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Volumn 27, Issue 1, 2012, Pages 132-141

A recent update of pharmacogenomics in drug-induced severe skin reactions

Author keywords

Adverse drug reactions; Drug allergic reaction; Genetic polymorphism; Immunotoxicology; Pharmacogenomics; Skin

Indexed keywords

CARBAMAZEPINE; HLA A ANTIGEN; HLA B ANTIGEN; HLA B15 ANTIGEN; HLA DR ANTIGEN; SULFAMETHOXAZOLE;

EID: 84863229185     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RV-116     Document Type: Review
Times cited : (45)

References (96)
  • 2
    • 0027500068 scopus 로고
    • Clinical classification of cases of toxic epidermal necrolysis, stevens-johnson syndrome, and erythema multiforme
    • Bastuji-Garin, S., Rzany, B., Stern, R. S., Shear, N. H., Naldi, L. and Roujeau, J. C.: Clinical classification of cases of toxic epidermal necrolysis, stevens-johnson syndrome, and erythema multiforme. Arch. Dermatol., 129: 92-96 (1993).
    • (1993) Arch. Dermatol. , vol.129 , pp. 92-96
    • Bastuji-Garin, S.1    Rzany, B.2    Stern, R.S.3    Shear, N.H.4    Naldi, L.5    Roujeau, J.C.6
  • 3
    • 0036595397 scopus 로고    scopus 로고
    • Cytotoxic t lymphocytes: All roads lead to death
    • Barry, M. and Bleackley, R. C.: Cytotoxic t lymphocytes: All roads lead to death. Nat. Rev. Immunol., 2: 401-409 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 401-409
    • Barry, M.1    Bleackley, R.C.2
  • 4
    • 70349148575 scopus 로고    scopus 로고
    • Calcium influx and signaling in cytotoxic T-lymphocyte lytic granule exocytosis
    • Pores-Fernando, A. T. and Zweifach, A.: Calcium influx and signaling in cytotoxic T-lymphocyte lytic granule exocytosis. Immunol. Rev., 231: 160-173 (2009).
    • (2009) Immunol. Rev. , vol.231 , pp. 160-173
    • Pores-Fernando, A.T.1    Zweifach, A.2
  • 5
  • 6
    • 0141741400 scopus 로고    scopus 로고
    • Perforin and the granule exocytosis cytotoxicity pathway
    • Catalfamo, M. and Henkart, P. A.: Perforin and the granule exocytosis cytotoxicity pathway. Curr. Opin. Immunol., 15: 522-527 (2003).
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 522-527
    • Catalfamo, M.1    Henkart, P.A.2
  • 7
    • 0742270336 scopus 로고    scopus 로고
    • The role of the secretory immunological synapse in killing by cd8+ ctl
    • Stinchcombe, J. C. and Griffiths, G. M.: The role of the secretory immunological synapse in killing by cd8+ ctl. Semin. Immunol., 15: 301-305 (2003).
    • (2003) Semin. Immunol. , vol.15 , pp. 301-305
    • Stinchcombe, J.C.1    Griffiths, G.M.2
  • 9
    • 0033674133 scopus 로고    scopus 로고
    • The role of perforin in infections and tumour surveillance
    • van den Broek, M. F. and Hengartner, H.: The role of perforin in infections and tumour surveillance. Exp. Physiol., 85: 681-685 (2000).
    • (2000) Exp. Physiol. , vol.85 , pp. 681-685
    • van den Broek, M.F.1    Hengartner, H.2
  • 11
    • 0036602982 scopus 로고    scopus 로고
    • Cytotoxic t lymphocytes in autoimmune and degenerative cns diseases
    • Neumann, H., Medana, I. M., Bauer, J. and Lassmann, H.: Cytotoxic t lymphocytes in autoimmune and degenerative cns diseases. Trends Neurosci., 25: 313-319 (2002).
