Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 8, 2009, Pages 1417-1424

  Dang, Haixia ^a   Chen, Ying ^a   Liu, Xinmin ^a   Wang, Qiong ^a   Wang, Liwei ^a   Jia, William ^b   Wang, Yuqing ^c  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

Chronic mild stress; Depression; Forced swimming test; Ginseng total saponins

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; GINSENOSIDE; MONOAMINE; PLANT GLYCOSIDE; SAPONIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; FORCED SWIMMING TEST; GINSENG; HIPPOCAMPUS; LATENT PERIOD; LOCOMOTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOGENIC MONOAMINES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; FLUOXETINE; FOOD PREFERENCES; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; PANAX; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SAPONINS; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 71549173390     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.07.020     Document Type: Article

References (69)

1. An L., Zhang Y.Z., Yu N.J., Liu X.M., Zhao N., Yuan L., et al. Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. Pharmacol Biochem Behav 89 (2008) 572-580
2. American Psychiatric Association. DSM IV-Diagnostic and Statistical Manual of Psychiatric Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
3. Bekris S., Antonious K., Daskas S., and Papadopoulous-Daifoti Z. Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav Brain Res 161 (2005) 45-59
4. Bland S.T., Tamlyn J.P., Barrientos R.M., Greenwood B.N., Watkins L.R., Campeau S., et al. Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress. Neuroscience 144 (2007) 1219-1228
5. Cha H.Y., Park J.H., Hong J.T., Yoo H.S., Song S., Hwang B.Y., et al. Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. Biol Pharm Bull 28 (2005) 1621-1625
6. Chen B., Dowlatshahi D., MacQueen G.M., Wang J.F., and Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50 (2001) 260-265
7. Choi S., Jung S.Y., Lee J.H., Sala F., Criado M., Mulet J., et al. Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur J Pharmacol 442 (2002) 37-45
8. Choi S., Lee J.H., Oh S., Rhim H., Lee S.M., and Nah S.Y. Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. Mol Cells 15 (2003) 108-103
9. De Foubert G., Carney S.L., Robinson C.S., Destexhe E.J., Tomlinson R., Hicks C.A., et al. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128 (2004) 597-604
10. Dulawa S.C., and Hen R. Recent advances in animal models of chronic antidepressant effect: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29 (2005) 771-783
11. Duman R.S., and Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59 (2006) 1116-1127
12. Duman R.S., Heninger G.R., and Nestler E.J. A molecular and cellular theory of depression. Arch Gen Psychiatry 54 (1997) 597-606
13. Duman R.S., Malberg J., Nakagawa S., and D'Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48 (2000) 732-739
14. Dwivedi Y., Rizavi H.S., Conley R.R., Roberts R.C., Tamminga C.A., and Pandey G.N. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60 (2003) 804-815
15. Einat H. Chronic oral administration of ginseng extract results in behavioral change but has no effect in mice models of affective and anxiety disorders. Phytother Res 21 (2007) 62-66
16. In: Elliott, J.M., Heal, D.J., Marsden, and C.A. (Eds). Experimental approaches to anxiety and depression (1992), John Wiley& Sons, Ltd., Chichester, England
17. Fawcett J.P., Bamji S.X., Causing C.G., Aloyz R., Ase A.R., Reader T.A., et al. Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS. J Neurosci 18 (1998) 2808-2821
18. Friedman W.J., Ibáñez C.F., Hallböök F., Persson H., Cain L.D., Dreyfus C.F., et al. Differential actions of neurotrophins in the locus coeruleus and basal forebrain. Exp Neurol 119 (1993) 72-78
19. Gorman J.M. Comorbid depression and anxiety spectrum disorders. Depress Anxiety 4 (1996-1997) 160-168
