메뉴 건너뛰기




Volumn 11, Issue 5, 2012, Pages 503-512

Fear extinction and BDNF: Translating animal models of PTSD to the clinic

Author keywords

Anxiety; Brain derived neurotrophic factor; Depression; Fear; Neurotrophic factor; PTSD; TrkB

Indexed keywords

7,8 DIHYDROXYFLAVONE; ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLOSERINE; ENDOCANNABINOID; HISTONE DEACETYLASE INHIBITOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR;

EID: 84863185677     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00801.x     Document Type: Review
Times cited : (217)

References (107)
  • 1
    • 33847250395 scopus 로고    scopus 로고
    • Mouse and rat BDNF gene structure and expression revisited
    • Aid, T., Kazantseva, A., Piirsoo, M., Palm, K. & Timmusk, T. (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci R 85, 525-535.
    • (2007) J Neurosci R , vol.85 , pp. 525-535
    • Aid, T.1    Kazantseva, A.2    Piirsoo, M.3    Palm, K.4    Timmusk, T.5
  • 2
    • 84863197038 scopus 로고    scopus 로고
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR).American Psychiatric Association, Washington, DC
    • American Psychiatric Association. (2000) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR).American Psychiatric Association, Washington, DC.
    • (2000)
  • 4
    • 79952728977 scopus 로고    scopus 로고
    • Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning
    • Andero, R., Heldt, S.A., Ye, K., Liu, X., Armario, A. & Ressler, K.J. (2011) Effect of 7, 8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry 168, 163-172.
    • (2011) Am J Psychiatry , vol.168 , pp. 163-172
    • Andero, R.1    Heldt, S.A.2    Ye, K.3    Liu, X.4    Armario, A.5    Ressler, K.J.6
  • 5
    • 84857208654 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats
    • Andero, R., Daviu, N., Escorihuela, R.M., Nadal, R. & Armario, A. (2012) 7, 8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 22, 399-408.
    • (2012) Hippocampus , vol.22 , pp. 399-408
    • Andero, R.1    Daviu, N.2    Escorihuela, R.M.3    Nadal, R.4    Armario, A.5
  • 6
    • 41749106682 scopus 로고    scopus 로고
    • BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice
    • Aso, E., Ozaita, A., Valdizán, E.M., Ledent, C., Pazos, A., Maldonado, R. & Valverde, O. (2008) BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J Neurochem 105, 565-572.
    • (2008) J Neurochem , vol.105 , pp. 565-572
    • Aso, E.1    Ozaita, A.2    Valdizán, E.M.3    Ledent, C.4    Pazos, A.5    Maldonado, R.6    Valverde, O.7
  • 11
    • 38649140454 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear
    • Bredy, T.W. & Barad, M. (2008) The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear. Learn Mem (Cold Spring Harbor, N.Y.) 15, 39-45.
    • (2008) Learn Mem (Cold Spring Harbor, N.Y.) , vol.15 , pp. 39-45
    • Bredy, T.W.1    Barad, M.2
  • 12
    • 34247224239 scopus 로고    scopus 로고
    • Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
    • Bredy, T.W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y.E. & Barad, M. (2007) Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem 14, 268-276.
    • (2007) Learn Mem , vol.14 , pp. 268-276
    • Bredy, T.W.1    Wu, H.2    Crego, C.3    Zellhoefer, J.4    Sun, Y.E.5    Barad, M.6
  • 14
    • 34249688577 scopus 로고    scopus 로고
    • Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo
    • Cao, L., Dhilla, A., Mukai, J., Blazeski, R., Lodovichi, C., Mason, C.A. & Gogos, J.A. (2007) Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo. Curr Biol 17, 911-921.
    • (2007) Curr Biol , vol.17 , pp. 911-921
    • Cao, L.1    Dhilla, A.2    Mukai, J.3    Blazeski, R.4    Lodovichi, C.5    Mason, C.A.6    Gogos, J.A.7
  • 15
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: a convergence point for many signalling pathways
    • Chao, M.V. (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4, 299-309.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 16
    • 2342550552 scopus 로고    scopus 로고
    • Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    • Chen, Z.Y., Patel, P.D., Sant, G., Meng, C.X., Teng, K.K., Hempstead, B.L. & Lee, F.S. (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24, 4401-4411.
