Animal models in autoimmune diseases: Lessons learned from mouse models for Sjögren's Syndrome

Clinical Reviews in Allergy and Immunology

Volumn 42, Issue 1, 2012, Pages 35-44

  Lee, Byung Ha ^a   Gauna, Adrienne E ^a   Pauley, Kaleb M ^b   Park, Yun Jong ^a   Cha, Seunghee ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^b CEDARVILLE UNIVERSITY   (United States)

Author keywords

Autoantibodies; Autoimmunity; Mouse models; Sj gren's syndrome; T B lymphocytes

Indexed keywords

AUTOIMMUNE DISEASE; B LYMPHOCYTE; CYTOMEGALOVIRUS; DRY EYE; GENETIC PREDISPOSITION; HUMAN; IMMUNE DYSREGULATION; IMMUNIZATION; LACRIMAL GLAND; LYMPHOCYTIC INFILTRATION; REVIEW; SALIVARY GLAND; SIALOADENITIS; SJOEGREN SYNDROME; XEROSTOMIA;

ANIMALS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; HUMANS; SJOGREN'S SYNDROME;

EID: 84863175416     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-011-8288-5     Document Type: Review

References (78)

1. DW Taebel 1990 The importance of animals in biomedical research Wis Med J 89 155 158
2. SD Wolf BN Dittel F Hardardottir CA Janeway Jr 1996 Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice J exp med 184 2271 2278 8976182 10.1084/jem.184.6.2271 1:STN:280: DyaK2s7jtVCiuw%3D%3D (Pubitemid 27023727)
3. AI Bolstad R Wassmuth HJ Haga R Jonsson 2001 HLA markers and clinical characteristics in Caucasians with primary Sjögren's syndrome J Rheumatol 28 1554 1562 11469461 1:CAS:528:DC%2BD3MXlsVymsrc%3D (Pubitemid 32660627)
4. P Perez JM Anaya S Aguilera, et al. 2009 Gene expression and chromosomal location for susceptibility to Sjögren's syndrome J Autoimmun 33 99 108 19523788 10.1016/j.jaut.2009.05.001 1:CAS:528:DC%2BD1MXpvF2mt7c%3D
5. Y Hu Y Nakagawa KR Purushotham MG Humphreys-Beher 1992 Functional changes in salivary glands of autoimmune disease-prone NOD mice Am J Physiol 263 E607 E614 1415679 1:CAS:528:DyaK3sXht1arsr4%3D
6. MG Humphreys-Beher 1996 Animal models for autoimmune disease-associated xerostomia and xerophthalmia Adv Dent Res 10 73 75 8934930 10.1177/ 08959374960100011501 1:STN:280:DyaK2s%2FovFShsA%3D%3D
7. N Delaleu H Immervoll J Cornelius R Jonsson 2008 Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations Arthritis Res Ther 10 R22 18289371 10.1186/ar2375 (Pubitemid 351386985)
8. N Roescher JL Vosters H Yin GG Illei PP Tak JA Chiorini 2011 Effect of soluble ICAM-1 on a Sjögren's syndrome-like phenotype in NOD mice is disease stage dependent PLoS One 6 e19962 21589878 10.1371/journal.pone.0019962 1:CAS:528:DC%2BC3MXmtlKks74%3D
9. JB Brayer S Cha H Nagashima, et al. 2001 IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren's syndrome Scand J Immunol 54 133 140 11439159 10.1046/j.1365-3083.2001.00958.x 1:CAS:528:DC%2BD3MXltl2ns7k%3D (Pubitemid 32592338)
10. S Cha J Brayer J Gao, et al. 2004 A dual role for interferon-gamma in the pathogenesis of Sjögren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse Scand J Immunol 60 552 565 15584966 10.1111/j.0300-9475. 2004.01508.x 1:CAS:528:DC%2BD2MXjs1OnsL4%3D (Pubitemid 39665100)
11. J Brayer J Lowry S Cha, et al. 2000 Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy J Rheumatol 27 1896 1904 10955330 1:CAS:528:DC%2BD3cXlvFeltr4%3D (Pubitemid 30670483)
12. S Cha H Nagashima VB Brown AB Peck MG Humphreys-Beher 2002 Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background Arthritis Rheum 46 1390 1398 12115247 10.1002/art.10258 1:CAS:528:DC%2BD38XksVynsLk%3D (Pubitemid 34525849)