    • (2002) Trends Neurosci , vol.25 , pp. 313-319
    • Neumann, H.1    Medana, I.M.2    Bauer, J.3    Lassmann, H.4
  • 12
    • 79957640618 scopus 로고    scopus 로고
    • Toxic epidermal necrolysis and stevens-johnson syndrome: A review
    • Gerull, R., Nelle, M. and Schaible, T.: Toxic epidermal necrolysis and stevens-johnson syndrome: A review. Crit. Care Med., 39: 1521-1532 (2011).
    • (2011) Crit. Care Med. , vol.39 , pp. 1521-1532
    • Gerull, R.1    Nelle, M.2    Schaible, T.3
  • 14
    • 0344951264 scopus 로고    scopus 로고
    • Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drugspecific t cell clones
    • Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P., Chadwick, D. W., Pichler, W. J., Pirmohamed, M. and Park, B. K.: Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drugspecific t cell clones. Mol. Pharmacol., 63: 732-741 (2003).
    • (2003) Mol. Pharmacol. , vol.63 , pp. 732-741
    • Naisbitt, D.J.1    Britschgi, M.2    Wong, G.3    Farrell, J.4    Depta, J.P.5    Chadwick, D.W.6    Pichler, W.J.7    Pirmohamed, M.8    Park, B.K.9
  • 16
    • 34047103842 scopus 로고    scopus 로고
    • Generation and characterization of antigen-specific cd4+, cd8+, and cd4+cd8+ t-cell clones from patients with carbamazepine hypersensitivity
    • Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K. and Naisbitt, D. J.: Generation and characterization of antigen-specific cd4+, cd8+, and cd4+cd8+ t-cell clones from patients with carbamazepine hypersensitivity. J. Allergy Clin. Immunol., 119: 973-981 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 973-981
    • Wu, Y.1    Farrell, J.2    Pirmohamed, M.3    Park, B.K.4    Naisbitt, D.J.5
  • 17
    • 82555166978 scopus 로고    scopus 로고
    • Shared and restricted t-cell receptor use is crucial for carbamazepine-induced stevens-johnson syndrome
    • Ko, T.M., Chung, W.H., Wei, C.Y., Shih, H.Y., Chen, J.K., Lin, C. H., Chen, Y.T. and Hung, S.I.: Shared and restricted t-cell receptor use is crucial for carbamazepine-induced stevens-johnson syndrome. J. Allergy Clin. Immunol., 128: 1266-1276 (2011).
    • (2011) J. Allergy Clin. Immunol. , vol.128 , pp. 1266-1276
    • Ko, T.M.1    Chung, W.H.2    Wei, C.Y.3    Shih, H.Y.4    Chen, J.K.5    Lin, C.H.6    Chen, Y.T.7    Hung, S.I.8
  • 18
    • 78649510318 scopus 로고    scopus 로고
    • Cytolytic cd4(+) t cells in viral immunity
    • Soghoian, D. Z. and Streeck, H.: Cytolytic cd4(+) t cells in viral immunity. Expert Rev. Vaccines, 9: 1453-1463 (2010).
    • (2010) Expert Rev. Vaccines , vol.9 , pp. 1453-1463
    • Soghoian, D.Z.1    Streeck, H.2
  • 19
    • 77958492710 scopus 로고    scopus 로고
    • The many face-lifts of cd4 t helper cells
    • Mucida, D. and Cheroutre, H.: The many face-lifts of cd4 t helper cells. Adv. Immunol., 107: 139-152 (2010).
    • (2010) Adv. Immunol. , vol.107 , pp. 139-152
    • Mucida, D.1    Cheroutre, H.2
  • 20
    • 73249135168 scopus 로고    scopus 로고
    • Cd4+cd25 + regulatory t cells in autoimmune arthritis
    • Oh, S., Rankin, A. L. and Caton, A. J.: Cd4+cd25 + regulatory t cells in autoimmune arthritis. Immunol. Rev., 233: 97-111 (2010).
