메뉴 건너뛰기




Volumn 13, Issue 20, 2003, Pages 3405-3408

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; DIHYDROPYRIDINE DIACID GLYCOGEN PHOSPHORYLASE INHIBITOR; ENZYME INHIBITOR; GLUCOSE; UNCLASSIFIED DRUG;

EID: 0141517124     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00798-4     Document Type: Article
Times cited : (79)

References (22)
  • 1
    • 85031079706 scopus 로고    scopus 로고
    • Fact Sheet No. 138. World Health Organization, Geneva, 2002
    • Fact Sheet No. 138. World Health Organization, Geneva, 2002.
  • 13
    • 85031079905 scopus 로고    scopus 로고
    • US Patent 4,145,432, 1979
    • (a) Sato, Y. US Patent 4,145,432, 1979.
    • Sato, Y.1
  • 14
    • 85031080257 scopus 로고    scopus 로고
    • US Patent 4,284,634, 1981
    • (b) Sato, Y. US Patent 4,284,634, 1981.
    • Sato, Y.1
  • 16
    • 85031073143 scopus 로고    scopus 로고
    • Treatment of the concentrated diacid compound with 2 equiv NaOH(aq) precluded formation of the maleic anhydride
    • Treatment of the concentrated diacid compound with 2 equiv NaOH(aq) precluded formation of the maleic anhydride.
  • 17
    • 85031079938 scopus 로고    scopus 로고
    • note
    • 50 values derived from inhibiting phosphorolysis of glycogen using recombinant human liver or muscle enzyme. The standard error for this assay (15%) arose from titration of an internal standard. Glucose-1-phosphate production was monitored via an enzymatic assay involving phosphoglucomutase/glucose-6-phosphate dehydrogenase-mediated NADH production (ex. 340 nm, em. 465 nm)
  • 18
    • 85031069265 scopus 로고    scopus 로고
    • note
    • Inhibition of glucagon-stimulated glycogenolysis in primary rat hepatocytes. The standard error for this assay (15%) derived from an internal standard. Inhibition of glucose production determined by digesting remaining glycogen and quantifying by monitoring glucose dehydrogenase-mediated NADPH production (ex. 340 nm, em. 465 nm).
  • 19
    • 85031079004 scopus 로고    scopus 로고
    • note
    • +: 552.14; found: 552.1.
  • 20
    • 85031081212 scopus 로고    scopus 로고
    • note
    • Glucose levels determined at indicated times post-dosing of either compound 29 or vehicle. Each curve represents a single group of n=7 animals, and timepoints therein an average of the group.
  • 21
    • 85031079549 scopus 로고    scopus 로고
    • note
    • max=12 nM, %F=4.5.
  • 22
    • 0004155427 scopus 로고
    • W.H. Freeman and Co.: New York
    • Stryer, L. Biochemistry; W.H. Freeman and Co.: New York, 1995; p 598.
    • (1995) Biochemistry , pp. 598
    • Stryer, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.