Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

Circulation Research

Volumn 89, Issue 1, 2001, Pages 20-25

  Sohal, Dawinder S ^a   Nghiem, Mai ^a   Crackower, Michael A ^a   Witt, Sandra A ^a   Kimball, Thomas R ^a   Tymitz, Kevin M ^a   Penninger, Josef M ^a   Molkentin, Jeffery D ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cardiac; Cre recombinase; Embryo; Genetics; Inducible gene expression

Indexed keywords

CRE RECOMBINASE; ESTROGEN RECEPTOR; HYBRID PROTEIN; MYOSIN HEAVY CHAIN; TAMOXIFEN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOARCHITECTURE; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GENE INACTIVATION; GENE LOCATION; GENETIC CODE; GENETIC MANIPULATION; HEART PERFORMANCE; LIGAND BINDING; MARKER GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

EID: 0035816733     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1301.092687     Document Type: Article

References (25)

1. Analysis of mammalian cis-regulatory DNA elements by homologous recombination
2. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
3. Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy
4. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state
5. Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system
6. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: Manipulation using the Cre/loxP system in transgenic mice
7. Death before birth: Clues from gene knockouts and mutations
8. Transgenic remodeling of the contractile apparatus in the mammalian heart
9. Inducible site-directed recombination in mouse embryonic stem cells
10. Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart: Cross-talk between cardiac hypertrophic signaling pathways
11. Mapping of myogenin transcription during embryogenesis using transgenes linked to the myogenin control region
12. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
13. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
14. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
15. Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer
16. Generalized lacZ expression with the ROSA26 Cre reporter strain
17. Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
18. Timing is everything in life: Conditional transgene expression in the cardiovascular system
19. Conditional transgene expression in the heart
20. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
21. i-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy
22. Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein
23. The effects of the antihormones RU486 and tamoxifen on fetoplacental development and placental bed vascularisation in the rat: A model for intrauterine fetal growth retardation
24. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
25. Proliferative lesions of oviduct and uterus in CD-1 mice exposed prenatally to tamoxifen