    • (2004) J Neurosci , vol.24 , pp. 4401-4411
    • Chen, Z.Y.1    Patel, P.D.2    Sant, G.3    Meng, C.X.4    Teng, K.K.5    Hempstead, B.L.6    Lee, F.S.7
  • 17
    • 21544461501 scopus 로고    scopus 로고
    • Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    • Chen, Z.Y., Ieraci, A., Teng, H., Dall, H., Meng, C.X., Herrera, D.G., Nykjaer, A., Hempstead, B.L. & Lee, F.S. (2005) Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci 25, 6156-6166.
    • (2005) J Neurosci , vol.25 , pp. 6156-6166
    • Chen, Z.Y.1    Ieraci, A.2    Teng, H.3    Dall, H.4    Meng, C.X.5    Herrera, D.G.6    Nykjaer, A.7    Hempstead, B.L.8    Lee, F.S.9
  • 19
    • 34147102736 scopus 로고    scopus 로고
    • Modulation of fear and anxiety by the endogenous cannabinoid system
    • Chhatwal, J.P. & Ressler, K.J. (2007) Modulation of fear and anxiety by the endogenous cannabinoid system. CNS Spectr 12, 211-220.
    • (2007) CNS Spectr , vol.12 , pp. 211-220
    • Chhatwal, J.P.1    Ressler, K.J.2
  • 20
    • 33745582492 scopus 로고    scopus 로고
    • Amygdala BDNF signaling is required for consolidation but not encoding of extinction
    • Chhatwal, J.P., Stanek-Rattiner, L., Davis, M. & Ressler, K.J. (2006) Amygdala BDNF signaling is required for consolidation but not encoding of extinction. Nature Neurosci 9, 870-872.
    • (2006) Nature Neurosci , vol.9 , pp. 870-872
    • Chhatwal, J.P.1    Stanek-Rattiner, L.2    Davis, M.3    Ressler, K.J.4
  • 21
    • 77249140499 scopus 로고    scopus 로고
    • Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear
    • Choi, D.C., Maguschak, K.A., Ye, K., Jang, S.-W., Myers, K.M. & Ressler, K.J. (2010a) Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. ProcNatl Acad Sci USA 107, 2675-2680.
    • (2010) ProcNatl Acad Sci USA , vol.107 , pp. 2675-2680
    • Choi, D.C.1    Maguschak, K.A.2    Ye, K.3    Jang, S.-W.4    Myers, K.M.5    Ressler, K.J.6
  • 22
    • 79952258566 scopus 로고    scopus 로고
    • Pharmacological enhancement of behavioral therapy: focus on posttraumatic stress disorder
    • Choi, D.C., Rothbaum, B.O., Gerardi, M. & Ressler, K.J. (2010b)Pharmacological enhancement of behavioral therapy: focus on posttraumatic stress disorder. Curr Top Behav Neurosci 2, 279-299.
    • (2010) Curr Top Behav Neurosci , vol.2 , pp. 279-299
    • Choi, D.C.1    Rothbaum, B.O.2    Gerardi, M.3    Ressler, K.J.4
  • 23
    • 77956392717 scopus 로고    scopus 로고
    • Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies
    • Cornelis, M.C., Nugent, N.R., Amstadter, A.B. & Koenen, K.C. (2010) Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. Curr Psychiatry Rep 12, 313-326.
    • (2010) Curr Psychiatry Rep , vol.12 , pp. 313-326
    • Cornelis, M.C.1    Nugent, N.R.2    Amstadter, A.B.3    Koenen, K.C.4
  • 25
    • 84856059838 scopus 로고    scopus 로고
    • 7,8-Dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease
    • Devi, L. & Ohno, M. (2012) 7, 8-Dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 37, 434-444.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 434-444
    • Devi, L.1    Ohno, M.2
  • 26
    • 59949096898 scopus 로고    scopus 로고
    • Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
    • D'Souza, D.C., Pittman, B., Perry, E. & Simen, A. (2009)Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology 202, 569-578.
