Binding of N-acetyl-N′-β-D-glucopyranosyl urea and N-benzoyl-N′-β-D-glucopyranosyl urea to glycogen phosphorylase b. Kinetic and crystallographic studies

European Journal of Biochemistry

Volumn 269, Issue 6, 2002, Pages 1684-1696

  Oikonomakos, Nikos G ^a   Kosmopoulou, Magda ^a   Zographos, Spyros E ^a   Leonidas, Demetres D ^a   Chrysina, Evangelia D ^a   Somsák, László ^b   Nagy, Veronika ^b   Praly, Jean Pierre ^c   Docsa, Tibor ^d   Tóth, Béla ^d   Gergely, Pál ^d  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITÉ LYON 1   (France)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Glucopyranosyl ureas; Glycogen metabolism; Glycogen phosphorylase; Inhibition; Structure

Indexed keywords

ENZYME INHIBITOR; GLUCOSE; GLYCOGEN PHOSPHORYLASE B; N ACETYL N' BETA DEXTRO GLUCOPYRANOSYL UREA; N BENZOYL N' BETA DEXTRO GLUCOPYRANOSYL UREA; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ELECTRICITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; GLYCOGEN METABOLISM; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL;

CRYSTALLOGRAPHY, X-RAY; GLUCOSE; GLYCOGEN PHOSPHORYLASE; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; UREA;

EID: 18344387526     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2002.02813.x     Document Type: Article

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