메뉴 건너뛰기




Volumn 7, Issue 4, 2011, Pages 259-267

Recent advances in design of glycogen phosphorylase inhibitors

Author keywords

Binding sites; Glycogen phosphory lase; Inhibitors; Type 2 diabetes

Indexed keywords

ADENOSINE PHOSPHATE; ANTIDIABETIC AGENT; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84863342432     PISSN: 15734080     EISSN: 18756662     Source Type: Journal    
DOI: 10.2174/157340811799860533     Document Type: Review
Times cited : (6)

References (57)
  • 1
    • 84964092503 scopus 로고
    • Mechanism of formation of hexosemonophosphate in muscle and isolation of a new phosphate ester
    • Cori, C. F.; Cori, G. T. Mechanism of formation of hexosemonophosphate in muscle and isolation of a new phosphate ester. Proc. Soc. Exp. Biol. Med., 1936, 34, 702-705.
    • (1936) Proc. Soc. Exp. Biol. Med , vol.34 , pp. 702-705
    • Cori, C.F.1    Cori, G.T.2
  • 3
    • 0024322304 scopus 로고
    • The allosteric transition of glycogen phosphorylase
    • Barford, D.; Johnson, L. N. The allosteric transition of glycogen phosphorylase. Nature, 1989, 340, 609-616.
    • (1989) Nature , vol.340 , pp. 609-616
    • Barford, D.1    Johnson, L.N.2
  • 4
    • 23644444478 scopus 로고    scopus 로고
    • Glycogen phosphorylase inhibition in type 2 diabetes therapy
    • Baker, D. J.; Timmons, J. A.; Greenhaff, P. L. Glycogen phosphorylase inhibition in type 2 diabetes therapy. Diabetes, 2005, 54, 2453-2459.
    • (2005) Diabetes , vol.54 , pp. 2453-2459
    • Baker, D.J.1    Timmons, J.A.2    Greenhaff, P.L.3
  • 5
    • 0035110957 scopus 로고    scopus 로고
    • Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus
    • Treadway, J. L.; Mendys, P.; Hoover, D. J. Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus. Expert Opin. Investig. Drugs, 2001, 10, 439-454.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 439-454
    • Treadway, J.L.1    Mendys, P.2    Hoover, D.J.3
  • 6
    • 0036889606 scopus 로고    scopus 로고
    • Glycogen phosphorylase as a molecular target for type 2 diabetes therapy
    • N.G., O. Glycogen phosphorylase as a molecular target for type 2 diabetes therapy. Curr. Protein Peptide Sci., 2002, 3, 561-586.
    • (2002) Curr. Protein Peptide Sci , vol.3 , pp. 561-586
  • 8
    • 0020481297 scopus 로고
    • Catalytic site of glycogen phosphorylase: Structure of the T state and specificity for. alpha.-D-glucose
    • Sprang, S. R.; Goldsmith, E. J.; Fletterick, R. J.; Withers, S. G.; Madsen, N. B. Catalytic site of glycogen phosphorylase: structure of the T state and specificity for.alpha.-D-glucose. Biochemistry (Mosc), 1982, 21, 5364-5371.
    • (1982) Biochemistry (Mosc) , vol.21 , pp. 5364-5371
    • Sprang, S.R.1    Goldsmith, E.J.2    Fletterick, R.J.3    Withers, S.G.4    Madsen, N.B.5
  • 10
    • 0026562948 scopus 로고
    • Glycogen phosphorylase: Control by phosphorylation and allosteric effectors
    • Johnson, L. Glycogen phosphorylase: control by phosphorylation and allosteric effectors. FASEB J., 1992, 6, 2274-2282.
    • (1992) FASEB J , vol.6 , pp. 2274-2282
    • Johnson, L.1
  • 11
    • 0034660681 scopus 로고    scopus 로고
    • A new allosteric site in glycogen phosphorylase b as a target for drug interactions
    • London, England
    • Oikonomakos, N. G.; Skamnaki, V. T.; Tsitsanou, K. E.; G Gavalas, N.; Johnson, L. N. A new allosteric site in glycogen phosphorylase b as a target for drug interactions. Structure (London, England: 1993), 2000, 8, 575-584.
    • (2000) Structure , vol.1993 , Issue.8 , pp. 575-584
    • Oikonomakos, N.G.1    Skamnaki, V.T.2    Tsitsanou, K.E.3    Gavalas, N.4    Johnson, L.N.5
  • 12
    • 0019325629 scopus 로고