    • (2010) Immunol. Rev. , vol.233 , pp. 97-111
    • Oh, S.1    Rankin, A.L.2    Caton, A.J.3
  • 22
    • 76249130394 scopus 로고    scopus 로고
    • In vitro detection of cytotoxic t and nk cells in peripheral blood of patients with various drug-induced skin diseases
    • Zawodniak, A., Lochmatter, P., Yerly, D., Kawabata, T., Lerch, M., Yawalkar, N. and Pichler, W. J.: In vitro detection of cytotoxic t and nk cells in peripheral blood of patients with various drug-induced skin diseases. Allergy, 65: 376-384 (2010).
    • (2010) Allergy , vol.65 , pp. 376-384
    • Zawodniak, A.1    Lochmatter, P.2    Yerly, D.3    Kawabata, T.4    Lerch, M.5    Yawalkar, N.6    Pichler, W.J.7
  • 23
    • 17644387197 scopus 로고    scopus 로고
    • Drug-induced exanthems
    • Yawalkar, N.: Drug-induced exanthems. Toxicology, 209: 131-134 (2005).
    • (2005) Toxicology , vol.209 , pp. 131-134
    • Yawalkar, N.1
  • 24
    • 33748563600 scopus 로고    scopus 로고
    • Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin diseases
    • Wittmann, M. and Werfel, T.: Interaction of keratinocytes with infiltrating lymphocytes in allergic eczematous skin diseases. Curr. Opin. Allergy Clin. Immunol., 6: 329-334 (2006).
    • (2006) Curr. Opin. Allergy Clin. Immunol. , vol.6 , pp. 329-334
    • Wittmann, M.1    Werfel, T.2
  • 25
    • 67649160590 scopus 로고    scopus 로고
    • Defective regulatory t cells in patients with severe drug eruptions: Timing of the dysfunction is associated with the pathological phenotype and outcome
    • Takahashi, R., Kano, Y., Yamazaki, Y., Kimishima, M., Mizukawa, Y. and Shiohara, T.: Defective regulatory t cells in patients with severe drug eruptions: Timing of the dysfunction is associated with the pathological phenotype and outcome. J. Immunol., 182: 8071-8079 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 8071-8079
    • Takahashi, R.1    Kano, Y.2    Yamazaki, Y.3    Kimishima, M.4    Mizukawa, Y.5    Shiohara, T.6
  • 27
    • 0034292414 scopus 로고    scopus 로고
    • Cd4 help-independent induction of cytotoxic cd8 cells to allogeneic p815 tumor cells is absolutely dependent on costimulation
    • Zhan, Y., Corbett, A. J., Brady, J. L., Sutherland, R. M. and Lew, A. M.: Cd4 help-independent induction of cytotoxic cd8 cells to allogeneic p815 tumor cells is absolutely dependent on costimulation. J. Immunol., 165: 3612-3619 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3612-3619
    • Zhan, Y.1    Corbett, A.J.2    Brady, J.L.3    Sutherland, R.M.4    Lew, A.M.5
  • 29
    • 48449102204 scopus 로고    scopus 로고
    • Natural killer cells: Detectors of stress
    • Luci, C. and Tomasello, E.: Natural killer cells: Detectors of stress. Int.J. Biochem. Cell Biol., 40: 2335-2340 (2008).
    • (2008) Int.J. Biochem. Cell Biol. , vol.40 , pp. 2335-2340
    • Luci, C.1    Tomasello, E.2
  • 32
    • 61449115971 scopus 로고    scopus 로고
    • Cd56bright natural killer (nk) cells: An important nk cell subset
    • Poli, A., Michel, T., Theresine, M., Andres, E., Hentges, F. and Zimmer, J.: Cd56bright natural killer (nk) cells: An important nk cell subset. Immunology, 126: 458-465 (2009).
    • (2009) Immunology , vol.126 , pp. 458-465
    • Poli, A.1    Michel, T.2    Theresine, M.3    Andres, E.4    Hentges, F.5    Zimmer, J.6
  • 35
    • 78349264226 scopus 로고    scopus 로고
    • Natural killer-dendritic cell interaction in lymphocyte responses in hypersensitivity reactions to betalactams
    • Chaves, P., Torres, M. J., Aranda, A., Lopez, S., Canto, F., Blanca, M. and Mayorga, C.: Natural killer-dendritic cell interaction in lymphocyte responses in hypersensitivity reactions to betalactams. Allergy, 65: 1600-1608 (2010).
