SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 4, Issue 10, 1994, Pages 1181-1184

The synthesis of BRL 49653 - a novel and potent antihyperglycaemic agent

(6) Cantello, Barrie C C a Cawthorne, Michael A a Haigh, David a Hindley, Richard M a Smith, Stephen A a Thurlby, Peter L a

a GLAXOSMITHKLINE (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 [4 [2 (3 PHENYLUREIDO)ETHOXY]BENZYL] 2,4 THIAZOLIDINEDIONE; 5 [4 [2 [N (2 BENZOXAZOLYL) N METHYLAMINO]ETHOXY]BENZYL] 2,4 THIAZOLIDINEDIONE; 5 [4 [2 [N METHYL N (2 PYRIDYL)AMINO]ETHOXY]BENZYL] 2,4 THIAZOLIDINEDIONE; AD 4743; ANTIDIABETIC AGENT; BRL 46950; BRL 48482; CIGLITAZONE; ENGLITAZONE; PIOGLITAZONE; ROSIGLITAZONE; THIAZOLIDINE DERIVATIVE; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION;

ANIMALIA;

EID: 0028335891 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)80325-5 Document Type: Article

Times cited : (125)

References (26)

1
- 0024160877
- (1988) Diabetes , vol.37 , pp. 1595-1607
- Reaven¹

2
- 0026681076
- (1992) Hypertension , vol.19 , pp. 403-418
- Epstein¹ Sowers²

3
- 0026569449
- Suupl. I
- (1992) Hypertension , vol.19 , pp. I 61-I 66
- Landsberg¹

4
- 0026271740
- (1991) Proc. Nutrition Soc. , vol.50 , pp. 619-630
- Bailey¹

5
- 0023935536
- (1988) Br. Med. J. , vol.296 , pp. 949-950
- Ferner¹ Neil²

6
- 77956819955
- (1989) Ann. Reports Med. Chem. , vol.25 , pp. 205-213
- Larson¹ Clark² Stevenson³

7
- 77956843172
- (1992) Ann. Reports Med. Chem. , vol.27 , pp. 219-226
- Colca¹ Tanis²

8
- 0020353926
- (1982) Chem. Pharm. Bull. , vol.30 , pp. 3580-3600
- Sohda¹ Mizuno² Imamiya³ Sugiyama⁴ Fujita⁵ Kawamatsu⁶

9
- 0020552510
- (1983) Diabetes , vol.32 , pp. 804-810
- Fujita¹ Sugiyama² Taketomi³ Sohda⁴ Kawamatsu⁵ Iwatsuka⁶ Suzuoki⁷

10
- 0001844288
- C.J. Bailey, P.R. Flatt, Smith-Gordon
- (1990) New Antidiabetic Drugs , vol.255-261
- Colca¹ Morton²

11
- 0025769847
- (1991) Chem. Pharm. Bull. , vol.39 , pp. 1440-1445
- Momose¹ Meguro² Ikeda³ Hatanaka⁴ Oi⁵ Sohda⁶

12
- 0024516539
- (1989) Journal of Medicinal Chemistry , vol.32 , pp. 421-428
- Yashioka¹ Fujita² Kanai³ Aizawa⁴ Kurumada⁵ Hasegawa⁶ Horikoshi⁷

13
- 0026030226
- (1991) J. Med. Chem. , vol.34 , pp. 319-325
- Clark¹ Goldstein² Volkmann³ Eggler⁴ Holland⁵ Hulin⁶ Stevenson⁷ Kreutter⁸ Gibbs⁹ Krupp¹⁰ Merrigan¹¹ Kelbaugh¹² Andrews¹³ Tickner¹⁴ Suleske¹⁵ Lamphere¹⁶ Rajeckas¹⁷ Kappeler¹⁸ McDermott¹⁹ Hutson²⁰ Johnson²¹ more..

14
- 0021280902
- (1984) Chem. Pharm. Bull. , vol.32 , pp. 2267-2278
- Sohda¹ Meguro² Kawamatsu³

15
- 24544469216
- Clog P is a calculated partition coefficient between 1-octanol and water. For recent papers on this subject see, for example
- (1993) Chem. Rev. , vol.93 , pp. 1281-1306
- Leo¹

16
- 0025892139
- (1991) Quant. Struct. Act. Relat. , vol.10 , pp. 109-117
- Lipinski¹ Fiese² Korst³

17
- 84908852222
- Clog P values were calculated in the MedChem program which was not parameterised for the 2,4-thiazolidinedione moiety and this group was replaced by a proton for these calculations. A correction factor determined by comparison of the calculated and experimental values for ciglitazone was applied in all cases.

18
- 84908852221
- Cantello, B.C.C. and Hindley, R.M., Eur. Patent Appl. EP 295828, 1988.

19
- 84908852220
- Compounds were administered by dietary admixture for 8 days to C57B1/6 ob/ob obese mice (10-12 weeks of age). Antihyperglycaemic activity was determined from the reduction in the area under the blood glucose versus time curve following administration of an oral glucose load (3g/kg body weight) to 5 hr fasted mice. The minimum effective does is defined as that which reduces the area under the glucose tolerance curve by 25% relative to controls.

20
- 84908852219
- Hindley, R.M., Eur. Patent Appl. EP 306228, 1989.

21
- 84908852218
- Cantello, B.C.C.; Cawthorne, M.A.; Cottam, G.P.; Duff, P.T.; Haigh, D.; Hindley, R.M.; Lister, C.A.; Smith, S.A. and Thurlby, P.L., manuscript in preparation.

22
- 4243462591
- Suppl. 1
- (1993) Diabetes , vol.42 , pp. 204A
- Cantello¹ Cawthorne² Hindley³ Holder⁴ Kirkham⁵ Lister⁶ Smith⁷ Young⁸

23
- 33947479100
- (1961) Chem. Rev. , vol.61 , pp. 463-521
- Brown¹

24
- 45949128998
- (1986) Tetrahedron Lett. , vol.27 , pp. 2409-2410
- Youn¹ Yon² Pak³

25
- 84908852217
- 2O).

26
- 0021715682
- (1984) Chem. Pharm. Bull. , vol.32 , pp. 4460-4465
- Sohda¹ Mizuno² Kawamatsu³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.