    • (2009) Psychopharmacology , vol.202 , pp. 569-578
    • D'Souza, D.C.1    Pittman, B.2    Perry, E.3    Simen, A.4
  • 28
    • 0028274040 scopus 로고
    • Mice lacking brain-derived neurotrophic factor develop with sensory deficits
    • Ernfors, P., Lee, K.F. & Jaenisch, R. (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147-150.
    • (1994) Nature , vol.368 , pp. 147-150
    • Ernfors, P.1    Lee, K.F.2    Jaenisch, R.3
  • 29
    • 78149267659 scopus 로고    scopus 로고
    • Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder
    • Frielingsdorf, H., Bath, K.G., Soliman, F., Difede, J., Casey, B.J. & Lee, F.S. (2010) Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder. Ann N Y Acad Sci 1208, 150-157.
    • (2010) Ann N Y Acad Sci , vol.1208 , pp. 150-157
    • Frielingsdorf, H.1    Bath, K.G.2    Soliman, F.3    Difede, J.4    Casey, B.J.5    Lee, F.S.6
  • 31
    • 58149470815 scopus 로고    scopus 로고
    • A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    • Gourley, S.L., Kedves, A.T., Olausson, P. & Taylor, J.R. (2009)A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology 34, 707-716.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 707-716
    • Gourley, S.L.1    Kedves, A.T.2    Olausson, P.3    Taylor, J.R.4
  • 32
    • 33846316386 scopus 로고    scopus 로고
    • Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus
    • Greenwood, B.N., Strong, P.V., Foley, T.E., Thompson, R.S. & Fleshner, M. (2007) Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus. Neuroscience 144, 1193-1208.
    • (2007) Neuroscience , vol.144 , pp. 1193-1208
    • Greenwood, B.N.1    Strong, P.V.2    Foley, T.E.3    Thompson, R.S.4    Fleshner, M.5
  • 34
    • 67349180729 scopus 로고    scopus 로고
    • Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior
    • Hammack, S.E., Cheung, J., Rhodes, K.M., Schutz, K.C., Falls, W.A., Braas, K.M. & May, V. (2009) Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior. Psychoneuroendocrinology 34, 833-843.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 833-843
    • Hammack, S.E.1    Cheung, J.2    Rhodes, K.M.3    Schutz, K.C.4    Falls, W.A.5    Braas, K.M.6    May, V.7
  • 36
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Heldt, S.A., Stanek, L., Chhatwal, J.P. & Ressler, K.J. (2007)Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 12, 656-670.
    • (2007) Mol Psychiatry , vol.12 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3    Ressler, K.J.4
  • 37
    • 55049124706 scopus 로고    scopus 로고
    • Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD)
    • CD007316.
    • Hetrick, S.E., Purcell, R., Garner, B. & Parslow, R. (2010)Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev CD007316.
    • (2010) Cochrane Database Syst Rev
    • Hetrick, S.E.1    Purcell, R.2    Garner, B.3    Parslow, R.4
  • 41
    • 0028988240 scopus 로고
    • Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
    • Kang, H. & Schuman, E.M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267, 1658-1662.
    • (1995) Science , vol.267 , pp. 1658-1662
    • Kang, H.1    Schuman, E.M.2
  • 43
    • 1842633560 scopus 로고    scopus 로고
    • Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity
    • Khaspekov, L.G., Brenz Verca, M.S., Frumkina, L.E., Hermann, H., Marsicano, G. & Lutz, B. (2004) Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity. Eur J Neurosci 19, 1691-1698.
    • (2004) Eur J Neurosci , vol.19 , pp. 1691-1698
    • Khaspekov, L.G.1    Brenz Verca, M.S.2    Frumkina, L.E.3    Hermann, H.4    Marsicano, G.5    Lutz, B.6
  • 44
    • 47949086547 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide regulates brain-derived neurotrophic factor exon IV expression through the VPAC1 receptor in the amphibian melanotrope cell
    • Kidane, A.H., Roubos, E.W. & Jenks, B.G. (2008) Pituitary adenylate cyclase-activating polypeptide regulates brain-derived neurotrophic factor exon IV expression through the VPAC1 receptor in the amphibian melanotrope cell. Endocrinology 149, 4177-4182.