13. BH Lee MA Tudares CQ Nguyen 2009 Sjögren's syndrome: an old tale with a new twist Arch Immunol Ther Exp 57 57 66 10.1007/s00005-009-0002-4
14. ME Doyle L Boggs R Attia, et al. 2007 Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition Am J Pathol 171 1224 1236 17823290 10.2353/ajpath.2007.070388 1:CAS:528:DC%2BD2sXht1Smtr%2FN (Pubitemid 47582896)
15. C Nguyen J Cornelius E Singson S Killedar S Cha AB Peck 2006 Role of complement and B lymphocytes in Sjögren's syndrome-like autoimmune exocrinopathy of NOD.B10-H2b mice Mol Immunol 43 1332 1339 16221495 10.1016/j.molimm.2005.09.003 1:CAS:528:DC%2BD28XhslKjtb0%3D (Pubitemid 43356373)
16. SJ Killedar SY Killedar SE Eckenrode, et al. 2006 Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis Lab Invest 86 1243 1260 17075579 10.1038/labinvest. 3700487 1:CAS:528:DC%2BD28Xht1akur3N (Pubitemid 44789914)
17. S Cha SC Van Blockland MA Versnel, et al. 2001 Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy Exp Clin Immunogenet 18 143 160 11549844 10.1159/000049194 1:CAS:528: DC%2BD3MXns1aisbc%3D (Pubitemid 32830559)
18. M Bulosan KM Pauley K Yo, et al. 2009 Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset Immunol Cell Biol 87 81 90 18936772 10.1038/icb.2008.70 1:CAS:528:DC%2BD1MXjtF2isA%3D%3D
19. WM Ridgway LB Peterson JA Todd, et al. 2008 Gene-gene interactions in the NOD mouse model of type 1 diabetes Adv Immunol 100 151 175 19111166 10.1016/S0065-2776(08)00806-7
20. L Stojanovich D Marisavljevich 2008 Stress as a trigger of autoimmune disease Autoimmun Rev 7 209 213 18190880 10.1016/j.autrev.2007.11.007
21. N Ishimaru R Arakaki M Watanabe M Kobayashi K Miyazaki Y Hayashi 2003 Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background Am J Pathol 163 1481 1490 14507655 10.1016/S0002-9440(10)63505-5 1:CAS:528:DC%2BD3sXotlegt70%3D (Pubitemid 37175095)
22. Y Ohyama VA Carroll U Deshmukh F Gaskin MG Brown SM Fu 2006 Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjögren's syndrome J Immunol 177 7391 7397 17082658 1:CAS:528:DC%2BD28XhtFGrtrbF (Pubitemid 44715109)
23. LA Lagenaur WC Manning J Vieira CL Martens ES Mocarski 1994 Structure and function of the murine cytomegalovirus sgg1 gene: a determinant of viral growth in salivary gland acinar cells J Virol 68 7717 7727 7966561 1:CAS:528:DyaK2MXitFymtbg%3D (Pubitemid 24362658)
24. VJ Cavanaugh Y Deng MP Birkenbach JS Slater AE Campbell 2003 Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland J Virol 77 1703 1717 12525604 10.1128/JVI.77.3.1703-1717.2003 1:CAS:528:DC%2BD3sXmtFygtw%3D%3D (Pubitemid 36109982)
25. M Fleck ER Kern T Zhou B Lang JD Mountz 1998 Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice Arthritis rheum 41 2175 2184 9870874 10.1002/1529-0131(199812)41:12<2175::AID- ART12>3.0.CO;2-I 1:STN:280:DyaK1M%2Fos1Chsw%3D%3D (Pubitemid 29009375)
26. K Skarstein AH Nerland M Eidsheim JD Mountz R Jonsson 1997 Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosis Scand J Immunol 46 373 378 9350288 10.1046/j.1365-3083.1997.d01-142.x 1:STN:280:DyaK1c%2FhtFelsQ%3D%3D (Pubitemid 27431859)
27. Y Ichikawa K Arimori M Yoshida, et al. 1995 Abnormal expression of apoptosis-related antigens, Fas and bcl-2, on circulating T-lymphocyte subsets in primary Sjögren's syndrome Clin Exp Rheumatol 13 307 313 7554556 1:STN:280:DyaK28%2FksVGgsA%3D%3D
28. M Fleck HG Zhang ER Kern HC Hsu U Muller-Ladner JD Mountz 2001 Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer Arthritis rheum 44 964 973 11315936 10.1002/1529-0131(200104) 44:4<964::AID-ANR154>3.0.CO;2-5 1:CAS:528:DC%2BD3MXpt12lurw%3D (Pubitemid 32319790)