    • (2010) Allergy , vol.65 , pp. 1600-1608
    • Chaves, P.1    Torres, M.J.2    Aranda, A.3    Lopez, S.4    Canto, F.5    Blanca, M.6    Mayorga, C.7
  • 36
    • 56549090945 scopus 로고    scopus 로고
    • The yin and yang of hla and kir in human disease
    • Kulkarni, S., Martin, M. P. and Carrington, M.: The yin and yang of hla and kir in human disease. Semin. Immunol., 20: 343-352 (2008).
    • (2008) Semin. Immunol. , vol.20 , pp. 343-352
    • Kulkarni, S.1    Martin, M.P.2    Carrington, M.3
  • 37
    • 77649271185 scopus 로고    scopus 로고
    • Cd94/nkg2c is a killer effector molecule in patients with stevens-johnson syndrome and toxic epidermal necrolysis
    • Morel, E, Escamochero, S, Cabanas, R, Diaz, R, Fiandor, A and Bellon, T: Cd94/nkg2c is a killer effector molecule in patients with stevens-johnson syndrome and toxic epidermal necrolysis. J. Allergy Clin. Immunol., 125:703-710, 710 e701-710 e708 (2010).
    • (2010) J. Allergy Clin. Immunol. , vol.125 , pp. 703-710
    • Morel, E.1    Escamochero, S.2    Cabanas, R.3    Diaz, R.4    Fiandor, A.5    Bellon, T.6
  • 45
    • 0042123683 scopus 로고    scopus 로고
    • Nkt cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine nkt cells
    • Kenna, T., Golden-Mason, L., Porcelli, S. A., Koezuka, Y., Hegarty, J. E., O'Farrelly, C. and Doherty, D. G.: Nkt cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine nkt cells. J. Immunol., 171: 1775-1779 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1775-1779
    • Kenna, T.1    Golden-Mason, L.2    Porcelli, S.A.3    Koezuka, Y.4    Hegarty, J.E.5    O'Farrelly, C.6    Doherty, D.G.7
  • 47
    • 0029112507 scopus 로고
    • Cd1-restricted cd4+ t cells in major histocompatibility complex class ii-deficient mice
    • Cardell, S., Tangri, S., Chan, S., Kronenberg, M., Benoist, C. and Mathis, D.: Cd1-restricted cd4+ t cells in major histocompatibility complex class ii-deficient mice. J. Exp. Med., 182: 993-1004 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 993-1004
    • Cardell, S.1    Tangri, S.2    Chan, S.3    Kronenberg, M.4    Benoist, C.5    Mathis, D.6
  • 48
    • 0037051896 scopus 로고    scopus 로고
    • Presence of a novel subset of nkt cells bearing an invariant v(alpha)19.1-j(alpha)26 tcr alpha chain
    • Shimamura, M. and Huang, Y. Y.: Presence of a novel subset of nkt cells bearing an invariant v(alpha)19.1-j(alpha)26 tcr alpha chain. FEBS Lett., 516: 97-100 (2002).
    • (2002) FEBS Lett , vol.516 , pp. 97-100
    • Shimamura, M.1    Huang, Y.Y.2
  • 49
    • 73249140727 scopus 로고    scopus 로고
    • Nkt cells: Friend or foe during viral infections?
    • Diana, J. and Lehuen, A.: Nkt cells: Friend or foe during viral infections? Eur. J. Immunol., 39: 3283-3291 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 3283-3291
    • Diana, J.1    Lehuen, A.2
  • 51
    • 34447622305 scopus 로고    scopus 로고
    • Nkt cells and autoimmune diseases: Unraveling the complexity
    • Miyake, S. and Yamamura, T.: Nkt cells and autoimmune diseases: Unraveling the complexity. Curr. Top. Microbiol. Immunol., 314: 251-267 (2007).