    • (2008) Endocrinology , vol.149 , pp. 4177-4182
    • Kidane, A.H.1    Roubos, E.W.2    Jenks, B.G.3
  • 45
    • 78649553360 scopus 로고    scopus 로고
    • The exclusive induction of extinction is gated by BDNF
    • Kirtley, A. & Thomas, K.L. (2010) The exclusive induction of extinction is gated by BDNF. Learn Mem 17, 612-619.
    • (2010) Learn Mem , vol.17 , pp. 612-619
    • Kirtley, A.1    Thomas, K.L.2
  • 46
    • 0027491104 scopus 로고
    • Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
    • Klein, R., Smeyne, R.J., Wurst, W., Long, L.K., Auerbach, B.A., Joyner, A.L. & Barbacid, M. (1993) Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75, 113-122.
    • (1993) Cell , vol.75 , pp. 113-122
    • Klein, R.1    Smeyne, R.J.2    Wurst, W.3    Long, L.K.4    Auerbach, B.A.5    Joyner, A.L.6    Barbacid, M.7
  • 49
    • 61449110124 scopus 로고    scopus 로고
    • Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment
    • Koenen, K.C., Aiello, A.E., Bakshis, E., Amstadter, A.B., Ruggiero, K.J., Acierno, R., Kilpatrick, D.G., Gelernter, J. & Galea, S. (2009) Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment. Am J Epidemiol 169, 704-711.
    • (2009) Am J Epidemiol , vol.169 , pp. 704-711
    • Koenen, K.C.1    Aiello, A.E.2    Bakshis, E.3    Amstadter, A.B.4    Ruggiero, K.J.5    Acierno, R.6    Kilpatrick, D.G.7    Gelernter, J.8    Galea, S.9
  • 50
    • 2342472745 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning
    • Koponen, E., Võikar, V., Riekki, R., Saarelainen, T., Rauramaa, T., Rauvala, H., Taira, T. & Castrén, E. (2004) Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci 26, 166-181.
    • (2004) Mol Cell Neurosci , vol.26 , pp. 166-181
    • Koponen, E.1    Võikar, V.2    Riekki, R.3    Saarelainen, T.4    Rauramaa, T.5    Rauvala, H.6    Taira, T.7    Castrén, E.8
  • 51
    • 0029021177 scopus 로고
    • Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
    • Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H. & Bonhoeffer, T. (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92, 8856-8860.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8856-8860
    • Korte, M.1    Carroll, P.2    Wolf, E.3    Brem, G.4    Thoenen, H.5    Bonhoeffer, T.6
  • 53
    • 35748972690 scopus 로고    scopus 로고
    • Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction
    • Lattal, K.M., Barrett, R.M. & Wood, M.A. (2007) Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci 121, 1125-1131.
    • (2007) Behav Neurosci , vol.121 , pp. 1125-1131
    • Lattal, K.M.1    Barrett, R.M.2    Wood, M.A.3
  • 54
    • 33646340680 scopus 로고    scopus 로고
    • No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder
    • Lee, H., Kang, R., Lim, S., Paik, J., Choi, M., Lee, M. (2006) No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder. Stress Health 22, 115-119.
    • (2006) Stress Health , vol.22 , pp. 115-119
    • Lee, H.1    Kang, R.2    Lim, S.3    Paik, J.4    Choi, M.5    Lee, M.6
  • 55
    • 77957837261 scopus 로고    scopus 로고
    • BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex
    • Lemtiri-Chlieh, F. & Levine, E.S. (2010) BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex. J Neurophysiol 104, 1923-1932.
    • (2010) J Neurophysiol , vol.104 , pp. 1923-1932
    • Lemtiri-Chlieh, F.1    Levine, E.S.2
  • 56
    • 80054705607 scopus 로고    scopus 로고
    • Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala
    • Li, C., Dabrowska, J., Hazra, R. & Rainnie, D.G. (2011)Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS ONE 6, e26065-e26065.
