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Volumn 29, Issue 5, 2012, Pages 815-822

Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-β/Smad signaling pathway

Author keywords

Bleomycin; Nitric oxide synthase; Oxymatrine; Pulmonary fibrosis; TGF Smad signaling pathway

Indexed keywords

BLEOMYCIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; OXYMATRINE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84863291618     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.923     Document Type: Article
Times cited : (43)

References (52)
  • 4
    • 0034011982 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement
    • American Thoracic Society. American Thoracic Society (ATS), and the European Respiratory Society (ERS)
    • American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161: 646-664, 2000.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 646-664
  • 5
    • 79952717349 scopus 로고    scopus 로고
    • An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
    • Raghu G, Collard HR, Egan JJ, et al: An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183: 788-824, 2011.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 788-824
    • Raghu, G.1    Collard, H.R.2    Egan, J.J.3
  • 6
    • 26844506715 scopus 로고    scopus 로고
    • Current and future therapeutic approaches in idiopathic pulmonary fibrosis
    • DOI 10.1183/09031936.05.00145004
    • Bouros D and Antoniou KM: Current and future therapeutic approaches in idiopathic pulmonary fibrosis. Eur Respir J 26: 693-702, 2005. (Pubitemid 41448670)
    • (2005) European Respiratory Journal , vol.26 , Issue.4 , pp. 693-702
    • Bouros, D.1    Antoniou, K.M.2
  • 7
    • 77951969449 scopus 로고    scopus 로고
    • Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro
    • Xu WS, Zhao KK, Miao XH, et al: Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro. World J Gastroenterol 16: 2028-2037, 2010.
    • (2010) World J Gastroenterol , vol.16 , pp. 2028-2037
    • Xu, W.S.1    Zhao, K.K.2    Miao, X.H.3
  • 8
    • 79951584353 scopus 로고    scopus 로고
    • Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance
    • Wang YP, Zhao W, Xue R, et al: Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance. Antiviral Res 89: 227-231, 2011.
    • (2011) Antiviral Res , vol.89 , pp. 227-231
    • Wang, Y.P.1    Zhao, W.2    Xue, R.3
  • 9
    • 52949129442 scopus 로고    scopus 로고
    • Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats
    • Zhao J, Yu S, Tong L, et al: Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats. Surg Today 38: 931-937, 2008.
    • (2008) Surg Today , vol.38 , pp. 931-937
    • Zhao, J.1    Yu, S.2    Tong, L.3
  • 10
    • 77949293053 scopus 로고    scopus 로고
    • Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia
    • Fan H, Li L, Zhang X, et al: Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators Inflamm 2009: 704706, 2009.
    • (2009) Mediators Inflamm , vol.2009 , pp. 704706
    • Fan, H.1    Li, L.2    Zhang, X.3
  • 11
    • 84863775306 scopus 로고    scopus 로고
    • Oxymatrine ameliorates L: -arginine-induced acute pancreatitis in rats
    • Jun 2, (Epub ahead of print)
    • Zhang Z, Wang Y, Dong M, Cui J, Rong D and Dong Q: Oxymatrine ameliorates L: -arginine-induced acute pancreatitis in rats. Inflammation: Jun 2, 2011 (Epub ahead of print).
    • (2011) Inflammation
    • Zhang, Z.1    Wang, Y.2    Dong, M.3    Cui, J.4    Rong, D.5    Dong, Q.6
  • 12
    • 84655176705 scopus 로고    scopus 로고
    • Oxymatrine diminishes the side population and inhibits the expression of beta-catenin in MCF-7 breast cancer cells
    • Zhang Y, Piao B, Hua B, et al: Oxymatrine diminishes the side population and inhibits the expression of beta-catenin in MCF-7 breast cancer cells. Med Oncol 28: (Suppl 1): S99-S107, 2010.
    • (2010) Med Oncol , vol.28 , Issue.SUPPL. 1
    • Zhang, Y.1    Piao, B.2    Hua, B.3
  • 13
    • 79959641621 scopus 로고    scopus 로고
    • Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c
    • Ling Q, Xu X, Wei X, et al: Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J Exp Clin Cancer Res 30: 66, 2011.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 66
