Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice

Clinical Nutrition

Volumn 27, Issue 1, 2008, Pages 158-167

  Jung, Un Ju ^a,f   Baek, Nam In ^b   Chung, Hae Gon ^c   Bang, Myun Ho ^b   Jeong, Tae Sook ^d   Tae Lee, Kyung ^b   Kang, Young Jin ^a   Lee, Mi Kyung ^e   Kim, Hye Jin ^a   Yeo, Jiyoung ^a   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c GangHwa Agricultural R and D Center   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e Sunchon National University   (South Korea)

^f Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Brassica rapa; Glucose regulating enzymes; Glucose tolerance; Insulin resistance; Lipid regulating enzymes; Type 2 diabetes

Indexed keywords

ALCOHOL; C PEPTIDE; CARNITINE PALMITOYLTRANSFERASE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; FAT DROPLET; FATTY ACID; FATTY ACID SYNTHASE; GLUCAGON; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE DEHYDROGENASE; GLYCOGEN; HEMOGLOBIN A1C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LIPID; MALATE DEHYDROGENASE; OXALOACETIC ACID; PHOSPHATIDATE PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PLANT EXTRACT; ROSIGLITAZONE; TRIACYLGLYCEROL; TURNIP EXTRACT; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GLUCAGON BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLYCOGEN LIVER LEVEL; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN TOLERANCE TEST; LIPID LIVER LEVEL; LIPID METABOLISM; LIVER PARENCHYMA; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT ROOT; PROTEIN BLOOD LEVEL; SOLVENT EXTRACTION; TRIACYLGLYCEROL BLOOD LEVEL; TURNIP;

ANIMALS; BLOOD GLUCOSE; BRASSICA RAPA; DIABETES MELLITUS, TYPE 2; ETHANOL; GLUCOKINASE; GLUCOSE-6-PHOSPHATASE; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; RANDOM ALLOCATION; THIAZOLIDINEDIONES; TREATMENT OUTCOME;

EID: 38949124062     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2007.09.009     Document Type: Article

References (52)

