Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model

Chemico-Biological Interactions

Volumn 193, Issue 1, 2011, Pages 12-21

  Khan, Mahaboob S ^a,b   Halagowder, Devaraj ^a   Devaraj, S Niranjali ^a  

^a UNIVERSITY OF MADRAS   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Apoptosis; Methylated flavone; NF kB pathway; Preneoplastic nodules; Wnt pathway

Indexed keywords

5,7 DIMETHOXY FLAVONE; BETA CATENIN; CASEIN KINASE II; CASPASE 3; CHRYSIN; CYCLIN D1; CYCLOOXYGENASE 2; DIETHYLNITROSAMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PROTEIN BAX; PROTEIN C JUN; PROTEIN P53; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; GENE ACTIVATION; GENE EXPRESSION; INFLAMMATION; LIVER CELL CARCINOMA; MALE; METHYLATION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASEIN KINASE II; CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; FLAVONES; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; LIVER NEOPLASMS; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PRECANCEROUS CONDITIONS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; WNT PROTEINS;

ANIMALIA; RATTUS;

EID: 79959999346     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.04.007     Document Type: Article

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