    • Ling, Q.1    Xu, X.2    Wei, X.3
  • 14
    • 79956224307 scopus 로고    scopus 로고
    • Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury
    • Dong XQ, Yu WH, Hu YY, Zhang ZY and Huang M: Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury. Inflamm Res 60: 533-539, 2011.
    • (2011) Inflamm Res , vol.60 , pp. 533-539
    • Dong, X.Q.1    Yu, W.H.2    Hu, Y.Y.3    Zhang, Z.Y.4    Huang, M.5
  • 15
    • 44849092456 scopus 로고    scopus 로고
    • Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis
    • Wu XL, Zeng WZ, Jiang MD, Qin JP and Xu H: Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis. World J Gastroenterol 14: 2100-2105, 2008.
    • (2008) World J Gastroenterol , vol.14 , pp. 2100-2105
    • Wu, X.L.1    Zeng, W.Z.2    Jiang, M.D.3    Qin, J.P.4    Xu, H.5
  • 16
    • 79955645935 scopus 로고    scopus 로고
    • The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: Role of nrf2 and hemeoxygenase-1 expression
    • Li M, Zhang X, Cui L, et al: The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: role of nrf2 and hemeoxygenase-1 expression. Biol Pharm Bull 34: 595-601, 2011.
    • (2011) Biol Pharm Bull , vol.34 , pp. 595-601
    • Li, M.1    Zhang, X.2    Cui, L.3
  • 17
    • 78649637007 scopus 로고    scopus 로고
    • Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens
    • Cao YG, Jing S, Li L, et al: Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens. Phytother Res 24: 1844-1849, 2010.
    • (2010) Phytother Res , vol.24 , pp. 1844-1849
    • Cao, Y.G.1    Jing, S.2    Li, L.3
  • 18
    • 49749085492 scopus 로고    scopus 로고
    • Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture
    • Chen X, Sun R, Hu J, et al: Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture. Basic Clin Pharmacol Toxicol 103: 278-286, 2008.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , pp. 278-286
    • Chen, X.1    Sun, R.2    Hu, J.3
  • 19
    • 33846850150 scopus 로고    scopus 로고
    • Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis
    • Hsu YC, Wang LF and Chien YW: Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis. Free Radic Biol Med 42: 599-607, 2007.
    • (2007) Free Radic Biol Med , vol.42 , pp. 599-607
    • Hsu, Y.C.1    Wang, L.F.2    Chien, Y.W.3
  • 20
    • 2342482002 scopus 로고    scopus 로고
    • Nitric oxide in health and disease of the respiratory system
    • DOI 10.1152/physrev.00034.2003
    • Ricciardolo FL, Sterk PJ, Gaston B and Folkerts G: Nitric oxide in health and disease of the respiratory system. Physiol Rev 84: 731-765, 2004. (Pubitemid 38823765)
    • (2004) Physiological Reviews , vol.84 , Issue.3 , pp. 731-765
    • Ricciardolo, F.L.M.1    Sterk, P.J.2    Gaston, B.3    Folkerts, G.4
  • 21
    • 0028026868 scopus 로고
    • Nitric oxide synthase: Aspects concerning structure and catalysis
    • Marletta MA: Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78: 927-930, 1994.
    • (1994) Cell , vol.78 , pp. 927-930
    • Marletta, M.A.1
  • 22
    • 0030915094 scopus 로고    scopus 로고
    • Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis
    • Saleh D, Barnes PJ and Giaid A: Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 155: 1763-1769, 1997. (Pubitemid 27216690)
    • (1997) American Journal of Respiratory and Critical Care Medicine , vol.155 , Issue.5 , pp. 1763-1769
    • Saleh, D.1    Barnes, P.J.2    Giaid, A.3
  • 23
    • 0032948112 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase as a potential therapeutic target
    • DOI 10.1146/annurev.pharmtox.39.1.191
    • Hobbs AJ, Higgs A and Moncada S: Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 39: 191-220, 1999. (Pubitemid 29222557)
    • (1999) Annual Review of Pharmacology and Toxicology , vol.39 , pp. 191-220
    • Hobbs, A.J.1    Higgs, A.2    Moncada, S.3
  • 24
    • 0033839060 scopus 로고    scopus 로고
    • Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin
    • DOI 10.1006/niox.2000.0297
    • Gurujeyalakshmi G, Wang Y and Giri SN: Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. Nitric Oxide 4: 399-411, 2000. (Pubitemid 30665222)