29. CC Whitacre 2001 Sex differences in autoimmune disease Nat Immunol 2 777 780 11526384 10.1038/ni0901-777 1:CAS:528:DC%2BD3MXmsFeiu7w%3D
30. N Ishimaru K Saegusa K Yanagi N Haneji I Saito Y Hayashi 1999 Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis Am J Pathol 155 173 181 10393849 10.1016/S0002-9440(10)65111-5 1:CAS:528:DyaK1MXkslegtLY%3D (Pubitemid 29318715)
31. E Kassi P Moutsatsou CE Sekeris HM Moutsopoulos MN Manoussakis 2003 Oestrogen receptors in cultured epithelial cells from salivary glands of Sjögren's syndrome patients Rheumatology (Oxford) 42 1120 1122 10.1093/rheumatology/keg290 1:STN:280:DC%2BD3szos1ektw%3D%3D (Pubitemid 37221010)
32. H Valimaa S Savolainen T Soukka, et al. 2004 Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands J Endocrinol 180 55 62 14709144 10.1677/joe.0.1800055 1:STN:280:DC%2BD2c%2Fht1OmtA%3D%3D (Pubitemid 38180757)
33. GJ Shim M Warner HJ Kim, et al. 2004 Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjögren's syndrome Proc Natl Acad Sci USA 101 12628 12633 15314222 10.1073/pnas.0405099101 1:CAS:528:DC%2BD2cXnsVentro%3D (Pubitemid 39127516)
34. N Ishimaru R Arakaki F Omotehara, et al. 2006 Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands Mol Cell Biol 26 2924 2935 16581768 10.1128/MCB.26.8.2924-2935.2006 1:CAS:528:DC%2BD28Xjs1Slsbs%3D
35. N Ishimaru R Arakaki S Yoshida A Yamada S Noji Y Hayashi 2008 Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy J exp med 205 2915 2927 19015307 10.1084/jem.20080174 1:CAS:528:DC%2BD1cXhsVClt7jJ
36. R Arakaki N Ishimaru Y Hayashi 2010 Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations Immunotherapy 2 339 346 20635899 10.2217/imt.10.18 1:CAS:528: DC%2BC3cXlvVWmsL4%3D
37. J Groom SL Kalled AH Cutler, et al. 2002 Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome J Clin Invest 109 59 68 11781351 1:CAS:528:DC%2BD38XjtlaktQ%3D%3D (Pubitemid 34052542)
38. M Batten J Groom TG Cachero, et al. 2000 BAFF mediates survival of peripheral immature B lymphocytes J Exp Med 192 1453 1466 11085747 10.1084/jem.192.10.1453 1:CAS:528:DC%2BD3cXotlaisrk%3D
39. CA Fletcher AP Sutherland JR Groom, et al. 2006 Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells Eur J Immunol 36 2504 2514 16906535 10.1002/eji.200636270 1:CAS:528:DC%2BD28XhtVWgs7zI (Pubitemid 44420606)
40. Y Qian J Qin G Cui, et al. 2004 Act1, a negative regulator in CD40- and BAFF-mediated B cell survival Immunity 21 575 587 15485634 10.1016/j.immuni. 2004.09.001 1:CAS:528:DC%2BD2cXpvVygtLg%3D (Pubitemid 39370512)
41. Y Qian N Giltiay J Xiao, et al. 2008 Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome Eur J Immunol 38 2219 2228 18624351 10.1002/eji.200738113 1:CAS:528: DC%2BD1cXhtVCltrjP
42. JL Ambrus Jr J Pippin A Joseph, et al. 1993 Identification of a cDNA for a human high-molecular-weight B-cell growth factor Proc Natl Acad Sci USA 90 6330 6334 8327514 10.1073/pnas.90.13.6330 1:CAS:528:DyaK3sXmtVWntLc%3D (Pubitemid 23191509)
43. L Shen L Suresh H Li, et al. 2009 IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans Clin Immunol 130 304 312 19038581 10.1016/j.clim.2008.10.006 1:CAS:528:DC%2BD1MXhsFKnu78%3D
44. L Shen C Zhang T Wang, et al. 2006 Development of autoimmunity in IL-14alpha-transgenic mice J Immunol 177 5676 5686 17015757 1:CAS:528: DC%2BD28XhtVans7%2FJ
45. L Shen L Suresh J Wu, et al. 2010 A role for lymphotoxin in primary Sjögren's disease J Immunol 185 6355 6363 20952683 10.4049/jimmunol.1001520 1:CAS:528:DC%2BC3cXhtlOhsbbJ