    • (2011) PLoS ONE , vol.6
    • Li, C.1    Dabrowska, J.2    Hazra, R.3    Rainnie, D.G.4
  • 57
    • 68749086071 scopus 로고    scopus 로고
    • Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats
    • Lin, Y., Ter Horst, G.J., Wichmann, R., Bakker, P., Liu, A., Li, X. & Westenbroek, C. (2009) Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats. Cereb Cortex 19, 1978-1989.
    • (2009) Cereb Cortex , vol.19 , pp. 1978-1989
    • Lin, Y.1    Ter Horst, G.J.2    Wichmann, R.3    Bakker, P.4    Liu, A.5    Li, X.6    Westenbroek, C.7
  • 58
    • 4544370251 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning
    • Liu, I.Y.C., Lyons, W.E., Mamounas, L.A. & Thompson, R.F. (2004) Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci 24, 7958-7963.
    • (2004) J Neurosci , vol.24 , pp. 7958-7963
    • Liu, I.Y.C.1    Lyons, W.E.2    Mamounas, L.A.3    Thompson, R.F.4
  • 60
    • 54849426071 scopus 로고    scopus 로고
    • Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    • Lubin, F.D., Roth, T.L. & Sweatt, J.D. (2008) Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci 28, 10576-10586.
    • (2008) J Neurosci , vol.28 , pp. 10576-10586
    • Lubin, F.D.1    Roth, T.L.2    Sweatt, J.D.3
  • 61
    • 80052167615 scopus 로고    scopus 로고
    • Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory
    • Maddox, S.A. & Schafe, G.E. (2011) Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory. Learn Mem 18, 579-593.
    • (2011) Learn Mem , vol.18 , pp. 579-593
    • Maddox, S.A.1    Schafe, G.E.2
  • 62
    • 84855297359 scopus 로고    scopus 로고
    • Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder
    • Mahan, A.L. & Ressler, K.J. (2012) Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci 35, 24-35.
    • (2012) Trends Neurosci , vol.35 , pp. 24-35
    • Mahan, A.L.1    Ressler, K.J.2
  • 64
    • 0032491387 scopus 로고    scopus 로고
    • Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate
    • Marini, A.M., Rabin, S.J., Lipsky, R.H. & Mocchetti, I. (1998)Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem 273, 29394-29399.
    • (1998) J Biol Chem , vol.273 , pp. 29394-29399
    • Marini, A.M.1    Rabin, S.J.2    Lipsky, R.H.3    Mocchetti, I.4
  • 65
    • 17744416410 scopus 로고    scopus 로고
    • Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats
    • Marmigere, F., Givalois, L., Rage, F., Arancibia, S. & Tapia-Arancibia, L. (2003) Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus 13, 646-655.
    • (2003) Hippocampus , vol.13 , pp. 646-655
    • Marmigere, F.1    Givalois, L.2    Rage, F.3    Arancibia, S.4    Tapia-Arancibia, L.5
  • 66
  • 69
    • 0036759627 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo
    • Messaoudi, E., Ying, S.-W., Kanhema, T., Croll, S.D. & Bramham, C.R. (2002) Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J Neurosci 22, 7453-7461.
    • (2002) J Neurosci , vol.22 , pp. 7453-7461
    • Messaoudi, E.1    Ying, S.-W.2    Kanhema, T.3    Croll, S.D.4    Bramham, C.R.5
  • 70
    • 82955229598 scopus 로고    scopus 로고
    • Fear extinction as a model for translational neuroscience: ten years of progress
    • Milad, M.R. & Quirk, G.J. (2012) Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol 63, 129-151.
    • (2012) Annu Rev Psychol , vol.63 , pp. 129-151
    • Milad, M.R.1    Quirk, G.J.2
  • 71
    • 70450196195 scopus 로고    scopus 로고
    • TrkB signalling pathways in LTP and learning
    • Minichiello, L. (2009) TrkB signalling pathways in LTP and learning. Nat Rev Neurosci 10, 850-860.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 850-860
    • Minichiello, L.1
  • 72
    • 0035059960 scopus 로고    scopus 로고
    • Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia
    • Molteni, R., Lipska, B.K., Weinberger, D.R., Racagni, G. & Riva, M.A. (2001) Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia. Mol Psychiatry 6, 285-292.
