Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: Associations with specific autoimmune manifestations

Arthritis Research and Therapy

Volumn 10, Issue 1, 2008, Pages

  Delaleu, Nicolas ^a   Immervoll, Heike ^a,b   Cornelius, Janet ^c   Jonsson, Roland ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; CD40 ANTIGEN; CD40 LIGAND; CHEMOKINE; CYTOKINE; GRANULOCYTE CHEMOTACTIC PROTEIN 2; GROWTH FACTOR; IMMUNOGLOBULIN G3; INTERLEUKIN 18; MUSCARINIC M3 RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG TARGETING; FACTORIAL ANALYSIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HYPOSALIVATION; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SALIVA LEVEL; SALIVARY GLAND FUNCTION; SALIVATION; SIALOADENITIS; SJOEGREN SYNDROME; STRAIN DIFFERENCE; TH2 CELL; ANIMAL; BLOOD; COMPARATIVE STUDY; METABOLISM; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; SALIVA;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BIOLOGICAL MARKERS; CHEMOKINES; CYTOKINES; FACTOR ANALYSIS, STATISTICAL; FEMALE; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SALIVA; SALIVATION; SIALADENITIS; SJOGREN'S SYNDROME;

EID: 40749104950     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2375     Document Type: Article

References (49)

1. Zinkernagel RM Hengartner H On immunity against infections and vaccines: credo 2004 Scand J Immunol 2004, 60:9-13. 10.1111/ j.0300-9475.2004.01460.x 15238068
2. Anderson CC Time, space and contextual models of the immunity tolerance decision: Bridging the geographical divide of Zinkernagel and Hengartner's 'Credo 2004' Scand J Immunol 2006, 63:249-256. 10.1111/ j.1365-3083.2006.01742.x 16623924
3. Cohn M A commentary on the Zinkernagel-Hengartner 'Credo 2004' Scand J Immunol 2005, 62:187-194. 10.1111/j.1365-3083.2005.001561.x 16179004
4. van der Greef J Martin S Juhasz P Adourian A Plasterer T Verheij ER McBurney RN The art and practice of systems biology in medicine: Mapping patterns of relationships J Proteome Res 2007, 6:1540-1559. 10.1021/ pr0606530 17373844
5. Delaleu N Jonsson R Koller MM Sjögren's syndrome Eur J Oral Sci 2005, 113:101-113. 10.1111/j.1600-0722.2004.00183.x 15819815
6. Jonsson R Bowman SJ Gordon T Sjögren's Syndrome Arthritis and Allied Conditions: A Textbook in Rheumatology Philadelphia, PA: Lippencott William & Wilkins Koopman W 15 2005, 2:1681-1706.
7. Robinson CP Brayer J Yamachika S Esch TR Peck AB Stewart CA Peen E Jonsson R Humphreys-Beher MG Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome Proc Natl Acad Sci USA 1998, 95:7538-7543. 22675 9636185 10.1073/ pnas.95.13.7538
8. Dawson LJ Stanbury J Venn N Hasdimir B Rogers SN Smith PM Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells Arthritis Rheum 2006, 54:1165-1173. 10.1002/art.21764 16572451
9. Gao J Cha S Jonsson R Opalko J Peck AB Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assay Arthritis Rheum 2004, 50:2615-2621. 10.1002/art.20371 15334476
10. Delaleu N Jonsson MV Jonsson R Disease mechanisms of Sjögren's syndrome Drug Discovery Today 2004, 1:329-336. 10.1016/ j.ddmec.2004.11.014
11. Fox RI Sjögren's syndrome Lancet 2005, 366:321-331. 10.1016/ S0140-6736(05)66990-5 16039337
12. Cha S Peck AB Humphreys-Beher MG Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: An update Crit Rev Oral Biol Med 2002, 13:5-16. 12097234
13. Jonsson MV Delaleu N Jonsson R Animal models of Sjögren's syndrome Clin Rev Allergy Immunol 2007, 32:215-224. 10.1007/s12016-007-8012-7 17992588
