IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse

Journal of Immunology

Volumn 179, Issue 1, 2007, Pages 382-390

  Nguyen, Cuong Q ^a   Gao, Jue Hua ^b,c   Kim, Hyuna ^a   Saban, Daniel R ^a,d   Cornelius, Janet G ^b   Peck, Ammon B ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD23 ANTIGEN; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STAT6 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DATA ANALYSIS; DIABETES MELLITUS; DRUG MECHANISM; GENE; GENE CONSTRUCT; LACRIMAL GLAND; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALIVARY GLAND; SALIVATION; SJOEGREN SYNDROME; STAT6 GENE; TH2 CELL; XEROPHTHALMIA; XEROSTOMIA;

EID: 34250820366     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.179.1.382     Document Type: Article

References (37)

1. Fox, R. I., and H. I. Kang. 1992. Pathogenesis of Sjögren's syndrome. Rheum. Dis. Clin. North Am. 18: 517-538.
2. Fox, R. I., and P. Michelson. 2000. Approaches to the treatment of Sjögren's syndrome. J. Rheumatol. 61(Suppl.): 15-21.
3. Jonsson, R., H. J. Haga, and T. P. Gordon. 2000. Current concepts on diagnosis, autoantibodies and therapy in Sjögren's syndrome. Scand. J. Rheumatol. 29: 341-348.
4. Vitali, C., S. Bombardieri, R. Jonsson, H. M. Moutsopoulos, E. L. Alexander, S. E. Carsons, T. E. Daniels, P. C. Fox, R. I. Fox, S. S. Kassan, et al. 2002. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheum. Dis. 61: 554-558.
5. Robinson, C. P., J. Brayer, S. Yamachika, T. R. Esch, A. B. Peck, C. A. Stewart, E. Peen, R. Jonsson, and M. G. Humphreys-Beher. 1998. Transfer of human serum IgG to non-obese diabetic Igμ null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome. Proc. Natl. Acad. Sci. USA 95: 7538-7543.
6. Robinson, C. P., S. Yamachika, D. I. Bounous, J. Brayer, R. Jonsson, R. Holmdahl, A. B. Peck, and M. G. Humphreys-Beher. 1998. A novel NOD-derived murine model of primary Sjögren's syndrome. Arthritis Rheum. 41: 150-156.
7. Sugai, S., Y. Masaki, and L. Dong. 2004. Lymphoproliferative disorders in patients with Sjögren's syndrome. Autoimmun. Rev. 3(Suppl. 1): S67-S69.
8. Kino-Ohsaki, J., I. Nishimori, M. Morita, K. Okazaki, Y. Yamamoto, S. Onishi, and M. A. Hollingsworth. 1996. Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome. Gastroenterology 110: 1579-1586.
9. Feist, E., U. Kuckelkorn, T. Dorner, H. Donitz, S. Scheffler, F. Hiepe, P. M. Kloetzel, and G. R. Burmester. 1999. Autoantibodies in primary Sjögren's syndrome are directed against proteasomal subunits of the α and β type. Arthritis. Rheum. 42: 697-702.
10. Billaut-Mulot, O., C. Cocude, V. Kolesnitchenko, M. J. Truong, E. K. Chan, E. Hachula, X. de la Tribonniere, A. Capron, and G. M. Bahr. 2001. SS-56, A novel cellular target of autoantibody responses in Sjögren's syndrome and systemic lupus erythematosus. J. Clin. Invest. 108: 861-869.
11. Harley, J. B., E. L. Alexander, W. B. Bias, O. F. Fox, T. T. Provost, M. Reichlin, H. Yamagata, and F. C. Arnett. 1986. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum. 29: 196-206.
12. Haneji, N., T. Nakamura, K. Takio, K. Yanagi, H. Higashiyama, I. Saito, S. Noji, H. Sugino, and Y. Hayashi. 1997. Identification of α-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science 276: 604-607.
13. Nguyen, K. H., J. Brayer, S. Cha, S. Diggs, U. Yasunari, G. Hilal, A. B. Peck, and M. G. Humphreys-Beher. 2000. Evidence for anti-muscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod mice. Arthritis Rheum. 43: 2297-2306.
14. Gao, J., S. Cha, R. Jonsson, J. Opalko, and A. B. Peck. 2004. Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum. 50: 2615-2621.
15. Waterman, S. A., T. P. Gordon, and M. Rischmueller. 2000. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. Arthritis Rheum. 43: 1647-1654.
16. Cavill, D., S. A. Waterman, and T. P. Gordon. 2003. Antiidiotypic antibodies neutralize autoantibodies that inhibit cholinergic neurotransmission. Arthritis Rheum. 48: 3597-3602.