    • (2007) Curr. Top. Microbiol. Immunol. , vol.314 , pp. 251-267
    • Miyake, S.1    Yamamura, T.2
  • 52
    • 77956910496 scopus 로고    scopus 로고
    • Role of nk cells and invariant nkt cells in multiple sclerosis
    • Sakuishi, K., Miyake, S. and Yamamura, T.: Role of nk cells and invariant nkt cells in multiple sclerosis. Results Probl. Cell Differ., 51: 127-147 (2010).
    • (2010) Results Probl. Cell Differ. , vol.51 , pp. 127-147
    • Sakuishi, K.1    Miyake, S.2    Yamamura, T.3
  • 54
    • 33747816149 scopus 로고    scopus 로고
    • Toxicophores: Investigations in drug safety
    • Williams, D. P.: Toxicophores: Investigations in drug safety. Toxicology, 226: 1-11 (2006).
    • (2006) Toxicology , vol.226 , pp. 1-11
    • Williams, D.P.1
  • 56
    • 0028352066 scopus 로고
    • Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions
    • Gaedigk, A., Spielberg, S. P. and Grant, D. M.: Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics, 4: 142-153 (1994).
    • (1994) Pharmacogenetics , vol.4 , pp. 142-153
    • Gaedigk, A.1    Spielberg, S.P.2    Grant, D.M.3
  • 58
    • 8644230009 scopus 로고    scopus 로고
    • Specific serum ige levels and fcepsilonribeta genetic polymorphism in patients with penicillins allergy
    • Qiao, H. L., Yang, J. and Zhang, Y. W.: Specific serum ige levels and fcepsilonribeta genetic polymorphism in patients with penicillins allergy. Allergy, 59: 1326-1332 (2004).
    • (2004) Allergy , vol.59 , pp. 1326-1332
    • Qiao, H.L.1    Yang, J.2    Zhang, Y.W.3
  • 59
    • 33749011412 scopus 로고    scopus 로고
    • Gene-gene interactions of il13 and il4ra variants in immediate allergic reactions to betalactam antibiotics. Pharmacogenet
    • Guéant-Rodriguez, R. M., Romano, A., Beri-Dexheimer, M., Viola, M., Gaeta, F. and Gueant, J. L.: Gene-gene interactions of il13 and il4ra variants in immediate allergic reactions to betalactam antibiotics. Pharmacogenet. Genomics, 16: 713-719 (2006).
    • (2006) Genomics , vol.16 , pp. 713-719
    • Guéant-Rodriguez, R.M.1    Romano, A.2    Beri-Dexheimer, M.3    Viola, M.4    Gaeta, F.5    Gueant, J.L.6
  • 60
    • 33745768840 scopus 로고    scopus 로고
    • Il-10 promoter and il4-ralpha gene snps are associated with immediate beta-lactam allergy in atopic women
    • Guglielmi, L., Fontaine, C., Gougat, C., Avinens, O., Eliaou, J. F., Guglielmi, P. and Demoly, P.: Il-10 promoter and il4-ralpha gene snps are associated with immediate beta-lactam allergy in atopic women. Allergy, 61: 921-927 (2006).
    • (2006) Allergy , vol.61 , pp. 921-927
    • Guglielmi, L.1    Fontaine, C.2    Gougat, C.3    Avinens, O.4    Eliaou, J.F.5    Guglielmi, P.6    Demoly, P.7
  • 61
    • 41049117206 scopus 로고    scopus 로고
    • Association of tumor necrosis factoralpha -308g> a polymorphism with ige-mediated allergy to betalactams in an italian population
    • Guéant-Rodriguez, R. M., Gueant, J. L., Viola, M., Tramoy, D., Gaeta, F. and Romano, A.: Association of tumor necrosis factoralpha -308g> a polymorphism with ige-mediated allergy to betalactams in an italian population. Pharmacogenomics J., 8: 162-168 (2008).