14. Jonsson MV Delaleu N Brokstad KA Berggreen E Skarstein K Impaired salivary gland function in NOD mice: Association with changes in cytokine profile but not with histopathologic changes in the salivary gland Arthritis Rheum 2006, 54:2300-2305. 10.1002/art.21945 16802370
15. Cha S Nagashima H Brown VB Peck AB Humphreys-Beher MG Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background Arthritis Rheum 2002, 46:1390-1398. 10.1002/art.10258 12115247
16. Robinson CP Yamachika S Bounous DI Brayer J Jonsson R Holmdahl R Peck AB Humphreys-Beher MG A novel NOD-derived murine model of primary Sjögren's syndrome Arthritis Rheum 1998, 41:150-156. 10.1002/ 1529-0131(199801)41:1<150::AID-ART18>3.0.CO;2-T 9433880
17. Wicker LS Appel MC Dotta F Pressey A Miller BJ DeLarato NH Fischer PA Boltz RC Jr Peterson LB Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes J Exp Med 1992, 176:67-77. 10.1084/jem.176.1.67 1613467
18. Hayashi Y Utsuyama M Kurashima C Hirokawa K Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice Clin Exp Immunol 1989, 78:120-126. 1534591 2805415
19. Mitsias DI Tzioufas AG Veiopoulou C Zintzaras E Tassios IK Kogopoulou O Moutsopoulos HM Thyphronitis G The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome Clin Exp Immunol 2002, 128:562-568. 1906267 12067313 10.1046/ j.1365-2249.2002.01869.x
20. Nguyen CQ Gao JH Kim H Saban DR Cornelius JG Peck AB IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse J Immunol 2007, 179:382-390. 17579059
21. Mehrad B Keane MP Strieter RM Chemokines as mediators of angiogenesis Thromb Haemost 2007, 97:755-762. 17479186
22. Leiter EH The NOD mouse: As model for insulin-dependent diabetes mellitus Current Protocols in Immunology John Wiley and Sons, Inc. Hoboken, NJ, USA Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W 1997:15.19.11-15.19.23.
23. Gao J Killedar S Cornelius JG Nguyen C Cha S Peck AB Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease J Autoimmun 2006, 26:90-103. 10.1016/j.jaut.2005.11.004 16413168
24. PANTHER Classification System http://www.pantherdb.org
25. Hu S Wang J Meijer J Ieong S Xie Y Yu T Zhou H Henry S Vissink A Pijpe J Kallenberg C Elashoff D Loo JA Wong DT Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome Arthritis Rheum 2007, 56:3588-3600. 10.1002/art.22954 17968930
26. Groom J Kalled SL Cutler AH Olson C Woodcock SA Schneider P Tschopp J Cachero TG Batten M Wheway J Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome J Clin Invest 2002, 109:59-68. 150825 11781351
27. Båve U Nordmark G Lövgren T Ronnelid J Cajander S Eloranta ML Alm GV Rönnblom L Activation of the type I interferon system in primary Sjögren's syndrome: A possible etiopathogenic mechanism Arthritis Rheum 2005, 52:1185-1195. 10.1002/art.20998 15818675
28. Parambil JG Myers JL Lindell RM Matteson EL Ryu JH Interstitial lung disease in primary Sjögren syndrome Chest 2006, 130:1489-1495. 10.1378/chest.130.5.1489 17099028
29. Tu WH Shearn MA Lee JC Hopper J Jr Interstitial nephritis in Sjögren's syndrome Ann Intern Med 1968, 69:1163-1170. 5725733
30. Moutsopoulos HM Balow JE Lawley TJ Stahl NI Antonovych TT Chused TM Immune complex glomerulonephritis in sicca syndrome Am J Med 1978, 64:955-960. 10.1016/0002-9343(78)90449-7 148842
31. Hjelmervik TO Lindqvist AK Petersen K Johannesson M Stavrum AK Johansson A Jonsson R Holmdahl R Bolstad AI The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice Arthritis Res Ther 2007, 9:R99. 2212552 17900348 10.1186/ar2300
32. Larsen MR Jensen SS Jakobsen LA Heegaard NH Exploring the sialiome using titanium dioxide chromatography and mass spectrometry Mol Cell Proteomics 2007, 6:1778-1787. 10.1074/mcp.M700086-MCP200 17623646
