Ca2+-dependent regulation of cardiac L-type Ca2+ channels: Is a unifying mechanism at hand?

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 4, 2001, Pages 639-650

  Anderson, Mark E ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Calmodulin binding domain; Calmodulin kinase; Facilitation; ICP domain; Inactivation; L type Ca2+channels

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM; DIVALENT CATION;

CALCIUM CURRENT; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CONFERENCE PAPER; EXCITATION CONTRACTION COUPLING; GENE EXPRESSION; HEART ARRHYTHMIA; HEART CONTRACTION; HEART VENTRICLE HYPERTROPHY; HUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CATIONS, DIVALENT; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 0034743560     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1354     Document Type: Conference Paper

References (78)

1. Calcium entry leads to inactivation of calcium channel in Paramecium
2. Enhancement of calcium current during digitalis inotropy in mammalian heart: Positive feed-back regulation by intracellular calcium?
3. 2+
4. Scarpa calcium currents in the A7r5 smooth muscle-derived cell line. Increase in current and selective removal of voltage-dependent inactivation by intracellular trypsin
5. 2+ channels does not affect their voltage sensor
6. Inactivation of calcium channels in mammalian heart cells: Joint dependence on membrane potential and intracellular calcium
7. 2+ channels is sensitive to cytoplasmic calcium
8. Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers
9. Ion-dependent inactivation of barium current through L-type calcium channels
10. Mechanisms of inactivation of L-type calcium channels in human atrial myocytes
11. Structural regions of the cardiac Ca channel alpha subunit involved in Ca-dependent inactivation
12. Calcium channels: Mechanisms of selectivity, permeation, and block
13. Mechanism of ion permeation through calcium channels
14. Regulation of the Na-conducting Ca channel during the cardiac action potential
15. Sodium-conducting channels in cardiac membranes in low calcium
16. Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell
17. Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle
18. 2+ channels and ryanodine receptors in cardiac myocytes
19. The effects of injection of calcium ions and calcium chelators on calcium channel inactivation in Helix neurones
20. Removal of Ca current inactivation in dialysed guinea-pig atrial cardioballs by Ca chelators
21. 2+ buffering in guinea pig ventricular cardiomyocytes
22. Voltage-dependent and calcium-dependent inactivation of calcium channel current in identified snail neurones
23. 2+ is buffered
24. 2+ current in guinea-pig myocytes
25. 2+ current in guinea-pig myocytes
26. Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II
27. 2+ current in rabbit ventricular myocytes
28. Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase
29. 2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx
30. 2+ release by the sarcoplasmic reticulum
31. The multifunctional calcium/calmodulin-dependent protein kinase: From form to function
32. Site-specific phosphorylation of the purified receptor for calcium-channel blockers by cAMP- and cGMP-dependent protein kinases, protein kinase C, calmodulin-dependent protein kinase II and casein kinase II
33. Modulation of cardiac ryanodine receptors of swine and rabbit by a phosphorylation-dephosphorylation mechanism
34. 2+/calmodulin-dependent phosphorylation or by intereaction with phospholamban
35. Ser16 prevails over Thr17 phospholamban phosphorylation in the beta-adrenergic regulation of cardiac relaxation
36. Activation of calmodulin by various metal cations as a function of ionic radius
37. 2+ current: A cellular mechanism for long Q-T arrhythmias
38. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
39. 2+ channels
40. Ca current facilitation during postrest recovery depends on Ca entry
41. Enzymatic gating of voltage-activated calcium channels
42. Inactivation of calcium channels in mammalian heart cells: Joint dependence on membrane potential and intracellular calcium
43. Trypsin and forskolin decrease the sensitivity of L-type calcium current to inhibition by cytoplasmic free calcium in guinea pig heart muscle cells
44. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
45. Calcium currents in a fast-twitch skeletal muscle of the rat
46. Molecular determinants of calcium-dependent inactivation in cardiac L-type calcium channels
47. 2+ channels by gbeta gamma and calmodulin via interactions with N and C termini of alpha 1C
48. 2+ channels
49. 2+-binding domains
50. 2+) channels
51. 2+ channel depends on calmodulin
52. 2+-dependent inactivation of L-type calcium channels
53. Calmodulin supports both inactivation and facilitation of L-type calcium channels
54. 2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the (alpha)1C subunit
55. Mutations in the EF-hand motif impair the inactivation of barium currents of the cardiac alpha1C channel
56. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits
57. Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit
58. 2+
59. 2+ channel inactivation. Segment exchange analysis of the carboxyl-terminal cytoplasmic motif encoded by exons 40-42 of the human alpha1C subunit gene
60. 2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C sub-unit
61. Sequence motifs for calmodulin recognition
62. 2+/calmodulin binds to an modulates P/Q-type calcium channels
63. 2+ current (ICa) facilitation is enhanced and fast inactivation is slowed by a calmodulin IQ-binding domain mimetic peptide
64. 2+ channels
65. Ca influx and sarcoplasmic reticulum Ca release in cardiac muscle activation during postrest recovery
66. Paradoxical twitch potentiation after rest in cardiac muscle: Increased fractional release of SR calcium
67. Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes
68. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
69. 2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes
70. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
71. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I: Experimental studies
72. Alterations in calcium handling in cardiac hypertrophy and heart failure
73. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure
74. Electrophysiological remodeling in hypertrophy and heart failure
75. ++/calmodulin-dependent protein kinase, decreases early afterdepolirizations in rabbit heart
76. Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current
77. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure
78. 2+ release causes myocyte depolarization - Underlying mechanism and threshold for triggered action potentials