1. Alberti K.G.M.M., and Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med 13 (1998) 539-553
2. McGarry J.D. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258 (1992) 766-770
3. Neef H., Declercq P., and Laekeman G. Hypoglycaemic activity of selected European plants. Phytother Res 9 (1995) 45-48
4. Ivorra M.D., Paya M., and Villar A. A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol 27 (1989) 243-275
5. Noël P.H., Pugh J.A., Larne A.C., and Marsh G. The use of traditional plant medicines for non-insulin dependent diabetes mellitus in South Texas. Phytother Res 11 (1997) 512-517
6. Romani A., Vignolini P., Isolani L., Ieri F., and Heimler D. HPLC-DAD/MS characterization of flavonoids and hydrocinnamic derivatives in turnip top (Brassica rapa L. Subsp. Sylvestris L.). J Agric Food Chem 54 (2006) 1342-1346
7. Schonhof I., Krumbein A., and Bruckner B. Genoypic effects on glucosinolates and sensory properties of broccoli and cauliflower. Nahrung 48 (2004) 25-33
8. Lim S.S., Jung Y.J., Hyun S.K., Lee Y.S., and Choi J.S. Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. Phytother Res 20 (2006) 825-830
9. 14C-glucose uptake in rat soleus muscle. Chem Biol Interact 149 (2004) 89-96
10. Vessal M., Hemmati M., and Vasei M. Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 135 (2003) 357-364
11. Aline M., Charles E.L., Marco R., Jeanne M., and Odile G.N. Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem 91 (2005) 571-577
12. Lee J.M., Son E.S., Oh S.S., and Han D.S. Contents of total flavonoid and biological activities of edible plants. Kor J Diet Cult 16 (2001) 504-514
13. American Institute of Nutrition. Report of ad hoc committee on standards for nutritional studies. J Nutr 110 (1980) 1717-1726
14. American Institute of Nutrition. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107 (1977) 1340-1348
15. Folch J., Lees M., and Sloan-Stanley G.H. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 226 (1956) 497-509
16. Hulcher P.H., and Oleson W.H. Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J Lipid Res 14 (1973) 625-631
17. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
18. Seifter S., Dayton S., Novic B., and Muntwyler E. The estimation of glycogen with the anthrone reagent. Arch Biochem Biophys 50 (1950) 191-200
19. Davidson A.L., and Arion W.J. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch Biochem Bophys 253 (1987) 156-167
20. Newgard C.B., Hirsch L.J., Foster D.W., and McGarry D.J. Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. J Biol Chem 258 (1995) 8046-8052
21. Alegre M., Ciudad C.J., Fillat C., and Guinovart J.J. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal Biochem 173 (1988) 185-189
22. Bentle L.A., and Lardy H.A. Interaction of anions and divalent metal ions with phosphopyruvate carboxykinase. J Biol Chem 251 (1976) 2916-2921
23. Carl M.N., Lakshmanan M.R., and Porter W.W. Fatty acid synthase from rat liver. Meth Enzymol 35 (1975) 37-44
24. 2+-dependent phosphatidate phosphohydrolase in pulmonary glycerolipid biosynthesis. Biochem Biophys Acta 796 (1984) 346-372
25. Markwell M.A.K., McGroarty E.J., Bieber L.L., and Tolbert N.E. The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney. J Biol Chem 248 (1973) 3426-3432
26. Lazarow P.B. Assay of peroxisomal β-oxidation of fatty acids. Meth Enzymol 72 (1981) 315-319
27. Shapiro D.J., Nordstrom J.L., Mitschelen J.J., Rodwell V.W., and Schimke R.T. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochem Biophys Acta 370 (1974) 369-377
28. Erickson S.K., Schrewsbery M.A., Brooks C., and Meyer D.J. Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of properties in vitro. J Lipid Res 21 (1980) 930-941
29. van Poppel G., Verhoeven D.T., Verhagen H., and Goldbohm R.A. Blassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol 472 (1999) 159-168
30. 1 cells and rats. Biol Pharm Bull 29 (2006) 2436-2441
31. Avignon A., Radauceanu A., and Monnier L. Nonfasting plasma glucose is a better marker of diabetic control than fasting plasma glucose in type 2 diabetes. Diabetes Care 20 (1997) 1822-1826
32. Shafrir E. Animal models of non-insulin dependent diabetes. Diabetes Metab Rev 8 (1992) 179-208
33. Doda R.F. Diabetes mellitus. In: Kaplan L.A., and Amadeo J.P. (Eds). Clinical chemistry (1996), Mosby-Year Book, St Louis, MO 613-641
34. DeFronzo R.A., Bonadonna R.C., and Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15 (1992) 318-368
35. Coleman D.L., and Hummel K.P. Studies with the mutation, diabetes, in the mouse. Diabetologia 3 (1967) 238-248
36. Nordlie R., Bode A.M., and Foster J.D. Recent advances in hepatic glucose-6-phosphate regulation and function. Proc Soc Exp Biol Med 203 (1993) 274-285
37. Hanson R.W., and Patel Y.M. Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme. Adv Enzymol 69 (1994) 203-281
38. Pilkis S.J., and Granner D.K. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54 (1992) 885-909
39. Stearns S.B., and Benzo C.A. Glucagon and insulin relationships in genetically diabetic (db/db) and in streptozotocin-induced diabetic mice. Horm Metab Res 10 (1978) 20-23
40. Kodama H., Fujita M., Yanazaki M., and Yamaguchi I. The possible role of age-related increase in the plasma glucagon/insulin ratio in the enhanced hepatic glucoenogenesis and hyperglycemia in genetically diabetic (C57BL/KsJ-db/db) mice. Jpn J Pharmacol 66 (1994) 281-287
41. Wagle S.R. Interrelationship of insulin and glucagon ratios on carbohydrate metabolism in isolated hepatocytes containing high glycogen. Biochem Biophys Res Commun 67 (1975) 1019-1027
42. Seitz H.J., Müller M.J., Nordmeyer P., Krone W., and Tarnowski W. Concentration of cyclic AMP in rat liver as a function of the insulin/glucagon ratio in blood under standardized physiological conditions. Endocrinology 99 (1976) 1313-1318
43. Shah P., Vella A., Basu A., Basu R., Schwenk W.F., and Rizza R. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 85 (2000) 4053-4059
44. Randle P.J., Kerbey A.L., and Espinal J. Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 4 (1988) 623-638
45. Randle P.J. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14 (1998) 263-283
46. Groop L.C., Bonadonna R.C., DelPrato S., Ratheiser K., and Zyck K. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. J Clin Invest 84 (1989) 205-213
47. Robinson W.V., Tamborlane D.J., Maggs D.G., et al. Effect of insulin on glycerol production in obese adolescents. Am J Physiol 274 (1998) 737-743
48. Fujiwara T., Yoshioka S., Yoshioka T., Ushiyama I., and Horikoshi H. Characterization of new oral antidiabetic agent CS-045 Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes 37 (1988) 1549-1558
49. Foley J.E. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus. Diabetes Care 15 (1992) 773-784
50. Tiikkainen M., Tamminen M., Hakkinen A.M., et al. Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res 10 (2002) 859-867
51. Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004) 147-152
52. Windmueller H.G., and Spaeth A.E. De novo synthesis of fatty acid in perfused rat liver as a determinant of plasma lipoprotein production. Arch Biochem Biophys 122 (1967) 362-369