20. Gronli J., Bramham C., Murison R., Kanhema T., Fiske E., Bjorvatn B., et al. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol Biochem Behav 85 (2006) 842-849
21. Heninger G.R., Charney D.S., and Sternberg D.E. Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Arch Gen Psychiatry 41 (1984) 398-402
22. Hu J., and Fu B.Z. Study on anti-depression of tricyclic drug and ginseng saponin. Hei Long Jiang Med J 27 (2003) 268-269
23. Huang E.J., and Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24 (2001) 677-736
24. Itoh T., Zang Y.F., Murai S., and Saito H. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice. Planta Med 55 (1989) 429-433
25. Ivy A.S., Rodriguez F.G., Garcia C., Chen M.J., and Russo-Neustadt A.A. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacol Biochem Behav 75 (2003) 81-88
26. Jans L., Riedel W.J., Markus C.R., and Blokland A. Serotonergic vulnerability and depression: assumptions, experimental evidence and implications. Mol Psychiatry 12 (2007) 522-543
27. Kang M., Pyun K.H., Jang C.G., Kim H., Bae H., and Shim I. Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. J Pharm Pharmacol 57 (2005) 651-656
28. Karege F., Vaudan G., Schwald M., Perroud N., and La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 136 (2005) 29-37
29. Katz R.J. Animal model of depression: pharmacological sensitivity of a hedonic deficit. Pharmacol Biochem Behav 16 (1982) 965-968
30. Kaufman J., and Charney D. Comorbidity of mood and anxiety disorders. Depress Anxiety 12 (2000) 69-76
31. Kennedy S.H. A review of antidepressant treatments today. Eur Neuropsychopharmacol 16 (2006) S619-623
32. Kennedy D.O., and Scholey A.B. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 75 (2003) 687-700
33. Kessler R.C., Berglund P., Demler O., Jin R., Koretz D., Merikangas K.R., et al. National Comrobidity Survey Replication. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289 (2003) 3095-3105
34. Kim H.S., Kang J.G., Seong Y.H., Nam K.Y., and Oh K.W. Blockade by ginseng total saponins of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol Biochem Behav 50 (1995) 23-27
35. Kim H.S., Kang J.G., and Oh K.W. Inhibition by ginseng total saponins of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen Pharmacol 26 (1995) 1071-1076
36. Kim H.S., Hong Y.T., Oh K.W., Seong Y.H., Rheu H.M., and Cho D.H. Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine induced hypersensitivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity on mice. Gen Pharmacol 30 (1998) 783-789
37. Kim H.S., Kim K., and Oh K. Ginseng total saponins inhibits nicotine induced hyperactivity and conditioned place preference in mice. J Ethnopharmacol 66 (1999) 83-90
38. Kim S., Ahn K., Oh T.H., Nah S.Y., and Rhim H. Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun 296 (2002) 247-254
39. Konstandi M., Johnson E., Lang M.A., Malamas M., and Marselos M. Noradrenaline, dopamine, serotonin: different effects of psychological stress on brain biogenic amines in mice and rats. Pharmacol Res 41 (2000) 341-346
40. Lee J.H., Jeong S.M., Lee B.H., Noh H.S., Kim B.K., Kim J.I., et al. Prevention of ginsenoside-induced desensitization of Ca2+-activated Cl-current by microinjection of inositol hexakisphophate in Xenopus laevis oocytes: involvement of GRK2 and beta-arrestin 1. J Biol Chem 279 (2004) 9912-9921
41. Lee B., Yang C.H., Hahm D.H., Lee H.J., Han S.M., Kim K.S., et al. Inhibitory effects of ginseng total saponins on behavioral sensitization and dopamine release induced by cocaine. Biol Pharm Bull 31 (2008) 436-441
42. Lind N.M., Vinther M., Hemmingsen R.P., and Hansen A.K. Validation of a digital video tracking system for recording pig locomotor behaviour. J Neurosci Methods 143 (2005) 123-132
43. Linde K., Berner M.M., and Kriston L. St John's wort for major depression. Cochrane Database Syst Rev 8 (2008) CD000448
44. Mai W.L., Wang Q., Liu X.M., Li Y.H., Chen S.G., Wang L.W., et al. Significant parameters in evaluation of spontaneous activity in mice. Acta Lab Anim Sci Sinca 16 (2008) 570-572
