Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 637-640

  Kopka, Ihor E ^a   Young, David N ^a   Lin, Linus S ^a   Mumford, Richard A ^a   Magriotis, Plato A ^a   MacCoss, Malcolm ^a   Mills, Sander G ^a   Riper, Gail Van ^a   McCauley, Ermengilda ^a   Egger, Linda E ^a   Kidambi, Usha ^a   Schmidt, John A ^a   Lyons, Kathryn ^a   Stearns, Ralph ^a   Vincent, Stella ^a   Colletti, Adria ^a   Wang, Zhen ^a   Tong, Sharon ^a   Wang, Junying ^a   Zheng, Song ^a   Owens, Karen ^a   Levorse, Dorothy ^a   Hagmann, William K ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BIO 1211; CD29 ANTIGEN ANTAGONIST; PHENYLALANINE DERIVATIVE; TR 14035; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; BENZENESULFONYL CHLORIDE; DIPEPTIDE; PHENYLALANINE; SULFONE; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DOG; DRUG ANTAGONISM; DRUG EFFECT; HAPLORHINI; METABOLIC CLEARANCE RATE; SHEEP; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BIOLOGICAL AVAILABILITY; DIPEPTIDES; DOGS; HAPLORHINI; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; METABOLIC CLEARANCE RATE; PHENYLALANINE; RATS; RATS, SPRAGUE-DAWLEY; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 18244399393     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00821-6     Document Type: Article

References (11)