메뉴 건너뛰기




Volumn 9, Issue 1, 2009, Pages 70-79

VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice

Author keywords

Angiogenesis; Pulmonary fibrosis; SU5416; VEGF; VEGFR 2(Flk 1)

Indexed keywords

BLEOMYCIN; COLLAGEN; INTERLEUKIN 13; LACTATE DEHYDROGENASE; SEMAXANIB; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 58149459331     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.10.002     Document Type: Article
Times cited : (59)

References (54)
  • 2
    • 0025089518 scopus 로고
    • Pathobiology of pulmonary fibrosis
    • Crouch E. Pathobiology of pulmonary fibrosis. Am J Physiol 259 (1990) L159-L184
    • (1990) Am J Physiol , vol.259
    • Crouch, E.1
  • 4
    • 0032864848 scopus 로고    scopus 로고
    • Angiogenesis inhibitor TNP-470 inhibits murine cutaneous wound healing
    • Klein S.A., Bond S.J., Gupta S.C., Yacoub O.A., and Anderson G.L. Angiogenesis inhibitor TNP-470 inhibits murine cutaneous wound healing. J Surg Res 82 (1999) 268-274
    • (1999) J Surg Res , vol.82 , pp. 268-274
    • Klein, S.A.1    Bond, S.J.2    Gupta, S.C.3    Yacoub, O.A.4    Anderson, G.L.5
  • 5
    • 0033137106 scopus 로고    scopus 로고
    • Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin- induced pulmonary fibrosis
    • Keane M.P., Belperio J.A., Moore T.A., Moore B.B., Arenberg D.A., Smith R.E., et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin- induced pulmonary fibrosis. J Immunol 162 (1999) 5511-5518
    • (1999) J Immunol , vol.162 , pp. 5511-5518
    • Keane, M.P.1    Belperio, J.A.2    Moore, T.A.3    Moore, B.B.4    Arenberg, D.A.5    Smith, R.E.6
  • 7
    • 0032954450 scopus 로고    scopus 로고
    • Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy
    • Fehrenbach H., Kasper M., Haase M., Schuh D., and Müller M. Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy. Anat Rec 254 (1999) 61-73
    • (1999) Anat Rec , vol.254 , pp. 61-73
    • Fehrenbach, H.1    Kasper, M.2    Haase, M.3    Schuh, D.4    Müller, M.5
  • 8
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Plate K.H., Breier G., Weich H.A., and Risau W. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359 (1992) 845-848
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 9
    • 0034595635 scopus 로고    scopus 로고
    • Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells
    • Rahimi N., Dayanir V., and Lashkari K. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 275 (2000) 16986-16992
    • (2000) J Biol Chem , vol.275 , pp. 16986-16992
    • Rahimi, N.1    Dayanir, V.2    Lashkari, K.3
  • 10
    • 0031008458 scopus 로고    scopus 로고
    • Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis
    • Ziche M., Morbidelli L., Choudhuri R., Zhang H.T., Donnini S., Granger H.J., et al. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99 (1997) 2625-2634
    • (1997) J Clin Invest , vol.99 , pp. 2625-2634
    • Ziche, M.1    Morbidelli, L.2    Choudhuri, R.3    Zhang, H.T.4    Donnini, S.5    Granger, H.J.6
  • 11
    • 0032960891 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates nuclear factor-κB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells
    • Marumo T., Schini-Kerth V.B., and Busse R. Vascular endothelial growth factor activates nuclear factor-κB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Diabetes 48 (1999) 1131-1137
    • (1999) Diabetes , vol.48 , pp. 1131-1137
    • Marumo, T.1    Schini-Kerth, V.B.2    Busse, R.3
  • 12
    • 0023914820 scopus 로고
    • Simple method of estimating severity of pulmonary fibrosis on a numerical scale
    • Ashcroft T., Simpson J.M., and Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41 (1988) 467-470
    • (1988) J Clin Pathol , vol.41 , pp. 467-470
    • Ashcroft, T.1    Simpson, J.M.2    Timbrell, V.3
  • 13
    • 33745996622 scopus 로고
    • The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid
    • Woessner J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch Biochem Biophys 93 (1961) 440-447
    • (1961) Arch Biochem Biophys , vol.93 , pp. 440-447
    • Woessner, J.F.1
  • 14
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147 (1995) 9
    • (1995) Am J Pathol , vol.147 , pp. 9
    • Weidner, N.1
  • 16
    • 0031201212 scopus 로고    scopus 로고
    • The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis
    • Keane M.P., Arenberg D.A., Lynch III J.P., Whyte R.I., Iannettoni M.D., Burdick M.D., et al. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 159 (1997) 1437-1443
    • (1997) J Immunol , vol.159 , pp. 1437-1443
    • Keane, M.P.1    Arenberg, D.A.2    Lynch III, J.P.3    Whyte, R.I.4    Iannettoni, M.D.5    Burdick, M.D.6
  • 19
    • 19944430164 scopus 로고    scopus 로고
    • Interferon-β inhibits bleomycin-induced lung fibrosis by decreasing transforming growth factor-β and thrombospondin
    • Azuma A., Li Y.J., Abe S., Usuki J., Matsuda K., Henmi S., Miyauchi Y., et al. Interferon-β inhibits bleomycin-induced lung fibrosis by decreasing transforming growth factor-β and thrombospondin. Am J Respir Cell Mol Biol 32 (2005) 93-98
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 93-98
    • Azuma, A.1    Li, Y.J.2    Abe, S.3    Usuki, J.4    Matsuda, K.5    Henmi, S.6    Miyauchi, Y.7
  • 20
    • 23244437424 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice
    • Hamada N., Kuwano K., Yamada M., Hagimoto N., Hiasa K., Egashira K., et al. Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice. J Immunol 175 2 (2005) 1224-1231
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 1224-1231
    • Hamada, N.1    Kuwano, K.2    Yamada, M.3    Hagimoto, N.4    Hiasa, K.5    Egashira, K.6
  • 21
    • 0016274433 scopus 로고
    • The pathogenesis of bleomycin-induced pulmonary fibrosis in mice
    • Adamson I.Y., and Bowden D.H. The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am J Pathol 77 (1974) 185-197
    • (1974) Am J Pathol , vol.77 , pp. 185-197
    • Adamson, I.Y.1    Bowden, D.H.2
  • 22
    • 0025234884 scopus 로고
    • Possible mechanisms of bleomycin-induced fibrosis
    • Chandler D.B. Possible mechanisms of bleomycin-induced fibrosis. Clin Chest Med 11 (1990) 21-30
    • (1990) Clin Chest Med , vol.11 , pp. 21-30
    • Chandler, D.B.1
  • 24
    • 23244437424 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice
    • Hamada N., Kuwano K., Yamada M., Hagimoto N., Hiasa K., Egashira K., et al. Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice. J Immunol 175 (2005) 1224-1231
    • (2005) J Immunol , vol.175 , pp. 1224-1231
    • Hamada, N.1    Kuwano, K.2    Yamada, M.3    Hagimoto, N.4    Hiasa, K.5    Egashira, K.6
  • 25
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong T.A., Shawver L.K., Sun L., Tang C., App H., Powell T.J., et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 59 (1999) 99-106
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6
  • 26
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications
    • Ellis L.M., Takahashi Y., Liu W., and Shaheen R.M. Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist 5 (2000) 11-15
    • (2000) Oncologist , vol.5 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 27
    • 0034488898 scopus 로고    scopus 로고
    • The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function
    • Mendel D.B., Schreck R.E., West D.C., Li G., Strawn L.M., Tanciongco S.S., et al. The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function. Clin Cancer Res 6 (2000) 4848-4858
    • (2000) Clin Cancer Res , vol.6 , pp. 4848-4858
    • Mendel, D.B.1    Schreck, R.E.2    West, D.C.3    Li, G.4    Strawn, L.M.5    Tanciongco, S.S.6
  • 28
    • 33750713086 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice
    • Sung S.H., Ziyadeh F.N., Wang A., Pyagay P.E., Kanwar Y.S., and Chen S. Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol 17 (2006) 3093-3104
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3093-3104
    • Sung, S.H.1    Ziyadeh, F.N.2    Wang, A.3    Pyagay, P.E.4    Kanwar, Y.S.5    Chen, S.6
  • 29
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart L., Kasahara Y., Alger L., Hirth P., Mc Mahon G., Waltenberger J., et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB 15 (2001) 427
    • (2001) FASEB , vol.15 , pp. 427
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6
  • 30
    • 33845582907 scopus 로고    scopus 로고
    • Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416
    • Loges S., Tinnefeld H., Metzner A., Jucker M., Butzal M., Bruweleit M., et al. Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416. Leuk Lymphoma 47 12 (2006) 2601-2609
    • (2006) Leuk Lymphoma , vol.47 , Issue.12 , pp. 2601-2609
    • Loges, S.1    Tinnefeld, H.2    Metzner, A.3    Jucker, M.4    Butzal, M.5    Bruweleit, M.6
  • 31