33. Fulkerson PC Zimmermann N Hassman LM Finkelman FD Rothenberg ME Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma J Immunol 2004, 173:7565-7574. 15585884
34. Lloyd CM Delaney T Nguyen T Tian J Martinez AC Coyle AJ Gutierrez-Ramos JC CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/ monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo J Exp Med 2000, 191:265-274. 10.1084/jem.191.2.265 10637271
35. Lebre MC Burwell T Vieira PL Lora J Coyle AJ Kapsenberg ML Clausen BE De Jong EC Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: A role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation Immunol Cell Biol 2005, 83:525-535. 10.1111/j.1440-1711.2005.01365.x 16174103
36. Dimitriou ID Kapsogeorgou EK Moutsopoulos HM Manoussakis MN CD40 on salivary gland epithelial cells: High constitutive expression by cultured cells from Sjögren's syndrome patients indicating their intrinsic activation Clin Exp Immunol 2002, 127:386-392. 1906327 11876766 10.1046/j.1365-2249.2002.01752.x
37. Clark LB Foy TM Noelle RJ CD40 and its ligand Adv Immunol 1996, 63:43-78. 8787629
38. Baudino L Azeredo da Silveira S Nakata M Izui S Molecular and cellular basis for pathogenicity of autoantibodies: Lessons from murine monoclonal autoantibodies Springer Semin Immunopathol 2006, 28:175-184. 10.1007/s00281-006-0037-0 16953439
39. Nguyen CQ Kim H Cornelius JG Peck AB Development of Sjögren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/ 6.NOD-Aec1Aec2 mice is dependent on complement component-3 J Immunol 2007, 179:2318-2329. 17675493
40. Quezada SA Bennett K Blazar BR Rudensky AY Sakaguchi S Noelle RJ Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation J Immunol 2005, 175:771-779. 16002673
41. Peguet-Navarro J Dalbiez-Gauthier C Moulon C Berthier O Reano A Gaucherand M Banchereau J Rousset F Schmitt D CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation J Immunol 1997, 158:144-152. 8977185
42. Kok MR Yamano S Lodde BM Wang J Couwenhoven RI Yakar S Voutetakis A Leroith D Schmidt M Afione S Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome Hum Gene Ther 2003, 14:1605-1618. 10.1089/104303403322542257 14633403
43. Saito I Haruta K Shimuta M Inoue H Sakurai H Yamada K Ishimaru N Higashiyama H Sumida T Ishida H Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10 J Immunol 1999, 162:2488-2494. 10072487
44. Zachlederova M Jarolim P Gene expression profiles of microvascular endothelial cells after stimuli implicated in the pathogenesis of vasoocclusion Blood Cells Mol Dis 2003, 30:70-81. 10.1016/ S1079-9796(03)00011-1 12667988
45. Okamoto H Yamamura M Morita Y Harada S Makino H Ota Z The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis Arthritis Rheum 1997, 40:1096-1105. 10.1002/art.1780400614 9182920
46. Olson TS Ley K Chemokines and chemokine receptors in leukocyte trafficking Am J Physiol Regul Integr Comp Physiol 2002, 283:R7-R28. 12069927
47. Strieter RM Gomperts BN Keane MP The role of CXC chemokines in pulmonary fibrosis J Clin Invest 2007, 117:549-556. 1804376 17332882 10.1172/ JCI30562
48. Bodolay E Koch AE Kim J Szegedi G Szekanecz Z Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases J Cell Mol Med 2002, 6:357-376. 10.1111/ j.1582-4934.2002.tb00514.x 12417052
49. Delaleu N Madureira AC Immervoll H Jonsson R Inhibition of experimental Sjögren's syndrome through immunization with heat-shock protein 60 kDa and its peptide aa437-460 Arthritis Rheum 54:2300-2305. 16802370