46. CQ Nguyen A Sharma BH Lee JX She RA Mcindoe AB Peck 2009 Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse Arthritis Res Ther 11 R56 19379516 10.1186/ar2676
47. TO Hjelmervik K Petersen I Jonassen R Jonsson AI Bolstad 2005 Gene expression profiling of minor salivary glands clearly distinguishes primary Sjögren's syndrome patients from healthy control subjects Arthritis Rheum 52 1534 1544 15880807 10.1002/art.21006 1:CAS:528:DC%2BD2MXkvFCisrs%3D (Pubitemid 40663945)
48. CP Robinson J Brayer S Yamachika, et al. 1998 Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome Proc Natl Acad Sci USA 95 7538 7543 9636185 10.1073/pnas.95.13.7538 1:CAS:528:DyaK1cXktFChuro%3D (Pubitemid 28293288)
49. CQ Nguyen J-H Gao H Kim DR Saban JG Cornelius AB Peck 2007 IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse J Immunol 179 382 390 17579059 1:CAS:528:DC%2BD2sXmsF2gsrY%3D (Pubitemid 46986555)
50. SC Van Blokland MA Versnel 2002 Pathogenesis of Sjögren's syndrome: characteristics of different mouse models for autoimmune exocrinopathy Clin Immunol 103 111 124 12027416 10.1006/clim.2002.5189 (Pubitemid 34596979)
51. RH Scofield S Asfa D Obeso R Jonsson BT Kurien 2005 Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjögren's syndrome J Immunol 175 8409 8414 16339583 1:CAS:528: DC%2BD2MXht12jt7vI (Pubitemid 41798408)
52. M Iizuka E Wakamatsu H Tsuboi, et al. 2010 Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren's syndrome-like sialoadenitis J Autoimmun 35 383 389 20864316 10.1016/j.jaut.2010.08.004 1:CAS:528:DC%2BC3cXhtlCgtrjK
53. FP Bymaster DL Mckinzie CC Felder J Wess 2003 Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system Neurochem Res 28 437 442 12675128 10.1023/A:1022844517200 1:CAS:528:DC%2BD3sXitFakurk%3D (Pubitemid 36314830)
54. BT Kurien S Asfa C Li Y Dorri R Jonsson RH Scofield 2005 Induction of oral tolerance in experimental Sjögren's syndrome autoimmunity Scand J Immunol 61 418 425 15882433 10.1111/j.1365-3083.2005.01593.x 1:CAS:528:DC%2BD2MXls1amsro%3D (Pubitemid 40695012)
55. M Ohlsson R Jonsson KA Brokstad 2002 Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigens during apoptosis in human ductal epithelial cells: a possible mechanism in the pathogenesis of Sjögren's syndrome Scand J Immunol 56 456 469 12410795 10.1046/j.1365-3083. 2002.01072-79.x 1:CAS:528:DC%2BD38XpsVWjsLY%3D (Pubitemid 35373682)
56. A Espinosa V Dardalhon S Brauner, et al. 2009 Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway J Exp Med 206 1661 1671 19635858 10.1084/jem.20090585 1:CAS:528:DC%2BD1MXps1enurg%3D
57. LJ Dawson PC Fox PM Smith 2006 Sjögrens syndrome-the non-apoptotic model of glandular hypofunction Rheumatology (Oxford) 45 792 798 10.1093/rheumatology/kel067 1:STN:280:DC%2BD28zotlSgsg%3D%3D (Pubitemid 43985364)
58. MS Soyfoo S Steinfeld C Delporte 2007 Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome Oral Dis 13 366 375 17577322 10.1111/j.1601-0825.2007.01376.x 1:STN:280:DC%2BD2szmt1Gnuw%3D%3D (Pubitemid 46934581)
59. A Sakai Y Sugawara T Kuroishi T Sasano S Sugawara 2008 Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18 J Immunol 181 2898 2906 18684981 1:CAS:528:DC%2BD1cXptlOjsb0%3D
60. CQ Nguyen MH Hu Y Li C Stewart AB Peck 2008 Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and mice Arthritis Rheum 58 734 743 18311793 10.1002/art.23214 1:CAS:528:DC%2BD1cXjslWqurc%3D (Pubitemid 351364871)