    • Proposals for the catalytic mechanism of glycogen phosphorylase b prompted by crystallographic studies on glucose 1-phosphate binding
    • Johnson, L. N.; Jenkins, J. A.; Wilson, K. S.; Stura, E. A.; Zanotti, G. Proposals for the catalytic mechanism of glycogen phosphorylase b prompted by crystallographic studies on glucose 1-phosphate binding. J. Mol. Biol., 1980, 140, 565-580.
    • (1980) J. Mol. Biol , vol.140 , pp. 565-580
    • Johnson, L.N.1    Jenkins, J.A.2    Wilson, K.S.3    Stura, E.A.4    Zanotti, G.5
  • 15
    • 0037648878 scopus 로고    scopus 로고
    • Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: Recent developments
    • Somsak, L.; Nagy, V.; Hadady, Z.; Docsa, T.; Gergely, P. Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments. Curr. Pharm. Des., 2003, 9, 1177-1189.
    • (2003) Curr. Pharm. Des , vol.9 , pp. 1177-1189
    • Somsak, L.1    Nagy, V.2    Hadady, Z.3    Docsa, T.4    Gergely, P.5
  • 20
    • 41949086319 scopus 로고    scopus 로고
    • Advances in glycogen phosphorylase inhibitor design
    • Oikonomakos, N. G.; Somsak, L. Advances in glycogen phosphorylase inhibitor design. Curr. Opin. Investig. Drugs, 2008, 9, 379-395.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 379-395
    • Oikonomakos, N.G.1    Somsak, L.2
  • 21
    • 0028988972 scopus 로고
    • Mutations in paired. alpha.-helixes at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity
    • Buchbinder, J. L.; Guinovart, J. J.; Fletterick, R. J. Mutations in paired.alpha.-helixes at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity. Biochemistry (Mosc), 1995, 34, 6423-6432.
    • (1995) Biochemistry (Mosc) , vol.34 , pp. 6423-6432
    • Buchbinder, J.L.1    Guinovart, J.J.2    Fletterick, R.J.3
  • 22
    • 0018867079 scopus 로고
    • The structures and related functions of phosphorylase a
    • Fletterick, R. J.; Madsen, N. B. The structures and related functions of phosphorylase a. Annu. Rev. Biochem., 1980, 49, 31-61.
    • (1980) Annu. Rev. Biochem , vol.49 , pp. 31-61
    • Fletterick, R.J.1    Madsen, N.B.2
  • 23
    • 0023860930 scopus 로고
    • Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes
    • Newgard, C. B.; Littman, D. R.; van Genderen, C.; Smith, M.; Fletterick, R. J. Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. J. Biol. Chem., 1988, 263, 3850-3857.
    • (1988) J. Biol. Chem , vol.263 , pp. 3850-3857
    • Newgard, C.B.1    Littman, D.R.2    van Genderen, C.3    Smith, M.4    Fletterick, R.J.5
  • 25
    • 9544234747 scopus 로고
    • Glycogen phosphorylase structures and function
    • Fletterick, R. J.; Sprang, S. R. Glycogen phosphorylase structures and function. Accounts Chem. Res., 1982, 15, 361-369.
    • (1982) Accounts Chem. Res , vol.15 , pp. 361-369
    • Fletterick, R.J.1    Sprang, S.R.2
  • 26
    • 0024343470 scopus 로고
    • Domain separation in the activation of glycogen phosphorylase a
    • Goldsmith, E. J.; Sprang; Hamlin, R.; Xuong, N. H.; Fletterick, R. J. Domain separation in the activation of glycogen phosphorylase a. Science, 1989, 245, 528-532.
    • (1989) Science , vol.245 , pp. 528-532
    • Goldsmith, E.J.1    Sprang2    Hamlin, R.3    Xuong, N.H.4    Fletterick, R.J.5
  • 27
    • 33746906704 scopus 로고    scopus 로고
    • Glycogen phosphorylase inhibitors
    • Henke, B. R.; Sparks, S. M. Glycogen phosphorylase inhibitors. Mini-Rev. Med. Chem., 2006, 6, 845-857.
    • (2006) Mini-Rev. Med. Chem , vol.6 , pp. 845-857
    • Henke, B.R.1    Sparks, S.M.2
  • 29
    • 69349102811 scopus 로고    scopus 로고
    • Synthesis and glycogen phosphorylase inhibitory activity of N-([beta]-d-glucopyranosyl)amides possessing 1,4-benzodioxane moiety