    • (2001) Mol Psychiatry , vol.6 , pp. 285-292
    • Molteni, R.1    Lipska, B.K.2    Weinberger, D.R.3    Racagni, G.4    Riva, M.A.5
  • 73
    • 77950423490 scopus 로고    scopus 로고
    • Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein
    • Molteni, R., Calabrese, F., Chourbaji, S., Brandwein, C., Racagni, G., Gass, P. & Riva, M.A. (2010) Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein. J Psychopharmacol 24, 595-603.
    • (2010) J Psychopharmacol , vol.24 , pp. 595-603
    • Molteni, R.1    Calabrese, F.2    Chourbaji, S.3    Brandwein, C.4    Racagni, G.5    Gass, P.6    Riva, M.A.7
  • 74
    • 80051934701 scopus 로고    scopus 로고
    • BDNF-TrkB signalling in fear learning: from genetics to neural networks
    • Musumeci, G. & Minichiello, L. (2011) BDNF-TrkB signalling in fear learning: from genetics to neural networks. Rev Neurosci 22, 303-315.
    • (2011) Rev Neurosci , vol.22 , pp. 303-315
    • Musumeci, G.1    Minichiello, L.2
  • 75
    • 33846478897 scopus 로고    scopus 로고
    • Mechanisms of fear extinction
    • Myers, K.M. & Davis, M. (2007) Mechanisms of fear extinction. Mol Psychiatry 12, 120-150.
    • (2007) Mol Psychiatry , vol.12 , pp. 120-150
    • Myers, K.M.1    Davis, M.2
  • 76
    • 78649650201 scopus 로고    scopus 로고
    • Glutamate receptors in extinction and extinction-based therapies for psychiatric illness
    • Myers, K.M., Carlezon, W.A. & Davis, M. (2011) Glutamate receptors in extinction and extinction-based therapies for psychiatric illness. Neuropsychopharmacology 36, 274-293.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 274-293
    • Myers, K.M.1    Carlezon, W.A.2    Davis, M.3
  • 77
    • 77954421126 scopus 로고    scopus 로고
    • The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus
    • Ninan, I., Bath, K.G., Dagar, K., Perez-Castro, R., Plummer, M.R., Lee, F.S. & Chao, M.V. (2010) The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci 30, 8866-8870.
    • (2010) J Neurosci , vol.30 , pp. 8866-8870
    • Ninan, I.1    Bath, K.G.2    Dagar, K.3    Perez-Castro, R.4    Plummer, M.R.5    Lee, F.S.6    Chao, M.V.7
  • 78
    • 74049140846 scopus 로고    scopus 로고
    • Genetics of anxiety and trauma-related disorders
    • Norrholm, S.D. & Ressler, K.J. (2009) Genetics of anxiety and trauma-related disorders. Neuroscience 164, 272-287.
    • (2009) Neuroscience , vol.164 , pp. 272-287
    • Norrholm, S.D.1    Ressler, K.J.2
  • 80
    • 0030176079 scopus 로고    scopus 로고
    • Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    • Patterson, S.L., Abel, T., Deuel, T.A., Martin, K.C., Rose, J.C. & Kandel, E.R. (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16, 1137-1145.
    • (1996) Neuron , vol.16 , pp. 1137-1145
    • Patterson, S.L.1    Abel, T.2    Deuel, T.A.3    Martin, K.C.4    Rose, J.C.5    Kandel, E.R.6
  • 81
    • 77953282058 scopus 로고    scopus 로고
    • Induction of fear extinction with hippocampal-infralimbic BDNF
    • Peters, J., Dieppa-Perea, L.M., Melendez, L.M. & Quirk, G.J. (2010) Induction of fear extinction with hippocampal-infralimbic BDNF. Science 328, 1288-1290.
