MEK inhibition suppresses the development of lung fibrosis in the bleomycin model

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 384, Issue 1, 2011, Pages 21-37

  Galuppo, Maria ^a   Esposito, Emanuela ^a,b   Mazzon, Emanuela ^b   Di Paola, Rosanna ^b   Paterniti, Irene ^a   Impellizzeri, Daniela ^a   Cuzzocrea, Salvatore ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

Author keywords

Apoptosis; Inflammation; Lung fibrosis; MAP kinases pathway; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 NITROTYROSINE; BLEOMYCIN; FAS LIGAND; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; LUNG FIBROSIS; LUNG INJURY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WEIGHT CHANGE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLEOMYCIN; BODY WEIGHT; BUTADIENES; FAS LIGAND PROTEIN; FLAVONOIDS; I-KAPPA B PROTEINS; INSTILLATION, DRUG; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG; MALE; MAP KINASE KINASE 1; MICE; MICE, INBRED STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEUTROPHILS; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY EDEMA; PULMONARY FIBROSIS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 79959378797     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0637-7     Document Type: Article

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