    • Czakó, Z.; Juhász, L.; Kenéz, Á.; Czifrák, K.; Somsák, L.; Docsa, T.; Gergely, P.; Antus, S. Synthesis and glycogen phosphorylase inhibitory activity of N-([beta]-d-glucopyranosyl)amides possessing 1,4-benzodioxane moiety. Bioorg. Med. Chem., 2009, 17, 6738-6741.
    • (2009) Bioorg. Med. Chem , vol.17 , pp. 6738-6741
    • Czakó, Z.1    Juhász, L.2    Kenéz, A.3    Czifrák, K.4    Somsák, L.5    Docsa, T.6    Gergely, P.7    Antus, S.8
  • 30
    • 48749129542 scopus 로고    scopus 로고
    • Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies
    • Jeon, C. Y.; Murray, M. B. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med., 2008, 5, e152.
    • (2008) PLoS Med , vol.5
    • Jeon, C.Y.1    Murray, M.B.2
  • 31
    • 65349185611 scopus 로고    scopus 로고
    • Synthetic studies in butenonyl Cglycosides: Preparation of polyfunctional alkanonyl glycosides and their enzyme inhibitory activity
    • Bisht, S. S.; Fatima, S.; Tamrakar, A. K.; Rahuja, N.; Jaiswal, N.; Srivastava, A. K.; Tripathi, R. P. Synthetic studies in butenonyl Cglycosides: Preparation of polyfunctional alkanonyl glycosides and their enzyme inhibitory activity. Bioorg. Med. Chem. Lett., 2009, 19, 2699-2703.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 2699-2703
    • Bisht, S.S.1    Fatima, S.2    Tamrakar, A.K.3    Rahuja, N.4    Jaiswal, N.5    Srivastava, A.K.6    Tripathi, R.P.7
  • 32
    • 0035899177 scopus 로고    scopus 로고
    • Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-glucoand d-xylopyranosylidene-spiro-(thio)hydantoins and N-(dglucopyranosyl) amides
    • Somsák, L.; Kovács, L.; Tóth, M.; Osz, E.; Szilágyi, L.; Györgydeák, Z.; Dinya, Z.; Docsa, T.; Tóth, B.; Gergely, P. Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-glucoand d-xylopyranosylidene-spiro-(thio)hydantoins and N-(dglucopyranosyl) amides. J. Med. Chem., 2001, 44, 2843-2848.
    • (2001) J. Med. Chem , vol.44 , pp. 2843-2848
    • Somsák, L.1    Kovács, L.2    Tóth, M.3    Osz, E.4    Szilágyi, L.5    Györgydeák, Z.6    Dinya, Z.7    Docsa, T.8    Tóth, B.9    Gergely, P.10
  • 37
    • 0033850521 scopus 로고    scopus 로고
    • Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: Inhibition and inactivation of glycogen phosphorylase by an activated metabolite
    • Bergans, N.; Stalmans, W.; Goldmann, S.; Vanstapel, F. Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphorylase by an activated metabolite. Diabetes, 2000, 49, 1419-1426.
    • (2000) Diabetes , vol.49 , pp. 1419-1426
    • Bergans, N.1    Stalmans, W.2    Goldmann, S.3    Vanstapel, F.4
  • 38
    • 0032882213 scopus 로고    scopus 로고
    • Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3- isopropyl 4-(2-chlorophenyl)-1,4-dihydro- 1-ethyl-2-methylpyridine- 3,5,6-tricarboxylate
    • Oikonomakos, N. G.; Tsitsanou, K. E.; Zographos, S. E.; Skamnaki, V. T.; Goldmann, S.; Bischoff, H. Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3- isopropyl 4-(2-chlorophenyl)-1,4-dihydro- 1-ethyl-2-methylpyridine- 3,5,6-tricarboxylate. Protein Sci., 1999, 8, 1930-1945.
    • (1999) Protein Sci , vol.8 , pp. 1930-1945
    • Oikonomakos, N.G.1    Tsitsanou, K.E.2    Zographos, S.E.3    Skamnaki, V.T.4    Goldmann, S.5    Bischoff, H.6
  • 40
    • 25844437477 scopus 로고    scopus 로고
    • Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases
    • Wen, X.; Sun, H.; Liu, J.; Wu, G.; Zhang, L.; Wu, X.; Ni, P. Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorg. Med. Chem. Lett., 2005, 15, 4944-4948.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 4944-4948
    • Wen, X.1    Sun, H.2    Liu, J.3    Wu, G.4    Zhang, L.5    Wu, X.6    Ni, P.7
  • 43
    • 0016787902 scopus 로고