    • (2010) Science , vol.328 , pp. 1288-1290
    • Peters, J.1    Dieppa-Perea, L.M.2    Melendez, L.M.3    Quirk, G.J.4
  • 82
    • 84855354003 scopus 로고    scopus 로고
    • BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity
    • Rakofsky, J.J., Ressler, K.J. & Dunlop, B.W. (2012) BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity. Mol Psychiatry 17, 22-35.
    • (2012) Mol Psychiatry , vol.17 , pp. 22-35
    • Rakofsky, J.J.1    Ressler, K.J.2    Dunlop, B.W.3
  • 83
    • 2442655323 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning
    • Rattiner, L.M., Davis, M., French, C.T. & Ressler, K.J. (2004a)Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. J Neurosci 24, 4796-4806.
    • (2004) J Neurosci , vol.24 , pp. 4796-4806
    • Rattiner, L.M.1    Davis, M.2    French, C.T.3    Ressler, K.J.4
  • 84
    • 10044289749 scopus 로고    scopus 로고
    • Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning
    • Rattiner, L.M., Davis, M. & Ressler, K.J. (2004b) Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learn Mem 11, 727-731.
    • (2004) Learn Mem , vol.11 , pp. 727-731
    • Rattiner, L.M.1    Davis, M.2    Ressler, K.J.3
  • 85
    • 33749010358 scopus 로고    scopus 로고
    • Neurotrophin-regulated signalling pathways
    • Reichardt, L.F. (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361, 1545-1564.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1545-1564
    • Reichardt, L.F.1
  • 86
    • 4644355629 scopus 로고    scopus 로고
    • Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear
    • Ressler, K.J., Rothbaum, B.O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L. & Davis, M. (2004) Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 61, 1136-1144.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 1136-1144
    • Ressler, K.J.1    Rothbaum, B.O.2    Tannenbaum, L.3    Anderson, P.4    Graap, K.5    Zimand, E.6    Hodges, L.7    Davis, M.8
  • 88
    • 78650169462 scopus 로고    scopus 로고
    • Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear
    • Sierra-Mercado, D., Padilla-Coreano, N. & Quirk, G.J. (2011)Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36, 529-538.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 529-538
    • Sierra-Mercado, D.1    Padilla-Coreano, N.2    Quirk, G.J.3
  • 90
    • 0028970281 scopus 로고
    • Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
    • Smith, M.A., Makino, S., Kvetnansky, R. & Post, R.M. (1995)Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15, 1768-1777.
    • (1995) J Neurosci , vol.15 , pp. 1768-1777
    • Smith, M.A.1    Makino, S.2    Kvetnansky, R.3    Post, R.M.4
  • 92
    • 77749279733 scopus 로고    scopus 로고
    • BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function
    • Spencer, J.L., Waters, E.M., Milner, T.A., Lee, F.S. & McEwen, B.S. (2010) BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function. Proc Natl Acad Sci USA 107, 4395-4400.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4395-4400
    • Spencer, J.L.1    Waters, E.M.2    Milner, T.A.3    Lee, F.S.4    McEwen, B.S.5
  • 94
    • 0034625450 scopus 로고    scopus 로고
    • Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels
    • Tabuchi, A., Nakaoka, R., Amano, K., Yukimine, M., Andoh, T., Kuraishi, Y. & Tsuda, M. (2000) Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels. J Biol Chem 275, 17269-17275.
    • (2000) J Biol Chem , vol.275 , pp. 17269-17275
    • Tabuchi, A.1    Nakaoka, R.2    Amano, K.3    Yukimine, M.4    Andoh, T.5    Kuraishi, Y.6    Tsuda, M.7
  • 95
    • 79952624303 scopus 로고    scopus 로고
    • Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder
    • Takei, S., Morinobu, S., Yamamoto, S., Fuchikami, M., Matsumoto, T. & Yamawaki, S. (2011) Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. J Psychiatr Res 45, 460-468.
    • (2011) J Psychiatr Res , vol.45 , pp. 460-468
    • Takei, S.1    Morinobu, S.2    Yamamoto, S.3    Fuchikami, M.4    Matsumoto, T.5    Yamawaki, S.6
  • 96
    • 79955916306 scopus 로고    scopus 로고
    • Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF
    • Valente, N.L.M., Vallada, H., Cordeiro, Q., Miguita, K., Bressan, R.A., Andreoli, S.B., Mari, J.J. & Mello, M.F. (2011) Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF. J Mol Neurosci 44, 59-67.
