y., T. W. Klein, C. A. Newton, R. Widen, and H. Friedman. 1987. Differential growth of Legionella pneumophila in guinea pig versus mouse macrophage cultures. Infect. Immun. 55:1369.
    • (1987) Infect. Immun. , vol.55 , pp. 1369
    • Yamamato, Y.1    Klein, T.W.2    Newton, C.A.3    Widen, R.4    Friedman, H.5
  • 31
    • 0027373385 scopus 로고
    • Antibody-mediated enhancement of Legionella pneumophila induced interleukin 1 activity
    • Widen, R. H., C. A. Newton, T. W. Klein, and H. Friedman. 1993. Antibody-mediated enhancement of Legionella pneumophila induced interleukin 1 activity. Infect. Immun. 61:4027.
    • (1993) Infect. Immun. , vol.61 , pp. 4027
    • Widen, R.H.1    Newton, C.A.2    Klein, T.W.3    Friedman, H.4
  • 32
    • 0028079788 scopus 로고
    • Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice: A murine model of human Legionnaires' disease
    • Brieland, J. K., P. T. Freeman, R. K. Kunkel, C. E. Chrisp, M. C. Hurley, J. C. Fantone, and N. C. Engleberg. 1994. Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice: a murine model of human Legionnaires' disease. Am. J. Pathol. 145:1537.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1537
    • Brieland, J.K.1    Freeman, P.T.2    Kunkel, R.K.3    Chrisp, C.E.4    Hurley, M.C.5    Fantone, J.C.6    Engleberg, N.C.7
  • 33
    • 0027417230 scopus 로고
    • Phenotypic modulation by Legionella pneumophila upon infection of macrophages
    • Abu Kwaik, Y., B. I. Eisenstein, and N. C. Engleberg. 1993. Phenotypic modulation by Legionella pneumophila upon infection of macrophages. Infect. Immun. 61:1320.
    • (1993) Infect. Immun. , vol.61 , pp. 1320
    • Abu Kwaik, Y.1    Eisenstein, B.I.2    Engleberg, N.C.3
  • 35
    • 0024522755 scopus 로고
    • A Legionella pneumophila gene encoding a species specific surface protein potentiates initiation of intracellular infection
    • Cianciotto, N. P., B. I. Eisenstein, C. H. Mody, G. B. Toews, and N. C. Engleberg NC. 1989. A Legionella pneumophila gene encoding a species specific surface protein potentiates initiation of intracellular infection. Infect. Immun. 57:1255.
    • (1989) Infect. Immun. , vol.57 , pp. 1255
    • Cianciotto, N.P.1    Eisenstein, B.I.2    Mody, C.H.3    Toews, G.B.4    N.C. Engleberg, N.C.5
  • 36
    • 0022641486 scopus 로고
    • In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection
    • Stein-Streilein, J., and J. Guffee. 1986. In vivo treatment of mice and hamsters with antibodies to asialo GM1 increases morbidity and mortality to pulmonary influenza infection. J. Immunol. 136:1435.
    • (1986) J. Immunol. , vol.136 , pp. 1435
    • Stein-Streilein, J.1    Guffee, J.2
  • 37
    • 0027993994 scopus 로고
    • Experimental murine pulmonary cryptococcosis: Differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans
    • Curtis, J. L., G. B. Huffnagle, C. H. Chen, M. L. Warnock, M. R. Gyetko, R. A. McDonald, P. J. Scott, and G. B. Toews. 1994. Experimental murine pulmonary cryptococcosis: differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of Cryptococcus neoformans. Lab. Invest. 71:113.
    • (1994) Lab. Invest. , vol.71 , pp. 113
    • Curtis, J.L.1    Huffnagle, G.B.2    Chen, C.H.3    Warnock, M.L.4    Gyetko, M.R.5    McDonald, R.A.6    Scott, P.J.7    Toews, G.B.8
  • 39
    • 0025866711 scopus 로고
    • Live vaccine strain of Francisella tularensis: Infection and immunity in mice
    • Fortier, A. H., M. V. Slayter, R. Ziemba, M. S. Meltzer, and C. A. Nacy. 1991. Live vaccine strain of Francisella tularensis: infection and immunity in mice. Infect. Immun. 59:2922.
    • (1991) Infect. Immun. , vol.59 , pp. 2922
    • Fortier, A.H.1    Slayter, M.V.2    Ziemba, R.3    Meltzer, M.S.4    Nacy, C.A.5
  • 40
    • 0023946308 scopus 로고
    • Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function
    • Blanchard, D. K., J. Y. Djeu, T. W. Klein, H. Friedman, and W. E. Stewart. 1988. Protective effects of tumor necrosis factor in experimental Legionella pneumophila infections of mice via activation of PMN function. J Leukucyte Biol. 43: 429.
