A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases

Cell Death and Disease

Volumn 1, Issue 2, 2010, Pages

  Ch'ng, J H ^a   Kotturi, S R ^b   Chong, A G L ^b   Lear, M J ^b   Tan, K S W ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Chloroquine; Clan CA cysteine protease; Malaria; Plasmodium falciparum; Programmed cell death; Verapamil

Indexed keywords

4 HYDROXY TAMOXIFEN; ALOXISTATIN; BENZYLOXYCARBONYLGLUTAMYLVALYLASPARTYL FLUROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLLEUCYL FLUROMETHYL KETONE; BENZYLOXYCARBONYLPHENYLALANYL FLUROMETHYL KETONE; BENZYLOXYCARBONYLPHENYLPHENYL FLUROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUROMETHYL KETONE; CASPASE INHIBITOR; CHLOROQUINE; COUMARIN; CYSTEINE PROTEINASE; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; PROTEINASE INHIBITOR; STAUROSPORINE; TAMOXIFEN; UNCLASSIFIED DRUG; CALCIUM; DNA; FLUORESCENT DYE; PROTOZOAL PROTEIN;

ANTIMALARIAL DRUG RESISTANCE; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DEATH; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; INTRACELLULAR SPACE; MALARIA; MAMMAL; METABOLISM; NECROSIS; PARASITE; PARASITOLOGY; REPRODUCIBILITY; SIGNAL TRANSDUCTION; STAINING; TIME;

MAMMALIA; PLASMODIUM FALCIPARUM;

ANIMALS; APOPTOSIS; CALCIUM; CHLOROQUINE; CYSTEINE PROTEASES; DNA; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; INTRACELLULAR SPACE; MALARIA; MAMMALS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; NECROSIS; PARASITES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; STAINING AND LABELING; TIME FACTORS;

EID: 79959211816     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.2     Document Type: Article

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