Design and synthesis of N 4,N 9-disubstituted spermines for non-viral siRNA delivery - Structure-activity relationship studies of sifection efficiency versus toxicity

Pharmaceutical Research

Volumn 26, Issue 2, 2009, Pages 286-295

  Soltan, Moustafa K ^a,b   Ghonaim, Hassan M ^a   El Sadek, Mohamed ^b   Kull, M Abou ^b   El Aziz, Lubna Abd ^b   Blagbrough, Ian S ^a  

^a University of Bath   (United Kingdom)

^b Zagazig University   (Egypt)

Author keywords

Lipopolyamines; N 4,N 9 dioleoyl spermine; NVGT; Primary skin cells; SiRNA delivery

Indexed keywords

FLUORESCEIN; LIPOPLEX; N4,N9 DIDECANOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DILAUROYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIMYRISTOLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIMYRISTOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIOLEOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIOLEYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIPALMITOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DIRETINOYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DISTEAROYL 1,12 DIAMINO 4,9 DIAZADODECANE; N4,N9 DISTEARYL 1,12 DIAMINO 4,9 DIAZADODECANE; NANOPARTICLE; SMALL INTERFERING RNA; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; FLUORESCENT DYE; LIPID; SPERMINE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG FORMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RNA BINDING; STRUCTURE ACTIVITY RELATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FEMALE; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; PARTICLE SIZE; RNA INTERFERENCE; SKIN; SYNTHESIS; UTERINE CERVIX TUMOR;

CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; FLUORESCENT DYES; HELA CELLS; HUMANS; LIPIDS; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; PARTICLE SIZE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SKIN; SPERMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 58549108764     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9731-z     Document Type: Article

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