    • The nature of the binding site for aromatic compounds in glycogen phosphorylase b
    • Soman, G.; Philip, G. The nature of the binding site for aromatic compounds in glycogen phosphorylase b. Biochem. J., 1975, 147,369.
    • (1975) Biochem. J , vol.147 , pp. 369
    • Soman, G.1    Philip, G.2
  • 44
    • 0018096015 scopus 로고
    • The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies
    • Kasvinsky, P. J.; Madsen, N. B.; Sygusch, J.; Fletterick, R.J. The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. J. Biol. Chem., 1978, 253, 3343-3351.
    • (1978) J. Biol. Chem , vol.253 , pp. 3343-3351
    • Kasvinsky, P.J.1    Madsen, N.B.2    Sygusch, J.3    Fletterick, R.J.4
  • 45
    • 0021102427 scopus 로고
    • Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site
    • Madsen, N. B.; Shechosky, S.; Fletterick, R. J. Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry (Mosc), 1983, 22, 4460-4465.
    • (1983) Biochemistry (Mosc) , vol.22 , pp. 4460-4465
    • Madsen, N.B.1    Shechosky, S.2    Fletterick, R.J.3
  • 46
    • 0020492229 scopus 로고
    • Analysis of an allosteric binding site: The nucleoside inhibitor site of phosphorylase a
    • Sprang, S.; Fletterick, R.; Stern, M.; Yang, D.; Madsen, N.; Sturtevant, J. Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase a. Biochemistry (Mosc), 1982, 21, 2036-2048.
    • (1982) Biochemistry (Mosc) , vol.21 , pp. 2036-2048
    • Sprang, S.1    Fletterick, R.2    Stern, M.3    Yang, D.4    Madsen, N.5    Sturtevant, J.6
  • 49
    • 78549255562 scopus 로고    scopus 로고
    • Computation as a tool for glycogen phosphorylase inhibitor design
    • Hayes, J. M.; Leonidas, D. D. Computation as a tool for glycogen phosphorylase inhibitor design. Mini Rev. Med. Chem., 2010, 10, 1156-1174.
    • (2010) Mini Rev. Med. Chem , vol.10 , pp. 1156-1174
    • Hayes, J.M.1    Leonidas, D.D.2
  • 50
    • 78549267168 scopus 로고    scopus 로고
    • Recent advances in the allosteric inhibition of glycogen phosphorylase
    • Loughlin, W. A. Recent advances in the allosteric inhibition of glycogen phosphorylase. Mini Rev. Med. Chem., 2010, 10, 1139-1155.
    • (2010) Mini Rev. Med. Chem , vol.10 , pp. 1139-1155
    • Loughlin, W.A.1
  • 51
    • 0036185751 scopus 로고    scopus 로고
    • The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug
    • Oikonomakos, N. G.; Zographos, S. E.; Skamnaki, V. T.; Archontis, G. The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug. Bioorg. Med. Chem., 2002, 10, 1313-1319.
    • (2002) Bioorg. Med. Chem , vol.10 , pp. 1313-1319
    • Oikonomakos, N.G.1    Zographos, S.E.2    Skamnaki, V.T.3    Archontis, G.4
  • 54
    • 13844311049 scopus 로고    scopus 로고
    • Co MFA and docking studies on glycogen phosphorylase a inhibitors as antidiabetic agents
    • Prathipati, P.; Pandey, G.; Saxena, A. K. Co MFA and docking studies on glycogen phosphorylase a inhibitors as antidiabetic agents. J. Chem. Inf. Model., 2005, 45, 136-145.
    • (2005) J. Chem. Inf. Model , vol.45 , pp. 136-145
    • Prathipati, P.1    Pandey, G.2    Saxena, A.K.3
  • 57
    • 0042011174 scopus 로고    scopus 로고
    • The binding of beta- and gamma-cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies
    • Pinotsis, N.; Leonidas, D. D.; Chrysina, E. D.; Oikonomakos, N. G.; Mavridis, I. M. The binding of beta- and gamma-cyclodextrins to glycogen phosphorylase b: kinetic and crystallographic studies. Protein Sci., 2003, 12, 1914-1924.
    • (2003) Protein Sci , vol.12 , pp. 1914-1924
    • Pinotsis, N.1    Leonidas, D.D.2    Chrysina, E.D.3    Oikonomakos, N.G.4    Mavridis, I.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.