Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling

Cardiovascular Research

Volumn 87, Issue 3, 2010, Pages 485-493

  Reil, Jan Christian ^a   Hohl, Mathias ^a   Oberhofer, Martin ^b   Kazakov, Andrey ^a   Kaestner, Lars ^b   Mueller, Patrick ^a   Adam, Oliver ^a   Maack, Christoph ^a   Lipp, Peter ^b   Mewis, Christian ^a   Allessie, Maurits ^c   Laufs, Ulrich ^a   Böhm, Michael ^a   Neuberger, Hans Ruprecht ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Atrial arrythmias; Atrial conduction disturbance; RacET; Structural remodelling

Indexed keywords

RAC1 PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EPICARDIUM MAPPING; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART CONDUCTION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE REFRACTORY PERIOD; HEART RIGHT ATRIUM; MOUSE; NONHUMAN; PATHOGENESIS; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTOLIC HEART FAILURE; WILD TYPE; ANIMAL; DRUG EFFECTS; ELECTROCARDIOGRAPHY; ENZYMOLOGY; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; HEART ARRHYTHMIA; HEART ATRIUM; HEART ATRIUM FUNCTION; HEART FAILURE; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE PRESSURE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TIME; TRANSGENIC MOUSE; UPREGULATION;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIAL FUNCTION; ELECTROCARDIOGRAPHY; FIBROSIS; GENE EXPRESSION REGULATION; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART FAILURE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, TRANSGENIC; RAC1 GTP-BINDING PROTEIN; TIME FACTORS; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 77954778326     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq079     Document Type: Article

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