β-Catenin and NF-κB cooperate to regulate the uPA/uPAR system in cancer cells

International Journal of Cancer

Volumn 128, Issue 6, 2011, Pages 1280-1292

  Moreau, Marie ^a,b   Mourah, Samia ^a,b,c   Dosquet, Christine ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c SAINT LOUIS HOSPITAL   (France)

Author keywords

catenin; cancer cells; nuclear factor kappaB; urokinase plasminogen activator; urokinase plasminogen activator receptor

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LITHIUM CHLORIDE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMALL INTERFERING RNA; SN 50; T CELL FACTOR 4 PROTEIN; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CELLULAR DISTRIBUTION; COLON CANCER; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SILENCING; GENETIC STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UPREGULATION;

BETA CATENIN; BLOTTING, WESTERN; BREAST NEOPLASMS; COLONIC NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NF-KAPPA B; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UP-REGULATION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 79551478911     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25455     Document Type: Article

References (33)

1. Friedl P, Wolf K,. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 362-74.
2. Werb Z,. ECM and cell surface proteolysis: regulating cellular ecology. Cell 1997; 91: 439-42.
3. Dano K, Behrendt N, Hoyer-Hansen G, Johnsen M, Lund LR, Ploug M, Romer J,. Plasminogen activation and cancer. Thromb Haemost 2005; 93: 676-81.
4. Duffy MJ,. The urokinase plasminogen activator system: role in malignancy. Curr Pharm Des 2004; 10: 39-49.
5. Hildenbrand R, Schaaf A, Dorn-Beineke A, Allgayer H, Sutterlin M, Marx A, Stroebel P,. Tumor stroma is the predominant uPA-, uPAR-. PAI-1-expressing tissue in human breast cancer: prognostic impact. Histol Histopathol 2009; 24: 869-77.
6. Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH,. Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 2007; 67: 3310-19.
7. McMahon B, Kwaan HC,. The plasminogen activator system and cancer. Pathophysiol Haemost Thromb 2008; 36: 184-94.
8. Hiendlmeyer E, Regus S, Wassermann S, Hlubek F, Haynl A, Dimmler A, Koch C, Knoll C, van Beest M, Reuning U, Brabletz T, Kirchner T, et al. Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. Cancer Res 2004; 64: 1209-14.
9. Nusse R,. Wnt signaling in disease and in development. Cell Res 2005; 15: 28-32.
10. Clevers H,. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-80.
11. McDonald SL, Silver A,. The opposing roles of Wnt-5a in cancer. Br J Cancer 2009; 101: 209-14.
12. Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A,. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Oncogene 2000; 19: 537-45.
13. Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I, Kerr D,. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 2009; 9: 489-99.
14. Kuraguchi M, Ohene-Baah NY, Sonkin D, Bronson RT, Kucherlapati R,. Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet 2009; 5: e1000367.
15. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A,. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 1999; 96: 5522-7.
16. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW,. Identification of c-MYC as a target of the APC pathway. Science 1998; 281: 1509-12.
17. Brabletz T, Jung A, Dag S, Hlubek F, Kirchner T,. beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999; 155: 1033-8.
18. Zhang X, Gaspard JP, Chung DC,. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 2001; 61: 6050-4.
19. Wang Q, Sun ZX, Allgayer H, Yang HS,. Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells. Oncogene 2010; 29: 128-38.
20. Legrand C, Polette M, Tournier JM, de Bentzmann S, Huet E, Monteau M, Birembaut P,. uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res 2001; 264: 326-36.
21. Novak U, Cocks BG, Hamilton JA,. A labile repressor acts through the NFkB-like binding sites of the human urokinase gene. Nucleic Acids Res 1991; 19: 3389-93.
22. Wang Y, Dang J, Wang H, Allgayer H, Murrell GA, Boyd D,. Identification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor. Eur J Biochem 2000; 267: 3248-54.
23. Hou B, Eren M, Painter CA, Covington JW, Dixon JD, Schoenhard JA, Vaughan DE,. Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site. J Biol Chem 2004; 279: 18127-36.
24. Cho HH, Song JS, Yu JM, Yu SS, Choi SJ, Kim DH, Jung JS,. Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells. FEBS Lett 2008; 582: 616-22.
25. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC,. beta-Catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell 2002; 2: 323-34.
26. Stambolic V, Ruel L, Woodgett JR,. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 1996; 6: 1664-8.
27. Sadot E, Conacci-Sorrell M, Zhurinsky J, Shnizer D, Lando Z, Zharhary D, Kam Z, Ben-Ze'ev A, Geiger B,. Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. J Cell Sci 2002; 115: 2771-80.
28. Vignjevic D, Schoumacher M, Gavert N, Janssen KP, Jih G, Lae M, Louvard D, Ben-Ze'ev A, Robine S,. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res 2007; 67: 6844-53.
29. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y,. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 2002; 21: 5861-7.
30. Takahashi Y, Nishikawa M, Suehara T, Takiguchi N, Takakura Y,. Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice. Int J Cancer 2008; 123: 2315-20.
31. Liu Y, Li QC, Miao Y, Xu HT, Dai SD, Wei Q, Dong QZ, Dong XJ, Zhao Y, Zhao C, Wang EH,. Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells. Cancer Sci 2009; 100: 441-8.
32. Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC,. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Mol Carcinog 2004; 39: 139-46.
33. Du Q, Zhang X, Cardinal J, Cao Z, Guo Z, Shao L, Geller DA,. Wnt/beta-catenin signaling regulates cytokine-induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-kappaB activation in cancer cells. Cancer Res 2009; 69: 3764-71.