Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling

Endocrinology

Volumn 147, Issue 7, 2006, Pages 3555-3562

  Löwenberg, Mark ^a   Tuynman, Jurriaan ^a   Scheffer, Meike ^a   Verhaar, Auke ^a   Vermeulen, Louis ^a   Van Deventer, Sander ^a   Hommes, Daniel ^a   Peppelenbosch, Maikel ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DACTINOMYCIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR; MIFEPRISTONE; PEPTIDE; PHOSPHATIDYLINOSITIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE FYN; S6 KINASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORINATION; GENOMICS; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WESTERN BLOTTING;

3T3 CELLS; ADIPOCYTES; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; MICE; PEPTIDES; PHOSPHORYLATION; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 33745131127     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-1602     Document Type: Article

References (33)

1. Amatruda JM, Livingston JN, Lockwood DH 1985 Cellular mechanisms in selected states of insulin resistance: human obesity, glucocorticoid excess, and chronic renal failure. Diabetes Metab Rev 1:293-317
2. Gurwitz JH, Bohn RL, Glynn RJ, Monane M, Mogun H, Avorn J 1994 Glucocorticoids and the risk for initiation of hypoglycemic therapy. Arch Intern Med 154:97-101
3. Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P, Dall'omo AM, Imbimbo B 1983 An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest 72:1814-1820
4. Czech MP, Corvera S 1999 Signaling mechanisms that regulate glucose transport. J Biol Chem 274:1865-1868
5. Chan TO, Rittenhouse SE, Tsichlis PN 1999 AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68:965-1014
6. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR 1994 Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911
7. Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, Macaulay SL 1999 A role for protein kinase Bβ/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol 19:7771-7781
8. Proud CG, Denton RM 1997 Molecular mechanisms for the control of translation by insulin. Biochem J 328:329-341
9. Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, Klip A 1999 Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19:4008-4018
10. White MF 1997 The insulin signalling system and the IRS proteins. Diabetologia 40 (Suppl 2):S2-S17
11. Buren J, Liu HX, Jensen J, Eriksson JW 2002 Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol 146:419-429
12. Turnbow MA, Keller SR, Rice KM, Garner CW 1994 Dexamethasone down-regulation of insulin receptor substrate-1 in 3T3-L1 adipocytes. J Biol Chem 269:2516-2520
13. Diks SH, Kok K, O'Toole T, Hommes DW, van Dijken P, Joore J, Peppelenbosch MP 2004 Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells. J Biol Chem 279:49206-49213
14. Houseman BT, Huh JH, Kron SJ, Mrksich M 2002 Peptide chips for the quantitative evaluation of protein kinase activity. Nat Biotechnol 20:270-274
15. Lowenberg M, Tuynman J, Bilderbeek J, Gaber T, Buttgereit F, van Deventer S, Peppelenbosch M, Hommes D 2005 Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn. Blood 106:1703-1710
16. Croxtall JD, Choudhury Q, Flower RJ 2000 Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 130:289-298
17. Ishibashi K, Imamura T, Sharma PM, Ugi S, Olefsky JM 2000 The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes. Endocrinology 141:4623-4628
18. Rice KM, Garner CW 1999 IGF-I regulates IRS-1 expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 255:614-617
19. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M 2005 IKK-βlinks inflammation to obesity-induced insulin resistance. Nat Med 11:191-198
20. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-βB. Nat Med 11:183-190
21. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
22. Liu G, Rondinone CM 2005 JNK: bridging the insulin signaling and inflammatory pathway. Curr Opin Investig Drugs 6:979-987
23. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM 2005 JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem 280:35361-35371
24. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293:1673-1677
25. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F 2003 Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374:1-20
26. Kamimura D, Ishihara K, Hirano T 2003 IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149:1-38
27. Garvey WT, Huecksteadt TP, Monzon R, Marshall S 1989 Dexamethasone regulates the glucose transport system in primary cultured adipocytes: different mechanisms of insulin resistance after acute and chronic exposure. Endocrinology 124:2063-2073
28. Lundgren M, Buren J, Ruge T, Myrnas T, Eriksson JW 2004 Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes. J Clin Endocrinol Metab 89:2989-2997
29. Saad MJ, Folli F, Araki E, Hashimoto N, Csermely P, Kahn CR 1994 Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone. Mol Endocrinol 8:545-557
30. Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Fujishiro M, Kikuchi M, Oka Y, Asano T 2000 Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes 49:1700-1708
31. Buttgereit F, Scheffold A 2002 Rapid glucocorticoid effects on immune cells. Steroids 67:529-534
32. Cato AC, Nestl A, Mink S 2002 Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE 2002:RE9.
33. Wehling M 1997 Specific, nongenomic actions of steroid hormones. Annu Rev Physiol 59:365-393