    • (2008) Pharmacogenomics J , vol.8 , pp. 162-168
    • Guéant-Rodriguez, R.M.1    Gueant, J.L.2    Viola, M.3    Tramoy, D.4    Gaeta, F.5    Romano, A.6
  • 64
  • 65
    • 0030918532 scopus 로고    scopus 로고
    • Penicilloyl peptides are recognized as t cell antigenic determinants in penicillin allergy
    • Padovan, E., Bauer, T., Tongio, M. M., Kalbacher, H. and Weltzien, H. U.: Penicilloyl peptides are recognized as t cell antigenic determinants in penicillin allergy. Eur. J. Immunol., 27: 1303-1307 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1303-1307
    • Padovan, E.1    Bauer, T.2    Tongio, M.M.3    Kalbacher, H.4    Weltzien, H.U.5
  • 67
    • 33745261626 scopus 로고    scopus 로고
    • Transfection of drug-specific t-cell receptors into hybridoma cells: Tools to monitor drug interaction with t-cell receptors and evaluate cross-reactivity to related compounds
    • Schmid, D. A., Depta, J. P., Luthi, M. and Pichler, W. J.: Transfection of drug-specific t-cell receptors into hybridoma cells: Tools to monitor drug interaction with t-cell receptors and evaluate cross-reactivity to related compounds. Mol. Pharmacol., 70: 356-365 (2006).
    • (2006) Mol. Pharmacol. , vol.70 , pp. 356-365
    • Schmid, D.A.1    Depta, J.P.2    Luthi, M.3    Pichler, W.J.4
  • 68
    • 0036674944 scopus 로고    scopus 로고
    • Late-onset allergy-like reactions to x-ray contrast media
    • Christiansen C. Late-onset allergy-like reactions to x-ray contrast media. Curr. Opin. Allergy Clin. Immunol., 2: 333-339 (2002).
    • (2002) Curr. Opin. Allergy Clin. Immunol. , vol.2 , pp. 333-339
    • Christiansen, C.1
  • 70
    • 79953664999 scopus 로고    scopus 로고
    • Delayed drug hypersensitivity: Models of t-cell stimulation
    • Adam, J., Pichler, W. J. and Yerly, D.: Delayed drug hypersensitivity: Models of t-cell stimulation. Br. J. Clin. Pharmacol., 71: 701-707 (2011).
    • (2011) Br. J. Clin. Pharmacol. , vol.71 , pp. 701-707
    • Adam, J.1    Pichler, W.J.2    Yerly, D.3
  • 71
    • 0030822702 scopus 로고    scopus 로고
    • Direct, mhc-dependent presentation of the drug sulfamethoxazole to human alphabeta t cell clones
    • Schnyder, B., Mauri-Hellweg, D., Zanni, M., Bettens, F. and Pichler, W. J.: Direct, mhc-dependent presentation of the drug sulfamethoxazole to human alphabeta t cell clones. J. Clin. Invest., 100: 136-141 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 136-141
    • Schnyder, B.1    Mauri-Hellweg, D.2    Zanni, M.3    Bettens, F.4    Pichler, W.J.5
  • 72
    • 68249128647 scopus 로고    scopus 로고
    • Harvesting candidate genes responsible for serious adverse drug reactions from a chemical- protein interactome
    • Yang, L., Chen, J. and He, L.: Harvesting candidate genes responsible for serious adverse drug reactions from a chemical- protein interactome. PLOS Comput. Biol., 5: e1000441 (2009).
    • (2009) PLOS Comput. Biol. , vol.5
    • Yang, L.1    Chen, J.2    He, L.3
  • 74
    • 0034123730 scopus 로고    scopus 로고
    • A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions
    • Reilly, T. P., Lash, L. H., Doll, M. A., Hein, D. W., Woster, P. M. and Svensson, C. K.: A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J. Invest. Dermatol., 114: 1164-1173 (2000).
