Efficient silencing of EGFP reporter gene with siRNA delivered by asymmetrical N4, N9-diacyl spermines

Molecular Pharmaceutics

Volumn 9, Issue 7, 2012, Pages 1862-1876

  Metwally, Abdelkader A ^a   Reelfs, Olivier ^a   Pourzand, Charareh ^a   Blagbrough, Ian S ^a  

^a University of Bath   (United Kingdom)

Author keywords

asymmetry; lipoplexes; polyamine; self assembly; spermine

Indexed keywords

1,12 DIPHTHALIMIDO 4,9 DIAZADODECANE; 1,12 DIPHTHALIMIDO N4 OLEOYL 4,9 DIAZADODECANE; ENHANCED GREEN FLUORESCENT PROTEIN; LIPOFECTAMINE; N4 ARACHIDONOYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 EICOSENOYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 ERUCOYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 LIGNOCEROYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 LINOLEOYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 NERVONOYL N9 OLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4 OLEOYL N9 STEAROYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIACYLSPERMINE DERIVATIVE; N4,N9 DIERUCOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIOLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; SMALL INTERFERING RNA; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL SURVIVAL; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENES, ERBB-1; GENES, REPORTER; GENETIC VECTORS; HELA CELLS; HUMANS; LIPIDS; RNA, SMALL INTERFERING; SPERMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84863302126     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200429n     Document Type: Article

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