61. GE Katsifis S Rekka NM Moutsopoulos S Pillemer SM Wahl 2009 Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis Am J Pathol 175 1167 1177 19700754 10.2353/ajpath.2009.090319 1:CAS:528:DC%2BD1MXhtF2isbrN
62. Y Yokota 2001 Id and development Oncogene 20 8290 8298 11840321 10.1038/sj.onc.1205090 1:CAS:528:DC%2BD38XhtVygtr0%3D (Pubitemid 34121899)
63. G Bain CB Cravatt C Loomans J Alberola-Ila SM Hedrick C Murre 2001 Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade Nat Immunol 2 165 171 11175815 10.1038/84273 1:CAS:528: DC%2BD3MXhtVOlsb0%3D (Pubitemid 33707937)
64. L Pan S Sato JP Frederick XH Sun Y Zhuang 1999 Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene Mol Cell Biol 19 5969 5980 10454544 1:CAS:528:DyaK1MXlslSqu78%3D (Pubitemid 29399302)
65. H Li M Dai Y Zhuang 2004 A T cell intrinsic role of Id3 in a mouse model for primary Sjögren's syndrome Immunity 21 551 560 15485632 10.1016/j.immuni.2004.08.013 1:CAS:528:DC%2BD2cXpvVygtLo%3D (Pubitemid 39370510)
66. Z Guo H Li M Han T Xu X Wu Y Zhuang 2011 Modeling Sjögren's syndrome with Id3 conditional knockout mice Immunol Lett 135 34 42 20932862 10.1016/j.imlet.2010.09.009 1:CAS:528:DC%2BC3MXpsFWltA%3D%3D
67. I Hayakawa TF Tedder Y Zhuang 2007 B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice Immunology 122 73 79 17472721 10.1111/j.1365-2567.2007.02614.x 1:CAS:528:DC%2BD2sXhtVehtLzK (Pubitemid 47222597)
68. J Sellam C Miceli-Richard JE Gottenberg, et al. 2008 Is inhibitor of differentiation 3 involved in human primary Sjögren's syndrome? Rheumatology (Oxford) 47 437 441 10.1093/rheumatology/ken013 1:CAS:528:DC%2BD1cXmslKht7g%3D
69. E Fayard G Moncayo BA Hemmings GA Hollander 2010 Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control Sci Signal 3 re5 20716765 10.1126/scisignal.3135re5
70. F Garcon DT Patton JL Emery, et al. 2008 CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer Blood 111 1464 1471 18006698 10.1182/blood-2007-08-108050 1:CAS:528:DC%2BD1cXhvFejurw%3D (Pubitemid 351213434)
71. JS Oak JA Deane MG Kharas, et al. 2006 Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase Proc Natl Acad Sci USA 103 16882 16887 17071741 10.1073/pnas.0607984103 1:CAS:528:DC%2BD28Xht1egurvP (Pubitemid 44737347)
72. DA Fruman G Bismuth 2009 Fine tuning the immune response with PI3K Immunol Rev 228 253 272 19290933 10.1111/j.1600-065X.2008.00750.x 1:CAS:528:DC%2BD1MXhsFGls7vI
73. JJ Hooks HM Moutsopoulos SA Geis NI Stahl JL Decker AL Notkins 1979 Immune interferon in the circulation of patients with autoimmune disease N Engl J Med 301 5 8 449915 10.1056/NEJM197907053010102 1:STN:280:DyaE1M7pvFCgsA%3D%3D (Pubitemid 9226519)
74. D Boumba FN Skopouli HM Moutsopoulos 1995 Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjögren's syndrome Br J Rheumatol 34 326 333 7788146 10.1093/rheumatology/34.4.326 1:STN:280:DyaK2MzgslyrtQ%3D%3D
75. J Gao S Killedar JG Cornelius C Nguyen S Cha AB Peck 2006 Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease J Autoimmun 26 90 103 16413168 10.1016/j.jaut.2005.11.004 1:CAS:528:DC%2BD28XotVCrtA%3D%3D (Pubitemid 43138879)
76. Nguyen CQ, Yin H, Lee BH, Chiorini JA, Peck AB (2011) IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer. Lab Invest 91(1):54-62
77. CQ Nguyen H Yin BH Lee WC Carcamo JA Chiorini AB Peck 2010 Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer Arthritis Res Ther 12 R220 21182786 10.1186/ar3207 1:CAS:528:DC%2BC3MXhtVSjtb4%3D
78. HC Hsu P Yang J Wang, et al. 2008 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice Nat Immunol 9 166 175 18157131 10.1038/ni1552 1:CAS:528:DC%2BD1cXovV2mtQ%3D%3D