    • (2011) J Mol Neurosci , vol.44 , pp. 59-67
    • Valente, N.L.M.1    Vallada, H.2    Cordeiro, Q.3    Miguita, K.4    Bressan, R.A.5    Andreoli, S.B.6    Mari, J.J.7    Mello, M.F.8
  • 97
    • 82955195856 scopus 로고    scopus 로고
    • The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism
    • Wang, Z., Baker, D.G., Harrer, J., Hamner, M., Price, M. & Amstadter, A. (2011) The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism. Depress Anxiety 28, 1067-1073.
    • (2011) Depress Anxiety , vol.28 , pp. 1067-1073
    • Wang, Z.1    Baker, D.G.2    Harrer, J.3    Hamner, M.4    Price, M.5    Amstadter, A.6
  • 99
    • 12344336804 scopus 로고    scopus 로고
    • Neuroprotection in experimental stroke with targeted neurotrophins
    • Wu, D. (2005) Neuroprotection in experimental stroke with targeted neurotrophins. NeuroRx 2, 120-128.
    • (2005) NeuroRx , vol.2 , pp. 120-128
    • Wu, D.1
  • 100
    • 0034666105 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB
    • Xu, B., Gottschalk, W., Chow, A., Wilson, R.I., Schnell, E., Zang, K., Wang, D., Nicoll, R.A., Lu, B. & Reichardt, L.F. (2000) The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J Neurosci 20, 6888-6897.
    • (2000) J Neurosci , vol.20 , pp. 6888-6897
    • Xu, B.1    Gottschalk, W.2    Chow, A.3    Wilson, R.I.4    Schnell, E.5    Zang, K.6    Wang, D.7    Nicoll, R.A.8    Lu, B.9    Reichardt, L.F.10
  • 101
    • 0037646486 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    • Yaka, R., He, D.Y., Phamluong, K. & Ron, D. (2003) Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem 278, 9630-9638.
    • (2003) J Biol Chem , vol.278 , pp. 9630-9638
    • Yaka, R.1    He, D.Y.2    Phamluong, K.3    Ron, D.4
  • 102
    • 21744436272 scopus 로고    scopus 로고
    • Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala
    • Yang, Y.L. & Lu, K.T. (2005) Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala. Neuroscience 134, 247-260.
    • (2005) Neuroscience , vol.134 , pp. 247-260
    • Yang, Y.L.1    Lu, K.T.2
  • 103
    • 58049196879 scopus 로고    scopus 로고
    • The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    • Yasuda, S., Liang, M.H., Marinova, Z., Yahyavi, A. & Chuang, D.M. (2009) The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Mol Psychiatry 14, 51-59.
    • (2009) Mol Psychiatry , vol.14 , pp. 51-59
    • Yasuda, S.1    Liang, M.H.2    Marinova, Z.3    Yahyavi, A.4    Chuang, D.M.5
  • 104
    • 0036523102 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
    • Ying, S.-W., Futter, M., Rosenblum, K., Webber, M.J., Hunt, S.P., Bliss, T.V.P. & Bramham, C.R. (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22, 1532-1540.
    • (2002) J Neurosci , vol.22 , pp. 1532-1540
    • Ying, S.-W.1    Futter, M.2    Rosenblum, K.3    Webber, M.J.4    Hunt, S.P.5    Bliss, T.V.P.6    Bramham, C.R.7
  • 105
  • 107
    • 1842763698 scopus 로고    scopus 로고
    • Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor
    • Zink, M., Otto, C., Zörner, B., Zacher, C., Schütz, G., Henn, F.A. & Gass, P. (2004) Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor. Neuroscience Lett 360, 106-108.
    • (2004) Neuroscience Lett , vol.360 , pp. 106-108
    • Zink, M.1    Otto, C.2    Zörner, B.3    Zacher, C.4    Schütz, G.5    Henn, F.A.6    Gass, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.