Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren's syndrome-like sialoadenitis

Journal of Autoimmunity

Volumn 35, Issue 4, 2010, Pages 383-389

  Iizuka, Mana ^a   Wakamatsu, Ei ^a,b   Tsuboi, Hiroto ^a   Nakamura, Yumi ^a,c   Hayashi, Taichi ^a   Matsui, Minoru ^d   Goto, Daisuke ^a   Ito, Satoshi ^a   Matsumoto, Isao ^a   Sumida, Takayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d Tokyo west Tokushukai Hospital   (Japan)

Author keywords

Autoimmune disease; Autoreactive T cells; M3 muscarinic acetylcholine receptor; Sj gren's syndrome

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; MUSCARINIC M3 RECEPTOR; RAG1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CYTOKINE PRODUCTION; HISTOLOGY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INOCULATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALIVARY GLAND; SIALOADENITIS; SJOEGREN SYNDROME; SPLEEN CELL;

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; AUTOANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HUMANS; IMMUNIZATION; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; RECEPTOR, MUSCARINIC M3; SALIVARY GLANDS; SIALADENITIS; SJOGREN'S SYNDROME;

EID: 77958150989     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2010.08.004     Document Type: Article

References (26)

1. Fox R.I., Stern M. Sjögren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand J Rheumatol Suppl 2002, 116:3-13.
2. Adamson T.C., Fox R.I., Frisman D.M., Howell F.V. Immunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal antibodies. J Immunol 1983, 130:203-208.
3. Sumida T., Namekawa T., Maeda T., Nishioka K. New T-cell epitope of Ro/SS-A 52 kD protein in labial salivary glands from patients with Sjögren's syndrome. Lancet 1996, 348:1667.
4. Matsumoto I., Maeda T., Takemoto Y., Hashimoto Y., Kimura F., Iwamoto I., et al. Alpha-amylase functions as a salivary gland-specific self T cell epitope in patients with Sjögren's syndrome. Int J Mol Med 1996, 3:485-490.
5. Sumida T. T cells and autoantigens in Sjögren's syndrome. Mod Rheumatol 2000, 10:193-198.
6. Naito Y., Matsumoto I., Wakamatsu E., Goto D., Sugiyama T., Matsumura R., et al. Muscarinic acetylcholine receptor autoantibodies in patient with Sjögren's syndrome. Ann Rheum Dis 2005, 64:510-511.
7. Dawson L.J., Stanbury J., Venn N., Hasdimir B., Rogers S.N., Smith P.M. Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum 2006, 54:1165-1173.
8. Matsui M., Motomura D., Karasawa H., Fujikawa T., Jiang J., Komiya Y., et al. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA 2000, 97:9579-9584.
9. Bacman S., Berra A., Sterin-Borda L., Borda E. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren's syndrome. Invest Ophthalmol Vis Sc 2001, 742:321-327.
10. Nakamura Y., Wakamatsu E., Matsumoto I., Tomiita M., Kohno Y., Mori M., et al. High prevalence of autoantibodies to muscarinic-3 acetylcholine receptor in patients with juvenile-onset Sjögren syndrome. Ann Rheum Dis 2001, 67:136-137.
11. null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome. Proc Natl Acad Sci USA 1998, 95:7538-7543.
12. Naito Y., Matsumoto I., Wakamatsu E., Goto D., Ito S., Tsutsumi A., et al. Altered peptide ligand regulate muscarinic acetylcholine receptor reactive T cells of patients with Sjögren's syndrome. Ann Rheum Dis 2006, 65:269-271.
13. Amagai M., Tsunoda K., Suzuki H., Nishifuji K., Koyasu S., Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 2000, 105:625-631.
14. Greenspan J.S., Daniels T.E., Talal N., Sylvester R.A. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol 1974, 37:217-229.
15. Skopouli F.N., Fox P.C., Galanopoulou V., Atkinson J.C., Jaffe E.S., Moutsopoulos H.M. T cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjögren's syndrome. J Rheumatol 1991, 18:210-214.
16. Gao J., Cha S., Jonsson R., Opalko J., Peck A.B. Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum 2004, 50:2615-2621.
17. Sumida T., Tsuboi H., Iizuka M., Nakamura Y., Matsumoto I. Functional role of M3 muscarinic acetylcholine receptor (M3R) reactive T cells and anti-M3R autoantibodies in patients with Sjögren's syndrome. Autoimmun Rev 2010, 9:615-617.
18. Sakai A., Sugawara Y., Kuroishi T., Sasano T., Sugawara S. Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol 2008, 181:2898-2906.
19. Nguyen C.Q., Hu M.H., Li Y., Stewart C., Peck A.B. Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome. Arthritis Rheum 2008, 58:734-743.
20. Beroukas D., Goodfellow R., Hiscock J., Jonsson R., Gordon T.P., Waterman S.A. Up-regulation of M3-muscarinic receptors in labial salivary gland acini in primary Sjögren's syndrome. Lab Invest 2002, 82:203-210.
21. Wang F., Jackson M.W., Maughan V., Cavill D., Smith A.J., Waterman S.A., et al. Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder. Arthritis Rheum 2004, 50:3637-3645.
22. Fox R.I., Luppi M., Pisa P., Kang H.I. Potential role of Epstein-Barr virus in Sjögren's syndrome and rheumatoid arthritis. J Rheumatol 1992, 19:18-24.
23. Font J., Tassies D., Garcia-Carrasco M., Ramos-Casals M., Cervera R., Reverter J.C., et al. Hepatitis G virus infection in primary Sjögren's syndrome: analysis in a series of 100 patients. Ann Rheum Dis 1998, 57:42-44.
24. Kamimura T., Sato H., Iwamoto M., Nara H., Torikoe K., Masuyama J., et al. Sjögren's syndrome associated with chronic hepatitis C, severe thrombocytopenia, hypertrophic cardiomyopathy, and diabetes mellitus. Intern Med 2005, 44:657-661.
25. Ohnishi Y., Tsutsumi A., Matsumoto I., Goto D., Ito S., Kuwana M., et al. Altered peptide ligands control type II collagen-reactive T cells from rheumatoid arthritis patients. Mod Rheumatol 2006, 16:226-228.
26. Iwanami K., Matsumoto I., Yoshiga Y., Inoue A., Kondo Y., Yamamoto K., et al. Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide. Arthritis Res Ther 2009, 11:R167.