45. Mamounas L.A., Blue M.E., Siuciak J.A., and Altar C.A. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 15 (1995) 7929-7939
46. Molteni R., Calabrese F., Bedogni F., Tongiorgi E., Fumagalli F., Racagni G., et al. Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions. Int J Neuropsychopharmacol 9 (2006) 307-317
47. Nah S.Y., Kim D.H., and Rhim H. Ginsenosides: Are any of them candidates for drugs acting on the central nervous system. CNS Drug Rev 13 (2007) 381-404
48. Nemeroff C.B. The burden of severe depression: a review of diagnositic Challenges and treatment alternatives. J Psychiatr Res 41 (2007) 189-206
49. Nguyen T.T., Matsumoto K., Yamasaki K., Nguyen M.D., Nguyen T.N., and Watanabe H. Crude saponin extracted from Vietnamese ginseng and its major constituent majonoside-R2 attenuate the psychological stress and foot-shock stress-induced antinociception in mice. Pharmacol Biochem Behav 52 (1995) 427-432
50. Nguyen T.T., Matsumoto K., Yamasaki K., Nguyen T.N., and Watanabe H. Effects of majonoside-R2 on pentobarbital sleep and gastric lesion in psychologically stressed mice. Pharmacol Biochem Behav 53 (1996) 957-963
51. Patten S.B. Major depression prevalence is very high, but the syndrome is a poor proxy for community populations' clinical treatment needs. Can J Psychiatry 53 (2008) 411-419
52. Petkov V. Effect of ginseng on the brain biogenic monoamines and 3′,5′-AMP system. Experiments on rats. Arzneimittelforschung 28 (1978) 388-393
53. Porsolt R.D., Bertin A., and Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229 (1977) 327-336
54. Rasmusson A.M., Shi L., and Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 27 (2002) 133-142
55. Rygula R., Abumaria N., Domenici E., Hiemke C., and Fuchs E. Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats. Behav Brain Res 174 (2006) 188-192
56. Sala F., Mulet J., Choi S., Jung S.Y., Nah S.Y., Rhim H., et al. Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. J Pharmacol Exp Ther 301 (2002) 1052-1059
57. Savegnago L., Jesse C.R., Pinto L.G., Rocha J.B., Nogueira C.W., and Zeni G. Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rat. Prog Neuro-Psychopharmacol Biol Psychiatry 31 (2007) 1261-1269
58. Schmidt H.D., and Duman R.S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 18 (2007) 391-418
59. Shim I., Won J., Song J., Kim S.E., and Huh S. Modulatory effect of ginseng total saponins on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the mouse. J Ethnopharmacol 70 (2000) 161-169
60. Siuciak J.A., Altar C.A., Wiegand S.J., and Lindsey R.M. Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3. Brain Res 633 (1994) 326-330
61. Sklair-Tavron L., and Nestler E.J. Opposing effect of morphine and the neurotrophins, NT-3, NT-4 and BDNF, on locus coeruleus neurons in vitro. Brain Res 702 (1995) 117-125
62. Smith M.A., Makino S., Kvetnanský R., and Post R.M. Effects of stress on neurotrophic factor expression in the rat brain. Ann N Y Acad Sci 771 (1995) 234-239
63. Vaidya V.A., Marek G.J., Aghaijanian G.K., and Duman R.S. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. J Neurosci 17 (1997) 2785-2795
64. Vaidya V.A., Terwilliger R.M., and Duman R.S. Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett 262 (1999) 1-4
65. Wei X.Y., Yang J.Y., Wang J.H., and Wu C.F. Anxiolytic effect of saponins from Panax quinquefolium in mice. J Ethnopharmacol 111 (2007) 613-618
66. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134 (1997) 319-329
67. Willner P., Towell A., Sampson D., Sophokleous S., and Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93 (1987) 358-364
68. Willner P., Muscat R., and Papp M. Chronic mild stress-induced anhedonia: a realistic model of depression. Neurosci Biobehav Rev 16 (1992) 525-534
69. Zhao H., Li Q., Zhang Z., Pei X., Wang J., and Li Y. Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related protein in hippocampus. Brain Res 1256 (2009) 111-122