In vitro evaluation of N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan for oral insulin delivery

Carbohydrate Polymers

Volumn 84, Issue 1, 2011, Pages 103-109

  Sonia, T A ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Controlled release; Microparticles; Mucoadhesion; Oral insulin; Quaternized chitosan

Indexed keywords

CONTROLLED RELEASE; MICRO-PARTICLES; MUCOADHESION; ORAL INSULIN; QUATERNIZED CHITOSAN;

AMMONIUM COMPOUNDS; CHITIN; CHITOSAN; CHLORINE COMPOUNDS; CONFOCAL MICROSCOPY; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DICHROISM; INSULIN; ZETA POTENTIAL;

MULTILAYERS;

RATTUS;

EID: 78951478230     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2010.10.070     Document Type: Article

References (18)

1. W.L. Dong, P. Kewin, and B. Ronald Physiochemical properties and blood compatibility of acylated chitosan nanoparticles Carbohydrate Polymers 58 2004 371 377
2. Q.X. Ji, D.Y. Zhong, R. Lu, W.Q. Zhang, J. Deng, and X.G. Chen In vitro evaluation of the biomedical properties of chitosan and quaternized chitosan for dental applications Carbohydrate Research 344 2009 1297 1302
3. A.F. Kotze, H.L. Luessen, B.J. de Leeuw, A.G. de Boer, J.C. Verhoef, and H.E. Junginger N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: In vitro evaluation in intestinal epithelial cells (Caco-2) Pharmaceutical Research 14 1997 1197 1202
4. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the follin phenol reagent Journal of Biological Chemistry 193 1951 265 275
5. H. Mika, O. Hiraku, and M. Yoshiharu Evaluation of Eudragit-coated chitosan microparticles as an oral immune delivery system International Journal of Pharmaceutics 297 2005 223 234
6. V.K. Mourya, and N.N. Inamdar Chitosan-modifications and applications: Opportunities galore Reactive and Functional Polymers 68 2008 1013 1051
7. V.K. Mourya, and N.N. Inamdar Trimethyl chitosan and its applications in drug delivery Journal of Material Science Materials in Medicine 20 2009 1057 1079
8. M.R. Rekha, and C.P. Sharma Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption Journal of Controlled Release 135 2009 144 151
9. S. Sajeesh, and C.P. Sharma Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery International Journal of Pharmaceutics 325 2006 147 154
10. S. Sajeesh, C. Vauthier, C. Gueutin, G. Ponchel, and C.P. Sharma Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery Acta Biomaterialia 6 2010 3072 3080
11. D. Sanju, S. Anil Kumar, and S. Vivek Ranjan Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods AAPSPharmSciTech 6 2007 1 7
12. N.G.M. Schipper, S. Olsson, J.A. Hoogstraate, A.G. deBoer, K.M. Varum, and P. Artursson Chitosan as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement Pharmaceutical Research 14 1997 1358 1361
13. D. Sgouras, and R. Duncan Methods for the evaluation of biocompatibility of soluble synthetic polymers which have potential for biomedical use. 1. Use of the tetrazolium-based colorimetric assay (MTT) as a preliminary screen for evaluation of in vitro cytotoxicity Journal of Material Science Materials in Medicine 1 1990 61 68
14. J. Smith, E. Wood, and M. Dornish Effect of chitosan on epithelial cell tight junctions Pharmaceutical Research 21 2004 43 49
15. J.M. Staddon, K. Herrenknecht, C. Smales, and L.L. Rubin Evidence that tyrosine phosphorylation may increase tight junction permeability Journal of Cell Science 108 1995 609 619
16. Y. Sun, and A.J. Wan Preparation of nanoparticles composed of chitosan and its derivatives as delivery systems for macromolecules Journal of Applied Polymer Science 105 2007 552 561
17. K. Suzuki, D. Oda, T. Shinonu, H. Saimoto, and Y. Shigemasa New selectively N-substituted quaternary ammonium chitosan derivatives Polymer Journal 32 2000 334 338
18. Y. Xu, Y. Du, R. Huang, and L. Gao Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammoniumchitosan chloride nanoparticle as a protein carrier Biomaterials 24 2003 5015 5022