17. Li, J., Y. M. Ha, N. Y. Ku, S. Y. Choi, S. J. Lee, S. B. Oh, J. S. Kim, J. H. Lee, E. B. Lee, Y. W. Song, and K. Park. 2004. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome. Lab. Invest. 84: 1430-1438.
18. Robinson, C. P., J. Cornelius, D. E. Bounous, H. Yamamoto, M. G. Humphreys-Beher, and A. B. Peck. 1998. Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity 27: 29-44.
19. Gao, J., S. Killedar, J. G. Cornelius, C. Nguyen, S. Cha, and A. B. Peck. 2006. Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J. Autoimmun. 26: 90-103.
20. Brayer, J. B., S. Cha, H. Nagashima, U. Yasunari, A. Lindberg, S. Diggs, J. Martinez, J. Goa, M. G. Humphreys-Beher, and A. B. Peck. 2001. IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren's syndrome. Scand. J. Immunol. 54: 133-140.
21. Nelms, K., A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul. 1999. The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol.17: 701-738.
22. Singh, R. R. 2003. IL-4 and many roads to lupus-like autoimmunity. Clin. Immunol. Immunopathol. 108: 73-79.
23. Linehan, L. A., W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton. 1998. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J. Immunol. 161: 302-310.
24. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signaling. Nature 380: 627-630.
25. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, et al. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380: 630-633.
26. Brayer, J. B., M. G. Humphreys-Beher, and A. B. Peck. 2001. Sjögren's syndrome: immunological response underlying the disease. Arch. Immunol. Ther. Exp. 49: 353-360.
27. Cha, S., A. B. Peck, and M. G. Humphreys-Beher. 2002. Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit. Rev. Oral Biol. Med. 13: 5-16.
28. Jonsson, R., S. J. Dowman, and T. Gordon. 2004. Sjögren's Syndrome. In Arthritis and Allied Conditions - A Textbook in Rheumatology, 15th Ed. W. J. Koopman and L. W. Moreland, eds. Lippincott Williams & Wilkins, Philadelphia, pp. 1681-1705.
29. Pourmand, N., M. Wahren-Herlenius, I. Gunnarsson, E. Svenungsson, B. Lofstrom, Y. Ioannou, D. A. Isenberg, and C. G. Magnusson. 1999. Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with Sjögren's syndrome and systemic lupus erythematosus. Ann. Rheum. Dis. 58: 623-629.
30. Maran, R., M. Dueymes, Y. L. Pennec, R. Casburn-Budd, Y. Shoenfeld, and P. Youinou. 1993. Predominance of IgG1 subclass of anti-Ro/SSA, but not anti-La/SSB antibodies in primary Sjögren's syndrome. J. Autoimmun. 6: 379-387.
31. Aparisi, L., A. Farre, L. Gomez-Cambronero, J. Martinez, G. De Las Heras, J. Corts, S. Navarro, J. Mora, M. Lopez-Hoyos, L. Sabater, et al. 2005. Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis. Gut 54: 703-709.
32. Harley, J. B., E. L. Alexander, W. B. Bias, O. F. Fox, T. T. Provost, M. Reichlin, H. Yamagata, and F. C. Arnett. 1986. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum. 29: 196-206.
33. Cha, S., E. Singson, J. Cornelius, J. P. Yagna, H. J. Knot, and A. B. Peck. 2006. Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren's syndrome-associated autoantibodies. J. Rheumatol. 33: 296-306.
34. Ohnishi, K., F. M. Ebling, B. Mitchell, R. R. Singh, B. H. Hahn, and B. P. Tsao. 1994. Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics. Int. Immunol. 6: 817-830.
35. Takahashi, S., L. Fossati, M. Iwamoto, R. Merino, R. Motta, T. Kobayakawa, and S. Izui. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97: 1597-1604.
36. Kono, D. H., D. Balomenos, M. S. Park, and A. N. Theofilopoulos. 2000. Development of lupus in BXSB mice is independent of IL-4. J. Immunol. 164: 38-42.
37. Singh, R. R., V. Saxena, S. Zang, L. Li, F. D. Finkelman, D. P. Witte, and C. O. Jacob. 2003. Differential contribution of IL-4 and STAT6 vs. STAT4 to the development of lupus nephritis. J. Immunol. 170: 4818-4825.