    • (2000) Nitric Oxide - Biology and Chemistry , vol.4 , Issue.4 , pp. 399-411
    • Gurujeyalakshmi, G.1    Wang, Y.2    Giri, S.N.3
  • 25
    • 0034960535 scopus 로고    scopus 로고
    • 3 mRNA transcripts in normal and fibrotic human lung
    • DOI 10.1136/thorax.56.7.549
    • Coker RK, Laurent GJ, Jeffery PK, du Bois RM, Black CM and McAnulty RJ: Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung. Thorax 56: 549-556, 2001. (Pubitemid 32588534)
    • (2001) Thorax , vol.56 , Issue.7 , pp. 549-556
    • Coker, R.K.1    Laurent, G.J.2    Jeffery, P.K.3    Du, B.R.M.4    Black, C.M.5    McAnulty, R.J.6
  • 26
    • 0025984699 scopus 로고
    • The role of TGF-beta in pulmonary fibrosis
    • Khalil N and Greenberg AH: The role of TGF-beta in pulmonary fibrosis. Ciba Found Symp 157: 194-211, 1991.
    • (1991) Ciba Found Symp , vol.157 , pp. 194-211
    • Khalil, N.1    Greenberg, A.H.2
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • -DeltaDeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 34248577489 scopus 로고    scopus 로고
    • Effects of curcumin in treatment of experimental pulmonary fibrosis: A comparison with hydrocortisone
    • DOI 10.1016/j.jep.2007.03.011, PII S0378874107001341
    • Xu M, Deng B, Chow YL, Zhao ZZ and Hu B: Effects of curcumin in treatment of experimental pulmonary fibrosis: a comparison with hydrocortisone. J Ethnopharmacol 112: 292-299, 2007. (Pubitemid 46756074)
    • (2007) Journal of Ethnopharmacology , vol.112 , Issue.2 , pp. 292-299
    • Xu, M.1    Deng, B.2    Chow, Y.-l.3    Zhao, Z.-z.4    Hu, B.5
  • 30
    • 0026734789 scopus 로고
    • Bleomycin stimulation of cytokine secretion by the human alveolar macrophage
    • Scheule RK, Perkins RC, Hamilton R and Holian A: Bleomycin stimulation of cytokine secretion by the human alveolar macrophage. Am J Physiol 262: L386-L391, 1992.
    • (1992) Am J Physiol , vol.262
    • Scheule, R.K.1    Perkins, R.C.2    Hamilton, R.3    Holian, A.4
  • 31
    • 0026059699 scopus 로고
    • Mechanisms of bleomycin-induced lung damage
    • Hay J, Shahzeidi S and Laurent G: Mechanisms of bleomycin-induced lung damage. Arch Toxicol 65: 81-94, 1991.
    • (1991) Arch Toxicol , vol.65 , pp. 81-94
    • Hay, J.1    Shahzeidi, S.2    Laurent, G.3
  • 32
    • 39149103740 scopus 로고    scopus 로고
    • The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    • DOI 10.1016/j.biocel.2007.08.011, PII S1357272507002877
    • Moeller A, Ask K, Warburton D, Gauldie J and Kolb M: The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 40: 362-382, 2008. (Pubitemid 351249887)
    • (2008) International Journal of Biochemistry and Cell Biology , vol.40 , Issue.3 , pp. 362-382
    • Moeller, A.1    Ask, K.2    Warburton, D.3    Gauldie, J.4    Kolb, M.5
  • 33
    • 80051718091 scopus 로고    scopus 로고
    • Modeling pulmonary fibrosis with bleomycin
    • Mouratis MA and Aidinis V: Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med 17: 355-361, 2011.
    • (2011) Curr Opin Pulm Med , vol.17 , pp. 355-361
    • Mouratis, M.A.1    Aidinis, V.2
  • 36
  • 38
    • 62949146206 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases
    • Vasakova M, Sterclova M, Kolesar L, et al: Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. Respir Med 103: 773-779, 2009.
    • (2009) Respir Med , vol.103 , pp. 773-779
    • Vasakova, M.1    Sterclova, M.2    Kolesar, L.3
  • 39
    • 79953011499 scopus 로고    scopus 로고
    • GW0742, a high affinity PPAR-beta/delta agonist reduces lung inflammation induced by bleomycin instillation in mice
    • Galuppo M, Di Paola R, Mazzon E, et al: GW0742, a high affinity PPAR-beta/delta agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol 23: 1033-1046, 2010.
    • (2010) Int J Immunopathol Pharmacol , vol.23 , pp. 1033-1046
    • Galuppo, M.1    Di Paola, R.2    Mazzon, E.3
  • 40
    • 79953733330 scopus 로고    scopus 로고
    • Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis
    • Di Paola R, Talero E, Galuppo M, et al: Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis. Respir Res 12: 41, 2011.
    • (2011) Respir Res , vol.12 , pp. 41