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Steward L., Kasahara Y., Alger L., Hirth P., McMahon G., Waltenberger J., et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB 15 (2001) 427
    • (2001) FASEB , vol.15 , pp. 427
    • Taraseviciene-Steward, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    McMahon, G.5    Waltenberger, J.6
  • 32
    • 23044499193 scopus 로고    scopus 로고
    • VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Li Z.D., Bork J.P., Krueger B., Patsenker E., Schulze-Krebs A., Hahn E.G., et al. VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Biochem Biophys Res Commun 334 4 (2005) 1049-1060
    • (2005) Biochem Biophys Res Commun , vol.334 , Issue.4 , pp. 1049-1060
    • Li, Z.D.1    Bork, J.P.2    Krueger, B.3    Patsenker, E.4    Schulze-Krebs, A.5    Hahn, E.G.6
  • 33
    • 0030641090 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine
    • Brown L.F., Detmar M., Claffey K., Nagy J.A., Feng D., Dvorak A.M., et al. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS 79 (1997) 233-269
    • (1997) EXS , vol.79 , pp. 233-269
    • Brown, L.F.1    Detmar, M.2    Claffey, K.3    Nagy, J.A.4    Feng, D.5    Dvorak, A.M.6
  • 34
    • 58149468649 scopus 로고    scopus 로고
    • Immunohistochemical characterisation of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR in chronic myeloid leukaemia (CML) patients treated with imatinib mesylate
    • Milojkovic D., Sahu S., Henderson J., Czepulkowski B.H., Salisbury J.R., Bellamy W.T., et al. Immunohistochemical characterisation of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR in chronic myeloid leukaemia (CML) patients treated with imatinib mesylate. Blood 104 (2004) 1999
    • (2004) Blood , vol.104 , pp. 1999
    • Milojkovic, D.1    Sahu, S.2    Henderson, J.3    Czepulkowski, B.H.4    Salisbury, J.R.5    Bellamy, W.T.6
  • 35
    • 0037344992 scopus 로고    scopus 로고
    • Pulmonary expression of vascular endothelial growth factor in sepsis
    • Tsokos M., Pufe T., Paulsen F., Anders S., and Mentlein R. Pulmonary expression of vascular endothelial growth factor in sepsis. Arch Pathol Lab Med 127 3 (2003) 331-335
    • (2003) Arch Pathol Lab Med , vol.127 , Issue.3 , pp. 331-335
    • Tsokos, M.1    Pufe, T.2    Paulsen, F.3    Anders, S.4    Mentlein, R.5
  • 37
    • 33846675282 scopus 로고    scopus 로고
    • Mechanisms underlying TGF-β1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis
    • Jeon S.H., Chae B.C., Kim H.A., Seo G.Y., Seo D.W., Chun G.T., et al. Mechanisms underlying TGF-β1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. J Leukoc Biol 81 (2007) 557-566
    • (2007) J Leukoc Biol , vol.81 , pp. 557-566
    • Jeon, S.H.1    Chae, B.C.2    Kim, H.A.3    Seo, G.Y.4    Seo, D.W.5    Chun, G.T.6
  • 38
    • 19944389541 scopus 로고    scopus 로고
    • Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts
    • Kobayashi T., Liu X., Wen F.Q., Fang Q., Abe S., Wang X.Q., et al. Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts. Biochem Biophys Res Commun 327 2 (2005) 393-398
    • (2005) Biochem Biophys Res Commun , vol.327 , Issue.2 , pp. 393-398
    • Kobayashi, T.1    Liu, X.2    Wen, F.Q.3    Fang, Q.4    Abe, S.5    Wang, X.Q.6
  • 39
    • 0032954450 scopus 로고    scopus 로고
    • Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy
    • Fehrenbach H., Kasper M., Haase M., Schuh D., and Müller M. Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy. Anat Rec 254 (1999) 61-73
    • (1999) Anat Rec , vol.254 , pp. 61-73
    • Fehrenbach, H.1    Kasper, M.2    Haase, M.3    Schuh, D.4    Müller, M.5
  • 41
    • 0033000530 scopus 로고    scopus 로고
    • Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis
    • Atamas S.P., Yurovsky V.V., Wise R., Wigley F.M., Goter Robinson C.J., Henry P., et al. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum 42 (1999) 1168-1178
    • (1999) Arthritis Rheum , vol.42 , pp. 1168-1178
    • Atamas, S.P.1    Yurovsky, V.V.2    Wise, R.3    Wigley, F.M.4    Goter Robinson, C.J.5    Henry, P.6
  • 42
    • 0043074624 scopus 로고    scopus 로고
    • Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients
    • Luzina I.G., Atamas S.P., Wise R., Wigley F.M., Choi J., Xiao H.Q., et al. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. Arthritis Rheum 48 (2003) 2262-2274
    • (2003) Arthritis Rheum , vol.48 , pp. 2262-2274