    • (2000) J. Invest. Dermatol. , vol.114 , pp. 1164-1173
    • Reilly, T.P.1    Lash, L.H.2    Doll, M.A.3    Hein, D.W.4    Woster, P.M.5    Svensson, C.K.6
  • 75
    • 23044473576 scopus 로고    scopus 로고
    • Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes
    • Roychowdhury, S., Vyas, P. M., Reilly, T. P., Gaspari, A. A. and Svensson, C. K.: Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes. J. Pharmacol. Exp. Ther., 314: 43-52 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 43-52
    • Roychowdhury, S.1    Vyas, P.M.2    Reilly, T.P.3    Gaspari, A.A.4    Svensson, C.K.5
  • 76
    • 0033956005 scopus 로고    scopus 로고
    • Blister fluid t lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (nk) inhibitory receptors
    • Le Cleach, L., Delaire, S., Boumsell, L., Bagot, M., Bourgault-Villada, I., Bensussan, A. and Roujeau, J. C.: Blister fluid t lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (nk) inhibitory receptors. Clin. Exp. Immunol., 119: 225-230 (2000).
    • (2000) Clin. Exp. Immunol. , vol.119 , pp. 225-230
    • le Cleach, L.1    Delaire, S.2    Boumsell, L.3    Bagot, M.4    Bourgault-Villada, I.5    Bensussan, A.6    Roujeau, J.C.7
  • 82
    • 34948839971 scopus 로고    scopus 로고
    • Hla-b*1502-bound peptides: Implications for the pathogenesis of carbamazepine- induced stevens-johnson syndrome
    • Yang, C. W., Hung, S. I., Juo, C. G., Lin, Y. P., Fang, W. H., Lu, I. H., Chen, S. T. and Chen, Y. T.: Hla-b*1502-bound peptides: Implications for the pathogenesis of carbamazepine- induced stevens-johnson syndrome. J. Allergy Clin. Immunol., 120: 870-877 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 870-877
    • Yang, C.W.1    Hung, S.I.2    Juo, C.G.3    Lin, Y.P.4    Fang, W.H.5    Lu, I.H.6    Chen, S.T.7    Chen, Y.T.8
  • 90
    • 77952937737 scopus 로고    scopus 로고
    • Hla-b*5901 is strongly associated with methazolamide- induced stevens-johnson syndrome/toxic epidermal necrolysis
    • Kim, S. H., Kim, M., Lee, K. W., Kang, H. R., Park, H. W. and Jee, Y. K.: Hla-b*5901 is strongly associated with methazolamide- induced stevens-johnson syndrome/toxic epidermal necrolysis. Pharmacogenomics, 11: 879-884 (2010).
    • (2010) Pharmacogenomics , vol.11 , pp. 879-884
    • Kim, S.H.1    Kim, M.2    Lee, K.W.3    Kang, H.R.4    Park, H.W.5    Jee, Y.K.6
  • 91
    • 12144260460 scopus 로고    scopus 로고
    • Predisposition to nevirapine hypersensitivity associated with hla- drb1*0101 and abrogated by low cd4 t-cell counts
    • Martin, A. M., Nolan, D., James, I., Cameron, P., Keller, J., Moore, C., Phillips, E., Christiansen, F. T. and Mallal, S.: Predisposition to nevirapine hypersensitivity associated with hla- drb1*0101 and abrogated by low cd4 t-cell counts. AIDS, 19: 97-99 (2005).
    • (2005) AIDS , vol.19 , pp. 97-99
    • Martin, A.M.1    Nolan, D.2    James, I.3    Cameron, P.4    Keller, J.5    Moore, C.6    Phillips, E.7    Christiansen, F.T.8    Mallal, S.9
  • 95
    • 34248589506 scopus 로고    scopus 로고
    • Association between hla-b*1502 allele and antiepileptic drug-induced cutaneous reactions in han chinese
    • Man, C. B., Kwan, P., Baum, L., Yu, E., Lau, K. M., Cheng, A. S. and Ng, M. H.: Association between hla-b*1502 allele and antiepileptic drug-induced cutaneous reactions in han chinese. Epilepsia, 48: 1015-1018 (2007).
    • (2007) Epilepsia , vol.48 , pp. 1015-1018
    • Man, C.B.1    Kwan, P.2    Baum, L.3    Yu, E.4    Lau, K.M.5    Cheng, A.S.6    Ng, M.H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.