    • Di Paola, R.1    Talero, E.2    Galuppo, M.3
  • 41
    • 79959378797 scopus 로고    scopus 로고
    • MEK inhibition suppresses the development of lung fibrosis in the bleomycin model
    • Galuppo M, Esposito E, Mazzon E, et al: MEK inhibition suppresses the development of lung fibrosis in the bleomycin model. Naunyn Schmiedebergs Arch Pharmacol 384: 21-37, 2011.
    • (2011) Naunyn Schmiedebergs Arch Pharmacol , vol.384 , pp. 21-37
    • Galuppo, M.1    Esposito, E.2    Mazzon, E.3
  • 42
    • 0036142953 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung
    • DOI 10.1309/W7T9-HW9V-V94B-R9KM
    • Lakari E, Soini Y, Saily M, Koistinen P, Paakko P and Kinnula VL: Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Am J Clin Pathol 117: 132-142, 2002. (Pubitemid 34052483)
    • (2002) American Journal of Clinical Pathology , vol.117 , Issue.1 , pp. 132-142
    • Lakari, E.1    Soini, Y.2    Saily, M.3    Koistinen, P.4    Paakko, P.5    Kinnula, V.L.6
  • 43
    • 1242306647 scopus 로고    scopus 로고
    • The Role of Transforming Growth Factor beta in Lung Development and Disease
    • DOI 10.1378/chest.125.2.754
    • Bartram U and Speer CP: The role of transforming growth factor beta in lung development and disease. Chest 125: 754-765, 2004. (Pubitemid 38223659)
    • (2004) Chest , vol.125 , Issue.2 , pp. 754-765
    • Bartram, U.1    Speer, C.P.2
  • 44
    • 0027425864 scopus 로고
    • Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice
    • Giri SN, Hyde DM and Hollinger MA: Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax 48: 959-966, 1993. (Pubitemid 23319618)
    • (1993) Thorax , vol.48 , Issue.10 , pp. 959-966
    • Giri, S.N.1    Hyde, D.M.2    Hollinger, M.A.3
  • 45
    • 0030709198 scopus 로고    scopus 로고
    • Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis
    • DOI 10.1016/S0006-2952(97)00343-2, PII S0006295297003432
    • Giri SN, Hyde DM, Braun RK, Gaarde W, Harper JR and Pierschbacher MD: Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis. Biochem Pharmacol 54: 1205-1216, 1997. (Pubitemid 27497247)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.11 , pp. 1205-1216
    • Giri, S.N.1    Hyde, D.M.2    Braun, R.K.3    Gaarde, W.4    Harper, J.R.5    Pierschbacher, M.D.6
  • 47
    • 79251639838 scopus 로고    scopus 로고
    • Therapeutic effect of a peptide inhibitor of TGF-beta on pulmonary fibrosis
    • Arribillaga L, Dotor J, Basagoiti M, et al: Therapeutic effect of a peptide inhibitor of TGF-beta on pulmonary fibrosis. Cytokine 53: 327-333, 2011.
    • (2011) Cytokine , vol.53 , pp. 327-333
    • Arribillaga, L.1    Dotor, J.2    Basagoiti, M.3
  • 49
    • 58149459331 scopus 로고    scopus 로고
    • VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice
    • Ou XM, Li WC, Liu DS, et al: VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice. Int Immunopharmacol 9: 70-79, 2009.
    • (2009) Int Immunopharmacol , vol.9 , pp. 70-79
    • Ou, X.M.1    Li, W.C.2    Liu, D.S.3
  • 50
    • 70249113403 scopus 로고    scopus 로고
    • Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats
    • Chen L, Wang T, Wang X, et al: Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats. Respir Res 10: 55, 2009.
    • (2009) Respir Res , vol.10 , pp. 55
    • Chen, L.1    Wang, T.2    Wang, X.3
  • 51
    • 73449146238 scopus 로고    scopus 로고
    • Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis
    • Zhao L, Wang X, Chang Q, et al: Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur J Pharmacol 627: 304-312, 2010.
    • (2010) Eur J Pharmacol , vol.627 , pp. 304-312
    • Zhao, L.1    Wang, X.2    Chang, Q.3
  • 52
    • 79958116138 scopus 로고    scopus 로고
    • Antifibrosis effects of total glucosides of Danggui-Buxue-Tang in a rat model of bleomycin-induced pulmonary fibrosis
    • Gao J, Huang Y, Li P, et al: Antifibrosis effects of total glucosides of Danggui-Buxue-Tang in a rat model of bleomycin-induced pulmonary fibrosis. J Ethnopharmacol 136: 21-26, 2011.
    • (2011) J Ethnopharmacol , vol.136 , pp. 21-26
    • Gao, J.1    Huang, Y.2    Li, P.3


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