    • Luzina, I.G.1    Atamas, S.P.2    Wise, R.3    Wigley, F.M.4    Choi, J.5    Xiao, H.Q.6
  • 43
    • 0036467531 scopus 로고    scopus 로고
    • Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling
    • Atamas S.P., Luzina I.G., Dai H., Wilt S.G., and White B. Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling. J Immunol 168 (2002) 1139-1145
    • (2002) J Immunol , vol.168 , pp. 1139-1145
    • Atamas, S.P.1    Luzina, I.G.2    Dai, H.3    Wilt, S.G.4    White, B.5
  • 44
    • 0031570120 scopus 로고    scopus 로고
    • CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts
    • empowski G.D., Chess P.R., and Phipps R.P. CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol 158 (1997) 4670-4677
    • (1997) J Immunol , vol.158 , pp. 4670-4677
    • empowski, G.D.1    Chess, P.R.2    Phipps, R.P.3
  • 45
    • 0242494298 scopus 로고    scopus 로고
    • Eosinophils and T lymphocytes possess distinct roles in bleomycin induced lung injury and fibrosis
    • Huaux F., Liu T., McGarry B., Ullenbruch M., Xing Z., and Phan S.H. Eosinophils and T lymphocytes possess distinct roles in bleomycin induced lung injury and fibrosis. J Immunol 171 (2003) 5470-5481
    • (2003) J Immunol , vol.171 , pp. 5470-5481
    • Huaux, F.1    Liu, T.2    McGarry, B.3    Ullenbruch, M.4    Xing, Z.5    Phan, S.H.6
  • 46
    • 2542449195 scopus 로고    scopus 로고
    • T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    • Hao Z., Hampel B., Yagita H., and Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med 199 (2004) 1355-1365
    • (2004) J Exp Med , vol.199 , pp. 1355-1365
    • Hao, Z.1    Hampel, B.2    Yagita, H.3    Rajewsky, K.4
  • 48
    • 0036862208 scopus 로고    scopus 로고
    • Modulation of human NK cell lines by vascular endothelial growth factor and receptor VEGFR-1 (FLT-1)
    • Chen W.S., Kitson R.P., and Goldfarb R.H. Modulation of human NK cell lines by vascular endothelial growth factor and receptor VEGFR-1 (FLT-1). In Vivo 16 (2002) 439-445
    • (2002) In Vivo , vol.16 , pp. 439-445
    • Chen, W.S.1    Kitson, R.P.2    Goldfarb, R.H.3
  • 49
    • 0036795836 scopus 로고    scopus 로고
    • Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients
    • Kanazawa H., Hirata K., and Yoshikawa J. Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients. Thorax 57 (2002) 885-888
    • (2002) Thorax , vol.57 , pp. 885-888
    • Kanazawa, H.1    Hirata, K.2    Yoshikawa, J.3
  • 50
    • 0024414604 scopus 로고
    • Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis
    • Piguet P.F., Collart M.A., Grau G.E., Kapanci Y., and Vassalli P. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170 (1989) 655-663
    • (1989) J Exp Med , vol.170 , pp. 655-663
    • Piguet, P.F.1    Collart, M.A.2    Grau, G.E.3    Kapanci, Y.4    Vassalli, P.5
  • 51
    • 0036080874 scopus 로고    scopus 로고
    • Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells
    • Liu X., Kohyama T., Wang H., Zhu Y.K., Wen F.Q., Kim H.J., et al. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am J Physiol 282 (2002) L1049-L1056
    • (2002) Am J Physiol , vol.282
    • Liu, X.1    Kohyama, T.2    Wang, H.3    Zhu, Y.K.4    Wen, F.Q.5    Kim, H.J.6
  • 52
    • 45949089317 scopus 로고    scopus 로고
    • Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
    • Shao D.D., Suresh R., Vakil V., Gomer R.H., and Pilling D. Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol 83 (2008) 1323-1333
    • (2008) J Leukoc Biol , vol.83 , pp. 1323-1333
    • Shao, D.D.1    Suresh, R.2    Vakil, V.3    Gomer, R.H.4    Pilling, D.5
  • 53
    • 7044260315 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    • Lee C.G., Link H., Baluk P., Homer R.J., Chapoval S., Bhandari V., et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 10 (2004) 1095-1103
    • (2004) Nat Med , vol.10 , pp. 1095-1103
    • Lee, C.G.1    Link, H.2    Baluk, P.3    Homer, R.J.4    Chapoval, S.5    Bhandari, V.6
  • 54
    • 0033796032 scopus 로고    scopus 로고
    • IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury
    • Corne J., Chupp G., Lee C.G., Homer R.J., Zhu Z., Chen Q., et al. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J Clin Invest 106 (2000) 783-791
    • (2000) J Clin Invest , vol.106 , pp. 783-791
    • Corne, J.1    Chupp, G.2    Lee, C.G.3    Homer, R.J.4    Zhu, Z.5    Chen, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.