    • (1988) J Leukucyte Biol. , vol.43 , pp. 429
    • Blanchard, D.K.1    Djeu, J.Y.2    Klein, T.W.3    Friedman, H.4    Stewart, W.E.5
  • 41
    • 0019409995 scopus 로고
    • Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens
    • Edelstein, P. H. 1981. Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens. J. Clin. Microbiol. 14:298.
    • (1981) J. Clin. Microbiol. , vol.14 , pp. 298
    • Edelstein, P.H.1
  • 42
    • 0016634425 scopus 로고
    • Prolonged C3 depletion by cobra venom factor in thymus-deprived mice and its implication for the role of C3 as an essential second signal for B-cell triggering
    • Pryjma, J., and J. H. Humphrey. 1975. Prolonged C3 depletion by cobra venom factor in thymus-deprived mice and its implication for the role of C3 as an essential second signal for B-cell triggering. Immunology 28:569.
    • (1975) Immunology , vol.28 , pp. 569
    • Pryjma, J.1    Humphrey, J.H.2
  • 43
    • 0029162728 scopus 로고
    • In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide
    • Brieland, J. K, D. G. Remick, P. T. Freeman, M. C. Hurley, J. C. Fantone, and N. C. Engleberg. 1995. In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide. Infect. Immun. 63:3253.
    • (1995) Infect. Immun. , vol.63 , pp. 3253
    • Brieland, J.K.1    Remick, D.G.2    Freeman, P.T.3    Hurley, M.C.4    Fantone, J.C.5    Engleberg, N.C.6
  • 44
    • 0028957254 scopus 로고
    • Immune complexes increase nitric oxide production by interferon-gamma-stimulated murine macrophage-like J744.16 cells
    • Mozaffarian, N., J. W. Berman, and A. Casadevall. 1995. Immune complexes increase nitric oxide production by interferon-gamma-stimulated murine macrophage-like J744.16 cells. J. Leukocyte Biol. 57:657.
    • (1995) J. Leukocyte Biol. , vol.57 , pp. 657
    • Mozaffarian, N.1    Berman, J.W.2    Casadevall, A.3
  • 45
    • 0027378459 scopus 로고
    • Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production
    • Polat, G. L., J. Laufer, I. Fabian, and J. H. Passwell. 1993. Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production. Immunology 80:287.
    • (1993) Immunology , vol.80 , pp. 287
    • Polat, G.L.1    Laufer, J.2    Fabian, I.3    Passwell, J.H.4
  • 46
    • 0023875737 scopus 로고
    • IFN-γ activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila
    • Nash, T. W., D. M. Libby, and M. A. Horwitz. 1988. IFN-γ activated human alveolar macrophages inhibit the intracellular multiplication of Legionella pneumophila. J. Immunol. 140:3978.
    • (1988) J. Immunol. , vol.140 , pp. 3978
    • Nash, T.W.1    Libby, D.M.2    Horwitz, M.A.3
  • 47
    • 0023000775 scopus 로고
    • Interferon-γ activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila
    • Bhardwaj, N., T. W. Nash, and M. A. Horwitz. 1986. Interferon-γ activated human monocytes inhibit the intracellular multiplication of Legionella pneumophila. J. Immunol. 137:2662.
    • (1986) J. Immunol. , vol.137 , pp. 2662
    • Bhardwaj, N.1    Nash, T.W.2    Horwitz, M.A.3
  • 48
    • 0023112361 scopus 로고
    • In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant γ interferon
    • Jenson, W. A., R. M. Rose, A. S. Wasserman, T. H. Kalb, K. Anton K, and H. G. Remold. 1987. In vitro activation of the antibacterial activity of human pulmonary macrophages by recombinant γ interferon. J. Infect. Dis. 155:574.
    • (1987) J. Infect. Dis. , vol.155 , pp. 574
    • Jenson, W.A.1    Rose, R.M.2    Wasserman, A.S.3    Kalb, T.H.4    K. Anton, K.5    Remold, H.G.6
  • 49
    • 0021169749 scopus 로고
    • Interaction between the Legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages: Influence of antibody, lymphokines, and hydrocortisone
    • Nash, T. W., D. M. Libby, and M. A. Horwitz. 1984. Interaction between the Legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages: influence of antibody, lymphokines, and hydrocortisone. J. Clin. Invest. 74:771.
    • (1984) J. Clin. Invest. , vol.74 , pp. 771
    • Nash, T.W.1    Libby, D.M.2    Horwitz, M.A.3


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