메뉴 건너뛰기




Volumn 14, Issue 13, 2008, Pages 2100-2105

Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis

Author keywords

Hepatic Fibrosis; Oxymatrine; TGF Smad signaling

Indexed keywords

CARBON TETRACHLORIDE; COLLAGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HEMATOXYLIN; MESSENGER RNA; OXYMATRINE; SMAD PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 44849092456     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.2100     Document Type: Article
Times cited : (49)

References (30)
  • 1
    • 33644850815 scopus 로고    scopus 로고
    • Antifibrotic agents for liver disease
    • Albanis E, Friedman SL. Antifibrotic agents for liver disease. Am J Transplant 2006; 6: 12-19
    • (2006) Am J Transplant , vol.6 , pp. 12-19
    • Albanis, E.1    Friedman, S.L.2
  • 2
    • 33744538682 scopus 로고    scopus 로고
    • Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    • Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 2006; 10: 76-99
    • (2006) J Cell Mol Med , vol.10 , pp. 76-99
    • Gressner, A.M.1    Weiskirchen, R.2
  • 3
    • 36349003677 scopus 로고    scopus 로고
    • Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture
    • Li Z, Dranoff JA, Chan EP, Uemura M, Sevigny J, Wells RG. Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology 2007; 46: 1246-1256
    • (2007) Hepatology , vol.46 , pp. 1246-1256
    • Li, Z.1    Dranoff, J.A.2    Chan, E.P.3    Uemura, M.4    Sevigny, J.5    Wells, R.G.6
  • 5
    • 33644895961 scopus 로고    scopus 로고
    • Molecular therapy for hepatic injury and fibrosis: Where are we?
    • Prosser CC, Yen RD, Wu J. Molecular therapy for hepatic injury and fibrosis: where are we? World J Gastroenterol 2006; 12: 509-515
    • (2006) World J Gastroenterol , vol.12 , pp. 509-515
    • Prosser, C.C.1    Yen, R.D.2    Wu, J.3
  • 12
    • 13544268721 scopus 로고    scopus 로고
    • Antifibrotic therapy in chronic liver disease
    • Rockey DC. Antifibrotic therapy in chronic liver disease. Clin Gastroenterol Hepatol 2005; 3: 95-107
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 95-107
    • Rockey, D.C.1
  • 13
    • 0041563743 scopus 로고    scopus 로고
    • Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms
    • Wu XL, Zeng WZ, Wang PL, Lei CT, Jiang MD, Chen XB, Zhang Y, Xu H, Wang Z. Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. World J Gastroenterol 2003; 9: 1559-1562
    • (2003) World J Gastroenterol , vol.9 , pp. 1559-1562
    • Wu, X.L.1    Zeng, W.Z.2    Wang, P.L.3    Lei, C.T.4    Jiang, M.D.5    Chen, X.B.6    Zhang, Y.7    Xu, H.8    Wang, Z.9
  • 14
    • 4043050607 scopus 로고    scopus 로고
    • The effects of Chinese national medicine of Huoxueruanjian compound on SMAD signal in hepatic stellate cell and its significance
    • Zhang G, Zhang FC, Wang TC, Liang KH. The effects of Chinese national medicine of Huoxueruanjian compound on SMAD signal in hepatic stellate cell and its significance. Zhonghua Ganzangbing Zazhi 2004; 12: 213-215
    • (2004) Zhonghua Ganzangbing Zazhi , vol.12 , pp. 213-215
    • Zhang, G.1    Zhang, F.C.2    Wang, T.C.3    Liang, K.H.4
  • 16
    • 3242802874 scopus 로고    scopus 로고
    • TGF-beta-induced SMAD signaling and gene regulation: Consequences for extracellular matrix remodeling and wound healing
    • Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci 2004; 35: 83-92
    • (2004) J Dermatol Sci , vol.35 , pp. 83-92
    • Schiller, M.1    Javelaud, D.2    Mauviel, A.3
  • 17
    • 34547101973 scopus 로고    scopus 로고
    • Signaling pathways of transforming growth factor beta family members
    • Zimowska M. Signaling pathways of transforming growth factor beta family members. Postepy Biochem 2006; 52: 360-366
    • (2006) Postepy Biochem , vol.52 , pp. 360-366
    • Zimowska, M.1
  • 18
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in tgf-beta signaling through Smads
    • Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 2005; 21: 659-693
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 19
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TCF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TCF-beta family signalling. Nature 2003; 425: 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 20
    • 34250203586 scopus 로고    scopus 로고
    • Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
    • Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol 2007; 27: 4488-4499
    • (2007) Mol Cell Biol , vol.27 , pp. 4488-4499
    • Zhang, S.1    Fei, T.2    Zhang, L.3    Zhang, R.4    Chen, F.5    Ning, Y.6    Han, Y.7    Feng, X.H.8    Meng, A.9    Chen, Y.G.10
  • 21
    • 33847716712 scopus 로고    scopus 로고
    • Negative regulation of TGF-beta receptor/Smad signal transduction
    • Itoh S, ten Dijke P. Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol 2007; 19: 176-184
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 176-184
    • Itoh, S.1    ten Dijke, P.2
  • 22
    • 33750322988 scopus 로고    scopus 로고
    • TGF-beta receptor-binding proteins: Complex interactions
    • Runyan CE, Poncelet AC, Schnaper HW. TGF-beta receptor-binding proteins: complex interactions. Cell Signal 2006; 18: 2077-2088
    • (2006) Cell Signal , vol.18 , pp. 2077-2088
    • Runyan, C.E.1    Poncelet, A.C.2    Schnaper, H.W.3
  • 23
    • 33846011104 scopus 로고    scopus 로고
    • Regulation of Smad activities
    • Xu L. Regulation of Smad activities. Biochim Biophys Acta 2006; 1759: 503-513
    • (2006) Biochim Biophys Acta , vol.1759 , pp. 503-513
    • Xu, L.1
  • 24
    • 36148970306 scopus 로고    scopus 로고
    • Identification of a Smad phosphatase
    • Hill CS. Identification of a Smad phosphatase. ACS Chem Biol 2006; 1: 346-348
    • (2006) ACS Chem Biol , vol.1 , pp. 346-348
    • Hill, C.S.1
  • 26
    • 0036177427 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation
    • Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002; 118: 211-215
    • (2002) J Invest Dermatol , vol.118 , pp. 211-215
    • Verrecchia, F.1    Mauviel, A.2
  • 27
    • 0036549082 scopus 로고    scopus 로고
    • Control of connective tissue gene expression by TGF beta: Role of Smad proteins in fibrosis
    • Verrecchia F, Mauviel A. Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep 2002; 4: 143-149
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 143-149
    • Verrecchia, F.1    Mauviel, A.2
  • 28
    • 0344873297 scopus 로고    scopus 로고
    • On and off: Proteasome and TGF-beta signaling
    • Zhang F, Laiho M. On and off: proteasome and TGF-beta signaling. Exp Cell Res 2003; 291: 275-281
    • (2003) Exp Cell Res , vol.291 , pp. 275-281
    • Zhang, F.1    Laiho, M.2
  • 29
    • 33846404135 scopus 로고    scopus 로고
    • Lu LG, Zeng MD, Mao YM, Wan MB, Li CZ, Chen CW, Fu QC, Wang JY, She WM, Cai X, Ye J, Zhou XQ, Wang H, Wu SM, Tang MF, Zhu JS, Chen WX. Oxymatrine in the treatment of chronic hepatitis B for one year: a multicenter random double-blind placebo-controlled trial. Zhonghua Ganzangbing Zazhi 2004; 12: 597-600
    • Lu LG, Zeng MD, Mao YM, Wan MB, Li CZ, Chen CW, Fu QC, Wang JY, She WM, Cai X, Ye J, Zhou XQ, Wang H, Wu SM, Tang MF, Zhu JS, Chen WX. Oxymatrine in the treatment of chronic hepatitis B for one year: a multicenter random double-blind placebo-controlled trial. Zhonghua Ganzangbing Zazhi 2004; 12: 597-600
  • 30
    • 38048999943 scopus 로고    scopus 로고
    • Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis
    • Liu J, Shi BN, He JF. Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis. Zhongguo Zhongxiyi Jiehe Zazhi 2005; 25: 989-992
    • (2005) Zhongguo Zhongxiyi Jiehe Zazhi , vol.25 , pp. 989-992
    • Liu, J.1    Shi, B.N.2    He, J.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.